keyword
https://read.qxmd.com/read/38412763/low-shear-stress-exacerbates-atherosclerosis-by-inducing-the-generation-of-neutrophil-extracellular-traps-via-piezo1-mediated-mechanosensation
#21
JOURNAL ARTICLE
Ying Zhu, Tian Wang, Yan Yang, Zining Wang, Xiaohui Chen, Liu Wang, Ruyan Niu, Zixin Sun, Chong Zhang, Yang Luo, Yijie Hu, Wei Gu
BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease largely influenced by hemodynamics. Neutrophil extracellular trap (NET)-mediated inflammation plays an important role in atherosclerosis. However, little is known about the relationship between low shear stress (LSS) and NET generation, as well as the underlying mechanism. METHODS: We induced LSS by partial ligation of the left carotid artery in high-fat diet-fed male ApoE-/- mice...
February 10, 2024: Atherosclerosis
https://read.qxmd.com/read/38409251/nlrp3-inflammasome-activation-and-netosis-positively-regulate-each-other-and-exacerbate-proinflammatory-responses-implications-of-netosis-inhibition-for-acne-skin-inflammation-treatment
#22
JOURNAL ARTICLE
Hyo Jeong Kim, Yun Sang Lee, Bok-Soon Lee, Chang-Hak Han, Sang Gyu Kim, Chul-Ho Kim
Inflammasomes are multiprotein complexes involved in the host immune response to pathogen infections. Thus, inflammasomes participate in many conditions, such as acne. Recently, it was shown that NETosis, a type of neutrophil cell death, is induced by bacterial infection and is involved in inflammatory diseases such as delayed wound healing in patients with diabetes. However, the relationship between inflammasomes and NETosis in the pathogenesis of inflammatory diseases has not been well studied. In this study, we determined whether NETosis is induced in P...
February 26, 2024: Cellular & Molecular Immunology
https://read.qxmd.com/read/38405901/-pneumocystis-murina-promotes-inflammasome-formation-and-netosis-during-pneumocystis-pneumonia
#23
Steven G Sayson, Alan Ashbaugh, Aleksey Porollo, Melanie T Cushion
Pneumocystis jirovecii pneumonia (PjP) poses a serious risk to individuals with compromised immune systems, such as individuals with HIV/AIDS or undergoing immunosuppressive therapies for cancer or solid organ transplants. Severe PjP triggers excessive lung inflammation, resulting in lung function decline and consequential alveolar damage, potentially culminating in acute respiratory distress syndrome. Non-HIV patients face a 30-60%mortality rate, emphasizing the need for a deeper understanding of inflammatory responses in PjP...
February 18, 2024: bioRxiv
https://read.qxmd.com/read/38403308/-traditional-chinese-medicines-target-neutrophil-extracellular-traps-to-treat-diseases-a-review
#24
REVIEW
Zhao Wang, Jun-Ping Zhang, Ying-Xi Yang
Neutrophil extracellular traps(NETs) are fibrous networks formed by neutrophils after a procedure called NETosis, with the function of capturing and killing pathogens. NETs are widely involved in the pathological processes of major diseases such as immune system diseases, respiratory diseases, metabolic diseases, cancers, and reperfusion injury. Therefore, regulating NETs has become one of the important ways to prevent and treat the above diseases. As an excellent traditional culture in China, traditional Chinese medicine has made outstanding contributions to the treatment of diseases...
January 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38398138/characterizing-the-inflammatory-profile-of-neutrophil-rich-triple-negative-breast-cancer
#25
JOURNAL ARTICLE
Fatma Al Qutami, Walaa AlHalabi, Aswathy Vijayakumar, Surendra Singh Rawat, Abubakr H Mossa, Manju Nidagodu Jayakumar, Baila Samreen, Mahmood Y Hachim
Breast cancer (BC) is one of the most common types of cancer in women in the United Arab Emirates. Immunogenic tumours, such as triple-negative breast cancer (TNBC), show increased neutrophil infiltration, which is associated with poor prognosis and limited efficacy of immunotherapy. This study aims to investigate in vitro the bidirectional effect of neutrophils on metastatic TNBC (MDA-MB-231) compared to less-metastatic luminal breast cancer (MCF-7) cell lines. We found that BC cells or their conditioned medium (CM) reduced the viability of neutrophil-like cells (HL60)...
