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https://www.readbyqxmd.com/read/29652595/stem-cells-for-skeletal-muscle-tissue-engineering
#1
Molly N Pantellic, Lisa Marie Larkin
Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the body's normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries. Because of the high social and medical cost associated with VML and suboptimal current surgical treatments, there is great interest in developing better VML therapies. Skeletal muscle tissue engineering (SMTE) is a promising alternative to traditional VML surgical treatments that use autogenic tissue grafts, and rather uses isolated stem cells with myogenic potential to generate de novo skeletal muscle tissues to treat VML...
March 14, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29649413/neural-stem-cells-derived-directly-from-adipose-tissue
#2
Eric David Petersen, Jessica R Zenchak, Olivia V Lossia, Ute Hochgeschwender
Neural stem cells are characterized as self-renewing cell populations with the ability to differentiate into the multiple tissue types of the central nervous system. These cells can differentiate into mature neurons, astrocytes, and oligodendrocytes. This category of stem cells has been shown to be a promisingly effective treatment for neurodegenerative diseases and neuronal injury. Most treatment studies with neural stem cells in animal models use embryonic brain derived neural stem cells. This approach presents both ethical and feasibility issues for translation to human patients...
March 16, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29626983/hematopoietic-changes-in-the-offspring-induced-by-maternal-overweight-effect-on-placenta-and-fetal-liver-populations
#3
Luana Leirós, Juliana Barbosa Torreão Dáu, Daphne Pinheiro, Ana Carolina Stumbo Machado, Alessandra Alves Thole, Erika Afonso Costa Cortez, Laís de Carvalho, Simone Nunes de Carvalho
INTRODUCTION: Bone marrow cells (BMC) from obese adult mice display an increased apoptosis rate over proliferation. Hematopoietic stem cells (HSC) form all blood cells and are important BMC used in cell therapy. Because it is known that prenatal development can be affected by adverse metabolic epigenetic programming from the maternal organism, this work aimed to investigate the effects of maternal overweight on placenta and fetal liver hematopoietic niches. METHODS: Overweight was induced in female mice by overfeeding during lactation...
April 2018: Placenta
https://www.readbyqxmd.com/read/29622661/isolation-of-a-multipotent-mesenchymal-stem-cell-like-population-from-human-adrenal-cortex
#4
Earn Gan, Wendy Robson, Peter Murphy, Robert Pickard, Simon Pearce, Rachel Oldershaw
BACKGROUND: The highly plastic nature of adrenal cortex suggests the presence of adrenocortical stem cells (ACSC) but the exact in vivo identity of ACSC remains elusive. A few studies have demonstrated the differentiation of adipose or bone marrow-derived mesenchymal stem cells (MSC) into steroid-producing cells. We therefore investigated the isolation of multipotent MSC from human adrenal cortex. METHODS: Human adrenals were obtained as discarded surgical material...
April 5, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29620445/induction-of-human-adipose-derived-mesenchymal-stem-cells-into-germ-lineage-using-retinoic-acid
#5
Haihui Liu, Mingtai Chen, Lulu Liu, Saisai Ren, Panpan Cheng, Hao Zhang
Accumulating evidence indicates that mesenchymal stem cells (MSCs) have been widely used in tissue engineering and regenerative medicine due to their multilineage differentiation potentials. Recent studies show that germ-like cells can also be derived from stem cells, such as human umbilical cord MSCs and human bone marrow MSCs in vitro. However, whether human adipose-derived MSCs (hAD-MSCs) can be induced into germ-like cells has never been reported. In this study, we isolated hAD-MSCs and confirmed that their characteristics were in accordance with that of MSCs established before...
