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Venlafax XR

Martin B Keller, Madhukar H Trivedi, Michael E Thase, Richard C Shelton, Susan G Kornstein, Charles B Nemeroff, Edward S Friedman, Alan J Gelenberg, James H Kocsis, David L Dunner, Robert M A Hirschfeld, Anthony J Rothschild, James M Ferguson, Alan F Schatzberg, John M Zajecka, Ronald D Pedersen, Bing Yan, Saeeduddin Ahmed, Jeff Musgnung, Philip T Ninan
OBJECTIVE: To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression. METHOD: Outpatients with recurrent unipolar depression (DSM-IV criteria; N = 1096) were randomly assigned in a 3:1 ratio to 10 weeks of treatment with venlafaxine ER or fluoxetine. Responders (17-item Hamilton Rating Scale for Depression [HAM-D(17)] total score <or= 12 and >or= 50% decrease from baseline) entered a 6-month, double-blind continuation phase on the same medication...
August 2007: Journal of Clinical Psychiatry
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