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https://www.readbyqxmd.com/read/29040465/the-fut2-secretor-variant-p-trp154ter-influences-serum-vitamin-b12-concentration-via-holo-haptocorrin-but-not-holo-transcobalamin-and-is-associated-with-haptocorrin-glycosylation
#1
Aneliya Velkova, Jennifer E L Diaz, Faith Pangilinan, Anne M Molloy, James L Mills, Barry Shane, Erica Sanchez, Conal Cunningham, Helen McNulty, Cheryl D Cropp, Joan E Bailey-Wilson, Alexander F Wilson, Lawrence C Brody
Vitamin B12 deficiency is common in older individuals. Circulating vitamin B12 concentration can be used to diagnose deficiency but this test has substantial false positive and false negative rates. We conducted genome-wide association studies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properties. We replicated reported associations between total circulating vitamin B12 concentrations and a common null variant in FUT2...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29040221/thermoeffector-responses-at-a-fixed-rate-of-heat-production-in-heart-failure-patients
#2
Bryce N Balmain, Ollie Jay, Norman R Morris, Kenji Shiino, Glenn M Stewart, Rohan Jayasinghe, Jonathan Chan, Surendran Sabapathy
PURPOSE: Heart failure (HF) patients appear to exhibit altered thermoregulatory responses during exercise in the heat. However, the extent to which these responses are altered due to physiological impairments independently of biophysical factors associated with differences in metabolic heat production (Hprod), evaporative heat balance requirements (Ereq) and/or body size, is presently unclear. Therefore, we examined thermoregulatory responses in 10 HF and 10 age-matched controls (CON) similar in body size during exercise at a fixed rate of Hprod, and therefore Ereq in a 30°C environment...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29036952/-a-clinical-analysis-of-20-patients-with-neurobrucellosis
#3
Y Ge, H Z Guan, S Y Fan, R Zhu, X J Ma, T S Li
Objective: To investigate the epidemiological and clinical features of 20 patients with neurobrucellosis (NB) . Methods: The epidemiological, clinical, laboratory and treatment data of patients diagnosed with NB from 2010 to 2016 in Peking Union Medical College Hospital were retrospectively analyzed. Results: Twelve (60%) patients reported the history of contact with infected animals and intake of raw milk product. The common manifestations included headache (85%, 17/20), fatigue (85%, 17/20), fever (80%, 16/20), weight loss (70%, 15/20), the signs included pathological reflection (70%, 15/20), decreased muscle strength(45%, 9/20)...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036882/biomineralization-of-fucoidan-peptide-blends-and-their-potential-applications-in-bone-tissue-regeneration
#4
Harrison T Pajovich, Ipsita A Banerjee
Fucoidan (Fuc), a natural polysaccharide derived from brown seaweed algae, and gelatin (Gel) were conjugated to form a template for preparation of biomimetic scaffolds for potential applications in bone tissue regeneration. To the Fuc-Gel we then incorporated the peptide sequence MTNYDEAAMAIASLN (MTN) derived from the E-F hand domain, known for its calcium binding properties. To mimic the components of the extracellular matrix of bone tissue, the Fuc-Gel-MTN assemblies were incubated in simulated body fluid (SBF) to induce biomineralization, resulting in the formation of β-tricalcium phosphate, and hydroxyapatite (HAp)...
September 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29036747/prevention-of-multidrug-resistant-infections-from-contaminated-duodenoscopes-position-statement-of-the-european-society-of-gastrointestinal-endoscopy-esge-and-european-society-of-gastroenterology-nurses-and-associates-esgena
#5
Ulrike Beilenhoff, Holger Biering, Reinhard Blum, Jadranka Brljak, Monica Cimbro, Jean-Marc Dumonceau, Cesare Hassan, Michael Jung, Christiane Neumann, Michael Pietsch, Lionel Pineau, Thierry Ponchon, Stanislav Rejchrt, Jean-François Rey, Verona Schmidt, Jayne Tillett, Jeanin van Hooft
Patients should be informed about the benefits and risks of endoscopic retrograde cholangiopancreatography (ERCP)Only specially trained and competent personnel should carry out endoscope reprocessing.Manufacturers of duodenoscopes should provide detailed instructions on how to use and reprocess their equipment.In the case of modifications to their equipment, manufacturers should provide updated instructions for use.Detailed reprocessing protocols based on the manufacturer's instructions for use should clearly lay out the different reprocessing steps necessary for each endoscope model...
