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Pneumococcal invasive disease

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https://www.readbyqxmd.com/read/28101913/nasopharyngeal-colonization-with-streptococcus%C3%A2-pneumoniae-triggers-dendritic-cell-dependent-antibody-responses-against-invasive-disease-in-mice
#1
Anne Dommaschk, Nadine Ding, Meritxell Tort Tarres, Lara F Bittersohl, Regina Maus, Jennifer Stolper, Danny Jonigk, Peter Braubach, Torsten Lippmann, Tobias Welte, Ulrich A Maus
Nasopharyngeal colonization with Streptococcus pneumoniae (Spn) is an important precondition for the development of pneumococcal pneumonia. At the same time, nasopharyngeal colonization with Spn has been shown to mount adaptive immune responses against Spn in mice and humans. Cellular responses of the nasopharyngeal compartment, including the nasal-associated lymphoid tissue (NALT), to pneumococcal colonization and their importance for developing adaptive immune responses are poorly defined. We show that nasopharyngeal colonization with S...
January 19, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28100596/genomic-epidemiology-of-penicillin-non-susceptible-pneumococci-with-non-vaccine-serotypes-causing-invasive-disease-in-the-usa
#2
Cheryl P Andam, Patrick K Mitchell, Alanna Callendrello, Qiuzhi Chang, Jukka Corander, Chrispin Chaguza, Lesley McGee, Bernard W Beall, William P Hanage
Conjugate vaccination against seven pneumococcal serotypes (PCV7) reduced disease prevalence due to antibiotic resistant strains throughout the 2000s; however, disease caused by resistant non-vaccine type (NVT) strains increased. Some of these emerging strains were derived from vaccine types (VT) that had changed their capsule by recombination. The introduction of vaccine targeting 13 serotypes (PCV13) in 2010 has led to concern that this scenario will repeat itself. We generated high quality draft genomes from 265 isolates of NVT pneumococci not susceptible to penicillin (PNSP) in 2009 and compared them with 581 isolates from 2012-2013, collected by the Active Bacterial Core surveillance (ABCs) of the Centers for Disease Control and Prevention (CDC)...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28096486/phage-derived-protein-induces-increased-platelet-activation-and-is-associated-with-mortality-in-patients-with-invasive-pneumococcal-disease
#3
Rahajeng N Tunjungputri, Fredrick M Mobegi, Amelieke J Cremers, Christa E van der Gaast-de Jongh, Gerben Ferwerda, Jacques F Meis, Nel Roeleveld, Stephen D Bentley, Alexander S Pastura, Sacha A F T van Hijum, Andre J van der Ven, Quirijn de Mast, Aldert Zomer, Marien I de Jonge
: To improve our understanding about the severity of invasive pneumococcal disease (IPD), we investigated the association between the genotype of Streptococcus pneumoniae and disease outcomes for 349 bacteremic patients. A pneumococcal genome-wide association study (GWAS) demonstrated a strong correlation between 30-day mortality and the presence of the phage-derived gene pblB, encoding a platelet-binding protein whose effects on platelet activation were previously unknown. Platelets are increasingly recognized as key players of the innate immune system, and in sepsis, excessive platelet activation contributes to microvascular obstruction, tissue hypoperfusion, and finally multiorgan failure, leading to mortality...
January 17, 2017: MBio
https://www.readbyqxmd.com/read/28095723/increased-long-term-mortality-after-survival-of-invasive-pneumococcal-disease-a-population-based-study
#4
Hans Kristian Floeystad, Are Holm, Leiv Sandvik, Didrik Frimann Vestrheim, Bjorn Brandsaeter, Dag Berild
OBJECTIVES: We studied if patients surviving hospitalization for invasive pneumococcal disease (IPD) have an increased long-term mortality. METHODS: In this population-based case-control study, we assessed adults discharged from Aker University Hospital in Oslo, Norway, from 1993 to 2008 after surviving IPD. Mortality among the study population was compared to the general Norwegian population using standardized mortality ratios (SMR). Median follow-up time was 7...
