keyword
MENU ▼
Read by QxMD icon Read
search

Cyclobenzaprine

keyword
https://www.readbyqxmd.com/read/27801921/a-case-of-ileus-and-st-segment-elevation
#1
Osama Siddique, Somwail Rasla, Seth Clark, Aravind Kokkirala
ST segment elevation is associated with non-cardiac pathologies but is not as well reported as myocardial infarction. We present a case of a 63-year-old man who was admitted for an overdose on cyclobenzaprine with signs of anti-cholinergic toxicity. He developed signs of ileus on imaging and became progressively obtunded. He was noted to have ST segment elevations on electrocardiogram (EKG) with no troponin elevation. Patient required urgent catheterization which showed normal coronary arteries. His bowel was decompressed subsequently resulting in resolution of the ST segment changes...
November 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27712567/development-and-optimization-of-controlled-porosity-osmotic-tablets-of-lamotrigine-solid-dispersion
#2
Gayatri C Patel, Megha Kasarwala
BACKGROUND: The purpose of this study was to investigate the application of a controlled porosity osmotic tablet (CPOT) utilizing solid dispersion (SD) of poorly soluble drug. The patents on Cyclobenzaprine HCl (US4968507 A) and Venlafaxine salts (EP 2085078 A1) helped in selection of drug and polymers. METHOD: The SDs having different ratio of drug to carrier (PVP K 30) were prepared by kneading method and optimized. Effect of three independent variables, total amount of osmogen (mannitol& potassium chloride), total amount of polymer (polyethylene oxide WSR 301, hydroxy propyl methyl cellulose K100 M), and polymer1: polymer 2 ratio was investigated using Box Behnken design...
October 4, 2016: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/27640607/comparison-of-naproxen-with-cyclobenzaprine-oxycodone-acetaminophen-and-placebo-for-the-treatment-of-acute-low-back-pain
#3
Michael Gottlieb, Abdoulie Njie
Clinical Question Does the addition of cyclobenzaprine or oxycodone with acetaminophen to naproxen result in improved functional outcomes at one week when compared to placebo in patients with acute low back pain? Article Chosen Friedman B, Dym A, Davitt, M, et al. Naproxen with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: a randomized clinical trial. JAMA 2015:20;314(15):1572-80. Study Objective The primary objective of this study was to compare functional outcomes at one week and three months after emergency department (ED) presentation for acute low back pain among patients prescribed naproxen plus one of the following: (1) oxycodone/acetaminophen; (2) cyclobenzaprine; or (3) placebo...
November 2016: CJEM
https://www.readbyqxmd.com/read/27610552/second-order-peer-reviews-of-clinically-relevant-articles-for-the-physiatrist-naproxen-with-cyclobenzaprine-oxycodone-acetaminophen-or-placebo-to-treating-acute-low-back-pain-a-randomized-clinical-trial
#4
Byron J Schneider, David J Kennedy, Dinesh Kumbhare
No abstract text is available yet for this article.
September 8, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27474822/purls-more-isn-t-better-with-acute-low-back-pain-treatment
#5
Kevin Frazer, James J Stevermer
Adding cyclobenzaprine or oxycodone/acetaminophen to naproxen for the treatment of acute low back pain does nothing more than increase adverse effects.
June 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27470645/exudative-erythema-multiforme-due-to-cyclobenzaprine
#6
E Gómez Torrijos, M García Arpa, C García Rodríguez, Y Mendez Díaz, J Borja Segade, P A Galindo Bonilla, J F Feo Brito, R García Rodríguez
No abstract text is available yet for this article.
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27436573/two-steps-modification-for-improvement-of-cyclobenzaprine-transdermal-delivery-releasing-from-patch-and-penetrating-through-skin
#7
Siji Lv, Peng Quan, Wei Wang, Liang Fang
The aim of this study was to improve the transdermal delivery of cyclobenzaprine (CBZ) from drug-in-adhesive patch which showed less side effects and better compliance. CBZ base was prepared and then characterized using differential scanning calorimetry (DSC). The interaction between CBZ and pressure-sensitive adhesive (PSA) was determined by Fourier Transform Infrared Spectroscopy (FT-IR). The influences of PSAs, penetration enhancers, patch thickness and drug content on the transdermal delivery of CBZ were studied thoroughly in vitro...
