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https://www.readbyqxmd.com/read/29334280/comparison-of-guidelines-for-the-use-of-tnf-inhibitors-for-psoriasis-in-the-united-states-canada-europe-and-the-united-kingdom-a-critical-appraisal-and-comprehensive-review
#1
Vidhi V Shah, Erica B Lee, Shivani Reddy, Elaine J Lin, Jashin J Wu
PURPOSE: To compare and contrast evidence-based CPGs from leading dermatological organizations for the use of tumor necrosis factor inhibitors (TNFi) in psoriasis. MATERIALS AND METHODS: Guidelines from the British National Institute for Health and Care Excellence (NICE), the British Association of Dermatologists (BAD), the American Academy of Dermatology (AAD), the National Psoriasis Foundation (NPF), and the Canadian Dermatology Association (CDA) were reviewed and compared...
January 15, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29325592/magnesium-sulphate-for-fetal-neuroprotection-to-prevent-cerebral-palsy-mag-cp-implementation-of-a-national-guideline-in-canada
#2
Dane A De Silva, Anne R Synnes, Peter von Dadelszen, Tang Lee, Jeffrey N Bone, Laura A Magee
BACKGROUND: Evidence supports magnesium sulphate (MgSO4) for women at risk of imminent birth at < 32-34 weeks to reduce the likelihood of cerebral palsy in the child. MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP) was a multifaceted knowledge translation (KT) strategy for this practice. METHODS: The KT strategy included national clinical practice guidelines, a national online e-learning module and, at MAG-CP sites, educational rounds, focus group discussions and surveys of barriers and facilitators...
January 11, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29324077/screening-of-23-%C3%AE-lactams-in-foodstuffs-by-lc-ms-ms-using-an-alkaline-quechers-like-extraction
#3
Thomas Bessaire, Claudia Mujahid, Andrea Beck, Adrienne Tarres, Marie-Claude Savoy, Pei-Mun Woo, Pascal Mottier, Aurélien Desmarchelier
A fast and robust high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) screening method was developed for the analysis of β-lactam antibiotics in foods of animal origin: eggs, raw milk, processed dairy ingredients, infant formula, and meat- and fish-based products including baby-foods. QuEChERS extraction with some adaptations enabled twenty-three drugs to be simultaneously monitored. Screening Target Concentrations were set at levels adequate to ensure compliance with current European, Chinese, US and Canadian regulations...
January 11, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29319488/canadian-urological-association-pediatric-urologists-of-canada-guidelines-on-the-investigation-and-management-of-antenatally-detected-hydronephrosis
#4
John-Paul Capolicchio, Luis H Braga, Konrad M Szymanski
No abstract text is available yet for this article.
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29319480/the-impact-of-patient-disease-and-treatment-related-factors-on-survival-in-patients-with-adrenocortical-carcinoma
#5
Nahid Punjani, Roderick Clark, Jonathan Izawa, Joseph Chin, Stephen E Pautler, Nicholas Power
INTRODUCTION: Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine tumour. Most present with advanced disease and have poor prognosis. Optimal treatment includes complete surgical resection. There is limited evidence for the efficacy of chemotherapy and radiation at different stages in this disease. There remain many inconsistencies with respect to diagnosis and workup. There is a lack of uniform guideline recommendations and consensus data. METHODS: We performed a retrospective chart review of all patients at London Health Sciences Centre between 1990 and 2015 using ICD coding...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29317937/evaluating-the-potential-for-pharmacists-to-prescribe-oral-anticoagulants-for-atrial-fibrillation
#6
Roopinder K Sandhu, Lisa M Guirguis, Tammy J Bungard, Erik Youngson, Lisa Dolovich, Jamie C Brehaut, Jeff S Healey, Finlay A McAlister
Background: Oral anticoagulant therapy (OAC) to prevent atrial fibrillation (AF)-related strokes remains poorly used. Alternate strategies, such as community pharmacist prescribing of OAC, should be explored. Methods: Approximately 400 pharmacists, half with additional prescribing authority (APA), randomly selected from the Alberta College of Pharmacists, were invited to participate in an online survey over a 6-week period. The survey consisted of demographics, case scenarios assessing appropriateness of OAC (based on the 2014 Canadian Cardiovascular Society AF guidelines) and perceived barriers to prescribing...