January 17, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28093269/invasive-disease-versus-urinary-antigen-confirmed-pneumococcal-community-acquired-pneumonia
#5
Adrian Ceccato, Antoni Torres, Catia Cilloniz, Rosanel Amaro, Albert Gabarrus, Eva Polverino, Elena Prina, Carolina Garcia-Vidal, Eva Muñoz-Conejero, Cristina Mendez, Isabel Cifuentes, Jorge Puig de la Bella Casa, Rosario Menendez, Michael S Niederman
OBJECTIVES: The burden of pneumococcal disease is measured only through patients with invasive pneumococcal disease. The urinary antigen test (UAT) for pneumococcus has exhibited a high sensitivity and specificity. We aimed to compare the pneumococcal pneumonias diagnosed as invasive disease with pneumococcal pneumonias defined by UAT. METHODS: Prospective observational study on consecutive non-immunosuppressed patients with community-acquired pneumonia from January 2000 to December 2014...
January 13, 2017: Chest
https://www.readbyqxmd.com/read/28062316/discovery-of-streptococcus-pneumoniae-serogroup-35-variants-in-australian-patients
#6
Megan Staples, Rikki M A Graham, Vicki Hicks, Janet Strachan, Anders Gonçalves da Silva, Jade Peverall, Veyatie Wicks, Amy V Jennison
OBJECTIVES: S. pneumoniae isolates from Australian invasive pneumococcal disease cases displaying an atypical 35B phenotype. Whole genome sequencing was used to analyse these strains and identify changes to the capsule gene regions. METHODS: Four atypical serogroup 35 isolates from Australian reference laboratories were unable to be assigned to one of the four known group 35 serotypes by the Quellung serotyping method. Genetic characterisation of the capsule locus was performed by bioinformatic analysis of whole genome sequencing data for all isolates RESULTS: Genetic analysis identified four independent disruptions to the wciG gene, which encodes an O-acetyltransferase responsible for the O-acetylation of the 6Galβ1 residue in the capsular polysaccharide repeat unit of serotype 35B...
January 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28062125/propensity-of-pneumococcal-carriage-serotypes-to-infect-the-lower-airways-of-children-with-chronic-endobronchial-infections
#7
Kim M Hare, Heidi C Smith-Vaughan, Anne B Chang, Susan Pizzutto, Helen L Petsky, Gabrielle B McCallum, Amanda J Leach
BACKGROUND: Chronic endobronchial infections in children are responsible for a high disease burden. Streptococcus pneumoniae is frequently isolated; however, few publications have described serotypes associated with non-invasive lower airway infection. METHODS: Paired nasopharyngeal (NP) swabs and bronchoalveolar lavage (BAL) fluids were collected from children undergoing bronchoscopy for chronic cough. NP swabs were also collected from asymptomatic children in otitis media surveillance studies (controls)...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28061505/effectiveness-of-the-23-valent-pneumococcal-polysaccharide-vaccine-ppv23-against-pneumococcal-disease-in-the-elderly-systematic-review-and-meta-analysis
#8
Gerhard Falkenhorst, Cornelius Remschmidt, Thomas Harder, Eva Hummers-Pradier, Ole Wichmann, Christian Bogdan
BACKGROUND: Routine vaccination of elderly people against pneumococcal diseases is recommended in many countries. National guidelines differ, recommending either the 23-valent polysaccharide vaccine (PPV23), the 13-valent conjugate vaccine (PCV13) or both. Considering the ongoing debate on the effectiveness of PPV23, we performed a systematic literature review and meta-analysis of the vaccine efficacy/effectiveness (VE) of PPV23 against invasive pneumococcal disease (IPD) and pneumococcal pneumonia in adults aged ≥60 years living in industrialized countries...
2017: PloS One
https://www.readbyqxmd.com/read/28060968/the-changing-epidemiology-of-invasive-pneumococcal-disease-after-the-introduction-of-pneumococcal-conjugate-vaccine-rhode-island-1997-2016
#9
Michael Gosciminski, Utpala Bandy, Karen Luther
No abstract text is available yet for this article.
