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Sanna L Lahtinen, Janne H Liisanantti, Meri M Poukkanen, Päivi A Laurila
BACKGROUND: Goal-directed fluid management using stroke volume variation (SVV) analysis is not well studied in free flap reconstruction surgery in patients with head and neck cancer. METHODS: Patients operated due to cancer of the head and neck with free flap reconstruction during 2008-2010 and 2012-2014 in Oulu University Hospital were retrospectively evaluated to determine the impact of SVV-guided fluid management on perioperative fluid balance, postoperative complications and hospital length of stay (LOS)...
October 19, 2016: Minerva Anestesiologica
Svv N Rao Sanapala, Harish Thangellapally, S Kondal Reddy, M Ashok Kumar, I Shyam Sunder Raju
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Anton Krige, Martin Bland, Thomas Fanshawe
BACKGROUND: Passive leg raising (PLR) is a so called self-volume challenge used to test for fluid responsiveness. Changes in cardiac output (CO) or stroke volume (SV) measured during PLR are used to predict the need for subsequent fluid loading. This requires a device that can measure CO changes rapidly. The Vigileo™ monitor, using third-generation software, allows continuous CO monitoring. The aim of this study was to compare changes in CO (measured with the Vigileo device) during a PLR manoeuvre to calculate the accuracy for predicting fluid responsiveness...
2016: Journal of Intensive Care
Margherita Tringali, Sylvette Wiener-Vacher, Maria Pia Bucci
AIM: The aim of this study was to understand the role played by visual information on the development of verticality and postural stability in healthy children. METHODS: The study comprised 66 healthy children from 4.0 to 15.7 years of age. Postural performances were recorded with a TechnoConcept platform. At the same time, the children's perception of subjective visual vertical (SVV) was recorded while they adjusted a vertical fluorescent line, either in the dark or in the presence of perturbing visual stimuli...
September 30, 2016: Acta Paediatrica
Nicole Arnold, Thomas Girke, Suhas Sureshchandra, Ilhem Messaoudi
: Primary infection with varicella zoster virus (VZV), a neurotropic alpha herpesvirus, results in varicella. VZV establishes latency in the sensory ganglia and can reactivate later in life to cause herpes zoster. The relationship between VZV and its host during acute infection in the sensory ganglia is not well understood due to limited access to clinical specimens. Intrabronchial inoculation of rhesus macaques with simian varicella virus (SVV), recapitulates the hallmarks of VZV infection in humans...
September 28, 2016: Journal of Virology
Joshua J Gnanasegaram, William J Parkes, Sharon L Cushing, Carmen L McKnight, Blake C Papsin, Karen A Gordon
Vestibular end organ impairment is highly prevalent in children who have sensorineural hearing loss (SNHL) rehabilitated with cochlear implants (CIs). As a result, spatial perception is likely to be impacted in this population. Of particular interest is the perception of visual vertical because it reflects a perceptual tilt in the roll axis and is sensitive to an imbalance in otolith function. The objectives of the present study were thus to identify abnormalities in perception of the vertical plane in children with SNHL and determine whether such abnormalities could be resolved with stimulation from the CI...
2016: Frontiers in Integrative Neuroscience
Nicole Arnold, Thomas Girke, Suhas Sureshchandra, Christina Nguyen, Maham Rais, Ilhem Messaoudi
Varicella Zoster Virus (VZV) is the causative agent of varicella and herpes zoster. Although it is well established that VZV is transmitted via the respiratory route, the host-pathogen interactions during acute VZV infection in the lungs remain poorly understood due to limited access to clinical samples. To address these gaps in our knowledge, we leveraged a nonhuman primate model of VZV infection where rhesus macaques are intrabronchially challenged with the closely related Simian Varicella Virus (SVV). Acute infection is characterized by immune infiltration of the lung airways, a significant up-regulation of genes involved in antiviral-immunity, and a down-regulation of genes involved in lung development...
