keyword
MENU ▼
Read by QxMD icon Read
search

Hepatectomy for hepatocellular carcinoma

keyword
https://www.readbyqxmd.com/read/29785036/a-novel-microrna-signature-predicts-survival-in-liver-hepatocellular-carcinoma-after-hepatectomy
#1
Qiang Fu, Fan Yang, Tengxiao Xiang, Guoli Huai, Xingxing Yang, Liang Wei, Hongji Yang, Shaoping Deng
Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In the current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for LIHC prognosis with survival analysis and a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed for overall survival (OS) prediction by comparing miRNA profiles in paired primary tumour and solid tumour normal tissues...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777455/combined-preoperative-albi-and-fib-4-is-associated-with-recurrence-of-hepatocellular-carcinoma-after-curative-hepatectomy
#2
Rui Liao, De-Wei Li, Cheng-You Du, Ming Li
BACKGROUND AND PURPOSE: Chronic inflammatory response is a risk factor for hepatocarcinogenesis and recurrence. This study aimed to develop a nomogram incorporating the combined albumin-bilirubin (ALBI) and fibrosis-4 (FIB-4) scores and the peritumoral inflammation score (PIS) to predict postoperative recurrence-free survival (RFS) of hepatocellular carcinoma (HCC). METHODS: The prognostic roles of preoperative ALBI and FIB-4 scores for HCC recurrence were investigated, and a nomogram was developed...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29770948/post-surgical-resection-prognostic-value-of-combined-opn-mmp7-and-psg9-plasma-biomarkers-in-hepatocellular-carcinoma
#3
Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao
Biomarkers for hepatocellular carcinoma (HCC) following curative resection are not currently sufficient for prognostic indication of overall survival (OS) and disease-free survival (DFS). The aim of this study was to investigate the prognostic performance of osteopontin (OPN), matrix metalloproteinase 7 (MMP7), and pregnancy specific glycoprotein 9 (PSG9) in patients with HCC. A total of 179 prospective patients with HCC provided plasma before hepatectomy. Plasma OPN, MMP7, and PSG9 levels were determined by enzyme-linked immunosorbent assay...
May 16, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29765248/preoperative-neutrophil-to-lymphocyte-ratio-as-a-prognostic-predictor-after-curative-intent-surgery-for-hepatocellular-carcinoma-experience-from-a-developing-country
#4
Danijel Galun, Aleksandar Bogdanovic, Jelena Djokic Kovac, Predrag Bulajic, Zlatibor Loncar, Marinko Zuvela
Purpose: The aim of the study was to evaluate a prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on long-term survival of cirrhotic and noncirrhotic hepatocellular cancer (HCC) patients managed by a curative-intent liver surgery in a developing country. Patients and methods: During the study period between November 1, 2001, and December 31, 2012, 109 patients underwent potentially curative hepatectomy for HCC. Data were retrospectively reviewed from the prospectively collected database...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29760565/genome-wide-association-pathway-analysis-to-identify-candidate-single-nucleotide-polymorphisms-and-molecular-pathways-associated-with-tp53-expression-status-in-hbv-related-hepatocellular-carcinoma
#5
Xiwen Liao, Long Yu, Xiaoguang Liu, Chuangye Han, Tingdong Yu, Wei Qin, Chengkun Yang, Guangzhi Zhu, Hao Su, Tao Peng
Background: The aim of this investigation was to identify candidate single nucleotide polymorphisms (SNPs) and molecular pathways associated with tumor protein p53 (TP53) expression status in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), clarify their potential mechanisms, and generate SNP-to-gene to pathway hypothesis. Materials and methods: Identify candidate Causal SNPs and Pathways (ICSNPathway) was used to perform pathway analysis based on the results of our previous genome-wide association study of TP53 expression status in 387 HBV-related HCC patients...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29758561/surgical-outcome-and-hepatic-regeneration-after-hepatic-resection-for-hepatocellular-carcinoma-in-elderly-patients
#6
Yoshihiro Inoue, Ryo Tanaka, Kensuke Fujii, Nao Kawaguchi, Masatsugu Ishii, Shinsuke Masubuchi, Masashi Yamamoto, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
INTRODUCTION: The rising proportion of elderly patients (aged 80 yearsor above) in our population means that more elderly patients are undergoing hepatectomy. METHODS: Five-hundred and thirty patients who underwent hepatectomy for hepatocellular carcinoma (HCC) were retrospectively analyzed with respect to their preoperative status and perioperative results, including remnant liver regeneration. The remnant liver volume was postoperatively measured with multidetector CT on postoperative day 7 and 1, 2, 5, and 12 months after surgery...
