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Kartik Kumar, Swati N Mandleywala, Michael P Gannon, Nathan Anthony Mark Estes, Jonathan Weinstock, Mark S Link
OBJECTIVE: Commotio cordis, sudden death with chest impact, occurs clinically despite chest wall protectors worn in sports. In an experimental model of commotio cordis, commercially available chest wall protectors failed to prevent ventricular fibrillation (VF). The goal of the current investigation was to develop a chest wall protector effective in the prevention of commotio cordis. DESIGN: In the Tufts experimental model of commotio cordis the ability of chest protectors to prevent VF was assessed...
March 24, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
M J Traynor, M B Brown, A Pannala, P Beck, G P Martin
Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram ER tablets and T-long capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural extended-release tablets in the presence of alcohol...
August 2008: Drug Development and Industrial Pharmacy
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