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Pneumococcal invasive disease

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https://www.readbyqxmd.com/read/28818600/a-reverse-hybridization-test-for-the-identification-of-76-pneumococcal-serotypes-42-individually-and-34-in-pairs
#1
José M Marimón, María Morales, Susana Gamen, Ana Manrique, María Ercibengoa, Gustavo Cilla
The S. PneumoStrip test is a recently developed reverse hybridization strip-based commercial assay that allows for the identification of 76 pneumococcal serotypes, 42 individually and 34 in pairs, according to their specific gene sequences. The test was validated with reference strains of 92 different pneumococcal serotypes and with a selection of 75 clinical isolates representing 55 serotypes, showing 100% sensitivity and specificity. The test was also applied to 64 pneumococcal invasive isolates (23 different serotypes) consecutively collected between June 2016 and March 2017, with 60 (93...
August 14, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28818567/a-protein-chimera-including-pspa-in-fusion-with-potd-is-protective-against-invasive-pneumococcal-infection-and-reduces-nasopharyngeal-colonization-in-mice
#2
T R Converso, C Goulart, M Darrieux, L C C Leite
Despite the success of the available polysaccharide-based vaccines against Streptococcus pneumoniae in preventing invasive diseases, this bacterium remains a major cause of death in many parts of the world. New vaccine strategies are needed in order to increase protection. Thus, the utilization of fusion proteins is being investigated as an alternative to the current formulations. In the present work, we demonstrate that a chimeric protein, composed of PspA and PotD in fusion is able to maintain the protective characteristics of both parental proteins, providing protection against systemic infection while reducing nasal colonization...
August 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28807606/effectiveness-of-different-vaccine-schedules-for-heptavalent-and-13-valent-conjugate-vaccines-against-pneumococcal-disease-in-the-community-of-madrid
#3
P Latasa, M Ordobás, M Garrido-Estepa, A Gil de Miguel, J C Sanz, M D Barranco, E Insúa, L García-Comas
INTRODUCTION: The heptavalent pneumococcal conjugate vaccine (PCV-7) was added to the childhood routine vaccination program in the Community of Madrid in November of 2006 with 3+1 recommended doses and a catch-up for those under 2years old. In June 2010, PCV-7 was replaced by 13-valent vaccine (PCV-13) with 2+1 recommended doses. In July of 2012, the PCV-13 was removed from the funded program and reintroduced again (2+1 recommended doses) in December 2014. In between, children were vaccinated privately with 3+1 recommended doses of PCV-13...
August 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28806737/effectiveness-of-the-13-valent-pneumococcal-conjugate-vaccine-in-preventing-invasive-pneumococcal-disease-in-children-aged-7-59-months-a-matched-case-control-study
#4
Ángela Domínguez, Pilar Ciruela, Sergi Hernández, Juan José García-García, Núria Soldevila, Conchita Izquierdo, Fernando Moraga-Llop, Alvaro Díaz, Mariona F de Sevilla, Sebastià González-Peris, Magda Campins, Sonia Uriona, Johanna Martínez-Osorio, Anna Solé-Ribalta, Gemma Codina, Cristina Esteva, Ana María Planes, Carmen Muñoz-Almagro, Luis Salleras
BACKGROUND: The 13-valent pneumococcal conjugate vaccine (PCV13) was licensed based on the results of immunogenicity studies and correlates of protection derived from randomized clinical trials of the 7-valent conjugate pneumococcal vaccine. We assessed the vaccination effectiveness (VE) of the PCV13 in preventing invasive pneumococcal disease (IPD) in children aged 7-59 months in a population with suboptimal vaccination coverage of 55%. METHODS: The study was carried out in children with IPD admitted to three hospitals in Barcelona (Spain) and controls matched by hospital, age, sex, date of hospitalization and underlying disease...
2017: PloS One
https://www.readbyqxmd.com/read/28803139/the-effect-of-age-on-the-manifestations-and-outcomes-of-invasive-pneumococcal-disease-in-adults
#5
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: While a considerable amount is known about the effect of age on the manifestations and outcomes of pneumonia, the same is not true for invasive pneumococcal disease . METHODS: This was a prospective, observational study of all cases (2435) of invasive pneumococcal disease in adults in Northern Alberta from 2000 to 2014. Rates of invasive pneumococcal disease/100,000, sociodemographic variables, clinical characteristics, and invasive pneumococcal disease -related outcomes were compared for the following age groups - 17 to 54, 55 -64, 65 to 74 and 75 years and over...