July 19, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27405366/variations-in-enzymatic-hydrolysis-efficiencies-for-amitriptyline-and-cyclobenzaprine-in-urine
#8
Kaylee R Mastrianni, L Andrew Lee, William E Brewer, Nagaraju Dongari, Michael Barna, Stephen L Morgan
A collaborative study was conducted to investigate discrepancies in recoveries of two commonly prescribed compounds, amitriptyline and cyclobenzaprine, in patient urine samples when hydrolyzed with different enzymes from different sources. A 2- to 10-fold increase in analyte recoveries was seen for patient samples hydrolyzed using a recombinant β-glucuronidase (IMCSzyme™) over samples hydrolyzed with β-glucuronidase from Haliotis rufescens We report outcomes from four commercially available β-glucuronidase enzymes (IMCSzyme™, Patella vulgata, Helix pomatia and H...
July 11, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27252902/novel-treatment-of-radicular-pain-with-a-multi-mechanistic-combination-topical-agent-a-case-series-and-literature-review
#9
Pegah Safaeian, Ryan Mattie, Matthew Hahn, Christopher T Plastaras, Zachary L McCormick
INTRODUCTION: Pharmacologic treatment of radicular pain with oral medications is limited by adverse effects and concern for dependence. While topical formulations have been explored in pain research, there is no published literature evaluating the efficacy in radicular pain. We present the first three cases of radicular pain successfully treated with a topical formulation of diclofenac, ibuprofen, baclofen, cyclobenzaprine, bupivacaine, gabapentin, and pentoxifylline (T7). CASE PRESENTATION: Case series evaluating T7 for treatment of radicular pain in a single, outpatient pain center...
April 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27175953/top-20-research-studies-of-2015-for-primary-care-physicians
#10
Mark H Ebell, Roland Grad
In 2015, a group of primary care clinicians with expertise in evidence-based practice performed monthly surveillance of more than 110 English-language clinical research journals. They identified 251 studies that addressed a primary care question and had the potential to change practice if valid (patient-oriented evidence that matters, or POEMs). Each study was critically appraised and disseminated to subscribers via e-mail, including members of the Canadian Medical Association who had the option to use a validated tool to assess the clinical relevance of each POEM and the benefits they expect for their practice...
May 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27059714/effect-of-potentially-inappropriate-use-of-antimuscarinic-medications-on-healthcare-use-and-cost-in-individuals-with-overactive-bladder
#11
Brandon T Suehs, Cralen Davis, Billy Franks, Thomas E Yuran, Daniel Ng, Jason Bradt, John Knispel, Maria Vassilakis, Todd Berner
OBJECTIVES: To examine potentially inappropriate medication (PIM) use in older adults initiating an antimuscarinic medication for the treatment of overactive bladder (OAB). DESIGN: Retrospective database analysis. SETTING: Medical and pharmacy claims data. PARTICIPANTS: Medicare Advantage Prescription Drug Plan members aged 65 and older newly initiated on an antimuscarinic OAB treatment were identified and assigned to PIM and non-PIM comparison groups based on 2012 American Geriatrics Society Beers Criteria and/or the presence of an anticholinergic medication interaction at the time of initiation of treatment (N = 66,275)...
April 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27056018/determination-of-degradation-products-of-cyclobenzaprine-hydrochloride-lidocaine-and-piroxicam-in-a-semi-topical-formulation-ms-ms-confirmation-of-unknown-impurities
#12
Bogdan Ionel Cioroiu, Ioana Cezara Grigoriu, Mona Elisabeta Cioroiu, Marius Niculaua, Roxana Lupuleasa, Mihai Ioan Lazar
Association of cyclobenzaprine hydrochloride, piroxicam and lidocaine in a topical formulation is one of the newest innovations in the pharmaceutical formulary field. In this study, a reversed-phase liquid chromatographic method was developed for the establishment of the impurities of cyclobenzaprine hydrochloride, lidocaine and piroxicam in the semisolid topical formulation. In this study, we not only determined 2,6-dimethylaniline, 2-pyrydilamine but also specified impurities of cyclobenzaprine hydrochloride (dibenzosuberenone, amitriptyline, carbinole, cyclobenzaprine N-oxide and anthrachinone)...
July 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27003556/treatment-patterns-associated-with-acr-recommended-medications-in-the-management-of-fibromyalgia-in-the-united-states
#13
Yifei Liu, Chunlin Qian, Mei Yang
BACKGROUND: Fibromyalgia (FM) affects up to 6% of U.S. adults, resulting in a significant burden on the health care system and poor quality of life for patients. Duloxetine, pregabalin, and milnacipran are approved for management of FM; however, consensus is lacking regarding optimal therapy. Patients with FM taking approved medications often do not experience meaningful symptom relief, and many experience intolerable adverse events. OBJECTIVE: To assess treatment patterns associated with available and commonly used medications for the management of FM using U...