October 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/29036520/lung-specific-overexpression-of-constitutively-active-ikk2-induces-pulmonary-and-systemic-inflammations-but-not-hypothalamic-inflammation-and-glucose-intolerance
#6
Minjie Chen, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Ziying Hu, Xiaobo Qin, Sufang Chen, Yuhao Zhang, Qi Cao, Yousef Abu-Amer, Zhekang Ying
The lung is constantly exposed to ambient pollutants such as ambient fine particulate matter (PM2.5), making it one of the most frequent locations of inflammation in the body. Given the establishment of crucial role of inflammation in the pathogenesis of cardiometabolic diseases, pulmonary inflammation is thus widely believed to be an important risk factor for cardiometabolic diseases. However, the causality between them has not yet been well established. To determine if pulmonary inflammation is sufficient to cause adverse cardiometabolic effects, SFTPC-rtTA+/-tetO-cre+/-pROSA-inhibitor κB kinase 2(IKK2)ca+/- (LungIKK2ca) and littermate SFTPC-rtTA+/-tetO-cre-/-pROSA-IKK2ca+/- wildtype (WT) mice were fed with doxycycline diet to induce constitutively active Ikk2 (Ikk2ca) overexpression in the lung and their pulmonary, systemic, adipose, and hypothalamic inflammations, vascular function, and glucose homeostasis were assessed...
July 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29036351/mirandola-2017-a-curated-knowledge-base-of-non-invasive-biomarkers
#7
Francesco Russo, Sebastiano Di Bella, Federica Vannini, Gabriele Berti, Flavia Scoyni, Helen V Cook, Alberto Santos, Giovanni Nigita, Vincenzo Bonnici, Alessandro Laganà, Filippo Geraci, Alfredo Pulvirenti, Rosalba Giugno, Federico De Masi, Kirstine Belling, Lars J Jensen, S Ren Brunak, Marco Pellegrini, Alfredo Ferro
miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29035737/rethinking-liquid-biopsy-microfluidic-assays-for-mobile-tumor-cells-in-human-body-fluids
#8
REVIEW
Kuang Hong Neoh, Ayon Ahmed Hassan, Anqi Chen, Yukun Sun, Peng Liu, Kai-Feng Xu, Alice S T Wong, Ray P S Han
Traditionally, liquid biopsy is a blood test involving the harvesting of tumor materials from peripheral blood. Tumor cells from non-blood body fluids have always been clinically available in cytological examinations but limited for use in differential diagnosis due to the low sensitivity of conventional cytopathology. With the recent significant progress in microfluidic and downstream molecular technologies, liquid biopsies have now evolved to include harvesting tumor cells and DNA fragments in all kinds of non-blood body fluids...
October 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/29035657/evaluation-of-mortality-rate-and-predictors-of-outcome-in-dogs-receiving-outpatient-treatment-for-parvoviral-enteritis
#9
Kathryn J Sarpong, Jennifer M Lukowski, Cassandra G Knapp
OBJECTIVE To determine mortality rates and prognostic factors for dogs with parvoviral enteritis receiving outpatient treatment. DESIGN Retrospective case series and case-control study. ANIMALS 130 client-owned dogs with a diagnosis of parvoviral enteritis between August 1, 2012, and January 31, 2015, that were treated with outpatient care. PROCEDURES Medical records were reviewed and data extracted regarding dog age, body weight, breed, and vaccination history; treatments administered; and short-term (≥ 3 day) outcome (determined via telephone call with owner)...
