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ANCA-associated vasculitis

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https://www.readbyqxmd.com/read/29902982/risk-factors-for-infectious-complications-of-anca-associated-vasculitis-a-cohort-study
#1
Liu Yang, Honglang Xie, Zhengzhao Liu, Yinghua Chen, Jinquan Wang, Haitao Zhang, Yongchun Ge, Weixin Hu
BACKGROUND: Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical characteristics and risk factors of severe infection in Chinese patients with AAV after immunosuppressive therapy. METHODS: A total of 248 patients with a new diagnosis of ANCA-associated vasculitis were included in this study. The incidence, time, site, and risk factors of severe infection by the induction therapies were analysed...
June 14, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29902281/circulating-immune-complexome-analysis-identified-anti-tubulin-%C3%AE-1c-as-an-inflammation-associated-autoantibody-with-promising-diagnostic-value-for-behcet-s-disease
#2
Yongjing Cheng, Xiaozhen Zhao, Yuling Chen, Yuhui Li, Rulin Jia, Lei Zhu, Cibo Huang, Xiaolin Sun, Haiteng Deng, Zhanguo Li
BACKGROUND: Behcet's disease (BD) is a chronic, multisystem-involved vasculitis and its pathogenesis remains elusive. No specific serological markers for BD diagnosis have been established. Identification of novel diagnostic biomarkers will be helpful in timely diagnostic and treatment for Behcet's disease. OBJECTIVE: To screen novel autoantigens or autoantibodies with potential diagnostic value in circulating immune complexes (CICs) from BD patients. METHODS: A proteomic strategy for immune complexome analysis was developed, in which CICs were separated from serum sample of 10 BD patients and 10 healthy controls and then subjected to Orbitrap mass spectrometry for autoantigen profiling...
2018: PloS One
https://www.readbyqxmd.com/read/29901014/idiopathic-interstitial-pneumonia-as-a-possible-cause-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-case-report
#3
Hiroshi Oiwa, Katsuhiro Ooi, Tetsu Oyama, Eiji Sugyama
There are conflicting data to date on the causal relationship between idiopathic interstitial pneumonia and antineutrophil cytoplasmic antibody (ANCA): (1) myeloperoxidase-ANCA may play a pathogenetic role in pulmonary fibrosis, or (2) pulmonary fibrosis may induce production of the antibody. In this article, we describe a case of an elderly female patient with microscopic polyangiitis that developed after positive conversion of myeloperoxidase-ANCA during the course of idiopathic interstitial pneumonia. Our experience as well as similar case reports may suggest that idiopathic interstitial pneumonia may induce production of ANCAs and even ANCA-associated vasculitis...
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29891418/frequency-treatment-evolution-and-factors-associated-with-the-presence-of-tracheobronchial-stenoses-in-granulomatosis-with-polyangiitis-retrospective-analysis-of-a-case-series-from-a-single-respiratory-referral-center
#4
Erika Marroquín-Fabián, Natllely Ruiz, Jorge Mena-Zúñiga, Luis Felipe Flores-Suárez
OBJECTIVES: Granulomatosis with polyangiitis-a primary systemic vasculitis-most frequent manifestations are respiratory. Airway disease can present with stenosis, and although subglottic stenosis (SGS) is well described, narrowing distal to the glottis has been more recently the focus of reporting. Our objectives, therefore, are to describe the frequency, characteristics, and treatment of tracheobronchial stenoses (TBS) in granulomatosis with polyangiitis (GPA) at our institution, a national referral center for respiratory diseases...
May 16, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29888703/pr3-anca-a-potential-biomarker-of-disease-activity-for-propylthiouracil-induced-anca-associated-vasculitis
#5
Akito Hasegawa, Atsushi Fujimoto, Daisuke Yuki, Ryota Hayashi, Atsuko Aizawa, Takako Ito, Riichiro Abe
No abstract text is available yet for this article.