January 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29317844/a-survey-of-adult-referrals-to-specialist-attention-deficit-hyperactivity-disorder-clinics-in-canada
#7
Larry J Klassen, C Matthew Blackwood, Christopher J Reaume, Samuel Schaffer, James G Burns
Background: Canadian guidelines encourage family physicians to diagnose/manage adults with uncomplicated attention-deficit/hyperactivity disorder (ADHD); specialist referral is recommended only for complex cases. This retrospective case review investigated adults referred to Canadian ADHD clinics. Methods: Adult ADHD specialists reviewed referral letters/charts of patients (aged ≥18 years and no family history/known/expressed childhood ADHD) from family physicians/psychiatrists over 2 years...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29314862/exploring-the-utility-of-cardiorespiratory-fitness-as-a-population-health-surveillance-indicator-for-children-and-youth-an-international-analysis-of-results-from-the-20-m-shuttle-run-test
#8
Justin J Lang
Emerging evidence has demonstrated the strong link between cardiorespiratory fitness and multiple aspects of health (i.e., physiological, physical, psychosocial, cognitive), independent of physical activity, among school-aged children and youth. Cardiorespiratory fitness is a trait that does not vary substantially from day-to-day, and provides an indication of recent physical activity levels, making it an important possible indicator of population health. Thus, the objective of this dissertation was to investigate the utility of cardiorespiratory fitness, measured using the 20-m shuttle run test, as a broad, holistic health indicator for population health surveillance among children and youth...
January 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29304160/a-retrospective-review-of-vital-signs-and-clinical-outcomes-of-febrile-infants-younger-than-3-months-old-presenting-to-the-emergency-department
#9
Shu-Ling Chong, Gene Yong-Kwang Ong, Wendy Yi Wen Chin, John Mingzhou Chua, Praseetha Nair, Alicia Shu Zhen Ong, Kee Chong Ng, Ian Maconochie
OBJECTIVES: Febrile infants younger than 3 months old present a diagnostic dilemma to the emergency physician. We aim to describe a large population of febrile infants less than 3 months old presenting to a pediatric emergency department (ED) and to assess the performance of current heart rate guidelines in the prediction of serious infections (SI). MATERIALS AND METHODS: We performed a retrospective review of febrile infants younger than 3 months old, between March 2015 and Feb 2016, in a large tertiary pediatric ED...
2018: PloS One
https://www.readbyqxmd.com/read/29301631/primary-prevention-with-statins%C3%A2-in%C3%A2-the%C3%A2-elderly
#10
REVIEW
Martin Bødtker Mortensen, Erling Falk
The burden of atherosclerotic cardiovascular disease (ASCVD) in high-income countries is mostly borne by the elderly. With increasing life expectancy, clear guidance on sensible use of statin therapy to prevent a first and potentially devastating ASCVD event is critically important to ensure a healthy aging population. Since 2013, 5 major North American and European guidelines on statin use in primary prevention of ASCVD have been released by the American College of Cardiology/American Heart Association, the UK National Institute for Health and Care Excellence, the Canadian Cardiovascular Society, U...
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29299769/the-direct-medical-costs-of-diseases-associated-with-human-papillomavirus-infection-in-manitoba-canada
#11
Christiaan H Righolt, Gurpreet Pabla, Salaheddin M Mahmud
BACKGROUND: The total direct cost of screening and treating all human papillomavirus-related diseases (HPV-RD) has not been measured in a single study. Accurate cost estimates are needed to inform decisions on intervention priorities and evaluate the cost-effectiveness of existing programs. We used province-wide clinical, administrative, and accounting databases to measure direct medical costs of HPV infection in Manitoba (Canada). METHODS: All persons 9 years or older with health insurance coverage in Manitoba between April 2000 and March 2015 were eligible...
January 4, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29298624/approach-to-initiating-qt-prolonging-oncology-drugs-in-the-ambulatory-setting
#12
Mário L de Lemos, Carrie Kung, Victoria Kletas, Nadine Badry, Isabell Kang
Since the introduction of regulatory drug approval guidance on the evaluation of QT interval prolongation, an increasing number of drug monographs has included cautions on the risk of QT prolongation. For example, QT prolongation is mentioned in the Canadian product monographs of 29 drugs commonly seen in oncology practice. This presents two major challenges. First, most guidelines and risk predictive tools for QT prolongation have been developed for hospitalized patients in acute care settings. In contrast, most QT-prolonging oncology drugs are used in medically stable patients in the ambulatory setting...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29297004/comparison-of-five-major-guidelines-for-statin-use-in-primary-prevention-in-a-contemporary-general-population
#13
Martin Bødtker Mortensen, Børge Grønne Nordestgaard
Background: Five major organizations recently published guidelines for using statins to prevent atherosclerotic cardiovascular disease (ASCVD): in 2013, the American College of Cardiology/American Heart Association (ACC/AHA); in 2014, the United Kingdom's National Institute for Health and Care Excellence (NICE); and in 2016, the Canadian Cardiovascular Society (CCS), the U.S. Preventive Services Task Force (USPSTF), and the European Society of Cardiology/European Atherosclerosis Society (ESC/EAS)...
