keyword
https://read.qxmd.com/read/38526761/intraoperative-kidney-replacement-therapy-in-acute-liver-failure
#1
JOURNAL ARTICLE
Daniel Henderson, Anish Gupta, Shina Menon, Akash Deep
Paediatric acute liver failure (PALF) is often characterised by its rapidity of onset and potential for significant morbidity and even mortality. Patients often develop multiorgan dysfunction/failure, including severe acute kidney injury (AKI). Whilst the management of PALF focuses on complications of hepatic dysfunction, the associated kidney impairment can significantly affect patient outcomes. Severe AKI requiring continuous kidney replacement therapy (CKRT) is a common complication of both PALF and liver transplantation...
March 25, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38492515/how-to-deal-with-renal-toxicities-from-immune-based-combination-treatments-in-metastatic-renal-cell-carcinoma-a-nephrological-consultation-for-oncologists
#2
REVIEW
Tucci Marcello, Cosmai Laura, Pirovano Marta, Campisi Ilaria, Re Sartò Giulia Vanessa, Porta Camillo, Gallieni Maurizio, Piergiorgio Messa
We are witnessing a revolution in the treatment of metastatic renal cell carcinoma (mRCC). Indeed, several immune-based combinations (ICI [immune checkpoint inhibitor] + ICI, or ICI + antiangiogenic agents) have been approved as first-line therapy for mRCC after demonstrating superior efficacy over the previous standard. Despite all the improvements made, safety remains a critical issue, adverse events (AEs) being the main reason for drug discontinuations or dose reductions, ultimately resulting in an increased risk of losing efficacy...
January 23, 2024: Cancer Treatment Reviews
https://read.qxmd.com/read/38486159/kidney-replacement-and-conservative-therapies-in-rhabdomyolysis-a-retrospective-analysis
#3
JOURNAL ARTICLE
Jonathan de Fallois, Robert Scharm, Tom H Lindner, Christina Scharf, Sirak Petros, Lorenz Weidhase
BACKGROUND: Toxic renal effects of myoglobin following rhabdomyolysis can cause acute kidney injury (AKI) with the necessity of kidney replacement therapy (KRT). Fast elimination of myoglobin seems notable to save kidney function and intensify kidney repair. Clinical data regarding efficacy of KRT in critical care patients with rhabdomyolysis and AKI are limited. This retrospective analysis aimed to identify differences between conservative therapy and different modalities of KRT regarding myoglobin elimination and clinical outcome...
March 14, 2024: BMC Nephrology
https://read.qxmd.com/read/38477662/point-of-care-ultrasound-pocus-training-curriculum-for-pediatric-nephrology-pcrrt-iconic-group-recommendations
#4
JOURNAL ARTICLE
Sidharth Kumar Sethi, John Mahan, Jieji Hu, Abhilash Koratala, Kritika Soni, Yogen Singh, Carolyn Abitbol, Marissa DeFreitas, Nathaniel Reisinger, Eduardo R Argaiz, Hui Kim Yap, Hamidreza Badeli, Meenal Kalra, Jonathan VanGeest, Nikhil Nair, James Raynor, Khalid A Alhasan, Mignon McCulloch, Timothy Bunchman, Vivek Sharma, Rupesh Raina
BACKGROUND: Point of care ultrasound (POCUS) is commonly used in adult specialties, pediatric emergency medicine, and neonatal and pediatric critical care. Specifically, in the field of pediatric nephrology, POCUS plays a valuable role in the critical inpatient and outpatient settings. However, the lack of guidelines and a standardized curriculum for POCUS in pediatric nephrology has led to substantial discrepancies in both clinical practice and training. METHODS: A multinational, multicenter survey regarding POCUS usefulness and training was sent to 225 pediatric nephrology residents, fellows, and physicians with expertise in pediatric nephrology...
March 13, 2024: Kidney360
https://read.qxmd.com/read/38476033/the-emergence-of-cultural-safety-within-kidney-care-for-indigenous-peoples-in-australia
#5
JOURNAL ARTICLE
Melissa Arnold-Ujvari, Elizabeth Rix, Janet Kelly
Cultural safety is increasingly recognised as imperative to delivering accessible and acceptable healthcare for First Nations Peoples within Australia and in similar colonised countries. A literature review undertaken to inform the inaugural Caring for Australians with Renal Insufficiency (CARI) guidelines for clinically and culturally safe kidney care for Aboriginal and Torres Strait Islander peoples revealed a timeline of the emergence of culturally safe kidney care in Australia. Thirty years ago, kidney care literature was purely biomedically focused, with culture, family and community viewed as potential barriers to patient 'compliance' with treatment...
