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https://www.readbyqxmd.com/read/29236922/effects-of-n-acetylcysteine-on-amphetamine-induced-sensitization-in-mice
#1
Ana P Herrmann, Roberta Andrejew, Radharani Benvenutti, Clarissa S Gama, Elaine Elisabetsky
OBJECTIVE: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. METHODS: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg...
December 11, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29190850/mri-cartilage-assessment-of-the-subtalar-and-midtarsal-joints-during-a-transcontinental-ultramarathon-new-insights-into-human-locomotion
#2
Uwe Hans-Werner Schütz, Christian Billich, Daniel Schoss, Meinrad Beer, Jutta Ellermann
MR measurements can be accurately performed during 4486 km of running, opening a window into in vivo assessment of hindfoot articular cartilage under extreme ultra-endurance loading. This observational cross-sectional study included 22 randomized participants of TransEurope FootRace between Italy and the North Cape, which was accompanied by a trailer-mounted 1.5T MRI scanner over 9 weeks. Four follow up MR examinations of subtalar and midtarsal joints were performed. Statistics of cartilage T2*  and thickness were obtained...
November 30, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29133160/the-changes-of-red-blood-cell-viscoelasticity-and-sports-anemia-in-male-24-hr-ultra-marathoners
#3
Che-Hung Liu, Yen-Fang Tseng, Jiun-I Lai, Yin-Quan Chen, Shih-Hao Wang, Wei-Fong Kao, Li-Hua Li, Yu-Hui Chiu, Chorng-Kuang How, Wen-Han Chang
BACKGROUND: In endurance sports, stress, dehydration and release of chemical factors have been associated with red blood cell (RBC) alterations of structure and function, which may contribute to sports anemia, a well-observed phenomenon during long-distance running. Until now, the investigation of the changes of viscoelastic properties of RBC membrane, a decisive factor of RBC deformability to avoid hemolysis, is lacking, especially in an Oriental population. METHODS: nineteen runners were prospectively recruited into our study...
November 10, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29118957/morphological-peculiarities-of-neuromuscular-junctions-among-different-fiber-types-effect-of-exercise
#4
Teet Seene, Maria Umnova, Priit Kaasik
The aim of our research was to examine whether there are differences in the morphology of neuromuscular junctions of different types of muscle fibers in rodents, and after their adaptation to six weeks endurance exercise training. After 5-day acclimation, Wistar rats were subjected to run with the speed 35 m/min during 6 week, 5 days per week and the training volume reached 60 min per day. Muscle samples for ultrastructural studies were fixed, dehydrated and embedded in Epon-812. Ultra-thin sections were cut from longitudinally and transversely oriented blocs, using 4 blocks from each animal...
June 27, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29117450/nutrition-strategies-before-and-during-ultra-endurance-event-a-significant-gap-between-science-and-practice
#5
Soyzana K Papadopoulou, Eleni E Xyla, Spyridon Methenitis, Konstantinos G Feidantsis, Yiannis Kotsis, Ioannis G Pagkalos, Maria N Hassapidou
The purpose of the present study was to investigate and assess the nutritional practices of open-water swimmers, during the preparation period and the competition, as well as their implications on performance and anthropometric parameters according to their age. Twenty-four (n=24) men open-water swimmers, twelve young (26.3±4.9yrs) and twelve older athletes (45.8±9.7yrs), participated in the present study. Nutritional behavior - intake-energy consumption, and anthropometric characteristics were evaluated prior to the Toroneos Gulf crossing (26Km)...