April 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29615915/application-of-mesenchymal-stem-cells-for-therapeutic-agent-delivery-in-anti-tumor-treatment
#6
REVIEW
Daria S Chulpanova, Kristina V Kitaeva, Leysan G Tazetdinova, Victoria James, Albert A Rizvanov, Valeriya V Solovyeva
Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circumvents the ethical concerns of working with embryonic or fetal stem cells, whilst still providing cells capable of differentiating into various cell lineages, such as adipocytes, osteocytes and chondrocytes. An important feature of MSCs is the low immunogenicity due to the lack of co-stimulatory molecules expression, meaning there is no need for immunosuppression during allogenic transplantation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29608395/an-engineered-cell-sheet-composed-of-human-islets-and-human-fibroblast-bone-marrow-derived-mesenchymal-stem-cells-or-adipose-derived-mesenchymal-stem-cells-an-in-vitro-comparison-study
#7
Hajime Imamura, Tomohiko Adachi, Tatsuya Kin, Shinichiro Ono, Yusuke Sakai, Toshiyuki Adachi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, A M James Shapiro, Susumu Eguchi
BACKGROUND: We previously reported the utility of engineered cell sheets composed of human islets and supporting cells in vitro and in vivo. It is unclear which type of supporting cell is most suitable for constructing cell sheets with human islets. The present study aimed to compare human fibroblasts, bone marrow-derived mesenchymal stem cells (BM-MSCs), and adipose-derived mesenchymal stem cells (ADSCs) as a supporting source for cell sheets. METHODS: Engineered cell sheets were fabricated with human islets using human fibroblasts, BM-MSCs, or ADSCs as supporting cells...
April 2, 2018: Islets
https://www.readbyqxmd.com/read/29587852/repair-of-bone-defects-in-rat-radii-with-a-composite-of-allogeneic-adipose-derived-stem-cells-and-heterogeneous-deproteinized-bone
#8
Jia Liu, Peng Zhou, Yu Long, Chunxia Huang, Danna Chen
BACKGROUND: In the bone tissue engineering domain, seed cells, scaffold and cell-scaffold composites are three focuses. In this study, the feasibility of using allogeneic adipose-derived stem cells(ADSCs) combined with heterogeneous deproteinized bone (HDB) to repair segmental radial defects was investigated by observing the repair of the defect area. METHODS: ADSCs were cultured in vitro, purified, antigen-detected and osteogenic differentiation potency-measured; then, the ADSCs of the third generation were seeded into HDB to prepare an ADSCs-HDB composite partly with osteogenesis induced cells...
March 27, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29582436/modifiers-of-mesenchymal-stem-cell-quantity-and-quality
#9
Athena L Russell, Rebecca Lefavor, Nisha Durand, Loren Glover, Abba C Zubair
BACKGROUND: Clinical trials involving mesenchymal stem cell (MSC) therapy have variable outcomes. We hypothesize this is largely attributed to donor-to-donor variability and tissue of origin. STUDY DESIGN AND METHODS: We examined proliferation rates, cytokine secretion profiles, and differentiation capability of seven bone marrow-derived MSCs (BM-MSCs) and 16 adipose tissue-derived MSCs (AD-MSCs) from 23 donors. RESULTS: AD-MSCs had the capacity to undergo more than 40 population doublings, while the BM-MSC proliferation rate was found to be considerably slower...
