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https://www.readbyqxmd.com/read/29913222/a-multifunctional-multimaterial-system-for-on-demand-protein-release
#1
REVIEW
Deniz Ceylan Tuncaboylu, Fabian Friess, Christian Wischke, Andreas Lendlein
In order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29912426/experimental-infection-of-syrian-hamsters-with-aerosolized-nipah-virus
#2
Olivier Escaffre, Terence Hill, Tetsuro Ikegami, Terry L Juelich, Jennifer K Smith, Lihong Zhang, David E Perez, Colm Atkins, Arnold Park, William S Lawrence, Satheesh K Sivasubramani, Jennifer E Peel, Johnny W Peterson, Benhur Lee, Alexander N Freiberg
Background: Nipah virus (NiV) is a paramyxovirus (genus henipavirus) that can cause severe respiratory illness and encephalitis in humans. Transmission occurs through consumption of NiV-contaminated foods, and contact with NiV-infected animals or human body fluids. However, it is unclear whether aerosols derived from aforesaid sources or others also contribute to transmission, and current knowledge on NiV-induced pathogenicity after small particle aerosol exposure is still limited. Methods: infectivity, pathogenicity and real-time dissemination of aerosolized NiV in Syrian hamsters was evaluated using NiV-Malaysia (NiV-M) and/or its recombinant expressing firefly luciferase (rNiV-Fluc NP)...
June 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29912380/update-efficacy-of-military-fluid-intake-guidance
#3
Adam J Luippold, Nisha Charkoudian, Robert W Kenefick, Scott J Montain, Jason K W Lee, Ya Shi Teo, Samuel N Cheuvront
Background: Fluid intake during military training is prescribed based on the interactions among work rates, environmental conditions, and uniform configurations. The efficacy of this guidance has not been empirically assessed in over a decade. To determine the acceptability of the fluid intake guidance, sweat losses were measured in a variety of conditions with modern uniform/body armor configurations and were then compared to prescribed fluid intakes for each condition (workload, environment, clothing)...
April 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29910305/the-three-month-effects-of-a-ketogenic-diet-on-body-composition-blood-parameters-and-performance-metrics-in-crossfit-trainees-a-pilot-study
#4
Wesley C Kephart, Coree D Pledge, Paul A Roberson, Petey W Mumford, Matthew A Romero, Christopher B Mobley, Jeffrey S Martin, Kaelin C Young, Ryan P Lowery, Jacob M Wilson, Kevin W Huggins, Michael D Roberts
Adopting low carbohydrate, ketogenic diets remains a controversial issue for individuals who resistance train given that this form of dieting has been speculated to reduce skeletal muscle glycogen levels and stifle muscle anabolism. We sought to characterize the effects of a 12-week ketogenic diet (KD) on body composition, metabolic, and performance parameters in participants who trained recreationally at a local CrossFit facility. Twelve participants (nine males and three females, 31 ± 2 years of age, 80...
January 9, 2018: Sports (Basel)
https://www.readbyqxmd.com/read/29909931/interventional-radiology-management-of-nonresectable-neoplasia
#5
REVIEW
William T N Culp
Whenever possible, surgical removal of tumors should be pursued because this likely allows for the best possible outcome for a particular patient; however, this may not be pursued for various reasons. In those situations, interventional radiology (IR) options can be considered as definitive therapy or palliation. Locoregional therapies such as intra-arterial chemotherapy and embolization/chemoembolization, while rarely reported in veterinary medicine, offer an alternative minimally invasive treatment option...
June 14, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29909673/risk-of-asphyxiation-from-vernagel-ingestion
#6
L Wickstone, A Shayah, F Agada
Vernagel (sodium polyacrylate) is a powder commonly used in hospitals worldwide for the management and disposal of body fluids. It reacts with fluids to form a semisolid gel. Its main use is to reduce spillages. If ingested, this substance presents significant risk of asphyxiation. There have been 15 reported cases of Vernagel ingestion in 6 years and 1 death from asphyxiation. We present the case of an elderly patient who was admitted following a fall. He accidentally ingested a sachet of Vernagel during the early hours of the morning...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29908646/an-unusual-case-of-suicide-by-methanol-ingestion
#7
Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi, Shin-Ichi Kubo
A female in her late teens purposely ingested alcohol fuel containing methanol to commit suicide, which she admitted on social media. She was found in distress by her parents and died at the hospital some hours later. Autopsy revealed swelling of the brain and edematous and congestive lungs. No other trauma or unusual findings were revealed at autopsy. Methanol was detected upon routine screening for alcohols by headspace gas chromatography with flame-ionization detection. To confirm the presence of methanol and its metabolite formic acid, a method with detection by mass spectrometry was used...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29907291/bifunctional-aptamer-mediated-catalytic-hairpin-assembly-for-the-sensitive-and-homogenous-detection-of-rare-cancer-cells
#8
Jumei Liu, Ye Zhang, Qianwen Zhao, Bo Situ, Jiamin Zhao, Shihua Luo, Bo Li, Xiaohui Yan, Pankaj Vadgama, Lei Su, Wen Ma, Wen Wang, Lei Zheng
The presence of cancer cells in body fluids confirms the occurrence of metastasis and guides treatment. A simple, fast, and homogeneous fluorescent method was developed to detect cancer cells based on catalytic hairpin assembly (CHA) and bifunctional aptamers. The bifunctional aptamer had a recognition domain for binding to target cancer cells and an initiator domain for triggering the CHA reaction. In the presence of target cells, the bifunctional aptamer was released from the inhibitor and initiated a cascade reaction of assembly and disassembly of the hairpins...