February 10, 2024: Cancers
https://read.qxmd.com/read/38395360/involvement-of-peptidylarginine-deiminase-4-in-eosinophil-extracellular-trap-formation-and-contribution-to-citrullinated-histone-signal-in-thrombi
#26
JOURNAL ARTICLE
Kimberly Martinod, Frederik Denorme, Severien Meyers, Marilena Crescente, Stijn Van Bruggen, Mathias Stroobants, Patrick M Siegel, Ramesh Grandhi, Katharina Glatz, Thilo Witsch
BACKGROUND: Extracellular traps formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing to thrombus stability. A key mechanism during NET formation is histone modification by the enzyme PAD4. Citrullinated histones, the product of PAD4 activity, are often attributed to neutrophils. Eosinophils also express high levels of PAD4 but the contribution of PAD4 to EET formation is not known. METHODS: We performed immunohistological analyses on thrombi, including a large, intact and eosinophil-containing thrombus retrieved from the right coronary artery using an aspiration catheter and stroke thrombi from thrombectomy retrieval...
February 21, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38392321/exploring-beyond-common-cell-death-pathways-in-oral-cancer-a-systematic-review
#27
REVIEW
Leonardo de Oliveira Siquara da Rocha, Everton Freitas de Morais, Lilianny Querino Rocha de Oliveira, Andressa Vollono Barbosa, Daniel W Lambert, Clarissa A Gurgel Rocha, Ricardo D Coletta
Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head and neck cancer in the world. Variable response and acquisition of resistance to traditional therapies show that it is essential to develop novel strategies that can provide better outcomes for the patient. Understanding of cellular and molecular mechanisms of cell death control has increased rapidly in recent years. Activation of cell death pathways, such as the emerging forms of non-apoptotic programmed cell death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis and paraptosis, may represent clinically relevant novel therapeutic opportunities...
February 6, 2024: Biology
https://read.qxmd.com/read/38387309/neutrophils-are-indispensable-for-adverse-cardiac-remodeling-in-heart-failure
#28
JOURNAL ARTICLE
Sergey Antipenko, Nicolas Mayfield, Miki Jinno, Matthias Gunzer, Mohamed Ameen Ismahil, Tariq Hamid, Sumanth D Prabhu, Gregg Rokosh
Persistent immune activation contributes significantly to left ventricular (LV) dysfunction and adverse remodeling in heart failure (HF). In contrast to their well-known essential role in acute myocardial infarction (MI) as first responders that clear dead cells and facilitate subsequent reparative macrophage polarization, the role of neutrophils in the pathobiology of chronic ischemic HF is poorly defined. To determine the importance of neutrophils in the progression of ischemic cardiomyopathy, we measured their production, levels, and activation in a mouse model of chronic HF 8 weeks after permanent coronary artery ligation and large MI...
February 21, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38384468/complexation-of-fungal-extracellular-nucleic-acids-by-host-ll-37-peptide-shapes-neutrophil-response-to-candida-albicans-biofilm
#29
JOURNAL ARTICLE
Magdalena Juszczak, Marcin Zawrotniak, Maria Rapala-Kozik
Candida albicans remains the predominant cause of fungal infections, where adhered microbial cells form biofilms - densely packed communities. The central feature of C. albicans biofilms is the production of an extracellular matrix (ECM) consisting of polymers and extracellular nucleic acids (eDNA, eRNA), which significantly impedes the infiltration of host cells. Neutrophils, as crucial players in the innate host defense, employ several mechanisms to eradicate the fungal infection, including NETosis, endocytosis, or the release of granules containing, among others, antimicrobial peptides (AMPs)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38380618/decreased-lung-metastasis-in-triple-negative-breast-cancer-following-locally-delivered-supratherapeutic-paclitaxel-loaded-polyglycerol-carbonate-nanoparticle-therapy
#30
JOURNAL ARTICLE
Robert C Sabatelle, Ngoc-Quynh Chu, William Blessing, Hussein Kharroubi, Eric Bressler, Lillian Tsai, Angela Shih, Mark W Grinstaff, Yolonda Colson
Breast cancer is among the most prevalent malignancies, accounting for 685,000 deaths worldwide in 2020, largely due to its high metastatic potential. Depending on the stage and tumor characteristics, treatment involves surgery, chemotherapy, targeted biologics, and/or radiation therapy. However, current treatments are insufficient for treating or preventing metastatic disease. Herein, we describe supratherapeutic paclitaxel-loaded nanoparticles (81 wt % paclitaxel) to treat the primary tumor and reduce the risk of subsequent metastatic lesions in the lungs...