September 28, 2016: Scientific Reports
Michael J Burke
Seneca Valley Virus isolate 001 (SVV-001) is an oncolytic RNA virus of the Picornaviridae family. It is also the first picornavirus discovered of the novel genus Senecavirus. SVV-001 replicates through an RNA intermediate, bypassing a DNA phase, and is unable to integrate into the host genome. SVV-001 was originally discovered as a contaminant in the cell culture of fetal retinoblasts and has since been identified as a potent oncolytic virus against tumors of neuroendocrine origin. SVV-001 has a number of features that make it an attractive oncolytic virus, namely, its ability to target and penetrate solid tumors via intravenous administration, inability for insertional mutagenesis, and being a self-replicating RNA virus with selective tropism for cancer cells...
2016: Oncolytic Virotherapy
T G V Cherpanath, B F Geerts, J J Maas, R B P de Wilde, A B Groeneveld, J R Jansen
BACKGROUND: Ventilator-induced dynamic hemodynamic parameters such as stroke volume variation (SVV) and pulse pressure variation (PPV) have been shown to predict fluid responsiveness in contrast to static hemodynamic parameters such as central venous pressure (CVP). We hypothesized that the ventilator-induced central venous pressure variation (CVPV) could predict fluid responsiveness. METHODS: Twenty-two elective cardiac surgery patients were studied post-operatively on the intensive care unit during mechanical ventilation with tidal volumes of 6-8 ml/kg without spontaneous breathing efforts or cardiac arrhythmia...
November 2016: Acta Anaesthesiologica Scandinavica
Hyo-Jung Kim, Seoyeon Kim, Jae Han Park, Ji-Soo Kim
Ocular and cervical vestibular-evoked myogenic potentials (VEMPs) evaluate the function of otolithic pathways in central as well as peripheral vestibular disorders. This study aimed to determine the associations and dissociations of otolithic dysfunction in lateral medullary infarction (LMI), the most well-known disorder of central vestibulopathy. At the Dizziness Clinic of a referral-based University Hospital, 45 patients with isolated LMI (28 men, mean age = 55.6 ± 12.5) had evaluation of the ocular tilt reaction (OTR), tilt of the subjective visual vertical (SVV), and ocular and cervical VEMPs from Janurary 2011 to August 2015 during the acute phase, 1-11 days from the symptom onset (median = 2 days)...
September 13, 2016: Journal of Neurology
Nathalie Linn Anikken Holme, Erling Bekkestad Rein, Maja Elstad
PURPOSE: Hypovolemia decreases preload and cardiac stroke volume. Cardiac stroke volume (SV) and its variability (cardiac stroke volume variability, SVV) have been proposed as clinical tools for detection of acute hemorrhage. We compared three non-invasive SV measurements and investigated if respiration-induced fluctuations in SV may detect mild and moderate hypovolemia in spontaneously breathing humans. METHODS: Ten healthy subjects underwent experimental central hypovolemia induced by lower body negative pressure to -60 mmHg or onset of presyncopal symptoms...
September 10, 2016: European Journal of Applied Physiology
Litten Bertelsen, Jesper Hastrup Svendsen, Lars Køber, Ketil Haugan, Søren Højberg, Carsten Thomsen, Niels Vejlstrup
BACKGROUND: Cardiovascular magnetic resonance (CMR) is considered the gold standard of cardiac volumetric measurements. Flow in the aortic root is often measured at the sinotubular junction, even though placing the slice just above valve level may be more precise. It is unknown how much flow measurements vary at different levels in the aortic root and which level corresponds best to left ventricle volumetry. METHODS: All patients were older than 70 years presenting with at least one of the following diagnoses: diabetes, hypertension, prior stroke and/or heart failure...
September 7, 2016: Journal of Cardiovascular Magnetic Resonance
Pongdhep Theerawit, Thotsaporn Morasert, Yuda Sutherasan
BACKGROUND: Currently, physicians employ pulse pressure variation (PPV) as a gold standard for predicting fluid responsiveness. However, employing ultrasonography in intensive care units is increasing, including using the ultrasonography for assessment of fluid responsiveness. Data comparing the performance of both methods are still lacking. This is the reason for the present study. MATERIALS AND METHODS: We conducted a prospective observational study in patients with sepsis requiring fluid challenge...
August 13, 2016: Journal of Critical Care
Mitsuhiro Aoki
BACKGROUND: The elderly often complain of faintness, lightheadedness, dizziness, and unsteadiness, which may be associated with the orthostatic hypotension (OH), but most of them are subclinical. The pathogenic mechanism of subjective symptoms in the elderly with OH is controversial. AIMS: The aim of this study was to assess the involvement of the irregularity of the vertical perception in the dizzy elderly with OH. METHODS: This study consisted of 403 patients seeking treatment for dizziness in our hospital...