October 31, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29906895/energy-dissipation-of-rigid-dipoles-in-a-viscous-fluid-under-the-action-of-a-time-periodic-field-the-influence-of-thermal-bath-and-dipole-interaction
#9
T V Lyutyy, V V Reva
Ferrofluid heating by an external alternating field is studied based on the rigid dipole model, where the magnetization of each particle in a fluid is supposed to be firmly fixed in the crystal lattice. Equations of motion, employing Newton's second law for rotational motion, the condition of rigid body rotation, and the assumption that the friction torque is proportional to angular velocity are used. This oversimplification permits us to expand the model easily: to take into account the thermal noise and interparticle interaction that allows us to estimate from unified positions the role of thermal activation and dipole interaction in the heating process...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906569/salival-%C3%AE-iduronidase-activity-as-a-potential-new-biomarker-for-the-diagnosis-and-monitoring-the-effect-of-therapy-in-mucopolysaccharidosis-i
#10
Jaap van Doorn, Brigitte T A van den Broek, Ans J Geboers, Gé-Ann Kuiper, J J Boelens, Peter M van Hasselt
Although disease progression in Mucopolysaccharidosis I (MPS-1) can be attenuated by hematopoietic cell transplantation (HCT), it is increasingly recognized that residual disease is substantial. Biomarkers that would allow us to evaluate the efficacy of HCT (and upcoming new therapies) in non-hematological tissues are needed. Current biomarkers, including the iduronidase (IDUA) activity in leukocytes, are not suitable for this purpose as they are assessed in tissues of hematological origin and may not reflect enzyme availability in non-hematologic tissues...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29906408/the-potential-for-liquid-biopsies-in-head-and-neck-cancer
#11
Matthew E Spector, Janice L Farlow, Catherine T Haring, J Chad Brenner, Andrew C Birkeland
Head and neck cancers consist of a heterogeneous group of cancers that are difficult to treat successfully. Limited screening options result in patients being diagnosed at advanced stages at presentation, and difficulty with treatment options and post-treatment surveillance can lead to poor outcomes. In this setting, tools for early and precise detection of disease will be highly valuable. Liquid biopsies, or use of analytes in blood, saliva, and other body fluid samples, provide new avenues for cancer screening with the potential for early detection, treatment modification, and surveillance of head and neck cancers...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29905804/relationship-between-postmortem-urine-and-blood-concentrations-of-ghb-furnishes-useful-information-to-help-interpret-drug-intoxication-deaths
#12
A W Jones, A Holmgren, F C Kugelberg, F P Busardò
This article reports the concentrations of gamma-hydroxybutyrate (GHB) in femoral blood and bladder urine in a case series of drug intoxication deaths (N = 37). GHB was determined in blood (B-GHB) and urine (U-GHB) by a GC-FID-GBL method and 30 mg/L was used as a cut-off concentration for reporting positive results. The mean (median) and range of GHB concentrations in bladder urine were 2,818 mg/L (1,900 mg/L) and 120-13,000 mg/L, respectively. These concentrations were appreciably higher than those in femoral blood, 637 mg/L (260 mg/L) and 30-9,200 mg/L, respectively...
June 14, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29905601/huge-bursitis-and-bursal-synovial-osteochondromatosis-associated-with-scapular-osteochondroma-mimicking-a-giant-calcific-mass-of-the-chest-wall-a-case-report
#13
Kutsi Tuncer, Emine Izgi, Bahar Cankaya, Hayri Ogul, Mecit Kantarci
Osteochondroma is the most common benign bone tumor but it rarely arises from the scapula. Scapulothoracic bursitis is quite rare and osteochondroma is one of the unusual causes of this condition. Synovial chondromatosis may occur extremely uncommonly in this bursa. We reported an unusual case of scapulothoracic bursitis with synovial chondromatosis which is caused by osteochondroma. To the best of our knowledge, there is no defined chondromatosis in the scapulothoracic bursa secondary to scapular osteochondroma in the literature...
