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https://www.readbyqxmd.com/read/29455797/from-the-editor-s-desk-march-2018
#1
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucman-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
March 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29449618/codon-based-co-occurrence-network-motifs-in-human-mitochondria
#2
Pramod Shinde, Camellia Sarkar, Sarika Jalan
The nucleotide polymorphism in the human mitochondrial genome (mtDNA) tolled by codon position bias plays an indispensable role in human population dispersion and expansion. Herein, genome-wide nucleotide co-occurrence networks were constructed using data comprised of five different geographical regions and around 3000 samples for each region. We developed a powerful network model to describe complex mitochondrial evolutionary patterns among codon and non-codon positions. We found evidence that the evolution of human mitochondria DNA is dominated by adaptive forces, particularly mutation and selection, which was supported by many previous studies...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29395458/corrigendum-to-alfapump%C3%A2-system-vs-large-volume-paracentesis-for-refractory-ascites-a-multicenter-randomized-controlled-study-j-hepatol-67-2017-940-949
#3
Christophe Bureau, Danielle Adebayo, Mael Chalret de Rieu, Laure Elkrief, Dominique Valla, Markus Peck-Radosavljevic, Anne McCune, Reyad Abbadi, Victor Vargas, Macarena Simon-Talero, Juan Cordoba, Paolo Angeli, Silvia Rosi, Stewart MacDonald, Massimo Malago, Maria Stepanova, Zobair M Younossi, Claudia Trepte, Randall Watson, Oleg Borisenko, Sun Sun, Neil Inhaber, Rajiv Jalan
No abstract text is available yet for this article.
January 29, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29347745/multiplexing-topologies-and-time-scales-the-gains-and-losses-of-synchrony
#4
Sergey Makovkin, Anil Kumar, Alexey Zaikin, Sarika Jalan, Mikhail Ivanchenko
Inspired by the recent interest in collective dynamics of biological neural networks immersed in the glial cell medium, we investigate the frequency and phase order, i.e., Kuramoto type of synchronization in a multiplex two-layer network of phase oscillators of different time scales and topologies. One of them has a long-range connectivity, exemplified by the Erdős-Rényi random network, and supports both kinds of synchrony. The other is a locally coupled two-dimensional lattice that can reach frequency synchronization but lacks phase order...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347340/mirror-node-correlations-tuning-synchronization-in-multiplex-networks
#5
Anil Kumar, Murilo S Baptista, Alexey Zaikin, Sarika Jalan
We show that the degree-degree correlations have a major impact on global synchronizability (GS) of multiplex networks, enabling the specification of synchronizability by only changing the degree-degree correlations of the mirror nodes while maintaining the connection architecture of the individual layer unaltered. If individual layers have nodes that are mildly correlated, the multiplex network is best synchronizable when the mirror degrees are strongly negatively correlated. If individual layers have nodes with strong degree-degree correlations, mild correlations among the degrees of mirror nodes are the best strategy for the optimization of GS...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29332649/isoniazid-and-rifampicin-heteroresistant-mycobacterium-tuberculosis-isolated-from-tuberculous-meningitis-patients-in-india
#6
Renu Gupta, Rajeev Thakur, Suman Kushwaha, Nupur Jalan, Pumanshi Rawat, Piyush Gupta, Amitesh Aggarwal, Meena Gupta, Vikas Manchanda
BACKGROUND: Heteroresistant Mycobacterium tuberculosis (mixture of susceptible and resistant subpopulations) is thought to be a preliminary stage to full resistance and timely detection, initiation of correct treatment is vital for successful anti tubercular therapy. The aim of this study was to detect multi drug resistant (MDR) and heteroresistant M. tuberculosis with the associated gene mutations from patients of tuberculous meningitis. METHODS: A total of 197 M...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29301493/pacbio-sequencing-of-copper-tolerant-xanthomonas-citri-reveals-presence-of-a-chimeric-plasmid-structure-and-provides-insights-into-reassortment-and-shuffling-of-transcription-activator-like-effectors-among-x-citri-strains
#7
Alberto M Gochez, Jose C Huguet-Tapia, Gerald V Minsavage, Deepak Shantaraj, Neha Jalan, Annett Strauß, Thomas Lahaye, Nian Wang, Blanca I Canteros, Jeffrey B Jones, Neha Potnis
BACKGROUND: Xanthomonas citri, a causal agent of citrus canker, has been a well-studied model system due to recent availability of whole genome sequences of multiple strains from different geographical regions. Major limitations in our understanding of the evolution of pathogenicity factors in X. citri strains sequenced by short-read sequencing methods have been tracking plasmid reshuffling among strains due to inability to accurately assign reads to plasmids, and analyzing repeat regions among strains...