November 8, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29070954/race-predictors-and-hemodynamic-alteration-after-an-ultra-trail-marathon-race
#6
Noppon Taksaudom, Natee Tongsiri, Amarit Potikul, Chawakorn Leampriboon, Apichat Tantraworasin, Anong Chaiyasri
OBJECTIVE: Unique rough-terrain ultra-trail running races have increased in popularity. Concerns regarding the suitability of the candidates make it difficult for organizers to manage safety regulations. The purpose of this study was to identify possible race predictors and assess hemodynamic change after long endurance races. METHODS: We studied 228 runners who competed in a 66 km-trail running race. A questionnaire and noninvasive hemodynamic flow assessment including blood pressure, heart rate, stroke volume, stroke volume variation, systemic vascular resistance, cardiac index, and oxygen saturation were used to determine physiologic alterations and to identify finish predictors...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29058466/changes-in-cardiac-and-muscle-biomarkers-following-an-uphill-only-marathon
#7
Alessandro Da Ponte, Nicola Giovanelli, Guglielmo Antonutto, Daniele Nigris, Francesco Curcio, Pietro Cortese, Stefano Lazzer
The aim of the study was to evaluate changes in cardiac troponin I levels (cTnI) and the main biomarkers of skeletal muscle damage after an uphill-only marathon, along with its relationship with athletes' physiological parameters. Twenty-two runners participated in the "Supermaratona dell'Etna" (43 km, 0-2850 m AMSL). Before and immediately after the race, body mass and hydration status were measured together with blood sampling. At the end of the race, mean cTnI increased significantly in all athletes (mean +900%), and in 52% of them the cTnI values were over the normal range...
October 23, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/29050040/maximal-fat-oxidation-is-related-to-performance-in-an-ironman-triathlon
#8
Jacob Frandsen, Stine Dahl Vest, Steen Larsen, Flemming Dela, Jørn W Helge
The aim of the present study was to investigate the relationship between maximal fat oxidation rate (MFO) measured during a progressive exercise test on a cycle ergometer and ultra-endurance performance. 61 male ironman athletes (age: 35±1 yrs. [23-47 yrs.], with a BMI of 23.6±0.3 kg/m2 [20.0-30.1 kg/m2], a body fat percentage of 16.7±0.7% [8.4-30.7%] and a VO2peak of 58.7±0.7 ml/min/kg [43.9-72.5 ml/min/kg] SEM [Range]) were tested in the laboratory between 25 and 4 days prior to the ultra-endurance event, 2016 Ironman Copenhagen...
November 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28955243/the-effect-of-a-100-km-ultra-marathon-under-freezing-conditions-on-selected-immunological-and-hematological-parameters
#9
Alena Žákovská, Beat Knechtle, Daniela Chlíbková, Marie Miličková, Thomas Rosemann, Pantelis T Nikolaidis
Although moderate exercise is beneficial for the human body and its immune system, exhaustive ultra-endurance performance in cold conditions might be harmful. The aim of this study was to examine the effect of a 100-km ultra-marathon under cold conditions (temperatures from -1°C to +1°C) on selected immunological, biochemical and hematological parameters. Participants were 15 runners (12 men and three women, age 40.3 ± 9.7 years, body mass 67.3 ± 9.0 kg and body height 1.74 ± 0.10 m, mean ± standard deviation)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28883046/case-studies-in-physiology-skeletal-muscle-mitochondrial-protein-synthesis-and-respiration-in-response-to-the-energetic-stress-of-an-ultra-endurance-race
#10
Adam R Konopka, William M Castor, Christopher A Wolff, Robert V Musci, Justin J Reid, Jaime L Laurin, Zackary J Valenti, Karyn L Hamilton, Benjamin F Miller
The 2016 Colorado Trail Race (CTR) was an ultra-endurance mountain bike race where competitors cycled for up to 24 hrs/day between altitudes of 1675 to 4025 meters to complete 800 kilometers and 21,000 meters of elevation gain. In one athlete, we had the unique opportunity to characterize skeletal muscle protein synthesis and mitochondrial respiration in response to a normal activity control period (CON) and the CTR. We hypothesized that mitochondrial protein synthesis would be elevated and mitochondrial respiration would be maintained during the extreme stresses of the CTR...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28847143/description-of-three-female-24-h-ultra-endurance-race-winners-in-various-weather-conditions-and-disciplines
#11
Daniela Chlíbková, Thomas Rosemann, Beat Knechtle, Pantelis T. Nikolaidis, Alena Žákovská, Karl Sudi
A The incidence of exercise-associated hyponatremia (EAH) is higher in women than in men. We present three cases of a very mild post-race EAH in female winners of three 24-h ultra races in various weather conditions and disciplines with post-race plasma sodium [Na⁺] levels of 134 mM (Case 1), 133 mM (Case 2) and 134 mM (Case 3). Moreover, Case 1 and Case 2 showed elevated creatine kinase concentrations of >10,000 U/l with an absence of renal function abnormality. The common characteristics were female sex, veteran recreational category, long race experience in the particular sports discipline, excellent race performance, similar total weekly training hours and the presence of luteal phase of the menstrual cycle during the race...