March 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/26965978/a-38-year-old-woman-with-an-osteolytic-rib-lesion
#14
Javi Hartenstine, Hope Jackson, Keith Mortman
A 38-year-old black woman with a medical history significant for hypertension and depression presented to the emergency department with a 2-week history of lower back pain. This visit was her second in 1 week with the same symptoms, after attaining minimal pain relief with cyclobenzaprine.
March 2016: Chest
https://www.readbyqxmd.com/read/26926618/cyclobenzaprine-in-the-treatment-of-low-back-pain
#15
Donald M Chaffee
No abstract text is available yet for this article.
February 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/26895022/drug-drug-interactions-between-the-anti-hepatitis%C3%A2-c-virus-3d-regimen-of-ombitasvir-paritaprevir-ritonavir-and-dasabuvir-and-eight-commonly-used-medications-in-healthy-volunteers
#16
Akshanth R Polepally, Jennifer R King, Bifeng Ding, Diana L Shuster, Emily O Dumas, Amit Khatri, Yi-Lin Chiu, Thomas J Podsadecki, Rajeev M Menon
BACKGROUND AND AIMS: The three direct-acting antiviral regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir (3D regimen) is approved for treatment of hepatitis C virus (HCV) genotype 1 infection. Drug-drug interaction (DDI) studies of the 3D regimen and commonly used medications were conducted in healthy volunteers to provide information on coadministering these medications with or without dose adjustments. METHODS: Three phase I studies evaluated DDIs between the 3D regimen (ombitasvir/paritaprevir/ritonavir 25/150/100 mg once daily + dasabuvir 250 mg twice daily) and hydrocodone bitartrate/acetaminophen (5/300 mg), metformin hydrochloride (500 mg), diazepam (2 mg), cyclobenzaprine hydrochloride (5 mg), carisoprodol (250 mg), or sulfamethoxazole/trimethoprim (SMZ/TMP) (800/160 mg twice daily), all administered orally...
August 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/26882304/acp-journal-club-in-acute-low-back-pain-adding-oxycodone-acetaminophen-or-cyclobenzaprine-to-naproxen-did-not-improve-pain-or-function
#17
COMMENT
Christopher R Carpenter
No abstract text is available yet for this article.
February 16, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/26797071/painful-ejaculation-with-cyclobenzaprine-a-case-report-and-literature-review
#18
Molly B Kraus, Christopher S Wie, Andrew W Gorlin, Eric S Wisenbaugh, David M Rosenfeld
INTRODUCTION: Sexual dysfunction is a well-known side effect of antidepressants. Painful ejaculation is a rare side effect that has been reported with the use of some psychiatric drugs such as triclyclic antidepressants. Cyclobenzaprine is a muscle relaxant that is structurally similar to tricyclic antidepressants. It is the most commonly prescribed muscle relaxant in the United States and accounts for 18% of all prescriptions written for chronic back pain. METHODS: A 55-year-old man was referred to our pain medicine clinic for evaluation and treatment of pain with ejaculation...
December 2015: Sexual Medicine
https://www.readbyqxmd.com/read/26734831/myalgias-and-myopathies-fibromyalgia
#19
REVIEW
Jason McCarthy
Fibromyalgia is a syndrome of chronic widespread pain typically accompanied by fatigue, nonrestorative sleep, cognitive dysfunction, and mood disorders. As defined by the 2010 American College of Rheumatology criteria, fibromyalgia affects approximately 5% of the population and is the second most common disorder, after osteoarthritis, for which patients are referred to rheumatology subspecialists. These criteria provide a framework for diagnosing fibromyalgia that does not require tender points and incorporates other symptoms of the syndrome in addition to pain...
January 2016: FP Essentials
https://www.readbyqxmd.com/read/26685496/skin-permeation-and-antinociception-of-compounded-topical-cyclobenzaprine-hydrochloride-formulations
#20
Evan Bryson, Rachel Hartman, John Arnold, Greg Gorman, Sarah Sweitzer, Scott Asbill
Cyclobenzaprine has been commonly compounded by pharmacists into topically applied dosage forms for the treatment of pain disorders. However, the efficacy and transdermal penetration of topically applied compounded cyclobenzaprine is currently unknown. In this study, the transdermal penetration of cyclobenzaprine was studied in Franz diffusion cells using porcine skin. Cyclobenzaprine was compounded in two commercially available bases; Lipobase, Lipoderm, and a standard poloxamer lecithin organogel. In addition, cyclobenzaprine was tested in an in vivo formalin pain model...
March 2015: International Journal of Pharmaceutical Compounding
keyword
keyword
66287
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"