November 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29035153/acute-and-chronic-kidney-injury-in-a-non-human-primate-model-of-partial-body-irradiation-with-bone-marrow-sparing
#10
Eric P Cohen, Kim G Hankey, Alexander W Bennett, Ann M Farese, George A Parker, Thomas J MacVittie
The development of medical countermeasures against acute and delayed multi-organ injury requires animal models predictive of the human response to radiation and its treatment. Late chronic injury is a well-known feature of radiation nephropathy, but acute kidney injury has not been reported in an appropriate animal model. We have established a single-fraction partial-body irradiation model with minimal marrow sparing in non-human primates. Subject-based medical management was used including parenteral fluids according to prospective morbidity criteria...
October 16, 2017: Radiation Research
https://www.readbyqxmd.com/read/29034844/microrna-cancer-and-diet-facts-and-new-exciting-perspectives
#11
Maria Letizia Motti, Stefania D'Angelo, Rosaria Meccariello
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs able to regulate gene expression at multiple levels. They are detected in tissues, blood, and other body fluids with high stability and have a recognized role in the maintaining of tissue homeostasis. Aberrant expression profile of miRNAs has been observed in several diseases, primarily cancer. As a consequence, the analysis of miRNA signature has recognized diagnostic and prognostic role in human diseases, and the development of miRNA-based therapies is currently under investigation...
October 13, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29033926/micrornas-in-taenia-solium-neurocysticercosis-insights-as-promising-agents-in-host-parasite-interaction-and-their-potential-as-biomarkers
#12
REVIEW
Renzo Gutierrez-Loli, Miguel A Orrego, Oscar G Sevillano-Quispe, Luis Herrera-Arrasco, Cristina Guerra-Giraldez
MicroRNAs (miRNAs) are short, endogenous, non-coding, single-stranded RNAs involved in post-transcriptional gene regulation. Although, several miRNAs have been identified in parasitic helminths, there is little information about their identification and function in Taenia. Furthermore, the impact of miRNAs in neurocysticercosis, the brain infection caused by larvae of Taenia solium is still unknown. During chronic infection, T. solium may activate numerous mechanisms aimed to modulate host immune responses...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033487/gingival-hyperplasia-should-drug-interaction-be-blamed-for
#13
Pramod Kumar Sharma, Arup Kumar Misra, Ankita Chugh, Vinay Kumar Chugh, Nitesh Gonnade, Surjit Singh
Gingival overgrowth (GO) is one of the common findings in clinical practice. There could be several causes including drugs associated with the GO. Carbamazepine (CBZ) and amlodipine are the drugs which are infrequently documented as a cause in inducing the gingival hyperplasia. Certain drugs in the body fluid might limit the population of plaque bacteria and alter their metabolism that in turn induce the inflammatory mediators and also activate the genetic and biochemical factors responsible for gingival fibroblast growth...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29033398/intensive-education-of-health-care-workers-improves-the-outcome-of-ebola-virus-disease-lessons-learned-from-the-2014-outbreak-in-sierra-leone
#14
Tracey Elizabeth Claire Jones-Konneh, Aya Murakami, Hiroyuki Sasaki, Shinichi Egawa
The rare and deadly Ebola virus disease (EVD) is caused by Ebola virus (EBOV) infection. The 2014-2015 EVD outbreak in West Africa was unprecedented. Person-to-person transmission of EBOV by direct contact with the body or bodily fluids of an infected person through broken skin or unprotected mucous membrane caused rapid outbreak in communities. Nosocomial infection was the cause of death of many health care workers (HCWs). This paper aims to reveal the importance and effect of intensive education of HCWs when combating an outbreak such as EVD...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29032047/reactivation-of-peroxidase-activity-in-human-saliva-samples-by-polyphenols
#15
Jana Gau, Jürgen Arnhold, Jörg Flemmig
OBJECTIVES: The enzyme lactoperoxidase (LPO), which is released into several body fluids like saliva, is an essential part to maintain the oral bacterial homeostasis by catalysing the oxidation of thiocyanate (SCN(-)) to hypo-thiocyanite ((-)OSCN). The formation of unreactive redox intermediates (like Compound II) leads to a decreased pseudo-halogenating enzyme activity, which is associated with a higher risk for oral infections. According to former studies with bovine LPO selected flavonoids were tested in respect to their potential to reactivate the enzymatic activity in a more physiological, human salivary system...