January 4, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29284946/to-compare-and-evaluate-the-sorption-and-solubility-of-four-luting-cements-after-immersion-in-artificial-saliva-of-different-ph-values
#8
Kadambari Bharali, Manjula Das, Silpi Jalan, Rajdeep Paul, Adrija Deka
Introduction: The word 'luting' is derived from a latin word 'Lutum' which means 'mud'. 'Luting' is a word that is often used to describe the use of a mouldable substance to seal a space or to cement two components together. Therefore in view of the clinical importance of dissolution of luting cements in the oral environment, an in vitro study was designed to compare the sorption and solubility of commercially available luting cements mainly zinc phosphate, Glass Ionomer cement, Resin Modified Glass Ionomer Cement and Resin Cement after immersion in artificial saliva of different ph values of 5 and 7...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29226396/editorial-alfapump-an-alternative-to-large-volume-paracentesis-for-patients-with-refractory-ascites
#9
EDITORIAL
S Macdonald, R Jalan
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29206839/development-of-an-organ-failure-score-in-acute-liver-failure-for-transplant-selection-and-identification-of-patients-at-high-risk-of-futility
#10
Francesco Figorilli, Antonella Putignano, Olivier Roux, Pauline Houssel-Debry, Claire Francoz, Catherine Paugam-Burtz, Olivier Soubrane, Banwari Agarwal, François Durand, Rajiv Jalan
INTRODUCTION: King's College Hospital criteria are currently used to select liver transplant candidates in acetaminophen-related acute liver failure (ALF). Although widely accepted, they show a poor sensitivity in predicting pre-transplant mortality and cannot predict the outcome after surgery. In this study we aimed to develop a new prognostic score that can allow patient selection for liver transplantation more appropriately and identify patients at high risk of futile transplantation...
2017: PloS One
https://www.readbyqxmd.com/read/29203029/modeling-pedestrian-gap-crossing-index-under-mixed-traffic-condition
#11
Mohamed M Naser, Adnan Zulkiple, Walid A Al Bargi, Nasradeen A Khalifa, Basil David Daniel
INTRODUCTION: There are a variety of challenges faced by pedestrians when they walk along and attempt to cross a road, as the most recorded accidents occur during this time. Pedestrians of all types, including both sexes with numerous aging groups, are always subjected to risk and are characterized as the most exposed road users. The increased demand for better traffic management strategies to reduce the risks at intersections, improve quality traffic management, traffic volume, and longer cycle time has further increased concerns over the past decade...
December 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/29194916/the-impact-of-obesity-in-cirrhotic-patients-with-septic-shock-a-retrospective-cohort-study
#12
Beverley Kok, Constantine J Karvellas, Juan G Abraldes, Rajiv Jalan, Vinay Sundaram, David Gurka, Sean Keenan, Aseem Kumar, Greg Martinka, Brian Bookatz, Gordon Wood, Anand Kumar
BACKGROUND & AIMS: The prevalence of obesity in cirrhosis is rising. The impact of obesity in the critically-ill cirrhotic patient with sepsis/septic shock has not been evaluated. This study aimed to examine the relationship between obesity and mortality in cirrhotic patients admitted to the intensive care unit with septic shock. METHODS: A retrospective cohort study of all cirrhotic patients with septic shock (n=362) and a recorded body mass index (BMI) from an international, multicenter (CATTS) database (1996-2015) was performed...
December 1, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29171941/extracorporeal-cellular-therapy-elad-in-severe-alcoholic-hepatitis-a-multinational-prospective-controlled-randomized-trial
#13
Julie Thompson, Natasha Jones, Ali Al-Khafaji, Shahid Malik, David Reich, Santiago Munoz, Ross MacNicholas, Tarek Hassanein, Lewis Teperman, Lance Stein, Andrés Duarte-Rojo, Raza Malik, Talal Adhami, Sumeet Asrani, Nikunj Shah, Paul Gaglio, Anupama Duddempudi, Brian Borg, Rajiv Jalan, Robert Brown, Heather Patton, Rohit Satoskar, Simona Rossi, Amay Parikh, Ahmed ElSharkawy, Parvez Mantry, Linda Sher, David Wolf, Marquis Hart, Charles Landis, Alan Wigg, Shahid Habib, Geoffrey McCaughan, Steven Colquhoun, Alyssa Henry, Patricia Bedard, Lee Landeen, Michael Millis, Robert Ashley, William Frank, Andrew Henry, Jan Stange, Ram Subramanian
Severe Alcoholic Hepatitis (sAH) is associated with a poor prognosis. There is no proven effective treatment for sAH, which is why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors and were tested in an extracorporeal liver treatment (ELAD) study to establish their effect on survival for subjects with sAH. Adults with sAH, bilirubin ≥8 mg/dL, Maddrey's Discriminant Function (DF) ≥32 and Model for End-Stage Liver Disease (MELD) score ≤35, were randomized to receive standard of care (SOC) only or 3-5 days of continuous ELAD treatment plus SOC...
