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"Neuroimaging"AND "spinal cord injury"

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https://www.readbyqxmd.com/read/28758543/inconsistencies-with-screening-for-traumatic-brain-injury-in-spinal-cord-injury-across-the-continuum-of-care
#1
Seema Sikka, Angela Vrooman, Librada Callender, David Salisbury, Monica Bennett, Rita Hamilton, Simon Driver
OBJECTIVE: Explore how traumatic brain injury (TBI) is screened among spinal cord injury (SCI) patients across the continuum of care. DESIGN: Retrospective chart review Setting: Emergency department, trauma, inpatient rehabilitation Participants: 325 patients with SCI from inpatient rehabilitation facility (IRF) between March 1, 2011 and December 31, 2014 were screened. 49 eligible subjects had traumatic SCI and received care in adjoining acute care (AC) hospital...
July 31, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28649492/relationship-between-brainstem-neurodegeneration-and-clinical-impairment-in-traumatic-spinal-cord-injury
#2
Patrick Grabher, Claudia Blaiotta, John Ashburner, Patrick Freund
BACKGROUND: Brainstem networks are pivotal in sensory and motor function and in recovery following experimental spinal cord injury (SCI). OBJECTIVE: To quantify neurodegeneration and its relation to clinical impairment in major brainstem pathways and nuclei in traumatic SCI. METHODS: Quantitative MRI data of 30 chronic traumatic SCI patients (15 with tetraplegia and 15 with paraplegia) and 23 controls were acquired. Patients underwent a full neurological examination...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28466257/cortical-representation-of-pain-and-touch-evidence-from-combined-functional-neuroimaging-and-electrophysiology-in-non-human-primates
#3
REVIEW
Li Min Chen
Human functional MRI studies in acute and various chronic pain conditions have revolutionized how we view pain, and have led to a new theory that complex multi-dimensional pain experience (sensory-discriminative, affective/motivational, and cognitive) is represented by concurrent activity in widely-distributed brain regions (termed a network or pain matrix). Despite these breakthrough discoveries, the specific functions proposed for these regions remain elusive, because detailed electrophysiological characterizations of these regions in the primate brain are lacking...
May 2, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28393423/are-midsagittal-tissue-bridges-predictive-of-outcome-after-cervical-spinal-cord-injury
#4
Eveline Huber, Patrice Lachappelle, Reto Sutter, Armin Curt, Patrick Freund
T2 -weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At 1 month postinjury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at 1 month post-injury were associated with neurological and functional recovery at 1-year follow-up...
May 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28385062/diffusion-tensor-imaging-parameter-obtained-during-acute-blunt-cervical-spinal-cord-injury-in-predicting-long-term-outcome
#5
Kathirkamanthan Shanmuganathan, Jiachen Zhuo, Hegang H Chen, Bizhan Aarabi, Jason Adams, Catriona Miller, Jay Menaker, Rao Gullapallie, Stuart E Mirvis
There are no reliable neuroimaging biomarkers to predict long term outcome following spinal cord injury. This prospective longitudinal study evaluates diffusion tensor imaging (DTI) in predicting long term outcome following cervical spinal cord injury (CSCI). We investigate the admission DTI parameters measured in 30 patients with CSCI, with 16 of them followed up to 1 year, and 15 volunteers serving as controls. All MRI examinations were performed within 24 hours of injury. DTI parameters were measured in patients and controls, avoiding areas of hemorrhage in patients and at corresponding upper/middle/lower regions of the spinal cord in controls...
April 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28089079/repeated-subarachnoid-administrations-of-autologous-mesenchymal-stromal-cells-supported-in-autologous-plasma-improve-quality-of-life-in-patients-suffering-incomplete-spinal-cord-injury
#6
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Celia Bonilla, Concepción Aguayo, Cecilia Fernández, Noemí Tapiador, Marta Sevilla, Carlos Morejón, Jesús Montilla, Francisco Martínez, Esperanza Marín, Salvador Bustamante, David Vázquez, Joaquín Carballido, Alicia Rodríguez, Paula Martínez, Coral García, Mercedes Ovejero, Marta V Fernández
BACKGROUND AIMS: Cell therapy with mesenchymal stromal cells (MSCs) offers new hope for patients suffering from spinal cord injury (SCI). METHODS: Ten patients with established incomplete SCI received four subarachnoid administrations of 30 × 10(6) autologous bone marrow MSCs, supported in autologous plasma, at months 1, 4, 7 and 10 of the study, and were followed until the month 12. Urodynamic, neurophysiological and neuroimaging studies were performed at months 6 and 12, and compared with basal studies...