January 6, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28057059/invasive-pneumococcal-disease-caused-by-mucoid-serotype-3-streptococcus-pneumoniae-a-case-report-and-literature-review
#10
Naomi Sugimoto, Yuka Yamagishi, Jun Hirai, Daisuke Sakanashi, Hiroyuki Suematsu, Naoya Nishiyama, Yusuke Koizumi, Hiroshige Mikamo
BACKGROUND: Among the different serotypes of Streptococcus pneumoniae, serotype 3 has received global attention. We report the fatal case of a 76-year-old Japanese man who had an invasive pneumococcal disease associated with pneumonia caused by serotype 3 S. pneumoniae. CASE PRESENTATION: The patient had a history of hypertension, laryngeal cancer, chronic obstructive pulmonary disease, and type 2 diabetes mellitus. Following a cerebral arteriovenous malformation hemorrhage, he underwent surgery to remove the hematoma and began rehabilitation...
January 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056828/pneumococcal-carriage-and-antibiotic-susceptibility-patterns-from-two-cross-sectional-colonization-surveys-among-children-aged-5-years-prior-to-the-introduction-of-10-valent-pneumococcal-conjugate-vaccine-kenya-2009-2010
#11
Miwako Kobayashi, Laura M Conklin, Godfrey Bigogo, Geofrey Jagero, Lee Hampton, Katherine E Fleming-Dutra, Muthoni Junghae, Maria da Gloria Carvalho, Fabiana Pimenta, Bernard Beall, Thomas Taylor, Kayla F Laserson, John Vulule, Chris Van Beneden, Lindsay Kim, Daniel R Feikin, Cynthia G Whitney, Robert F Breiman
BACKGROUND: Pneumococci are spread by persons with nasopharyngeal colonization, a necessary precursor to invasive disease. Pneumococcal conjugate vaccines can prevent colonization with vaccine serotype strains. In 2011, Kenya became one of the first African countries to introduce the 10-valent pneumococcal conjugate vaccine (PCV10) into its national immunization program. Serial cross-sectional colonization surveys were conducted to assess baseline pneumococcal colonization, antibiotic resistance patterns, and factors associated with resistance...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28051086/neutrophilic-nlrp3-inflammasome-dependent-il-1%C3%AE-secretion-regulates-the-%C3%AE-%C3%AE-t17-cell-response-in-respiratory-bacterial-infections
#12
M Hassane, D Demon, D Soulard, J Fontaine, L E Keller, E C Patin, R Porte, I Prinz, B Ryffel, A Kadioglu, J-W Veening, J-C Sirard, C Faveeuw, M Lamkanfi, F Trottein, C Paget
Traditionally regarded as simple foot soldiers of the innate immune response limited to the eradication of pathogens, neutrophils recently emerged as more complex cells endowed with a set of immunoregulatory functions. Using a model of invasive pneumococcal disease, we highlighted an unexpected key role for neutrophils as accessory cells in innate interleukin (IL)-17A production by lung resident Vγ6Vδ1(+) T cells via nucleotide-binding oligomerization domain receptor, pyrin-containing 3 (NLRP3) inflammasome-dependent IL-1β secretion...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28049447/invasive-pneumococcal-disease-among-adults-in-japan-april-2013-to-march-2015-disease-characteristics-and-serotype-distribution
#13
Munehisa Fukusumi, Bin Chang, Yoshinari Tanabe, Kengo Oshima, Takaya Maruyama, Hiroshi Watanabe, Koji Kuronuma, Kei Kasahara, Hiroaki Takeda, Junichiro Nishi, Jiro Fujita, Tetsuya Kubota, Tomimasa Sunagawa, Tamano Matsui, Kazunori Oishi
BACKGROUND: In Japan, the clinical characteristics and recent serotype distribution among adult patients of invasive pneumococcal disease (IPD) have not been fully investigated since the introduction of the pneumococcal conjugate vaccine (PCV) in children. From November 2010, PCV7 was encouraged by an official program, funded by government, subsequently included in the routine schedule in April 2013, and replaced with a PCV13 in November 2013. METHODS: Between April 2013 and March 2015, patients with IPD older than 15 years were evaluated based on the enhanced national surveillance in ten prefectures of Japan...