February 21, 2024: Biomacromolecules
https://read.qxmd.com/read/38378550/mechanisms-of-endothelial-activation-hypercoagulation-and-thrombosis-in-covid-19-a-link-with-diabetes-mellitus
#31
REVIEW
Inés Valencia, Jairo Lumpuy-Castillo, Giselle Magalhaes, Carlos F Sánchez-Ferrer, Óscar Lorenzo, Concepción Peiró
Early since the onset of the COVID-19 pandemic, the medical and scientific community were aware of extra respiratory actions of SARS-CoV-2 infection. Endothelitis, hypercoagulation, and hypofibrinolysis were identified in COVID-19 patients as subsequent responses of endothelial dysfunction. Activation of the endothelial barrier may increase the severity of the disease and contribute to long-COVID syndrome and post-COVID sequelae. Besides, it may cause alterations in primary, secondary, and tertiary hemostasis...
February 20, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38370726/tamm-horsfall-protein-augments-neutrophil-netosis-during-urinary-tract-infection
#32
Vicki Mercado-Evans, Claude Chew, Camille Serchejian, Alexander Saltzman, Marlyd E Mejia, Jacob J Zulk, Ingrid Cornax, Victor Nizet, Kathryn A Patras
Urinary neutrophils are a hallmark of urinary tract infection (UTI), yet the mechanisms governing their activation, function, and efficacy in controlling infection remain incompletely understood. Tamm-Horsfall glycoprotein (THP), the most abundant protein in urine, uses terminal sialic acids to bind an inhibitory receptor and dampen neutrophil inflammatory responses. We hypothesized that neutrophil modulation is an integral part of THP-mediated host protection. In a UTI model, THP-deficient mice showed elevated urinary tract bacterial burdens, increased neutrophil recruitment, and more severe tissue histopathological changes compared to WT mice...
February 5, 2024: bioRxiv
https://read.qxmd.com/read/38369729/pathogenesis-guided-rational-engineering-of-nanotherapies-for-the-targeted-treatment-of-abdominal-aortic-aneurysm-by-inhibiting-neutrophilic-inflammation
#33
JOURNAL ARTICLE
Kaiyao Hu, Ling Zhong, Wenjie Lin, Guanli Zhao, Wendan Pu, Zhiqiang Feng, Min Zhou, Jun Ding, Jianxiang Zhang
Abdominal aortic aneurysm (AAA) remains a fatal disease in the elderly. Currently, no drugs can be clinically used for AAA therapy. Considering the pivotal role of neutrophils in the pathogenesis of AAA, herein we propose the targeted therapy of AAA by site-specifically regulating neutrophilic inflammation. Based on a luminol-conjugated α-cyclodextrin material (LaCD), intrinsically anti-inflammatory nanoparticles (NPs) were engineered by simple nanoprecipitation, which were examined as a nanotherapy (defined as LaCD NP)...
February 18, 2024: ACS Nano
https://read.qxmd.com/read/38360057/macrophage-1-antigen-exacerbates-histone-induced-acute-lung-injury-and-promotes-neutrophil-extracellular-trap-formation
#34
JOURNAL ARTICLE
Tomohiro Mizuno, Fumihiko Nagano, Kazuo Takahashi, Shigeki Yamada, Kazuhiro Fruhashi, Shoichi Maruyama, Naotake Tsuboi
Acute lung injury (ALI), which occurs in association with sepsis, trauma, and coronavirus disease 2019 (COVID-19), is a serious clinical condition with high mortality. Excessive platelet-leukocyte aggregate (PLA) formation promotes neutrophil extracellular trap (NET) release and thrombosis, which are involved in various diseases, including ALI. Macrophage-1 antigen (Mac-1, CD11b/CD18), which is expressed on the surface of leukocytes, is known to promote NET formation. This study aimed to elucidate the role of Mac-1 in extracellular histone-induced ALI...
February 15, 2024: FEBS Open Bio
https://read.qxmd.com/read/38355030/non-criteria-antiphospholipid-antibodies-and-calprotectin-as-potential-biomarkers-in-pediatric-antiphospholipid-syndrome
#35
JOURNAL ARTICLE
Elizabeth E Sloan, Katarina Kmetova, Somanathapura K NaveenKumar, Lyndsay Kluge, Emily Chong, Claire K Hoy, Srilakshmi Yalavarthi, Cyrus Sarosh, Jeanine Baisch, Lynnette Walters, Lorien Nassi, Julie Fuller, Jessica L Turnier, Virginia Pascual, Tracey B Wright, Jacqueline A Madison, Jason S Knight, Ayesha Zia, Yu Zuo
Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0...