October 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29031608/steroidogenesis-unanswered-questions
#16
REVIEW
Walter L Miller
Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid structures and measuring steroid concentrations in body fluids. The molecular biology revolution radically revolutionized studies of steroidogenesis with the cloning of known steroidogenic enzymes, by identifying novel factors, and delineating the genetic basis of known and newly discovered diseases. Unfortunately, this dramatic success has led many young research-oriented endocrinologists to regard steroidogenesis as a 'solved area'...
October 11, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29031578/short-term-exposure-to-bisphenol-a-affects-water-and-salt-intakes-differently-in-male-and-ovariectomised-female-rats
#17
Paula Nuñez, Juan Arguelles, Carmen Perillan
Thirst and sodium appetite are motivational states that lead to the search for and ingestion of water and sodium, thus contributing to maintenance of hydromineral balance. Oestrogens affect fluid intake and sodium preference. Bisphenol A (BPA) is an environmental endocrine-disrupting substance with oestrogenic activity. Whether there are sex differences in the ingestive effects of BPA is unknown. Therefore, the aim of the present work was to determine the effect of short-term treatment of low doses of BPA on thirst and sodium appetite in adult male and ovariectomised Wistar rats...
October 12, 2017: Appetite
https://www.readbyqxmd.com/read/29031206/inhibitory-effect-of-triperygium-wilfordii-polyglucoside-on-dipeptidyl-peptidase-i-in-vivo-and-in-vitro
#18
Jingjing Wang, Yi Chu, Xiaoying Zhou
BACKGROUD: Dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease is derived from granule immune cells including mast cell, neutrophils, and toxicity T cells. DPPI can activate serine proteases by removal of dipeptides from N-termini of the pro-proteases, resulting in granule immune cells activation which involved in physiological or pathological responses. Triperygium Wilfordii Polyglucoside (TWP) is one of the traditional Chinese medicines, and commonly used in rheumatoid arthritis (RA) treatment...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030761/monitoring-the-effects-of-a-lepidopteran-insecticide-flubendiamide-on-the-biology-of-a-non-target-dipteran-insect-drosophila-melanogaster
#19
Saurabh Sarkar, Sumedha Roy
Various organisms are adversely affected when subjected to chronic fluoride exposure. This highly electronegative ion present in several insecticide formulations is found to be lethal to target pests. In the present study, Drosophila melanogaster is treated with sub-lethal concentrations of a diamide insecticide formulation, Flubendiamide. Chronic exposure to the diamide (0.5-100 μg/mL) was found to be responsible for increase in fluoride ion concentration in larval as well as adult body fluid. Interestingly, 100 μg/mL Flubendiamide exposure resulted in 107 and 298% increase in fluoride ion concentration whereas only 23 and 52% of Flubendiamide concentration increase in larval and adult body fluid, respectively...
October 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29030727/-parenteral-nutrition-in-premature-babies-with-a-birth-weight-1500g-a%C3%A2-systematic-single-center-analysis-and-comparison-with-current-guidelines
#20
Melanie Sirch, Martin Poryo, Mona Butte, Ulrike Lindner, Ludwig Gortner, Michael Zemlin, Holger Nunold, Sascha Meyer
BACKGROUND: Parenteral and enteral nutrition are essential for both growth and development of preterm infants. Based on the results of many studies, the rate of nutritional growth and the amount of substrate delivered parenterally are under debate. OBJECTIVE: The main aim of this study was to assess parenteral nutrition in very and extremely immature preterm infants, i.e. very low birth weight (VLBW, birth weight <1500g) and extremely low birth weight (ELBW, birth weight <1000g) neonates, and to compare the amount of parenterally delivered substrate in our neonatal intensive care unit (NICU) to current German guidelines...
October 13, 2017: Wiener Medizinische Wochenschrift
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