keyword
MENU ▼
Read by QxMD icon Read
search

Critical power

keyword
https://www.readbyqxmd.com/read/29151207/rapid-prediction-of-multi-dimensional-nmr-data-sets-using-fandas
#1
Siddarth Narasimhan, Deni Mance, Cecilia Pinto, Markus Weingarth, Alexandre M J J Bonvin, Marc Baldus
Solid-state NMR (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments. In the last few years, ssNMR has made significant progress in uncovering structure and dynamics of proteins in their native cellular environments [1-4]. Additionally, ssNMR has proven to be useful in studying large biomolecular complexes as well as membrane proteins at the atomic level [5]. In such studies, innovative labeling schemes have become a powerful approach to tackle spectral crowding...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29149319/from-bouncing-back-to-nurturing-emergence-reframing-the-concept-of-resilience-in-health-systems-strengthening
#2
Edwine W Barasa, Keith Cloete, Lucy Gilson
Recent health system shocks such as the Ebola disease outbreak have focused global health attention on the notion of resilient health systems. In this commentary, we reflect on the current framing of the concept of resilience in health systems discourse and propose a reframing. Specifically, we propose that: (1) in addition to sudden shocks, health systems face the ongoing strain of multiple factors. Health systems need the capacity to continue to deliver services of good quality and respond effectively to wider health challenges...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29144871/consistency-ensured-parametric-tests-for-critical-events-of-composite-endpoints
#3
Mohammad F Huque, Mohamed Alosh, Matthew Guerra
Composite endpoints (CEs) are commonly used in clinical trials when clinically important events are rare or when the disease is multifaceted. However, components of a CE often differ markedly in their clinical importance. The overall treatment effect on the composite can be driven by less-important, yet more frequently occurring, components, with no effects on some clinically important components. These situations create difficulties in interpreting the results of the CE. The literature has proposed several approaches for handling these conditions, for example, by setting requirements on the results of the clinically important components...
November 16, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29144725/inhibition-of-acinetobacter-derived-cephalosporinase-adc-exploring-the-carboxylate-recognition-site-using-novel-%C3%AE-lactamase-inhibitors
#4
Emilia Caselli, Chiara Romagnoli, Rachel A Powers, Magdalena A Taracila, Alexandra A Bouza, Hollister C Swanson, Kali A Smolen, Francesco Fini, Bradley J Wallar, Robert A Bonomo, Fabio Prati
Boronic acids are attracting a lot of attention as -lactamase inhibitors, and in particular compound S02030 (Ki = 44 nM) proved to be a good lead compound against ADC-7 (Acinetobacter Derived Cephalosporinase), one of the most significant resistance determinants in A. baumannii. The atomic structure of the ADC-7/S02030 complex highlighted the importance of critical structural determinants for recognition of the boronic acids. Herein, to elucidate the role in recognition of the R2-carboxylate, which mimics the C3/C4 found in -lactams, we designed, synthesized, and characterized six derivatives of S02030 (3a)...
November 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29144282/substrate-effects-in-high-gain-low-operating-voltage-snse2-photoconductor
#5
Krishna Murali, Sangeeth Kallatt, Kausik Majumdar
High gain photoconductive devices find wide spread applications in low intensity light detection. Ultra-thin layered materials have recently attracted a lot of attention from researchers in this regard. However, in general, a large operating voltage is required to obtain large responsivity in these devices. In addition, the characteristics are often confounded by substrate induced trap effects. Here we report multi-layer SnSe2 based photoconductive devices using two different structures: (1) SiO2 substrate supported interdigitated electrode (IDE), and (2) suspended channel...
November 16, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29143636/a-review-of-measures-of-women-s-empowerment-and-related-gender-constructs-in-family-planning-and-maternal-health-program-evaluations-in-low-and-middle-income-countries
#6
Mahua Mandal, Arundati Muralidharan, Sara Pappa
BACKGROUND: Evidence suggests that gender-integrated interventions, which actively seek to identify and integrate activities that address the role of gender norms and dynamics, improve family planning (FP) and maternal health (MH). To understand the link between the gender components of interventions and FP and MH outcomes, it is critical to examine the gender measures used in evaluations. METHODS: We conducted a systematic review of evaluations of gender-integrated FP and MH interventions in low- and middle-income countries...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29143635/a-systematic-review-of-concepts-related-to-women-s-empowerment-in-the-perinatal-period-and-their-associations-with-perinatal-depressive-symptoms-and-premature-birth
#7
Esmeralda R Garcia, Ilona S Yim
BACKGROUND: The perinatal period, which we here define as pregnancy and the first year postpartum, is a time in women's lives that involves significant physiological and psychosocial change and adjustment, including changes in their social status and decision-making power. Supporting women's empowerment at this particular time in their lives may be an attractive opportunity to create benefits for maternal and infant health outcomes such as reductions in perinatal depressive symptoms and premature birth rates...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29141909/local-fitness-landscapes-predict-yeast-evolutionary-dynamics-in-directionally-changing-environments
#8
Florien A Gorter, Mark G M Aarts, Bas J Zwaan, J Arjan G M de Visser
The fitness landscape is a concept that is widely used for understanding and predicting evolutionary adaptation. The topography of the fitness landscape depends critically on the environment, with potentially far-reaching consequences for evolution under changing conditions. However, few studies have assessed directly how empirical fitness landscapes change across conditions, or validated the predicted consequences of such change. We previously evolved replicate yeast populations in the presence of either gradually increasing or constant high concentrations of the heavy metals cadmium (Cd), nickel (Ni), and zinc (Zn), and analysed their phenotypic and genomic changes...