August 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28799161/performance-factors-in-a-mountain-ultramarathon
#12
Pascal Balducci, Michel Clémençon, Robin Trama, Yoann Blache, Christophe Hautier
This study aimed to determine mountain ultra-marathon (MUM) performance factors in a large group of endurance mountain runners. Maximal aerobic speed (MAS) was assessed one week prior to the MUM. The level and graded (10%) energy cost of running, stiffness, knee extensors force (KEf), and jump height on a counter movement jump (CMJ) were measured in 24 male ultra runners before (pre) and immediately after (post) the Interlacs Trail (75 km and 3 930/3 700 m d+/d-). Performance time was correlated with MAS (r=- 0...
October 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28790928/enhanced-right-chamber-remodeling-in-endurance-ultra-trail-athletes-compared-to-marathon-runners-detected-by-standard-and-speckle-tracking-echocardiography
#13
Kristian Ujka, Luca Bastiani, Gennaro D'Angelo, Bruna Catuzzo, Alessandro Tonacci, Simona Mrakic-Sposta, Alessandra Vezzoli, Guido Giardini, Lorenza Pratali
Background: Strenuous and endurance exercise training have been associated with morphological and functional heart remodeling. Two-dimensional speckle-tracking echocardiography (STE) is a novel technique that allows an accurate quantification of global myocardium deformation. Our aim was to evaluate together left and right cardiac remodeling in different long-distance running athletes: marathon runners (42 km) (M) and endurance mountain runners (>300 Km) (UT). Methods: A total of 92 athletes (70 males, 76%) including 47 M [age 45 ± 7 years; training: 18 (9-53) years(*)days/week], 45 UT [age 42 ± 9, training: 30 (15-66) years(*)days/week] underwent conventional echocardiography and STE (Beyond Diogenes 2...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28682407/selective-protein-transport-through-ultra-thin-suspended-reduced-graphene-oxide-nanopores
#14
Dae-Sik Lee, Seokhan Park, Yong Duk Han, Jae Eun Lee, Hu Young Jeong, Hyun C Yoon, Moon Yeon Jung, Sang Ouk Kim, Sung-Yool Choi
The nanoporous free-standing graphene membrane is of great interest in high performance separation technology. In particular, the separation of biological molecules with similar sizes is one of the key challenges in the purification of biomaterials. Here, we report a reliable, cost-effective, and facile method for the fabrication of a graphene-based nanosieve and its application in the separation of similar-size proteins. A suspended reduced graphene oxide (rGO) nanosieve with ultra-thin, large-area, well-ordered, and dense 15 nm-sized pores was fabricated using block copolymer (BCP) lithography...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28566803/greater-muscle-damage-in-athletes-with-actn3-r577x-rs1815739-gene-polymorphism-after-an-ultra-endurance-race-a-pilot-study
#15
T Belli, A H Crisp, R Verlengia
In this study, we aimed to investigate the influence of ACTN3 R577X gene polymorphism on muscle damage responses in athletes competing in an ultra-endurance race. Twenty moderate to well-trained ultra-runners who had entered in an official 37.1 km adventure race (22.1 km mountain biking, 10.9 km trekking, 4.1 km water trekking, 30 m rope course, and orienteering) volunteered for the study. Blood samples were collected for genotyping and analysis of muscle protein levels before and after the race. Percentage changes (pre- to post-race) of serum myoglobin [XX = 5,377% vs...