May 14, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29753515/long-term-prognostic-impact-of-osteopontin-and-dickkopf-related-protein-1-in-patients-with-hepatocellular-carcinoma-after-hepatectomy
#7
Hyerim Byeon, Seung Duk Lee, Eun-Kyung Hong, Dong Eun Lee, Bo Hyun Kim, Yunsung Seo, Jungnam Joo, Sung-Sik Han, Seong Hoon Kim, Sang-Jae Park
BACKGROUND: New biomarkers are essential for improving the prediction of the survival and prognosis of patients with hepatocellular carcinoma (HCC). Alpha-fetoprotein (AFP) is the most widely used biomarker, but the low sensitivity and specificity limit its clinical applications. The diagnostic and prognostic capabilities of osteopontin (OPN), dickkopf-related protein 1 (DKK1), and a combination of these biomarkers are being studied. METHODS: From January 2006 to December 2008, patients undergoing hepatectomy for HCC were screened and their serum stored in tumor banks was analyzed...
May 6, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29747235/pure-laparoscopic-hepatectomy-with-augmented-reality-assisted-indocyanine-green-fluorescence-versus-open-hepatectomy-for-hepatocellular-carcinoma-with-liver-cirrhosis-a-propensity-analysis-at-a-single-center
#8
Tan To Cheung, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Simon Hing Yin Tsang, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Chung Mau Lo
INTRODUCTION: Laparoscopic hepatectomy is considered an acceptable treatment of choice in selected patients with primary hepatocellular carcinoma (HCC). Whether indocyanine green (ICG) immunofluorescence, a new technology, may improve surgery outcomes has yet to be tested. The aim of the present study was to investigate and compare the effect of ICG fluorescence imaging on the outcomes of pure laparoscopic hepatectomy and open hepatectomy for primary HCC with background cirrhosis. METHODS: From January 2015 to June 2016, 20 patients with HCC and liver cirrhosis underwent laparoscopic hepatectomy with ICG immunofluorescence...
May 10, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29744338/left-hepatectomy-with-concomitant-cavo-atrial-and-biliary-tumor-thrombectomy-for-invasive-hepatocellular-carcinoma-a-video-report
#9
EDITORIAL
Lidia Castagneto Gissey, Layla Musleh, Germano Mariano, Giovanni Vennarecci, Andrea Scotti, Marco Colasanti, Roberto Luca Meniconi, Alessandra Campanelli, Cristian Astudillo Diaz, Giuseppe Maria Ettorre
No abstract text is available yet for this article.
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29731904/peritumoral-overexpression-of-zbp-89-is-associated-with-unfavorable-disease-free-survival-rates-in-patients-with-hepatocellular-carcinoma-following-hepatectomy
#10
Qiu-Shuang Wang, Chen Chen, Jing Zhan, Xie-Fan Fang, George G Chen, Sheng-Li Yang, Ren-Wang Chen, Fan Tong, Jian-Li Hu
Previous studies have revealed that the peritumoral environment has a profound influence on tumor initiation and progression. Zinc-binding protein-89 (ZBP-89) has been observed to be involved with tumor development, recurrence, and metastasis. High intratumoral expression of ZBP-89 has been associated with improved prognosis in several tumor types. However, the prognostic values of peritumoral expression of ZBP-89 remain to be elucidated in patients with hepatocellular carcinoma (HCC) following curative resection...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29729074/liver-regeneration-accelerates-hepatitis-b-virus-related-tumorigenesis-of-hepatocellular-carcinoma
#11
Chiao-Fang Teng, Hong-Yi Chang, Hung-Wen Tsai, Wen-Chuan Hsieh, Yu-Hao Kuo, Ih-Jen Su, Yih-Jyh Lin
Although partial hepatectomy (PH) to remove tumors provides a potential cure of hepatocellular carcinoma (HCC), long-term survival of hepatitis B virus (HBV)-related HCC patients after PH remains a big challenge. Early recurrence within two years post-PH is associated with the dissemination of primary HCC. However, late recurrence after two years post-PH is supposed due to the de novo or a secondary tumor. Since PH initiates liver regeneration (LR), we hypothesize that LR may accelerate tumorigenesis through activation of pre-existing precancerous lesions in the remaining liver...
May 4, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29725882/a-rare-case-of-a-spontaneously-ruptured-secondary-hepatic-malignant-lymphoma
#12
Ko Oshita, Toshiyuki Itamoto, Akihiko Oshita, Hideki Nakahara, Takashi Nishisaka
BACKGROUND: Although secondary liver involvement of the lymphoma is common and occurs in 50% of patients with non-Hodgkin's lymphoma, liver tumor rupture in malignant lymphoma is extremely rare. We report a case of a spontaneously ruptured secondary liver involvement of non-Hodgkin's lymphoma that was successfully treated with transcatheter arterial embolization (TAE) to obtain hemostasis, and subsequent hepatectomy and systemic chemotherapy. To the best of our knowledge, this is only the second reported case of a ruptured hepatic lymphoma...
