Elizabeth E Sloan, Katarina Kmetova, Somanathapura K NaveenKumar, Lyndsay Kluge, Emily Chong, Claire K Hoy, Srilakshmi Yalavarthi, Cyrus Sarosh, Jeanine Baisch, Lynnette Walters, Lorien Nassi, Julie Fuller, Jessica L Turnier, Virginia Pascual, Tracey B Wright, Jacqueline A Madison, Jason S Knight, Ayesha Zia, Yu Zuo
Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0...
February 12, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society