June 8, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29887327/myeloperoxidase-anca-positive-granulomatosis-with-polyangiitis-is-a-distinct-subset-of-anca-associated-vasculitis-a-retrospective-analysis-of-455-patients-from-a-single-center-in-china
#6
Dong-Yuan Chang, Zhi-Ying Li, Min Chen, Ming-Hui Zhao
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA) directed to proteinase 3 (PR3) used to be considered the serologic marker for granulomatosis with polyangiitis (GPA). However, patients with myeloperoxidase (MPO)-ANCA positive GPA have been increasingly reported. The aim of this study was to analyze the clinical and pathological characteristics and outcome of Chinese patients with MPO-ANCA positive GPA. METHODS: The clinical and renal histology data, renal outcomes, response to treatment, relapse and mortality were compared between patients with MPO-ANCA positive GPA and MPO-ANCA positive microscopic polyangiitis (MPA) as well as proteinase 3 (PR3)-ANCA positive GPA...
May 9, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29885746/the-treatment-outcomes-of-rituximab-for-intractable-otitis-media-with-anca-associated-vasculitis
#7
Masahiro Okada, Koichiro Suemori, Daiki Takagi, Masato Teraoka, Hiroyuki Yamada, Jun Ishizaki, Takuya Matsumoto, Hitoshi Hasegawa, Naohito Hato
OBJECTIVE: To investigate treatment outcomes, hearing outcomes, and adverse effects of rituximab (RTX) for intractable otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV). METHODS: Twenty-three patients who met the criteria proposed by the OMAAV study group were included. RTX was used for patients who had difficulty achieving induction of remission using glucocorticoids (GC) and intravenous cyclophosphamide (IVCY). RESULTS: Six patients were treated with RTX (RTX group), while 17 patients did not require RTX for induction of remission (non-RTX group)...
June 6, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29879042/pulmonary-renal-syndrome-a-case-report-of-diffuse-alveolar-hemorrhage-in-association-with-anca-negative-pauci-immune-glomerulonephritis
#8
Lakshmi Saladi, Danial Shaikh, Muhammad Saad, Enny Cancio-Rodriguez, Vivette D D'Agati, Boris Medvedovsky, Kalpana A Uday, Muhammad Adrish
RATIONALE: Pulmonary renal syndrome (PRS) is a term most commonly used to describe a combination of glomerulonephritis and pulmonary hemorrhage as a manifestation of a multisystem autoimmune disease. It is usually associated with ANCA vasculitis and anti-GBM disease. Diffuse alveolar hemorrhage in a patient with ANCA and anti-GBM negative pauci-immune glomerulonephritis is rare and optimal management is unknown. PATIENT CONCERNS: An 85-year-old man with hypertension, diabetes mellitus, prostate cancer and recently diagnosed pauci-immune necrotizing glomerulonephritis presented to our emergency department with worsening dyspnea and pedal edema for several days...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29872033/co-presentation-of-giant-cell-arteritis-and-granulomatosis-with-polyangiitis-a-case-report-and-review-of-literature
#9
Haitham H Hassane, Mirza M Beg, Chokkalingam Siva, Celso Velázquez
BACKGROUND Systemic vasculitis can present with a multitude of symptoms involving multiple organ systems. Clinicians should avoid anchoring bias and be cognizant that different types of vasculitides can be present in the same patient and that the diagnosis of one should not preclude the subsequent diagnosis of another. CASE REPORT A 67-year-old woman was referred for evaluation of episodes of epistaxis and recurrent severe sinusitis. Her physical examination showed nasal congestion and purpuric rash on the lower extremities...