August 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28801724/pneumococcal-meningitis-and-endocarditis-in-an-infant-possible-improved-survival-with-factor-v-leiden-mutation
#6
Sitikant Mohapatra, Assaf Doulah, Elspeth Brown
Streptococcus pneumoniae infections continue to remain associated with high morbidity and mortality. Although the incidence of invasive meningeal and/or lung disease are not uncommon, Streptococcus pneumoniae endocarditis is rare especially in healthy pediatric population. New studies have suggested a strong association between factor V leiden (FVL) mutation and favorable outcomes in critically ill children. A healthy 10 month old presented with sepsis and meningeal signs, was later confirmed to have Streptococcus pneumoniae meningitis and endocarditis...
August 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28792379/streptococcus-pneumoniae-and-lytic-antibiotic-therapy-are-we-adding-insult-to-injury-during-invasive-pneumococcal-disease-and-sepsis
#7
Lauren April Brown, Andrea M Mitchell, Tim J Mitchell
Streptococcus pneumoniae (S. pneumoniae), otherwise known as 'the pneumococcus', is a fascinating microbe that continues to pose a significant problem to public health. Currently there are no specific National Institute for Clinical Excellence (NICE) or British Thoracic Society (BTS) clinical guidelines referring to the treatment of invasive pneumococcal infection. NICE clinical guidelines suggest the use of lytic β-lactam antibiotic regimens for the management of community-acquired pneumonia and bacterial meningitis; infections for which S...
August 10, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28783380/streptococcus-pneumoniae-serotype-19a-worldwide-epidemiology
#8
Raul Isturiz, Heather L Sings, Betsy Hilton, Adriano Arguedas, Ralf-René Reinert, Luis Jodar
Streptococcus pneumoniae causes mucosal and invasive diseases with high morbidity and mortality. Introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) into routine infant immunization programs worldwide resulted in serotype 19A becoming a leading cause of the remaining pneumococcal disease burden in vaccinated and unvaccinated individuals. This article reviews the impact of the latest generation PCVs (10-valent PCV, PCV10, and 13-valent PCV, PCV13) on serotype 19A. Areas covered: This article covers immune responses elicited by PCV7, PCV10 and PCV13 against serotype 19A and their impact on nasopharyngeal (NP) carriage and disease in vaccinated and unvaccinated populations using data from surveillance systems, randomized controlled trials, and observational studies...
August 7, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28780980/impact-of-the-hajj-on-pneumococcal-carriage-and-the-effect-of-various-pneumococcal-vaccines
#9
REVIEW
Sophie Edouard, Jaffar A Al-Tawfiq, Ziad A Memish, Saber Yezli, Philippe Gautret
BACKGROUND: The Islamic Hajj pilgrimage is the largest annual mass gathering in the world. The overcrowding of people promotes the acquisition, spread and transmission of respiratory pathogens, including Streptococcus pneumoniae. It is estimated that about 33% of pilgrims are at risk of invasive pneumococcal disease. METHODS: We conducted a methodological review according to the Preferred Reporting Items for Systematic Reviews and meta-Analysis guidelines. The objective was to summarize the available data regarding the prevalence of pneumococcal carriage among Hajj pilgrims and about carriage acquisition and circulation of S...
August 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28780272/current-challenges-in-the-accurate-identification-of-streptococcus-pneumoniae-and-its-serogroups-serotypes-in-the-vaccine-era
#10
REVIEW
Rosemol Varghese, Ranjith Jayaraman, Balaji Veeraraghavan
Streptococcus pneumoniae is a major cause of pneumonia, meningitis and other invasive diseases resulting in high mortality and morbidity among children under the age of five. Inaccurate identification of S. pneumoniae masks the exact estimation of disease burden and could delay treatment options. This is the common problem most frequently faced in developing countries due to several reasons that include poor infrastructure, insensitive operational procedures and lack of expertise. Inconsistent methods for phenotypic detection often delay the early identification and confirmation of S...