February 12, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38349409/coagulation-and-inflammation-in-covid-19-reciprocal-relationship-between-inflammatory-and-coagulation-markers
#36
REVIEW
Rasoul Ebrahimi, Fatemeh Nasri, Tahereh Kalantari
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), formerly known as 2019-nCoV. Numerous cellular and biochemical issues arise after COVID-19 infection. The severe inflammation that is caused by a number of cytokines appears to be one of the key hallmarks of COVID-19. Additionally, people with severe COVID-19 have coagulopathy and fulminant thrombotic events. We briefly reviewed the COVID-19 disease at the beginning of this paper. The inflammation and coagulation markers and their alterations in COVID-19 illness are briefly discussed in the parts that follow...
February 13, 2024: Annals of Hematology
https://read.qxmd.com/read/38339001/inhibiting-neutrophil-extracellular-traps-protects-against-ultraviolet-b-induced-skin-damage-effects-of-hochu-ekki-to-and-dnase-i
#37
JOURNAL ARTICLE
Issei Inaba, Keiichi Hiramoto, Yurika Yamate, Akihiro Morita, Tomonari Tsutsumi, Hiroyuki Yasuda, Eisuke F Sato
UV-B radiation induces sunburn, and neutrophils are pivotal in this inflammation. In this study, we examined the potential involvement of neutrophil extracellular traps (NETs) in ultraviolet B (UVB)-induced skin inflammation, correlating the skin inflammation-mitigating effects of Hochu-ekki-to on UV-B irradiation and NETs. To elucidate NET distribution in the dorsal skin, male ICR mice, exposed to UVB irradiation, were immunohistologically analyzed to detect citrullinated histone H3 (citH3) and peptidylarginine deiminase 4 (PAD4)...
January 31, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338744/a-narrative-review-the-role-of-nets-in-acute-respiratory-distress-syndrome-acute-lung-injury
#38
REVIEW
Xinyu Zhou, Jiajia Jin, Tangfeng Lv, Yong Song
Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and the alleviation and treatment of ARDS remains a major research focus. There are various causes of ARDS, among which pneumonia and non-pulmonary sepsis are the most common. Trauma and blood transfusion can also cause ARDS. In ARDS, the aggregation and infiltration of neutrophils in the lungs have a great influence on the development of the disease. Neutrophils regulate inflammatory responses through various pathways, and the release of neutrophils through neutrophil extracellular traps (NETs) is considered to be one of the most important mechanisms...
January 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38337844/the-role-of-neutrophil-extracellular-traps-in-the-outcome-of-malignant-epitheliomas-significance-of-ca215-involvement
#39
REVIEW
Mihai Emanuel Himcinschi, Valentina Uscatescu, Georgiana Gherghe, Irina Stoian, Adelina Vlad, Delia Codruța Popa, Daniel Coriu, Andrei Anghel
Neutrophil extracellular traps (NETs) were originally discovered as a part of the innate immune response of the host to bacteria. They form a web-like structure that can immobilize microorganisms or exhibit direct antimicrobial properties, such as releasing reactive oxygen species (ROS). NETs are established when neutrophils undergo a sort of cellular death following exposure to ROS, chemokines, cytokines, or other soluble factors. This process results in the release of the neutrophil's DNA in a web-like form, which is decorated with citrullinated histones (H3/H4-cit), neutrophil elastase (NE), and myeloperoxidase (MPO)...
February 2, 2024: Diagnostics
https://read.qxmd.com/read/38336763/nod1-deficiency-ameliorates-the-progression-of-diabetic-retinopathy-by-modulating-bone-marrow-retina-crosstalk
#40
JOURNAL ARTICLE
Jingwen Qiu, Jing Wu, Wenwen Chen, Yu Ruan, Jingning Mao, Shue Li, Xuan Tang, Lei Zhao, Shengbing Li, Ke Li, Dongfang Liu, Yaqian Duan
BACKGROUND: Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) plays a pivotal role in inducing metabolic inflammation in diabetes. Additionally, the NOD1 ligand disrupts the equilibrium of bone marrow-derived hematopoietic stem/progenitor cells, a process that has immense significance in the development of diabetic retinopathy (DR). We hypothesized that NOD1 depletion impedes the advancement of DR by resolving bone marrow dysfunction. METHODS: We generated NOD1-/- -Akita double-mutant mice and chimeric mice with hematopoietic-specific NOD1 depletion to study the role of NOD1 in the bone marrow-retina axis...
February 9, 2024: Stem Cell Research & Therapy
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