March 12, 2024: Nursing Inquiry
https://read.qxmd.com/read/38461657/hierarchical-endpoints-in-critical-care-a-post-hoc-exploratory-analysis-of-the-standard-versus-accelerated-initiation-of-renal-replacement-therapy-in-acute-kidney-injury-and-the-intensity-of-continuous-renal-replacement-therapy-in-critically-ill-patients-trials
#6
JOURNAL ARTICLE
Fernando G Zampieri, Ary Serpa-Neto, Ron Wald, Rinaldo Bellomo, Sean M Bagshaw
PURPOSE: To perform a post-hoc reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) and the Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients (RENAL) trials through hierarchical composite endpoint analysis using win ratio (WR). MATERIAL AND METHODS: All patients with complete information from the STARRT-AKI (which compared accelerated versus standard approaches for renal replacement therapy - RRT initiation) and RENAL (which compared two different RRT doses in critically ill patients) trials were selected...
March 9, 2024: Journal of Critical Care
https://read.qxmd.com/read/38458376/addressing-housing-issues-among-people-with-kidney-disease-importance-challenges-and-recommendations
#7
JOURNAL ARTICLE
Tessa K Novick, Ben King
Kidney disease disproportionately impacts people with low socioeconomic status, and low socioeconomic status is associated with worse outcomes for people with kidney disease. Unstable housing, which includes housing insecurity and homelessness, is increasing due to rising housing costs. There is mounting evidence that unstable housing and other health-related social needs are partially driving worse outcomes for people with low socioeconomic status. In this perspective, we consider challenges to addressing housing for people with kidney disease, such as difficulty with identification of those with unstable housing, strict eligibility criteria for housing support, inadequate supply of affordable housing, and flaws in communities' prioritization of affordable housing...
March 6, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38452996/achieving-consensus-severity-graded-definitions-of-fontan-associated-complications-to-characterize-fontan-circulatory-failure
#8
JOURNAL ARTICLE
Kurt R Schumacher, Ari Cedars, Kiona Allen, David Goldberg, Adrianna Batazzi, Garrett Reichle, Frank DiPaola, David Selewski, Melissa Cousino, David N Rosenthal
BACKGROUND: Fontan physiology leads to chronic changes in other organ systems that may affect long-term survival and the success of heart transplantation. Inadequate assessment and treatment of the extra-cardiac effects of Fontan may contribute to poor outcomes. Severity graded/ordinal consensus definitions of Fontan complications are lacking which limits understanding of how Fontan-specific morbidity affects patient outcomes. METHODS AND RESULTS: A panel of Fontan patient and physiology experts, including pediatric, adult congenital, heart failure, and critical care cardiology, and pediatric nephrology, hepatology and psychology, convened to develop definitions of Fontan complications...
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38442936/-prognostic-risk-factors-of-catheter-related-bloodstream-infection-in-patients-with-maintenance-hemodialysis
#9
JOURNAL ARTICLE
Caihe Chen, Shuyan Ma, Wenhui Huang
OBJECTIVE: To analyze the pathogen distribution and prognostic risk factors of catheter-related bloodstream infection (CRBSI) in patients with maintenance hemodialysis (MHD) during non-hospitalization. METHODS: A retrospective comparative study was conducted. Thirty-four patients of MHD with semi-permanent catheter admitted to the department of nephrology of Gansu Provincial Hospital from January 2020 to May 2023 due to CRBSI during non-hospitalization were enrolled...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38416215/acute-kidney-injury-in-children-undergoing-cardiac-surgery-predictive-value-of-kidney-arterial-doppler-based-variables
#10
JOURNAL ARTICLE
Fabiane M De Souza, Aline V De Carvalho, Isabel S Ferraz, Ana P Damiano, Marcelo B Brandão, Roberto J N Nogueira, Tiago H De Souza
BACKGROUND: Acute kidney injury (AKI) is a common condition in critically ill children and is associated with increased morbidity and mortality. This study aimed to assess the performance of point-of-care ultrasonography to predict AKI in children undergoing cardiac surgery. METHODS: In this prospective study, consecutive children underwent kidney Doppler ultrasound examination within 24 h following cardiac surgery, and an experienced operator obtained both renal resistive index (RRI) and renal pulsatility index (RPI)...
February 28, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38410373/assessment-of-clinical-pharmacist-interventions-using-a-web-based-application-in-a-saudi-arabian-tertiary-hospital
#11
JOURNAL ARTICLE
Rana Omar AlKhanbashi, Yahya AlNoamy, Reham Ghandorah, Razan Mohammed Awan, Hala AlButi
OBJECTIVES: Medication-related problems are a top concern of clinical pharmacists. Medication-related problems can cause patient harm and increase the number of visits, hospital admissions, and length of hospital stay. The objective was to assess clinical pharmacy medication-related problem-related interventions in a tertiary care setting. METHODS: A retrospective cohort study was conducted at King Fahad Armed Forces Hospital in Jeddah (Saudi Arabia) between June 2021 and June 2022...