November 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29156208/from-the-editor-s-desk-december-2017
#14
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucman-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
December 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29092446/is-repulsion-good-for-the-health-of-chimeras
#15
Sarika Jalan, Saptarshi Ghosh, Bibhabasu Patra
Yes! Very much so. A chimera state refers to the coexistence of a coherent-incoherent dynamical evolution of identically coupled oscillators. We investigate the impact of multiplexing of a layer having repulsively coupled oscillators on the occurrence of chimeras in the layer having attractively coupled identical oscillators. We report that there exists an enhancement in the appearance of the chimera state in one layer of the multiplex network in the presence of repulsive coupling in the other layer. Furthermore, we show that a small amount of inhibition or repulsive coupling in one layer is sufficient to yield the chimera state in another layer by destroying its synchronized behavior...
October 2017: Chaos
https://www.readbyqxmd.com/read/29067149/the-impact-of-rifaximin-%C3%AE-on-the-hospital-resource-use-associated-with-the-management-of-patients-with-hepatic-encephalopathy-a-retrospective-observational-study-impress
#16
Mark Hudson, Amr Radwan, Paola Di Maggio, Riccardo Cipelli, Stephen D Ryder, John F Dillon, William Jonathan Cash, Robert T Przemioslo, Mark Wright, Debbie L Shawcross, Rajiv Jalan, Sushma Saksena, Michael Allison, Paul Richardson, Elizabeth Farrington, Richard J Aspinall
OBJECTIVE: To compare all-cause and liver-related hospital resource use in the 6 and 12 months pre-rifaximin-α and post-rifaximin-α initiation in UK patients with hepatic encephalopathy (HE). DESIGN: A UK multicentre, retrospective, observational study. Patients' medical records were reviewed for demographics, clinical outcomes and adverse events (AEs) to rifaximin-α. Details of hospital admissions/attendances in the 6 and 12 months pre-rifaximin-α and post-rifaximin-α initiation were extracted from hospital electronic databases...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29059474/ducts-in-a-dish-bioengineered-biliary-scaffolds-for-regenerative-medicine
#17
Nidhi Jalan-Sakrikar, Robert C Huebert
No abstract text is available yet for this article.
October 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29050635/from-the-editor-s-desk-november-2017
#18
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucmann-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
November 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29023872/cell-death-markers-in-cirrhotic-patients-with-acute-decompensation
#19
Stewart Macdonald, Fausto Andreola, Patrik Bachtiger, Alex Amoros, Marco Pavesi, Rajeshwar Mookerjee, Yu Bao Zheng, Henning Grønbaek, Alexander L Gerbes, Elsa Sola, Paolo Caraceni, Richard Moreau, Pere Gines, Vicente Arroyo, Rajiv Jalan
The aims of this study were to determine the role of cell death in cirrhotic patients with acute decompensation (AD) and acute on chronic liver failure (ACLF) using plasma-based biomarkers. The patients studied were part of the CANONIC study (N=337; AD: 258; ACLF: 79); additional cohorts included healthy volunteers, stable cirrhotic patients and a group of 16 AD patients for histological studies. Caspase-cleaved keratin 18 (cK18) and keratin 18 (K18), which reflect apoptotic and total cell death respectively and cK18:K18 ratio (apoptotic index) were measured in the plasma by ELISA...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28950611/optimized-evolution-of-networks-for-principal-eigenvector-localization
#20
Priodyuti Pradhan, Alok Yadav, Sanjiv K Dwivedi, Sarika Jalan
Network science is increasingly being developed to get new insights about behavior and properties of complex systems represented in terms of nodes and interactions. One useful approach is investigating the localization properties of eigenvectors having diverse applications including disease-spreading phenomena in underlying networks. In this work, we evolve an initial random network with an edge rewiring optimization technique considering the inverse participation ratio as a fitness function. The evolution process yields a network having a localized principal eigenvector...
August 2017: Physical Review. E
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