March 26, 2018: Transfusion
https://www.readbyqxmd.com/read/29581449/adipose-mesenchymal-stem-cells-from-osteoporotic-donors-preserve-functionality-and-modulate-systemic-inflammatory-microenvironment-in-osteoporotic-cytotherapy
#10
Chen-Xi Zheng, Bing-Dong Sui, Nu Liu, Cheng-Hu Hu, Tao He, Xin-Yi Zhang, Pan Zhao, Ji Chen, Kun Xuan, Yan Jin
Maintenance of bone homeostasis against diseased microenvironments remains as a major challenge. Recently, mesenchymal stem cells (MSCs) have been unravelled as potent microenvironmental modulators, the systemic infusion of which in cytotherapy can prevent or rescue extensive bone loss via anti-inflammation. However, MSCs also accept microenvironmental regulations; particularly, MSCs from bone marrow (BMMSCs) are prone to pathological microenvironmental factors of bone. In this study, we discovered that BMMSCs from osteoporotic donors of ovariectomized (OVX) mice lost their anti-inflammatory capability and failed to prevent bone loss when infused back into OVX recipients...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29575235/bone-marrow-or-adipose-tissue-mesenchymal-stem-cells-comparison-of-the-therapeutic-potentials-in-mice-model-of-acute-liver-failure
#11
Hossein Zare, Shahram Jamshidi, Mohammad M Dehghan, Mona Saheli, Abbas Piryaei
Acute liver failure (ALF) is a lethal disease with limited life-saving therapy. Because lack of whole organ donors for liver transplantation, a substitute treatment strategy is needed for these patients. Preclinical and clinical findings have proved that treatment with mesenchymal stem cells (MSCs) is beneficial for recovery from ALF. In this approach, however, the appropriate sources of these cells are unclear. In the present study, we investigated and compared the therapeutic potentials of bone marrow-mesenchymal stem cells (BM-MSC) with those of adipose tissue (AT-MSC) in carbon tetrachloride (CCL4)-induced acute liver failure in mice...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29570699/microrna-194-regulates-the-development-and-differentiation-of-sensory-patches-and-statoacoustic-ganglion-of-inner-ear-by-fgf4
#12
Hui Cao, Jianbo Shi, Jintao Du, Kaitian Chen, Chang Dong, Di Jiang, Hongyan Jiang
BACKGROUND MicroRNA 194 is involved in the differentiation of various types of cells, such as adipose derived stem cells, human embryonic stem cells, and bone marrow mesenchymal stem cells. Previously, we found that miR-194 was highly expressed in the inner ear sensory patch and neurons in mice embryos. However, the role of miR-194 in the development of the inner ear and its underlying mechanism have not been elucidated yet. MATERIAL AND METHODS The expression level of miR-194 has been altered by using antisense morpholino oligonucleotides (MO) and synthesized miRNAs in zebrafish...
March 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29565801/mesenchymal-stem-cells-of-dental-origin-for-inducing-tissue-regeneration-in-periodontitis-a-mini-review
#13
REVIEW
Beatriz Hernández-Monjaraz, Edelmiro Santiago-Osorio, Alberto Monroy-García, Edgar Ledesma-Martínez, Víctor Manuel Mendoza-Núñez
Periodontitis is a chronic disease that begins with a period of inflammation of the supporting tissues of the teeth table and then progresses, destroying the tissues until loss of the teeth occurs. The restoration of the damaged dental support apparatus is an extremely complex process due to the regeneration of the cementum, the periodontal ligament, and the alveolar bone. Conventional treatment relies on synthetic materials that fill defects and replace lost dental tissue, but these approaches are not substitutes for a real regeneration of tissue...
March 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29559604/-angiogenic-ability-of-3-different-tissues-derived-mesenchymal-stem-cells-on-endothelial-progenitor-cells
#14
Siqi Wang, Haiyuan Lu, Lamei Cheng
To compare the ability between bone marrow-derived mesenchymal stem cells (MSCs) (BM-MSCs) and adipose-derived MSCs (AD-MSCs) or umbilical cord-derived MSCs (UC-MSCs) on promotion of vessels formation and vessels stabilization relevant to the functions of EPCs.
