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Injury prevention, cycling

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https://www.readbyqxmd.com/read/29044770/effects-of-forced-passive-and-voluntary-exercise-on-spinal-motoneurons-changes-after-peripheral-nerve-injury
#1
Ariadna Arbat-Plana, Xavier Navarro, Esther Udina
After peripheral nerve injury, there are important changes at the spinal level that can lead to disorganization of the central circuitry and thus, compromise functional recovery even if axons are able to successfully regenerate and reinnervate their target organs. Physical rehabilitation is a promising strategy to modulate these plastic changes and thus, to improve functional recovery after damage of the nervous system. Forced exercise in a treadmill is able to partially reverse the synaptic stripping and the loss of perineuronal nets that motoneurons suffer after peripheral nerve injury in animal models...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29019561/atorvastatin-can-prevent-hepatic-remote-reperfusion-injury
#2
Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo-Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda
BACKGROUND: Some studies have shown that statins have a promising effect on protection against reperfusion injury. AIM: To evaluate the ability of ischemic postconditioning, statins and both associated to prevent or minimize reperfusion injury in the liver of rats subjected to ischemia and reperfusion by abdominal aorta clamping. METHOD: Were used 41 Wistar rats, which were distributed into five groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + statin (IPC+S), statin (S) and Sham...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28988766/estimation-of-the-future-remnant-liver-function-is-a-better-tool-to-predict-post-hepatectomy-liver-failure-than-platelet-based-liver-scores
#3
T Chapelle, B Op de Beeck, A Driessen, G Roeyen, B Bracke, V Hartman, I Huyghe, S Morrison, D Ysebaert, S Francque
INTRODUCTION: Recently, there has been increasing interest in the preoperative prediction and prevention of post-hepatectomy liver failure (PHLF). This is a particular concern in colorectal liver metastases (CRLM), when surgery follows potentially hepatotoxic chemotherapy. Platelet-based liver scores (PBLS) such as APRI and FIB-4 are predictive of chemotherapy-associated liver injury (CALI) and PHLF. Estimation of the future liver remnant function (eFLRF) by combining (99m)Tc-Mebrofenin Hepatobiliary Scintigraphy (HBS(BSA)) with future liver remnant volume ratio (FLRV%), is predictive of PHLF and related mortality...
September 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28954135/self-harm-throughout-all-life-cycles-profile-of-victims-using-urgent-and-emergency-care-services-in-brazilian-state-capitals
#4
Camila Alves Bahia, Joviana Quintes Avanci, Liana Wernersbach Pinto, Maria Cecilia de Souza Minayo
The aim of the study was to characterize the profile of victims of self-inflicted injuries, who were attended at urgent and emergency care services in Brazilian state capitals, by using the "Viva Survey" database of 2014. Descriptive statistics of the self-inflicted injuries by gender, as well as logistic regression analysis, were performed. The evaluated characteristics were age, gender, race/skin color, education, area of residence, characteristics of the event, alcohol use and the outcome of the case. The results showed that almost 10% of the surveyed cases that were treated by emergency medical services in relation to violence were due to self-inflicted injuries: of particular note were the cases involving females and adults...
September 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28946719/effects-of-remote-ischemic-conditioning-methods-on-ischemia-reperfusion-injury-in-muscle-flaps-an-experimental-study-in-rats
#5
Durdane Keskin, Ramazan Erkin Unlu, Erkan Orhan, Gamze Erkilinç, Nihal Bogdaycioglu, Fatma Meric Yilmaz
BACKGROUND: The aim of this study was to investigate the effects of remote ischemic conditioning on ischemia-reperfusion injury in rat muscle flaps histopathologically and biochemically. METHODS: Thirty albino rats were divided into 5 groups. No procedure was performed in the rats in group 1, and only blood samples were taken. A gracilis muscle flap was elevated in all the other groups. Microclamps were applied to the vascular pedicle for 4 hours in order to achieve tissue ischemia...
September 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28945822/head-injury-patterns-in-helmeted-and-non-helmeted-cyclists-admitted-to-a-london-major-trauma-centre-with-serious-head-injury
#6
Anna E Forbes, John Schutzer-Weissmann, David A Menassa, Mark H Wilson
BACKGROUND: Cycle use across London and the UK has increased considerably over the last 10 years. With this there has been an increased interest in cycle safety and injury prevention. Head injuries are an important cause of mortality and morbidity in cyclists. This study aimed to ascertain the frequency of different head injury types in cyclists and whether wearing a bicycle helmet affords protection against specific types of head injury. METHODS: A retrospective observational study of all cyclists older than 16 years admitted to a London Major Trauma Centre between 1st January 2011 and 31st December 2015 was completed...