August 27, 2016: Aging Clinical and Experimental Research
Tatiana Bremova, Siegbert Krafczyk, Stanislavs Bardins, Jörg Reinke, Michael Strupp
We investigated whether vestibular dysfunction may cause or contribute to postural imbalance and falls in patients with Niemann-Pick type C disease (NP-C). Eight patients with NP-C disease and 20 healthy controls were examined using the video-based head impulse test (vHIT) and caloric irrigation to investigate horizontal canal function as well as ocular- and cervical vestibular evoked myogenic potentials (o- and cVEMP), and binocular subjective visual vertical estimation (SVV) for otolith function, and static posturography...
November 2016: Journal of Neurology
A Zouabi, G Quarck, T Martin, M Grespinet, A Gauthier
Daytime activity is largely regulated by the day/night pattern. During the diurnal period individuals manage their balance, spatial orientation and consequently their perception of the vertical. Only six studies have attempted to evaluate postural control at different times of the day. The findings prove contradictory as two studies indicate postural control changes in the day while four others conclude that there is no time-of-day effect. The aim of our study is to evaluate the effect of time of day on postural control and perception of the vertical...
August 18, 2016: Chronobiology International
Julia A Müller, Christopher J Bockisch, Alexander A Tarnutzer
OBJECTIVE: Acute unilateral peripheral-vestibular hypofunction (UVH) shifts the subjective visual vertical (SVV) ipsilesionally, triggering central compensation that usually eliminates shifts when upright. We hypothesized that compensation is worse when roll-tilted. METHODS: We quantified SVV errors and variability in different roll-tilted positions (0°, ±45°, ±90°) in patients with chronic UVH affecting the superior branch (SVN; n=4) or the entire (CVN; n=9) vestibular nerve...
October 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Ole Broch, Jochen Renner, Patrick Meybohm, Martin Albrecht, Jan Höcker, Assad Haneya, Markus Steinfath, Berthold Bein, Matthias Gruenewald
OBJECTIVES: The reliability of dynamic and volumetric variables of fluid responsiveness in the presence of pericardial effusion is still elusive. The aim of the present study was to investigate their predictive power in a porcine model with hemodynamic relevant pericardial effusion. DESIGN: A single-center animal investigation. PARTICIPANTS: Twelve German domestic pigs. INTERVENTIONS: Pigs were studied before and during pericardial effusion...
October 2016: Journal of Cardiothoracic and Vascular Anesthesia
Teiji Sawa, Mao Kinoshita, Atsushi Kainuma, Koichi Akiyama, Yoshifumi Naito, Hideya Kato, Fumimasa Amaya, Keiji Shigemi
Arterial pulse waveform analysis (APWA) with a semi-invasive cardiac output monitoring device is popular in perioperative hemodynamic and fluid management. However, in APWA, evaluation of hemodynamic data is not well discussed. In this study, we analyzed how we visually interpret hemodynamic data, including stroke volume variation (SVV) and stroke volume (SV) derived from APWA. We performed arithmetic estimation of the SVV-SV relationship and applied measured values to this estimation. We then collected measured values in six anesthesia cases, including three liver transplantations and three other types of surgeries, to apply them to this SVV-SVI (stroke volume variation index) plot...
August 4, 2016: Journal of Clinical Monitoring and Computing
Xiaobao Zhang, Jiying Feng, Pin Zhu, Hengfei Luan, Yong Wu, Zhibin Zhao
BACKGROUND: Both hypovolemia and hypervolemia are connected with increased morbidity and mortality in the treatment and prognosis of patients. An accurate assessment of volume state allows the optimization of organ perfusion and oxygen supply. Recently, ultrasonography has been used to detect hypovolemia in critically ill patients and perioperative patients. The objective of our study was to assess the correlation between inferior vena cava (IVC) variation obtained with ultrasound and stroke volume variation (SVV) measured by the Vigileo/FloTrac monitor, as fluid responsiveness indicators, in patients undergoing anesthesia for surgery...
July 2016: Journal of Surgical Research
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