June 13, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29904278/salivary-exosomes-emerging-roles-in-systemic-disease
#14
REVIEW
Yineng Han, Lingfei Jia, Yunfei Zheng, Weiran Li
Saliva, which contains biological information, is considered a valuable diagnostic tool for local and systemic diseases and conditions because, similar to blood, it contains important molecules like DNA, RNA, and proteins. Exosomes are cell-derived vesicles 30-100 nm in diameter with substantial biological functions, including intracellular communication and signalling. These vesicles, which are present in bodily fluids, including saliva, are released upon fusion of multivesicular bodies (MVBs) with the cellular plasma membrane...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29903999/high-throughput-identification-of-mammalian-secreted-proteins-using-species-specific-scheme-and-application-to-human-proteome
#15
Jian Zhang, Haiting Chai, Song Guo, Huaping Guo, Yanling Li
Secreted proteins are widely spread in living organisms and cells. Since secreted proteins are easy to be detected in body fluids, urine, and saliva in clinical diagnosis, they play important roles in biomarkers for disease diagnosis and vaccine production. In this study, we propose a novel predictor for accurate high-throughput identification of mammalian secreted proteins that is based on sequence-derived features. We combine the features of amino acid composition, sequence motifs, and physicochemical properties to encode collected proteins...
June 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29903984/bolus-ingestion-of-whey-protein-immediately-post-exercise-does-not-influence-rehydration-compared-to-energy-matched-carbohydrate-ingestion
#16
Gethin H Evans, Lewis Mattin, Isabelle Ireland, William Harrison, Adora M W Yau, Victoria McIver, Tristan Pocock, Elizabeth Sheader, Lewis J James
Whey protein is a commonly ingested nutritional supplement amongst athletes and regular exercisers; however, its role in post-exercise rehydration remains unclear. Eight healthy male and female participants completed two experimental trials involving the ingestion of 35 g of whey protein (WP) or maltodextrin (MD) at the onset of a rehydration period, followed by ingestion of water to a volume equivalent to 150% of the amount of body mass lost during exercise in the heat. The gastric emptying rates of the solutions were measured using 13 C breath tests...
June 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29903422/efficacy-of-bladder-irrigation-in-preventing-urinary-tract-infections-associated-with-short-term-catheterization-in-comatose-patients-a-randomized-controlled-clinical-trial
#17
Farahnaz Ramezani, Mahnaz Khatiban, Farshid Rahimbashar, Ali Reza Soltanian
BACKGROUND: Bladder irrigation can be performed to prevent catheter-associated urinary tract infections (CAUTI), but its efficacy has been not reported in short-term indwelling urinary catheterization. This clinical trial aimed to examine the efficacy of bladder irrigation with normal saline solution in preventing CAUTI in comatose patients admitted to intensive care units. MATERIALS AND METHODS: Eligible patients were randomized to the experimental group or control group...
June 11, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29902505/short-term-heat-exposure-promotes-hippocampal-neurogenesis-via-activation-of-angiotensin-ii-type-1-receptor-in-adult-rats
#18
Yuka Koyama, Takao Mukuda, Sawako Hamasaki, Hironobu Nakane, Toshiyuki Kaidoh
Angiotensin II (Ang II) synthesized in response to body fluid loss caused by actions such as sweating and breathing is today considered as one of the essential factors for promoting hippocamal neurogenesis. Because heat-stimuli, along with exercise, increases systemic levels of Ang II, the effects of short-term heat exposure on hippocampal neurogenesis were examined in adult male rats. When rats were exposed daily to a 1 h heat treatment (36.0 ± 0.1°C) during a 7 d experimental period, the number of doublecortin-immunoreactive newborn cells in the hippocampal dentate gyrus was increased approximately 1...
June 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29902339/dirofilaria-repens-an-etiological-factor-or-an-incidental-finding-in-cytologic-and-histopathologic-biopsies-from-dogs
#19
Katarzyna Paździor-Czapula, Iwona Otrocka-Domagała, Patrycja Myrdek, Mateusz Mikiewicz, Michał Gesek
Dirofilaria repens is an endemic, zoonotic parasite of carnivores, causing subcutaneous dirofilariasis, which is mostly asymptomatic. The aim of this study was to describe 22 cases of canine subcutaneous dirofilariasis. The cytologic and histopathologic samples were collected from dogs, which presented with various clinical signs such as cutaneous/subcutaneous nodules, hydropericardium, ascites, and lymphadenomegaly. The cytologic or histopathologic examination revealed purulent, pyogranulomatous, granulomatous or eosinophilic dermatitis/panniculitis, and the presence of D repens microfilariae or adults...
June 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29901801/a-survey-of-temperature-management-practices-among-burn-centers-in-north-america
#20
Kaitlin A Pruskowski, Julie A Rizzo, Beth A Shields, Rodney K Chan, Ian R Driscoll, Matthew P Rowan, Kevin K Chung
Maintaining body temperature is a unique challenge with burn care. We sought to describe core temperature goals in the operating room (OR) and the methods used to achieve and maintain these goals, along with current methods of warming in the intensive care unit (ICU), the perception of effect of increased ambient temperature on work performance, and concerns with contamination of sterile fields due to increased ambient temperature. A 24 question survey was disseminated to burn centers in the United States and Canada...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
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