2017: PloS One
https://www.readbyqxmd.com/read/28941870/temporal-changes-in-motor-variability-during-prolonged-lifting-lowering-and-the-influence-of-work-experience
#7
Alireza Sedighi, Maury A Nussbaum
Existing research indicates that repetitive motions are strongly correlated with the development of work-related musculoskeletal disorders (WMSDs). Resulting from the redundant degrees-of-freedom in the human body, there are variations in motions that occur while performing a repetitive task. These variations are termed motor variability (MV), and may be beneficial for reducing WMSD risks. To better understand the potential role of MV in preventing injury risk, we evaluated the effects of fatigue on MV using data collected during a lab-based prolonged, repetitive lifting/lowering task...
September 15, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28939680/mobilizing-transit-amplifying-cell-derived-ectopic-progenitors-prevents-hair-loss-from-chemotherapy-or-radiation-therapy
#8
Wen-Yen Huang, Shih-Fan Lai, Hsien-Yi Chiu, Michael Chang, Maksim Plikus, Chih-Chieh Chan, You-Tzung Chen, Po-Nien Tsao, Tsung-Lin Yang, Hsuan-Shu Lee, Peter Chi, Sung-Jan Lin
Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sensitive transit-amplifying cells (TAC) that maintain hair growth. How genotoxicity-induced HF injury is repaired remains unclear. We report here that HF mobilize ectopic progenitors from distinct TAC compartments for regeneration in adaptation to the severity of dystrophy induced by ionizing radiation (IR)...
September 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28939212/fortilin-a-potential-target-for-the-prevention-and-treatment-of-human-diseases
#9
Decha Pinkaew, Ken Fujise
Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca(2+)) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28939132/peak-hyperammonemia-and-atypical-acute-liver-failure-the-eruption-of-an-urea-cycle-disorder-during-hyperemesis-gravidarum
#10
REVIEW
Nicolas Weiss, Fanny Mochel, Marika Rudler, Sophie Demeret, Pascal Lebray, Filomena Conti, Damien Galanaud, Chris Ottolenghi, Jean-Paul Bonnefont, Marc Dommergues, Jacques Bernuau, Dominique Thabut
BACKGROUND: Inborn urea cycle deficiencies are under-recognized metabolic causes of hyperammonaemia in adults. METHODS: A 28-year-old primigravida, 7-week pregnant woman affected by hyperemesis gravidarum developed acute liver injury and then acute liver failure (ALF) in less than 48 hours. RESULTS: Because the patient developed atypical features, especially mildly elevated serum transaminases contrasting with very high blood ammonia levels (281 μmol/l), concomitant with normal serum creatinine, an inborn error of metabolism was suspected...
September 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28924314/comparison-between-standing-broad-jump-test-and-wingate-test-for-assessing-lower-limb-anaerobic-power-in-elite-sportsmen
#11
Anup Krishnan, Deep Sharma, Madhu Bhatt, Apoorv Dixit, P Pradeep
BACKGROUND: Lower limb explosive power is an important motor quality for sporting performance and indicates use of anaerobic energy systems like stored ATP and Creatine phosphate system. Weightlifting, Fencing and Wrestling use it for monitoring and identification of potential sportsmen. The Wingate test and Standing Broad Jump (SBJ) test are reliable and accurate tests for its assessment. This study conducted on elite Indian sportsmen tries to analyse feasibility of use of the SBJ test in sports and military medicine when Wingate test is impractical...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28895052/the-effects-of-periostin-in-a-rat-model-of-isoproterenol-mediated-cardiotoxicity
#12
Mahmut Sözmen, Alparslan K Devrim, Yonca B Kabak, Tuba Devrim, Mert Sudagidan
Periostin is an extracellular matrix protein from fasciclin family, and it plays an important role in the cell adhesion, migration, and growth of the organism. Periostin prevents apoptosis while stimulating cardiomyocytes. The present study was designed to investigate cardioprotective effects of the recombinant murine periostin peptide administration in a rat model of isoproterenol (ISO)-induced myocardial injury. The experiment was performed on 84 adult male Sprague Dawley rats in 4 groups (n = 21): control group (1), periostin-treated group (2), ISO-treated group (3), and ISO + periostin-treated group (4)...
September 11, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28887239/atorvastatin-protects-kidney-from-remote-reperfusion-injury
#13
Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda, João Victor Durães Gomes Oliva, Letícia do Espirito Santo Dias, Murillo Henrique Martins de Almeida, Trícia Luna Sampaio
BACKGROUND: There is a need to find an effective treatment against reperfusion injury. The aim of the present study was to evaluate the capacity of the ischemic postconditioning and statin to prevent renal reperfusion injury. DESIGN AND SETTING: An experimental study developed at Universidade Anhanguera-Uniderp. METHODS: A total of 41 Wistar rats were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postconditioning (IPC), postconditioning + statin (IPC + S), statin (S), and sham...