 Methods: In vitro, co-culture blood vessel test was performed to compare the angiogenic ability between BM-MSCs, AD-MSCs or UC-MSCs. In vivo, angiogenic assay dependent on basement membrane matrix Matrigel and immunohistochemistry were performed to compare the ability of vessels formation functions between BM-MSCs and AD-MSCs or UC-MSCs...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29554460/reporting-of-mesenchymal-stem-cell-preparation-protocols-and-composition-a-systematic-review-of-the-clinical-orthopaedic-literature
#15
Patrick G Robinson, Iain R Murray, Christopher C West, Ewan B Goudie, Li Y Yong, Timothy O White, Robert F LaPrade
BACKGROUND: Mesenchymal stem cells (MSCs) are increasingly being used in the treatment of a wide variety of sports-related conditions. Despite this enthusiasm, the biological properties of MSCs and their effects on musculoskeletal tissue healing remain poorly understood. MSC-based strategies encompass cell populations with heterogeneous phenotypes isolated from multiple tissues and using different methods. Therefore, comprehensive reporting of the source, preparation methods, and characteristics of MSC strategies is essential to enable interpretation of results...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29550266/fat-bone-interaction-within-the-bone-marrow-milieu-impact-on-hematopoiesis-and-systemic-energy-metabolism
#16
REVIEW
C P Hawkes, S Mostoufi-Moab
The relationship between fat, bone and systemic metabolism is a growing area of scientific interest. Marrow adipose tissue is a well-recognized component of the bone marrow milieu and is metabolically distinct from current established subtypes of adipose tissue. Despite recent advances, the functional significance of marrow adipose tissue is still not clearly delineated. Bone and fat cells share a common mesenchymal stem cell (MSC) within the bone marrow, and hormones and transcription factors such as growth hormone, leptin, and peroxisomal proliferator-activated receptor γ influence MSC differentiation into osteoblasts or adipocytes...
March 14, 2018: Bone
https://www.readbyqxmd.com/read/29549561/role-of-marrow-adipocytes-in-regulation-of-energy-metabolism-and-bone-homeostasis
#17
REVIEW
Jillian Cornish, Tao Wang, Jian-Ming Lin
PURPOSE OF REVIEW: The goal of this review is to gain a better understanding of marrow adipocyte development, its regulation of energy, and its characterization responsible for bone homeostasis. RECENT FINDINGS: Despite major advances in uncovering the complex association of bone-fat in the marrow, the underlying basic biological process of adipose tissue development, as well as its interaction with bone homeostasis in pathophysiological conditions, is still not well understood...
March 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29544858/osteoarthritis-and-stem-cell-therapy-in-humans-a-systematic-review
#18
REVIEW
David S Jevotovsky, Allyson R Alfonso, Thomas A Einhorn, Ernest S Chiu
OBJECTIVE: Osteoarthritis (OA) is a leading cause of disability in the world. Mesenchymal stem cells (MSCs) have been studied to treat OA. This review was performed to systematically assess the quality of literature and compare the procedural specifics surrounding MSC therapy for osteoarthritis. DESIGN: PubMed, CINAHL, EMBASE and Cochrane Central Register of Controlled Trials were searched for studies using MSCs for OA treatment (final search December 2017). Outcomes of interest included study evidence level, patient demographics, MSC protocol, treatment results and adverse events...
March 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29531282/shelf-life-evaluation-of-clinical-grade-chondrogenic-induced-aged-adult-stem-cells-for-cartilage-regeneration
#19
C C Ude, W T Seet, S Sharen Aini, B S Aminuddin, B H I Ruszymah
The study objectives include, enhancing the proliferations of aged bone marrow stem cells (BMSCs) and adipose stem cells (ADSCs); and evaluating the shelf lives of clinical grade chondrogenically induced cells from both samples. ADSCs and BMSCs from 56 patients (76 ± 8 yrs) were proliferated using basal medium (FD) and at (5, 10, 15, 20 and 25) ng/ml of basal fibroblast growth factor (bFGF). They were induced to chondrogenic lineage and stored for more than 120 hrs in FD, serum, Dulbecco's phosphate buffered saline (DPBS) and saline at 4 °C...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29529399/angiogenesis-in-peripheral-arterial-disease
#20
REVIEW
Chakradhari Inampudi, Emmanuel Akintoye, Tomo Ando, Alexandros Briasoulis
Peripheral arterial disease (PAD) refers to narrowing of the peripheral arteries and atherosclerosis is the most important cause. In patients with PAD, revascularization is the preferred therapeutic strategy; nonetheless several patients are not deemed candidates for it due to advanced disease or several comorbidities. The main target of therapeutic angiogenesis is to promote development of new arterial vessels and improve perfusion of ischemic tissue. Angiogenic growth factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), administered intramuscularly or intra-arterially, have been shown to promote angiogenesis and development of collateral vasculature in preclinical studies...
March 9, 2018: Current Opinion in Pharmacology
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