January 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28046133/whole-genome-sequencing-of-39-invasive-streptococcus-pneumoniae-sequence-type-199-isolates-revealed-switches-from-serotype-19a-to-15b
#14
Oliwia Makarewicz, Marie Lucas, Christian Brandt, Leonie Herrmann, Andreas Albersmeier, Christian Rückert, Jochen Blom, Alexander Goesmann, Mark van der Linden, Jörn Kalinowski, Mathias W Pletz
Streptococcus pneumoniae is a major pathogen that causes different invasive pneumococcal diseases (IPD). The pneumococcal polysaccharide capsule is a main virulence factor. More than 94 capsule types have been described, but only a limited number of capsule types accounted for the majority of IPD cases before the introduction of pneumococcal vaccines. After the introduction of the conjugated pneumococcal vaccine PCV7, which covered the seven most frequent serotypes in IPD in the USA, an increase in IPD caused by non-vaccine serotypes was observed, and serotype 19A, which belongs to sequence type (ST) 199, was among the most prevalent STs...
2017: PloS One
https://www.readbyqxmd.com/read/28043237/invasive-pneumococcal-disease-surveillance-1-july-to-30-september-2016
#15
Rachael Corvisy, Jennie Hood
No abstract text is available yet for this article.
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28043236/invasive-pneumococcal-disease-surveillance-1-april-to-30-june-2016
#16
Anna Glynn-Robinson, Kate Pennington, Cindy Toms
No abstract text is available yet for this article.
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28039377/detection-of-serotype-distribution-and-drug-resistance-of-streptococcus-pneumoniae-isolated-from-pediatric-patients
#17
Junrong Wang, Fenqin Liu, Peiran Ao, Xianneng Li, Haixiao Zheng, Di Wu, Nina Zhang, Junping Yu, Junhui Yuan, Xiuying Wu
OBJECTIVE: To analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from pediatric patients in a Chinese hospital. METHODS: From October 2011 to May 2014, we collected 284 isolates (including 217 noninvasive and 67 invasive strains). We tested the antimicrobial susceptibility of these specimens using the Epsilomer test and disk diffusion method, and the expression of macrolide resistant genes ermB and mefA by polymerase chain reaction...
December 29, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/28032483/indirect-effects-of-pneumococcal-conjugate-vaccines-in-national-immunization-programs-for-children-on-adult-pneumococcal-disease
#18
REVIEW
Young Keun Kim, David LaFon, Moon H Nahm
The pneumococcal conjugate vaccine (PCV) was developed to overcome the limitations of the pneumococcal polysaccharide vaccine, which produces poor immunogenicity in infants younger than 2 years. As many countries have included PCVs in national immunization programs for children, the incidence of invasive pneumococcal disease caused by vaccine type Streptococcus pneumoniae has declined markedly, not only among the vaccinated pediatric population, but also among unvaccinated adults. In this review, we present a concise overview of the indirect effects of mass pediatric PCV immunization on unvaccinated adults...
December 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28009001/real-time-qpcr-improves-meningitis-pathogen-detection-in-invasive-bacterial-vaccine-preventable-disease-surveillance-in-fiji
#19
Eileen M Dunne, Silivia Mantanitobua, Shalini P Singh, Rita Reyburn, Evelyn Tuivaga, Eric Rafai, Lisi Tikoduadua, Barbara Porter, Catherine Satzke, Janet E Strachan, Kimberly K Fox, Kylie M Jenkins, Adam Jenney, Silo Baro, E Kim Mulholland, Mike Kama, Fiona M Russell
As part of the World Health Organization Invasive Bacterial-Vaccine Preventable Diseases (IB-VPD) surveillance in Suva, Fiji, cerebrospinal fluid (CSF) samples from suspected meningitis patients of all ages were examined by traditional methods (culture, Gram stain, and latex agglutination for bacterial antigen) and qPCR for Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Of 266 samples tested, pathogens were identified in 47 (17.7%). S. pneumoniae was the most common pathogen detected (n = 17) followed by N...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28006650/rise-of-multidrug-resistant-non-vaccine-serotype-15a-streptococcus-pneumoniae-in-the-united-kingdom-2001-to-2014
#20
Carmen Sheppard, Norman K Fry, Shazad Mushtaq, Neil Woodford, Rosy Reynolds, Regina Janes, Rachel Pike, Robert Hill, Maimuna Kimuli, Peter Staves, Michel Doumith, Timothy Harrison, David M Livermore
Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001-2014; (ii) Public Health England's (PHE) invasive isolate surveillance from 2005-2014 and (iii) referral to PHE for resistance investigation from 2005-2014. Serotype 15A increased in all series, with many representatives showing triple resistance to macrolides, tetracyclines and penicillin...
December 15, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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