November 15, 2017: Genetics
https://www.readbyqxmd.com/read/29141634/the-effects-of-neoliberal-policies-on-access-to-healthcare-for-people-with-disabilities
#9
Dikaios Sakellariou, Elena S Rotarou
Neoliberal reforms lead to deep changes in healthcare systems around the world, on account of their emphasis on free market rather than the right to health. People with disabilities can be particularly disadvantaged by such reforms, due to their increased healthcare needs and lower socioeconomic status. In this article, we analyse the impacts of neoliberal reforms on access to healthcare for disabled people. This article is based on a critical analytical review of the literature and on two case studies, Chile and Greece...
November 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29141507/sandwiched-white-adipose-tissue-a-novel-microphysiological-system-of-human-adipose-tissue
#10
Frank H Lau, Kelly Vogel, John P Luckett, Maxwell Hunt, Alicia Meyer, Camille L Rogers, Oren Tessler, Charles L Dupin, Hugo St Hilaire, Kazi N Islam, Trivia Frazier, Jeffrey Gimble, Steven Scahill
White adipose tissue (WAT) is a critical organ in both health and disease. However, physiologically faithful tissue culture models of primary human WAT remain limited, at best. Here we describe a novel WAT culture system in which primary human WAT is sandwiched between tissue-engineered sheets of adipose-derived stromal cells. This construct, called "sandwiched white adipose tissue" (SWAT), can be defined as a Microphysiological System (MPS) since it is a tissue-engineered, multicellular, 3D organ construct produced using human cells...
November 16, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29141425/macromolecules-with-amphiphilic-monomer-units-at-interface-of-two-immiscible-liquids
#11
A A Glagoleva, V V Vasilevskaya
The adsorption of macromolecules with amphiphilic monomer units at the liquid-liquid interface was studied. The amphiphilic structure of monomer units with groups selectively interacting with α and β liquids was described by the A-graft-B dumbbell model. The calculations were performed for the symmetrical interaction of A and B groups with liquids, different selectivity parameters ξ and degree of polymerization N. The simulations indicate a three-step adsorption scenario, including non-adsorbed, weak and strong localization states...
November 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29141140/n-heterocyclic-carbene-self-assembled-monolayers-on-gold-as-surface-plasmon-resonance-biosensors
#12
Zhijun Li, Kim A Munro, Iraklii I Ebralidze, Mina R Narouz, J Daniel Padmos, Hongxia Hao, Cathleen M Crudden, J Hugh Horton
Surface plasmon resonance (SPR)-based biosensing is a powerful tool to study the recognition processes between biomole-cules in real-time without need for labels. The use of thiol chemistry is a critical component in surface functionalization of various SPR biosensor surfaces on gold. However, its use is hampered by the high propensity for oxidation of the gold-thiol linkage even in ambient atmosphere, resulting in a short lifetime of SPR sensor chips unless strict precautions are taken. Herein, we describe an approach to overcome this limitation by employing highly robust self-assembled monolayers (SAMs) of alkylated N-heterocyclic carbenes (NHCs) on gold...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29140080/vapor-assisted-solution-approach-for-high-quality-perovskite-ch3nh3pbbr3-thin-films-for-high-performance-green-light-emitting-diodes-applications
#13
Huifang Ji, Zhifeng Shi, Xuguang Sun, Ying Li, Sen Li, Lingzhi Lei, Di Wu, Tingting Xu, Xinjian Li, Guotong Du
Vapor-assisted solution method was developed to prepare the high-quality organic-inorganic halide perovskite CH3NH3PbBr3 (MAPbBr3) thin films. We detailedly investigated the effect of evaporation time and temperature of MABr powder on the microstructure, crystallinity and optical characterizations of MAPbBr3 thin films, and a controllable morphology evolution with varying surface coverage was observed. Temperature-dependent and time-resolved photoluminescence (PL) measurements were carried out to investigate the optical transition mechanisms and carrier recombination dynamics of MAPbBr3 thin films...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29138657/community-health-worker-interventions-are-key-to-optimal-infant-immunization-coverage-evidence-from-a-pretest-posttest-experiment-in-mwingi-kenya
#14
Japheth Mativo Nzioki, James Ouma, James Hebert Ombaka, Rosebella Ongutu Onyango