March 2017: Cytotherapy
https://www.readbyqxmd.com/read/27907952/neurology-of-critical-care
#7
Eelco F M Wijdicks
It is a truism that care of the patient with an acutely severe neurologic illness starts with a full neurologic examination. Neurologic examination is followed by tests (neuroimaging and laboratory) resulting in a diagnosis (presumptive or definitive) and treatment (definitive or preemptive) and followed by admission for supportive care and more treatment. The sequence of decisions depends on the diagnosis, but treatment may be needed to diagnose a neurologic disorder. To find out what underlies the acute presentation of certain neurologic conditions requires (1) interpretation of neurologic findings, (2) interpretation of neuroimaging, (3) linking laboratory abnormalities to certain clinical neurologic findings, and (4) evaluation of improvement or refractoriness after treatment...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27720818/sct-spinal-cord-toolbox-an-open-source-software-for-processing-spinal-cord-mri-data
#8
Benjamin De Leener, Simon Lévy, Sara M Dupont, Vladimir S Fonov, Nikola Stikov, D Louis Collins, Virginie Callot, Julien Cohen-Adad
For the past 25 years, the field of neuroimaging has witnessed the development of several software packages for processing multi-parametric magnetic resonance imaging (mpMRI) to study the brain. These software packages are now routinely used by researchers and clinicians, and have contributed to important breakthroughs for the understanding of brain anatomy and function. However, no software package exists to process mpMRI data of the spinal cord. Despite the numerous clinical needs for such advanced mpMRI protocols (multiple sclerosis, spinal cord injury, cervical spondylotic myelopathy, etc...
January 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27417400/neuroimaging-of-the-traumatic-spine
#9
REVIEW
Marcel Wolf, Marc-André Weber
The article summarizes classification schemes of spinal trauma and rules to decide on proper imaging modality after a spinal trauma. High-risk factors that recommend imaging are, for instance, age 65 years or older, a dangerous trauma mechanism, and paresthesia in the extremities. More recent classification schemes include evaluation of the posterior ligamentous complex, for which MR imaging is the best modality, and to give therapeutic recommendations for conservative or surgical management. MR imaging is the imaging method of choice when spinal cord injury, cord compression, or ligamentous injury is suspected...
August 2016: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27311799/an-approach-to-personalized-cell-therapy-in-chronic-complete-paraplegia-the-puerta-de-hierro-phase-i-ii-clinical-trial
#10
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Celia Bonilla, Concepcion Aguayo, Jesús Montilla, Salvador Bustamante, Joaquin Carballido, Esperanza Marin, Francisco Martinez, Avelino Parajon, Cecilia Fernandez, Laura De Reina
BACKGROUND AIMS: Cell transplantation in patients suffering spinal cord injury (SCI) is in its initial stages, but currently there is confusion about the results because of the disparity in the techniques used, the route of administration, and the criteria for selecting patients. METHODS: We conducted a clinical trial involving 12 patients with complete and chronic paraplegia (average time of chronicity, 13.86 years; SD, 9.36). The characteristics of SCI in magnetic resonance imaging (MRI) were evaluated for a personalized local administration of expanded autologous bone marrow mesenchymal stromal cells (MSCs) supported in autologous plasma, with the number of MSCs ranging from 100 × 10(6) to 230 × 10(6)...