2024: SAGE Open Medicine
https://read.qxmd.com/read/38408970/dose-of-nafamostat-mesylate-during-continuous-kidney-replacement-therapy-in-critically-ill-patients-a-two-centre-observational-study
#12
JOURNAL ARTICLE
Shinya Kameda, Akinori Maeda, Shun Maeda, Yutaro Inoue, Kazunari Takahashi, Akira Kageyama, Kent Doi, Tomoko Fujii
BACKGROUND: Nafamostat mesylate is an anticoagulant used for critically ill patients during continuous kidney replacement therapy (CKRT), characterised by its short half-life. However, its optimal dosage remains unclear. This study aimed to explore the optimal dosage of nafamostat mesylate during CKRT. METHODS: We conducted a two-centre observational study. We screened all critically ill adult patients who required CKRT in the intensive care unit (ICU) from September 2013 to August 2021; we included patients aged ≥ 18 years who received nafamostat mesylate during CKRT...
February 26, 2024: BMC Nephrology
https://read.qxmd.com/read/38407240/toward-equitable-kidney-function-estimation-in-critical-care-practice-guidance-from-the-society-of-critical-care-medicine-s-diversity-equity-and-inclusion-in-renal-clinical-practice-task-force
#13
JOURNAL ARTICLE
Todd A Miano, Erin F Barreto, Molly McNett, Niels Martin, Ankit Sakhuja, Adair Andrews, Rajit K Basu, Enyo Ama Ablordeppey
OBJECTIVES: Accurate glomerular filtration rate (GFR) assessment is essential in critically ill patients. GFR is often estimated using creatinine-based equations, which require surrogates for muscle mass such as age and sex. Race has also been included in GFR equations, based on the assumption that Black individuals have genetically determined higher muscle mass. However, race-based GFR estimation has been questioned with the recognition that race is a poor surrogate for genetic ancestry, and racial health disparities are driven largely by socioeconomic factors...
February 26, 2024: Critical Care Medicine
https://read.qxmd.com/read/38386072/concurrent-use-of-continuous-kidney-replacement-therapy-during-extracorporeal-membrane-oxygenation-what-pediatric-nephrologists-need-to-know-pcrrt-iconic-practice-points
#14
JOURNAL ARTICLE
Rupesh Raina, Nikhil Nair, Jonathan Pelletier, Matthew Nied, Tarik Whitham, Kush Doshi, Tara Beck, Goeto Dantes, Sidharth Kumar Sethi, Yap Hui Kim, Timothy Bunchman, Kahild Alhasan, Lisa Lima, Isabella Guzzo, Dana Fuhrman, Matthew Paden
Extracorporeal membrane oxygenation (ECMO) provides temporary cardiorespiratory support for neonatal, pediatric, and adult patients when traditional management has failed. This lifesaving therapy has intrinsic risks, including the development of a robust inflammatory response, acute kidney injury (AKI), fluid overload (FO), and blood loss via consumption and coagulopathy. Continuous kidney replacement therapy (CKRT) has been proposed to reduce these side effects by mitigating the host inflammatory response and controlling FO, improving outcomes in patients requiring ECMO...
February 22, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38381939/point-of-care-ultrasound-for-the-assessment-of-post-renal-transplant-recipients
#15
JOURNAL ARTICLE
Michael Uy, Cameron Lam, Yanbo Guo, Rahul Bansal, Richard Hae, Azim Gangji, Christine Ribic, Shahid Lambe
INTRODUCTION: Postoperative imaging for deceased donor renal transplants is often delayed, as these surgeries occur after-hours These delays can be critical in identifying immediate complications. To our knowledge, there are no formal training programs for point-of-care ultrasound (POCUS) in this setting; therefore, we aimed to develop and evaluate a feasible and practical POCUS curriculum for the assessment of a renal transplant graft. METHODS: Urology and nephrology transplant physicians completed a three-hour online course, followed by a five-hour hands-on seminar for sonographic scanning...