June 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29869147/microscopic-polyangiitis-necrotizing-glomerulonephritis-associated-with-pregnancy-case-with-a-20-year-clinical-course-and-review-of-the-literature
#10
Yoichi Oshima, Tatsuya Suwabe, Yuji Marui, Noriko Hayami, Eiko Hasegawa, Masayuki Yamanouchi, Rikako Hiramatsu, Keiichi Sumida, Masahiro Kawada, Akinari Sekine, Hiroki Mizuno, Masahiko Oguro, Junichi Hoshino, Naoki Sawa, Yasuo Ishii, Takeshi Fujii, Kenichi Ohashi, Kenmei Takaichi, Yoshifumi Ubara
A 29-year-old woman with past medical history of hypertension was referred to our hospital for the evaluation of kidney dysfunction (serum creatinine 1.0 mg/dL), proteinuria (0.54 g/gCre), and microscopic hematuria. Renal biopsy before the first pregnancy was supportive for benign nephrosclerosis with no evidence of vasculitis. After her second pregnancy and delivery when she was 32 years old, she developed proteinuria of 3.2 g/gCre, hematuria, and elevated serum creatinine level of 2.6 mg/dL. Second renal biopsy revealed necrotizing glomerulonephritis and her serum MPO-ANCA was positive, leading to the diagnosis of MPA/renal-limited vasculitis (RLV)...
June 5, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29808456/late-onset-pneumocystis-jirovecii-pneumonia-pjp-in-patients-with-anca-associated-vasculitis
#11
El Hakem Matraiah, Nkiruka Olisaka, Mariana Philipos, David Walbaum, Paula Dospinescu, Nicholas Fluck, Neil Basu, Dana Kidder
Immunosuppression in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is complicated by increasing risk of infections including opportunistic infections like Pneumocystis jirovecii pneumonia (PJP). Available evidence on risk factors and indications for prophylaxis in AAV is derived from PJP occurring early in the course of AAV. In this retrospective study, we characterized the profile of PJP in patients with AAV. PJP cases were identified retrospectively based on positive polymerase chain reaction test from electronic record followed by confirmation from medical records over a 10-year period...
May 28, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29807863/cochlear-implantation-in-patients-with-bilateral-deafness-caused-by-otitis-media-with-anca-associated-vasculitis-omaav-a-report-of-four-cases
#12
Takeshi Watanabe, Haruo Yoshida, Kan Kishibe, Yuka Morita, Naohiro Yoshida, Haruo Takahashi, Yasuaki Harabuchi
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without systemic symptoms but with initial symptoms related to the ear, such as hearing loss, otalgia, and dizziness, has recently been reported. We have categorized this condition as otitis media with AAV (OMAAV), and have recently proposed its diagnostic criteria. METHODS: To determine the effectiveness of cochlear implantation (CI) in patients with profound hearing loss due to OMAAV...
May 25, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29805941/long-term-clinical-course-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-patients-off-maintenance-therapy
#13
Eric J Gapud, Rebecca Manno, Philip Seo, Mohamad Hanouneh, Duvuru Geetha
Objectives The optimal duration of maintenance immunosuppressive therapy in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is still controversial. The aim of our study is to describe the characteristics and outcomes of patients with AAV who were able to stop maintenance agents completely while remaining on daily prednisone (< 5 mg) for at least 36 months. Materials and methods AAV patients treated at our center from 2000 to 2016 and who were not on maintenance agents while remaining on prednisone < 5 mg daily for at least 36 months were identified by the providers, and their records were retrospectively reviewed...
March 26, 2018: Curēus
https://www.readbyqxmd.com/read/29790303/association-between-reappearance-of-myeloperoxidase-antineutrophil-cytoplasmic-antibody-and-relapse-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-subgroup-analysis-of-nationwide-prospective-cohort-studies
#14
Haruki Watanabe, Ken-Ei Sada, Yoshinori Matsumoto, Masayoshi Harigai, Koichi Amano, Hiroaki Dobashi, Shouichi Fujimoto, Joichi Usui, Kunihiro Yamagata, Tatsuya Atsumi, Shogo Banno, Takahiko Sugihara, Yoshihiro Arimura, Seiichi Matsuo, Hirofumi Makino
OBJECTIVE: The aim of this study was to evaluate clinical links between levels of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and relapse in patients with ANCA-associated vasculitis (AAV) using a data set from two nationwide prospective cohort studies. METHODS: From the cohort studies, 477 MPO-ANCA positive patients, who achieved remission during the 6 months after remission induction therapy, were enrolled. We measured MPO-ANCA levels at months 0, 3, 6, 12, 18, 24, and at the time of relapse...