August 2, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28768668/a-combination-of-recombinant-bcg-expressing-pneumococcal-proteins-induces-cellular-and-humoral-immune-responses-and-protects-against-pneumococcal-colonization-and-sepsis
#11
Cibelly Goulart, Dunia Rodriguez, Alex I Kanno, Thiago Rojas Converso, Ying-Jie Lu, Richard Malley, Luciana C Leite
Pneumococcal diseases remain a substantial cause of mortality in young children in developing countries. The development of potentially serotype-transcending vaccines has been extensively studied; ideally such a vaccine should include antigens that are able to induce protection against colonization (likely mediated by IL-17A) and protection against invasive disease (likely mediated by antibody). The use of strong adjuvants or alternative delivery systems that are able to improve the immunological response of recombinant proteins has been proposed, but poses potential safety and practical concerns in children...
August 2, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28767518/bayesian-model-averaging-with-change-points-to-assess-the-impact-of-vaccination-and-public-health-interventions
#12
Esra Kürüm, Joshua L Warren, Cynthia Schuck-Paim, Roger Lustig, Joseph A Lewnard, Rodrigo Fuentes, Christian A W Bruhn, Robert J Taylor, Lone Simonsen, Daniel M Weinberger
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) prevent invasive pneumococcal disease and pneumonia. However, some low- and middle-income countries have yet to introduce PCV into their immunization programs due, in part, to lack of certainty about the potential impact. Assessing PCV benefits is challenging because specific data on pneumococcal disease is often lacking, and it can be difficult to separate the effects of factors other than the vaccine that could also affect pneumococcal disease rates...
July 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28756964/key-features-of-invasive-pneumococcal-isolates-recovered-in-lima-peru-determined-through-whole-genome-sequencing
#13
Paulina Hawkins, Erik Mercado, Sopio Chochua, Maria E Castillo, Isabel Reyes, Eduardo Chaparro, Rebecca Gladstone, Stephen D Bentley, Robert F Breiman, Benjamin J Metcalf, Bernard Beall, Theresa J Ochoa, Lesley McGee
Before PCV7 introduction, invasive pneumococcal disease (IPD) was responsible for approximately 12,000-18,000 deaths annually among children <5years in Latin America. In Peru, PCV7 was introduced in 2009. We used whole genome sequencing to deduce key features of invasive strains collected in Lima, Peru from 2006 to 2011. We sequenced 212 IPD isolates from 16 hospitals in Lima pre (2006-2009; n=133) and post (2010-2011; n=79) PCV7 introduction; 130 (61.3%) isolates were from children≤5years old. CDC's Streptococcus lab bioinformatics pipeline revealed serotypes, sequence types (STs), pilus genes, PBP types and other resistance determinants...
July 22, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28751095/a-comprehensive-review-of-immunization-practices-in-solid-organ-transplant-and-hematopoietic-stem-cell-transplant-recipients
#14
REVIEW
Pearlie P Chong, Robin K Avery
BACKGROUND: Vaccine-preventable diseases, especially influenza, varicella, herpes zoster, and invasive pneumococcal infections, continue to lead to significant morbidity and mortality in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients. METHODS: We highlight guideline recommendations for the use of key vaccines in SOT and HSCT recipients and to review the latest evidence and developments in the field. RESULTS: Physicians should vaccinate individuals with end-stage organ disease, as vaccine seroresponse rates are higher pretransplantation...
July 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28742023/genome-wide-identification-of-lineage-and-locus-specific-variation-associated-with-pneumococcal-carriage-duration
#15
John A Lees, Nicholas J Croucher, David Goldblatt, François Nosten, Julian Parkhill, Claudia Turner, Paul Turner, Stephen D Bentley
Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially in low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for disease, but variability in its duration is currently only understood at the serotype level. Here we developed a model to calculate the duration of carriage episodes from longitudinal swab data, and combined these results with whole genome sequence data. We estimated that pneumococcal genomic variation accounted for 63% of the phenotype variation, whereas the host traits considered here (age and previous carriage) accounted for less than 5%...
July 25, 2017: ELife
https://www.readbyqxmd.com/read/28738889/influence-of-the-pneumococcal-conjugate-vaccines-on-the-temporal-variation-of-pneumococcal-carriage-and-the-nasal-microbiota-in-healthy-infants-a-longitudinal-analysis-of-a-case-control-study
#16
Moana Mika, Josua Maurer, Insa Korten, Aurélie Allemann, Suzanne Aebi, Silvio D Brugger, Weihong Qi, Urs Frey, Philipp Latzin, Markus Hilty
BACKGROUND: Bacterial colonization of the upper airways is a prerequisite for subsequent invasive disease. With the introduction of the 7- and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13), changes in pneumococcal upper airway colonization have been described. It is, however, less evident whether the vaccines lead to compositional changes of the upper airway microbiota. Here, we performed a case-control study using samples from a longitudinal infant cohort from Switzerland...