August 2016: Cytotherapy
https://www.readbyqxmd.com/read/27299114/spinal-cord-injury-without-radiological-abnormality-in-an-8-months-old-female-child-a-case-report
#11
Kunal R Bansal, Ajay S Chandanwale
INTRODUCTION: Spinal cord injury in children frequently occurs without fracture or dislocation. SCIWORA is a syndrome occurring when the spinal cord sustains neural damage during a traumatic event without positive radiographic findings. The incidence of SCIWORA was found to be 8% to 32% in various studies with very few cases documented in children below the age of 1 year. We report such a case of spinal cord injury without radiological abnormality in an 8 months old female child. CASE REPORT: An 8 months old female child was brought to the emergency room after a history of fall from the bed four days back...
January 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27241448/the-contribution-of-neurophysiology-in-the-diagnosis-and-management-of-cervical-spondylotic-myelopathy-a-review
#12
REVIEW
R Nardone, Y Höller, F Brigo, V N Frey, P Lochner, S Leis, S Golaszewski, E Trinka
STUDY DESIGN: Topical review of the literature. OBJECTIVE: The objective of this review article was to assess indications and usefulness of various neurophysiological techniques in diagnosis and management of cervical spondylogenic myelopathy (CSM). METHODS: The MEDLINE, accessed by Pubmed and EMBASE electronic databases, was searched using the medical subject headings: 'compressive myelopathy', 'cervical spondylotic myelopathy (CSM)', 'cervical spondylogenic myelopathy', 'motor evoked potentials (MEPs)', 'transcranial magnetic stimulation', 'somatosensory evoked potentials (SEPs)', 'electromyography (EMG)', 'nerve conduction studies (NCS)' and 'cutaneous silent period (CSP)'...
October 2016: Spinal Cord
https://www.readbyqxmd.com/read/26954693/alterations-in-cortical-sensorimotor-connectivity-following-complete-cervical-spinal-cord-injury-a-prospective-resting-state-fmri-study
#13
Akinwunmi Oni-Orisan, Mayank Kaushal, Wenjun Li, Jack Leschke, B Douglas Ward, Aditya Vedantam, Benjamin Kalinosky, Matthew D Budde, Brian D Schmit, Shi-Jiang Li, Vaishnavi Muqeet, Shekar N Kurpad
Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI...
2016: PloS One
https://www.readbyqxmd.com/read/26882492/spinal-cord-injury-without-radiographic-abnormality-sciwora-in-adults-mri-type-predicts-early-neurologic-outcome
#14
C K Boese, D Müller, R Bröer, P Eysel, B Krischek, H C Lehmann, P Lechler
OBJECTIVES: The present study aimed to analyse the clinical and neuroimaging features of a consecutive series of adult patients with spinal cord injury without radiographic abnormality (SCIWORA) receiving early magnetic resonance imaging (MRI), and to apply the recently proposed MRI classification system. METHODS: Grade of neurologic impairment at admission and discharge was reported according to the American Spinal Injury Association Impairment Scale (AIS). A detailed analysis and categorisation of the extra- and intramedullary MRI findings was performed, and the relationship between imaging type and neurological outcome was described...
October 2016: Spinal Cord
https://www.readbyqxmd.com/read/26375137/t-14-in-vivo-imaging-of-neuroinflammation-in-neurotrauma-preclinical-models-colon-potential-for-clinical-translation
#15
J L Tremoleda, O Thau-Zuchman, M Davies, J Foster, I Khan, W Trigg, J Sosabowski, S J Mather, A Michael-Titus
INTRODUCTION: The development of clinically meaningful biomarkers for CNS traumatic injury is a major area in neurotrauma modelling. Neuroimaging is evolving as a major approach to characterize pathophysiology, improve diagnosis and test new therapies. Imaging the microglial response by targeting the up- regulation of the 18 kDa translocator protein (TSPO) following CNS injury, is a main diagnostic approach for investigating the neuroinflammatory (NI) response after CNS injury in vivo...