Introduction: Immunization is a powerful and cost-effective health intervention which averts an estimated 2 to 3 million deaths every year. Kenya has a high infant and under five mortality and morbidity rates. Increasing routine child immunization coverage is one way of reducing child morbidity and mortality rates in Kenya. Community Health Workers (CHWs) have emerged as critical human resources for health in developing countries. The Community Strategy (CS) is one of the CHW led interventions promoting Maternal and Child Health (MCH) in Kenya...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29137711/novel-free-radical-mediated-lipid-peroxidation-biomarkers-in-newborn-plasma
#15
Ángel Sánchez-Illana, Sudhin Thayyil, Paolo Montaldo, Dorothea Jenkins, Guillermo Quintás, Camille Oger, Jean-Marie Galano, Claire Vigor, Thierry Durand, Máximo Vento, Julia Kuligowski
Oxidative stress derived from perinatal asphyxia appears to be closely linked to neonatal brain damage and lipid peroxidation biomarkers have shown to provide predictive power of oxidative stress related pathologies in situations of hypoxia and reoxygenation in the newborn. The objective of this work was to develop and validate of a comprehensive liquid chromatography tandem mass spectrometry approach for the quantitative profiling of 28 isoprostanoids in newborn plasma samples covering a broad range of lipid peroxidation product classes...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29137552/clinical-governance-breakdown-australian-cases-of-wilful-blindness-and-whistleblowing
#16
Sonja Cleary, Maxine Duke
BACKGROUND: After their attempts to have patient safety concerns addressed internally were ignored by wilfully blind managers, nurses from Bundaberg Base Hospital and Macarthur Health Service felt compelled to 'blow the whistle'. Wilful blindness is the human desire to prefer ignorance to knowledge; the responsibility to be informed is shirked. OBJECTIVE: To provide an account of instances of wilful blindness identified in two high-profile cases of nurse whistleblowing in Australia...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29136139/rad-seq-reveals-patterns-of-additive-polygenic-variation-caused-by-spatially-varying-selection-in-the-american-eel-anguilla-rostrata
#17
Charles Babin, Pierre-Alexandre Gagnaire, Scott A Pavey, Louis Bernatchez
The American Eel (Anguilla rostrata) has an exceptional life cycle characterised by panmictic reproduction at the species scale, random dispersal and selection in a highly heterogeneous habitat extending from subtropical to subarctic latitudes. The genetic consequences of spatially-varying selection in this species have been investigated for decades, revealing subtle clines in allele frequency at a few loci that contrast with complete panmixia on the vast majority of the genome. Because reproduction homogenizes allele frequencies every generation, sampling size and genomic coverage are critical to reach sufficient power to detect selected loci in this context...
November 10, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29135786/are-rcp-and-critical-power-equivalent-the-issue-of-mean-response-time
#18
Jan Boone, Jan G Bourgois
No abstract text is available yet for this article.
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29134577/perspective-taking-and-theory-of-mind-in-hide-and-seek
#19
Chris N H Street, Walter F Bischof, Alan Kingstone
Does theory of mind play a significant role in where people choose to hide an item or where they search for an item that has been hidden? Adapting Anderson's "Hide-Find Paradigm" Anderson et al. (Action, Perception and Performance, 76, 907-913, 2014) participants viewed homogenous or popout visual arrays on a touchscreen table. Their task was to indicate where in the array they would hide an item, or to search for an item that had been hidden, by either a friend or a foe. Critically, participants believed that their sitting location at the touchtable was the same as-or opposite to-their partner's location...
November 13, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29134414/pax3-promotes-cell-migration-and-cxcr4-gene-expression-in-neural-crest-cells
#20
Man Xu, Yongle Li, Jinfeng Du, Hengrong Lin, Sixian Cao, Zuming Mao, Ronghua Wu, Mei Liu, Yan Liu, Qiyou Yin
Neural crest (NC) cells are a multipotent cell population with powerful migration ability during development. C-X-C chemokine receptor type 4 (CXCR4) is a chemokine receptor implicated to mediate NC migration in various species, whereas the underlying mechanism is not well documented yet. PAX3 is a critical transcription factor for the formation of neural crest and the migration and differentiation of NCs. In this study, we retrieved a potential PAX3 binding element in the promoter of the CXCR4 gene, and we further found that PAX3 could promote the expression of CXCR4 and facilitate the migration of NCs...
November 13, 2017: Journal of Molecular Neuroscience: MN
keyword
keyword
6631
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"