January 2, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29296003/retinopathy-of-prematurity-practices-a-national-survey-of-canadian-neonatal-intensive-care-units
#14
Kourosh Sabri, Mary Angela Woodward, Bethany Easterbrook, Sandesh Shivananda
OBJECTIVE: To examine current level three Neonatal Intensive Care Unit (NICU) practices related to ROP screening and treatment. STUDY DESIGN: A cross-sectional survey was sent to 29 level three NICU's across Canada to survey current screening inclusion criteria, treatment options, supportive care and post-screening events for ROP. RESULT: 22/29 (76%) level three NICU's responded. Ten different ROP screening inclusion criteria were found to be in use with significant variation in gestational age and birth weight criteria...
January 2, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29284322/maximizing-nutrition-support-practice-and-measuring-adherence-to-nutrition-support-guidelines-in-a-canadian-tertiary-care-icu
#15
Michele E McCall, Alice Adamo, Katherine Latko, Ashley K Rieder, Nicole Durand, Tova Nathanson
OBJECTIVE: New comprehensive guidelines for nutrition support (NS) in the intensive care unit (ICU) can be used to improve quality of care and benchmark current practice. The objective of this study was to (a) compare NS practices in our medical/surgical ICU (MSICU) to 18 recommendations described in the Canadian Clinical Practice Guidelines and Society of Critical Care Medicine/American Society of Parenteral and Enteral Nutrition guidelines, (b) determine the percentage of goal calories and protein delivered, and (c) identify the barriers to successful NS delivery...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29283088/compliance-of-the-recurrent-renal-stone-former-with-current-best-practice-guidelines
#16
Derek Bos, Kevin Kim, Jen Hoogenes, Shahid Lambe, Bobby Shayegan, Edward D Matsumoto
INTRODUCTION: Patient compliance to best practice guidelines is a significant factor in preventing renal stone recurrence. While patient compliance has been historically poor, there remains a paucity of data in the renal stone setting. We evaluated compliance of the recurrent renal stone former with current Canadian Urological Association (CUA) best practice guidelines. METHODS: A prospective, cross-sectional study design was used to evaluate patient compliance...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29280818/attitudes-toward-and-management-of-fibromyalgia-a-national-survey-of-canadian-rheumatologists-and-critical-appraisal-of-guidelines
#17
Arnav Agarwal, Yvgeniy Oparin, Lauren Glick, Mary-Ann Fitzcharles, Jonathan D Adachi, Matthew D Cooper, Lucas Gallo, Laura Wong, Jason W Busse
BACKGROUND: Canadian rheumatologists' attitudes toward and management of fibromyalgia remain uncertain. OBJECTIVE: The aim of this study was to explore management strategies and attitudes of Canadian rheumatologists toward fibromyalgia and concordance with guideline recommendations. METHODS: We administered a 17-item cross-sectional survey to Canadian rheumatologists and explored the concordance between respondents' management practices with the 2012 Canadian Guidelines for the diagnosis and management of fibromyalgia...
December 27, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29280445/the-influence-of-health-insurance-policy-on-radiation-oncology-physician-sbrt-sabr-use-practices-a-north-american-survey
#18
Jenny Guo, Hyun Kim, Ingrid Kalchman, Tu D Dan, Tingting Zhan, Maria Werner-Wasik
PURPOSE: European data suggest that 8-fraction stereotactic body radiation therapy (SBRT) regimens may be similar in efficacy with less toxicity than ≤5-fraction SBRT for central lung lesions. However, under current Centers for Medicare and Medicaid Services guidelines, SBRT in the United States (US) is reimbursed for only ≤5 fractions, whereas there are no such restrictions for reimbursement in Canada. We hypothesize that US-specific SBRT reimbursement policies influence the use of ≥5-fraction SBRT in US academic centers in comparison with comparable Canadian centers...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29276160/management-and-outcome-of-reduced-fetal-movements-is-ultrasound-necessary
#19
Nasser Abu Awad, Thomas Jordan, Robert Mundle, Dan Farine
OBJECTIVE: To review the management and outcome of pregnancies of women presenting to obstetrical triage with decreased fetal movements (DFM). STUDY DESIGN: A retrospective review of women presenting with DFMs to two large Canadian obstetrical centres with a combined 9490 deliveries per year. The charts were reviewed for compliance with the Canadian guidelines for demographics (age, parity, GA, comorbidities, etc.), pregnancy management (admission vs. discharge, need to deliver), and pregnancy outcomes (mortality, morbidity, GA at delivery, Apgar scores, etc...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29274717/no-283-treatments-for-overactive-bladder-focus-on-pharmacotherapy
#20
Roxana Geoffrion
OBJECTIVE: To provide guidelines for pharmacotherapy to treat overactive bladder syndrome (OAB). OPTIONS: Pharmacotherapy for OAB includes anticholinergic (antimuscarinic) drugs and vaginal estrogen. Both oral and transdermal anticholinergic preparations are available. OUTCOMES: To provide understanding of current available evidence concerning safety and clinical efficacy of pharmacotherapy for OAB; to guide selection of anticholinergic therapy based on individual patient characteristics...
January 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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