December 21, 2023: Canadian Urological Association Journal
https://read.qxmd.com/read/38344604/t-cell-acute-lymphoblastic-leukemia-in-crisis-hyperleukocytosis-tumor-lysis-syndrome-and-innovative-approaches
#16
Gordon White, Mariel Duchow, Levy Amar
T-cell acute lymphoblastic leukemia (T-ALL) is a rare hematologic malignancy with a unique set of clinical challenges when it occurs in adults. This case report presents the complex management of a 32-year-old male with T-ALL who developed symptomatic hyperleukocytosis and tumor lysis syndrome. Upon presentation, the patient exhibited a constellation of critical clinical and laboratory findings, including leukocytosis, anemia, thrombocytopenia, hyperkalemia, high-anion gap metabolic acidosis, and acute kidney injury...
January 2024: Curēus
https://read.qxmd.com/read/38336628/bioactive-adrenomedullin-and-interleukin-6-in-covid-19-potential-biomarkers-of-acute-kidney-injury-and-critical-illness
#17
JOURNAL ARTICLE
Simon B Leininger, Stephan T Staudner, Manuel J Vogel, Julian Mustroph, Ute Hubauer, Stefan Wallner, Petra Lehn, Ralph Burkhardt, Christine Meindl, Frank Hanses, Markus Zimmermann, Lars S Maier, Julian Hupf, Carsten G Jungbauer
BACKGROUND: The aim of this study was to investigate whether bioactive adrenomedullin (bio-ADM) and interleukin-6 (IL-6) are related to acute kidney injury (AKI) and severe illness in COVID-19 patients. METHODS: 153 patients with COVID-19 admitted to the emergency department (ED) were included. Blood samples were collected from each patient at admission. Bio-ADM and IL-6, as well as DPP3 and routinely measured markers were evaluated regarding the endpoints AKI (22/128 hospitalized patients) and a composite endpoint of admission to intensive care unit and/or in-hospital death (n = 26/153 patients)...
February 9, 2024: BMC Nephrology
https://read.qxmd.com/read/38331827/quality-of-life-measures-and-their-psychometric-properties-used-in-african-chronic-kidney-disease-populations-a-systematic-review-using-cosmin-methodology
#18
JOURNAL ARTICLE
Moustapha Faye, Florian Manneville, Adama Faye, Luc Frimat, Francis Guillemin
BACKGROUND: If any benefit is to be derived from the use of the health-related quality of life (HRQoL) questionnaires in chronic kidney disease (CKD) patients, they should be validated and culturally adapted to the target population. We aimed to critically appraise the psychometric properties of HRQoL questionnaires used in African populations with CKD. METHODS: Web of Science, Embase, PubMed and PsycINFO databases were searched. Psychometric validation studies of HRQoL questionnaires reporting at least one psychometric property of the COSMIN checklist in CKD African population, published up to October 16, 2023 were included and independently assessed for methodological quality and level of measurement properties by using the COSMIN methodology...
February 9, 2024: BMC Nephrology
https://read.qxmd.com/read/38322506/assessing-discharge-communication-and-follow-up-of-acute-kidney-injury-in-british-columbia-a-retrospective-chart-review
#19
JOURNAL ARTICLE
Peter Birks, Bader Al-Zeer, Daniel Holmes, Rami Elzayat, Mark Canney, Ognjenka Djurdjev, Tianyi Selena Shao, Yuyan Zheng, Samuel A Silver, Adeera Levin
BACKGROUND AND OBJECTIVE: Acute kidney injury (AKI) affects up to 20% of hospitalizations and is associated with chronic kidney disease, cardiovascular disease, increased mortality, and increased health care costs. Proper documentation of AKI in discharge summaries is critical for optimal monitoring and treatment of these patients once discharged. Currently, there is limited literature evaluating the quality of discharge communication after AKI. This study aimed to evaluate the accuracy and quality of documentation of episodes of AKI at a tertiary care center in British Columbia, Canada...
2024: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/38300007/forecasting-the-future-supply-of-pediatric-subspecialists-in-the-united-states-2020-2040
#20
JOURNAL ARTICLE
Erin Fraher, Andy Knapton, Emily McCartha, Laurel K Leslie
Concerns persist about whether the United States has an adequate supply of pediatric subspecialists and whether they are appropriately distributed across the nation to meet children's health needs. This article describes the data and methods used to develop a workforce projection model that estimates the future supply of 14 pediatric subspecialities certified by the American Board of Pediatrics at the national and US census region and division levels from 2020 to 2040. The 14 subspecialties include adolescent medicine, pediatric cardiology, child abuse pediatrics, pediatric critical care medicine, developmental-behavioral pediatrics, pediatric emergency medicine, pediatric endocrinology, pediatric gastroenterology, pediatric hematology-oncology, pediatric infectious diseases, neonatal-perinatal medicine, pediatric nephrology, pediatric pulmonology, and pediatric rheumatology...
February 1, 2024: Pediatrics
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