July 24, 2017: Microbiome
https://www.readbyqxmd.com/read/28737858/the-effects-of-pneumococcal-conjugate-vaccine-pcv7-and-pcv13-on-turkish-children-with-invasive-pneumococcal-disease-a-single-center-experience
#17
Halil Özdemir, Caner Yıldız, Selin Nar Ötgün, Hatice Erkol, Adem Karbuz, Bilge Aldemir Kocabaş, Tuğçe Tural Kara, Ayşegül Gözalan, Rıza Durmaz, Ergin Çiftçi, Derya Aysev, Erdal İnce
INTRODUCTION: The aim of this prospective single-center study was to determine the changings in incidence of invasive pneumococcal disease (IPD), serotype distribution and the antimicrobial resistance patterns of S. pneumoniae in children with IPD after the period (1 to 7 years) of vaccination with PCV7 (2008) and PCV13 (2011). POPULATION AND METHODS: The study was conducted on 39 Turkish children with IPD between ages 1 month and 18 years in Ankara, Turkey. Streptococcus pneumoniae was identified using standard laboratory procedures from blood, cerebrospinal fluid (CSF), pleural fluid, and other sterile body fluids and tissues...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737627/direct-and-indirect-effectiveness-of-the-ten-valent-pneumococcal-conjugate-vaccine-against-carriage-in-a-cluster-randomized-trial
#18
Arto A Palmu, Maija Toropainen, Tarja Kaijalainen, Lotta Siira, Mika Lahdenkari, Heta Nieminen, Ritva K Syrjänen, Terhi M Kilpi, Jukka Jokinen
Finnish Invasive Pneumococcal disease (FinIP) vaccine trial was designed to evaluate effectiveness of ten-valent pneumococcal conjugate vaccine (PHiD-CV10, GSK). We conducted two satellite studies to evaluate PHiD-CV10 effectiveness against pneumococcal carriage in FinIP-vaccinated children (long-term direct and indirect effectiveness combined) and in their unvaccinated siblings (indirect effectiveness within the family).FinIP was a cluster-randomized trial, where >47000 children <19 months of age were recruited 2009-2010...
July 21, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28737622/changes-in-the-nature-and-severity-of-invasive-pneumococcal-disease-in-children-before-and-after-the-7-valent-and-13-valent-pneumococcal-conjugate-vaccine-programs-in-calgary-canada
#19
Leah J Ricketson, Nicholas G Conradi, Otto G Vanderkooi, James D Kellner
BACKGROUND: Since the introduction of childhood pneumococcal conjugate vaccines, invasive pneumococcal disease (IPD) incidence has decreased in children and the predominant serotypes causing disease have changed. This study describes changes in the clinical features of IPD in children (<18 years) before and after conjugate vaccine introduction. METHODS: The Calgary Area Streptococcus pneumoniae Epidemiology Research (CASPER) study collects information on all IPD cases in Calgary, Alberta, Canada...
July 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28736993/molecular-characterization-of-streptococcus-pneumoniae-particularly-serotype19a-st320-that-emerged-in-krasnoyarsk-russia
#20
Irina N Protasova, Tsai-Wen Wan, Natalya V Bakhareva, Wei-Chun Hung, Wataru Higuchi, Yasuhisa Iwao, Tatyana A Yelistratova, Natalya A Ilyenkova, Yelena S Sokolovskaya, Galina P Martynova, Ivan V Reva, Galina V Reva, Sergey V Sidorenko, Lee-Jene Teng, Olga V Peryanova, Alla B Salmina, Tatsuo Yamamoto
Streptococcus pneumoniae, a common human pathogen, colonizes the nasopharynx and causes diseases including acute otitis media (AOM). We herein report pneumococcal serotype distributions in children before and after PCV7 vaccination and in patients with pneumococcal disease in Siberian Russia (Krasnoyarsk). Analyses included antimicrobial susceptibility testing, ST typing, a pulsed-field gel electrophoresis analysis, virulence-related surface protein gene (VSG) typing with novel primers, and a structural analysis by scanning electron microscopy...
July 23, 2017: Microbiology and Immunology
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