October 2015: Shock
https://www.readbyqxmd.com/read/26289818/hal%C3%A2-exoskeleton-training-improves-walking-parameters-and-normalizes-cortical-excitability-in-primary-somatosensory-cortex-in-spinal-cord-injury-patients
#16
Matthias Sczesny-Kaiser, Oliver Höffken, Mirko Aach, Oliver Cruciger, Dennis Grasmücke, Renate Meindl, Thomas A Schildhauer, Peter Schwenkreis, Martin Tegenthoff
BACKGROUND: Reorganization in the sensorimotor cortex accompanied by increased excitability and enlarged body representations is a consequence of spinal cord injury (SCI). Robotic-assisted bodyweight supported treadmill training (BWSTT) was hypothesized to induce reorganization and improve walking function. OBJECTIVE: To assess whether BWSTT with hybrid assistive limb® (HAL®) exoskeleton affects cortical excitability in the primary somatosensory cortex (S1) in SCI patients, as measured by paired-pulse somatosensory evoked potentials (ppSEP) stimulated above the level of injury...
2015: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/26199589/strategies-to-avoid-a-missed-diagnosis-of-co-occurring-concussion-in-post-acute-patients-having-a-spinal-cord-injury
#17
David S Kushner
Research scientists and clinicians should be aware that missed diagnoses of mild-moderate traumatic brain injuries in post-acute patients having spinal cord injuries may approach 60-74% with certain risk factors, potentially causing clinical consequences for patients, and confounding the results of clinical research studies. Factors leading to a missed diagnosis may include acute trauma-related life-threatening issues, sedation/intubation, subtle neuropathology on neuroimaging, failure to collect Glasgow Coma Scale scores or duration of posttraumatic amnesia, or lack of validity of this information, and overlap in neuro-cognitive symptoms with emotional responses to spinal cord injuries...
June 2015: Neural Regeneration Research
https://www.readbyqxmd.com/read/26125597/simultaneous-brain-cervical-cord-fmri-reveals-intrinsic-spinal-cord-plasticity-during-motor-sequence-learning
#18
Shahabeddin Vahdat, Ovidiu Lungu, Julien Cohen-Adad, Veronique Marchand-Pauvert, Habib Benali, Julien Doyon
The spinal cord participates in the execution of skilled movements by translating high-level cerebral motor representations into musculotopic commands. Yet, the extent to which motor skill acquisition relies on intrinsic spinal cord processes remains unknown. To date, attempts to address this question were limited by difficulties in separating spinal local effects from supraspinal influences through traditional electrophysiological and neuroimaging methods. Here, for the first time, we provide evidence for local learning-induced plasticity in intact human spinal cord through simultaneous functional magnetic resonance imaging of the brain and spinal cord during motor sequence learning...
June 2015: PLoS Biology
https://www.readbyqxmd.com/read/26110798/tracking-trauma-induced-structural-and-functional-changes-above-the-level-of-spinal-cord-injury
#19
REVIEW
Eveline Huber, Armin Curt, Patrick Freund
PURPOSE OF REVIEW: This review will highlight the latest findings from neuroimaging studies that track structural and functional changes within the central nervous system at both the brain and spinal cord levels following acute human spinal cord injury (SCI). The putative, underlying biological mechanisms of structural change (e.g. degradation of neural tissue) rostral to the lesion site will be discussed in relation to animal models of SCI and their potential value in clinical studies of human SCI...
August 2015: Current Opinion in Neurology
https://www.readbyqxmd.com/read/25999842/relationship-between-structural-brainstem-and-brain-plasticity-and-lower-limb-training-in-spinal-cord-injury-a-longitudinal-pilot-study
#20
Michael Villiger, Patrick Grabher, Marie-Claude Hepp-Reymond, Daniel Kiper, Armin Curt, Marc Bolliger, Sabina Hotz-Boendermaker, Spyros Kollias, Kynan Eng, Patrick Freund
Rehabilitative training has shown to improve significantly motor outcomes and functional walking capacity in patients with incomplete spinal cord injury (iSCI). However, whether performance improvements during rehabilitation relate to brain plasticity or whether it is based on functional adaptation of movement strategies remain uncertain. This study assessed training improvement-induced structural brain plasticity in chronic iSCI patients using longitudinal MRI. We used tensor-based morphometry (TBM) to analyze longitudinal brain volume changes associated with intensive virtual reality (VR)-augmented lower limb training in nine traumatic iSCI patients...
2015: Frontiers in Human Neuroscience
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