May 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29790004/exploring-sex-specific-differences-in-the-presentation-and-outcomes-of-anca-associated-vasculitis-a-nationwide-registry-based-cohort-study
#15
Rune Bjørneklett, Vilde Solbakken, Leif Bostad, Anne-Siri Fismen
PURPOSE: Sex-specific differences in the risk of end-stage renal disease (ESRD) in patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) stratified by histological classification have not been previously investigated. METHODS: Patients with biopsy-verified pauci-immune necrotizing GN and positive ANCA serology in the Norwegian Kidney Biopsy Registry between 1991 and 2012 were included. Patients with ESRD during follow-up were identified from the Norwegian Renal Registry...
May 22, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29780146/propylthiouracil-induced-otitis-media-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#16
Rika Tanaka, Yasuhiro Shimojima, Hideaki Moteki, Dai Kishida, Ken-Ichi Ueno, Yoshiki Sekijima
We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves' disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. However, clinical remission was immediately achieved after initiating prednisolone together with PTU withdrawal...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29765786/nasal-septal-perforation-in-propylthiouracil-induced-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#17
Yusho Ishii, Tsuyoshi Shirai, Yousuke Hoshi, Yoko Fujita, Yuko Shirota, Hiroshi Fujii, Tomonori Ishii, Hideo Harigae
Here, we present the case of a 29-year-old woman with nasal septal perforation and positive myeloperoxidase- (MPO-) anti-neutrophil cytoplasmic antibody (ANCA). She had been diagnosed with Graves' disease and had been treated with propylthiouracil (PTU) for 14 months. A biopsy of the nasal septum revealed an infiltration of inflammatory cells, with no evidence of malignancy or granulomatous change. Because of the use of PTU, destructive nasal lesion, and positive MPO-ANCA, she was diagnosed with drug-induced ANCA-associated vasculitis (AAV) and was treated with prednisolone and methotrexate after the cessation of PTU...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29763902/prognostic-factors-of-renal-involvement-in-systemic-sclerosis
#18
Edoardo Rosato, Antonietta Gigante, Biagio Barbano, Maria Ludovica Gasperini, Rosario Cianci, Maurizio Muscaritoli
BACKGROUND/AIMS: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was to evaluate type and evolution of renal involvement for a period of five years. METHODS: 121 SSc patients (100 F, 21 M) with mean age of 54.9 ± 13.8, disease duration of 9 ± 6 years, of which 62 had a diffused form and 59 limited form were enrolled...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29760925/methimazole-induced-anca-associated-vasculitis-with-diffuse-alveolar-haemorrhage
#19
Naoki Arai, Kenji Nemoto, Shuji Oh-Ishi, Mizu Nonaka, Kenji Hayashihara, Takefumi Saito
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) caused by methimazole (MMI) is known to be relatively rare; therefore, the optimal therapeutic approach for these cases remains to be established. A 59-year-old man who was treated with MMI for a diagnosis of Graves' disease was referred to our hospital because of progressive haemoptysis. The patient was diagnosed with diffuse alveolar haemorrhage (DAH) secondary to AAV based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum and the results of bronchoalveolar lavage fluid...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29755460/proteinase-3-interferes-with-c1q-mediated-clearance-of-apoptotic-cells
#20
Pascale Tacnet-Delorme, Julie Gabillet, Simon Chatfield, Nathalie Thieblemont, Philippe Frachet, Véronique Witko-Sarsat
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheumatoid arthritis. During apoptosis, PR3 is co-externalized with phosphatidylserine (PS) and is known to modulate the clearance of apoptotic cells through a calreticulin (CRT)-dependent mechanism...
2018: Frontiers in Immunology
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