September 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28862980/management-of-chronic-wounds-diagnosis-preparation-treatment-and-follow-up
#14
Subhas Gupta, Charles Andersen, Joyce Black, Jean de Leon, Caroline Fife, John C Lantis Ii, Jeffrey Niezgoda, Robert Snyder, Bauer Sumpio, William Tettelbach, Terry Treadwell, Dot Weir, Ronald P Silverman
Management of chronic wounds remains challenging in terms of prevalence and complexity. Considerable progress has been made in understanding the science of wound healing during the past decade, sparking volumes of publications and the development of hundreds of dressing and therapy options. There is a need for a simpli ed overview of evidence-based criteria to assist in the accurate diagnosis and appropriate management of chronic wounds in all care settings. An expert panel of 11 wound healing specialists experienced in various care settings convened to discuss best practices and recommended guidelines for managing major chronic wound types...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28844036/from-state-of-the-art-cell-therapy-to-endogenous-cardiac-repair
#15
Werner Mohl, Timothy D Henry, Dejan Milasinovic, Filomain Nguemo, Juergen Hescheler, Emerson C Perin
Clinical heart failure prevention and contemporary therapy often involve breaking the vicious cycle of global haemodynamic consequences of myocardial decay. The lack of effective regenerative therapies results in a primary focus on preventing further deterioration of cardiac performance. The cellular transplantation hypothesis has been evaluated in many different preclinical models and a handful of important clinical trials. The primary expectation that cellular transplants will be embedded into failing myocardium and fuse with existing functioning cells appears unlikely...
August 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28830536/the-preventive-effect-of-the-bounding-exercise-programme-on-hamstring-injuries-in-amateur-soccer-players-the-design-of-a-randomized-controlled-trial
#16
S Van de Hoef, B M A Huisstede, M S Brink, N de Vries, E A Goedhart, F J G Backx
BACKGROUND: Hamstring injuries are the most common muscle injury in amateur and professional soccer. Most hamstring injuries occur in the late swing phase, when the hamstring undergoes a stretch-shortening cycle and the hamstring does a significant amount of eccentric work. The incidence of these injuries has not decreased despite there being effective injury prevention programmes focusing on improving eccentric hamstring strength. As this might be because of poor compliance, a more functional injury prevention exercise programme that focuses on the stretch-shortening cycle might facilitate compliance...
August 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28829390/perceived-injury-risk-among-junior-cricketers-a-cross-sectional-survey
#17
Prasanna J Gamage, Lauren V Fortington, Caroline F Finch
Understanding how junior athletes perceive injury risks when participating in sport and the environment they play in is an important component of injury prevention. This study investigates how Sri Lankan junior cricketers (n = 365, aged 11-14 years, boys) perceive injury risks associated with playing cricket. The study used a Sri Lankan modification of an Australian junior cricket injury risk perception survey that considered playing cricket versus other sports, different cricket playing positions and roles, and different ground conditions...
August 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28828361/driving-pressure-and-mechanical-power-new-targets-for-vili-prevention
#18
REVIEW
Tommaso Tonetti, Francesco Vasques, Francesca Rapetti, Giorgia Maiolo, Francesca Collino, Federica Romitti, Luigi Camporota, Massimo Cressoni, Paolo Cadringher, Michael Quintel, Luciano Gattinoni
Several factors have been recognized as possible triggers of ventilator-induced lung injury (VILI). The first is pressure (thus the 'barotrauma'), then the volume (hence the 'volutrauma'), finally the cyclic opening-closing of the lung units ('atelectrauma'). Less attention has been paid to the respiratory rate and the flow, although both theoretical considerations and experimental evidence attribute them a significant role in the generation of VILI. The initial injury to the lung parenchyma is necessarily mechanical and it could manifest as an unphysiological distortion of the extracellular matrix and/or as micro-fractures in the hyaluronan, likely the most fragile polymer embedded in the matrix...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28810996/rhabdomyolysis-after-crawling-military-training
#19
Danit Atias-Varon, Haggai Sherman, Ran Yanovich, Yuval Heled
INTRODUCTION: Rhabdomyolysis is a syndrome characterized by muscle necrosis followed by release of intracellular muscle contents into the circulation. Exertional rhabdomyolysis (ER) occurs in response to nonfamiliar and/or excessive, prolonged, or repetitive exercises, with eccentric characteristics. In military populations, due to the type of intense, all out physical loads, ER is a significant threat, particularly when training under heat stress. However, many other etiologies exist, and clinical presentations vary greatly...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28799580/risk-prediction-of-acute-kidney-injury-by-timp-2-%C3%A2-igfbp7
#20
M Kimmel, M Schanz, M D Alscher
Acute kidney injury (AKI) is a common syndrome with increased mortality, a heavy burden of illness and high cost. The Kidney Disease Improving Global Outcomes (KDIGO) criteria for staging of AKI have been validated in large patient cohorts and classify AKI into three stages. In order to achieve prevention or early therapy, the focus of scientific interest is early detection and risk prediction of AKI. The combination of the two cell cycle arrest markers [TIMP-2]·[IGFBP7] in the urine shows good results in the risk prediction of AKI in different clinical settings (intensive care medicine, sepsis, cardiac surgery, emergency department)...
June 2017: Drugs of Today
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