June 2017: Biology of Sport
https://www.readbyqxmd.com/read/28535849/calf-endurance-and-achilles-tendon-structure-in-classical-ballet-dancers
#16
Jennifer A Zellers, Katrina van Ostrand, Karin Grävare Silbernagel
Optimal lower leg function is critical for ballet dancers to meet their occupational requirements. Achilles tendon injury is particularly detrimental to ballet dancers. While standardized measures have been validated and incorporated into clinical practice for use in people with Achilles tendon injury, normative ranges specific to the dancer population have not been described. The purpose of this pilot study was to observe the performance of pre-professional ballet students and professional ballet dancers on a well-established test battery for lower leg functional performance as well as ultra-sonographic evaluation of the structure of their Achilles tendons...
June 15, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28512433/reported-hydration-beliefs-and-behaviors-without-effect-on-plasma-sodium-in-endurance-athletes
#17
Daniela Chlíbková, Pantelis T Nikolaidis, Thomas Rosemann, Beat Knechtle, Josef Bednář
Purpose: Little information is available on the association of hydration beliefs and behaviors in endurance athletes and exercise-associated hyponatremia (EAH). The aim of the present study was to determine hydration beliefs and behaviors in endurance athletes. Method: A 100 and 38 recreational athletes [107 mountain bikers (MTBers) and 31 runners] competing in seven different endurance and ultra-endurance races completed pre- and post-race questionnaires, and a subgroup of 113 (82%) participants (82 MTBers and 31 runners) also provided their blood samples...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28488921/sex-differences-in-world-record-performance-the-influence-of-sport-discipline-and-competition-duration
#18
Øyvind Sandbakk, Guro Strøm Solli, Hans-Christer Holmberg
In the present review, we summarize scientific knowledge concerning sex differences in world record performance and the influence of sport discipline and competition duration. In addition, we discuss how physiological factors relate to sex dimorphism. While cultural factors played a major role in the rapid improvement of performance of women relative to men up until the 1990’s, sex differences between the world’s best athletes in most events have remained relatively stable at approximately 8-12%. The exceptions are events in which upper-body power is a major contributor, where this difference is more than 12%, and ultra-endurance swimming, where the gap is now less than 5%...
May 10, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28469746/low-carbohydrate-high-fat-diet-can-it-help-exercise-performance
#19
Chen-Kang Chang, Katarina Borer, Po-Ju Lin
Low-carbohydrate-high-fat (LCHF) diets have been used as a means of weight loss and control of symptoms in several clinical conditions. There is emerging evidence that the metabolic changes induced by LCHF diets enhance endurance performance. The aims of this review are to examine the evidence of LCHF diets in improving various aspects of athletic performance. Long-term LCHF dietary intake may help control body weight and fat mass while maintaining lean body mass in athletes in weight-sensitive sports. LCHF-adapted endurance athletes can reach the maximal fat oxidation rate of approximately 1...
February 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28463452/the-effects-of-two-different-exercise-programs-on-the-ultrastructural-features-of-the-sciatic-nerve-and-soleus-muscle-after-sciatic-crush
#20
Leandro Viçosa Bonetti, TAíS Malysz, Jocemar Ilha, Silvia Barbosa, Matilde Achaval, Maria Cristina Faccioni-Heuser
Peripheral nerve injuries constitute a significant medical problem and the recovery is critically dependent on post-injury treatment. In this study, following sciatic nerve crush, we investigated the effects of a 4-week endurance training program (ET) and balance and coordination training program (BCT) on the ultrastructural features of the sciatic nerve and soleus muscle. The animals were randomly divided into Sham, non-trained (NT), ET, and BCT groups each of which included three animals. Ultra-thin cross and longitudinal sections (70-85 nm) were digitized and analyzed comparatively...
April 30, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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