May 3, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29702975/primary-functioning-hepatic-paraganglioma-mimicking-hepatocellular-carcinoma-a-case-report-and-literature-review
#13
Wei Liao, Ze-Yang Ding, Binhao Zhang, Lin Chen, Gan-Xun Li, Jing-Jing Wu, Bixiang Zhang, Xiao-Ping Chen, Peng Zhu
INTRODUCTION: Hepatic paraganglioma (HPGL) originates from the sympathetic nervous tissue in the liver, and is an extremely rare type of the sympathetic paragangliomas. Till now, only 11 HPGL cases have been reported. CASE PRESENTATION: A 49-year-old woman presented to our hospital with a lesion in the right lobe of the liver, which grew from 2 to 6 cm in 2 years. In addition, she had a 6-year history of diabetes. The patient was initially diagnosed as hepatocellular carcinoma and hepatectomy was performed...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29699859/clinical-significance-of-macroscopic-no-margin-hepatectomy-for-hepatocellular-carcinoma
#14
Seiji Oguro, Jiro Yoshimoto, Hiroshi Imamura, Yoichi Ishizaki, Seiji Kawasaki
BACKGROUND: Hepatectomy with a sufficient margin is often impossible for hepatocellular carcinomas that are close to the large intrahepatic vascular structures, and macroscopically complete resection along the tumor capsule is the only choice. The aim of this retrospective study was to evaluate the clinical significance of macroscopic no-margin hepatectomy (MNMH). METHODS: Among patients undergoing macroscopically curative resection for untreated hepatocellular carcinoma, outcomes were compared between patients undergoing MNMH (n = 87) and those undergoing hepatectomy with a macroscopic margin (n = 192)...
April 24, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29699571/safety-and-efficacy-of-dehydrated-ethanol-soaking-of-the-operative-field-in-the-treatment-of-spontaneous-hepatocellular-carcinoma-rupture
#15
Jian Sun, Yue Zhu, Yao-Rong Peng, Wen-Bin Li, He-Yun Zhang, Zhen-Yu Zhou, Lin Wang, An-de Ma, Jie Wang
BACKGROUND: The aim of our study was to evaluate the clinical safety and value of ethanol surgical field infiltration (ESFI), combined with distilled water peritoneal lavage (DWPL), after hepatectomy in patients with hepatocellular carcinoma (HCC) rupture. METHODS: Rat liver tissue samples were soaked in dehydrated ethanol for different soaking times, and 18 rats were assigned to three groups that underwent different soaking methods of the hepatectomy cut surface...
April 26, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29697442/relationship-between-sarcopenic-obesity-and-outcomes-of-hepatectomy-for-hepatocellular-carcinoma
#16
Jiong-Jie Yu, Xin-Fei Xu, Hao Xing, Chao Li, Ming-Da Wang, Tian Yang
No abstract text is available yet for this article.
April 24, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29696328/does-intermittent-pringle-maneuver-increase-postoperative-complications-after-hepatectomy-for-hepatocellular-carcinoma-a-randomized-controlled-trial
#17
Kit Fai Lee, John Wong, Sunny Y S Cheung, Charing C N Chong, Joyce W Y Hui, Vivian Y F Leung, Simon C H Yu, Paul B S Lai
BACKGROUND: In a previous study, we have shown that intermittent Pringle maneuver (IPM) might increase postoperative complications after hepatectomy for various indications. Complications which thought to be related to IPM were ascites, pleural effusion, wound infection and intra-abdominal collection. The aim of this study was to test the hypothesis that applying IPM during hepatectomy for hepatocellular carcinoma (HCC) could increase postoperative complications. METHODS: Between January 2013 and October 2016, eligible patients who received elective open hepatectomy for HCC were randomized to have IPM or no Pringle maneuver (NPM)...
April 25, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29695575/laparoscopic-left-hepatectomy-for-ruptured-hepatocellular-carcinoma-controlled-after-transcatheter-arterial-embolization-case-report-and-review-of-the-literature
#18
Shohei Yoshiya, Kentaro Iwaki, Akihiro Sakai, Shunsuke Fujita, Takahide Kawasaki, Fumitaka Yoshizumi, Shoji Hiroshige, Masahiro Okamoto, Kengo Fukuzawa, Akira Motohiro, Yoshihiko Maehara
BACKGROUND: Although spontaneous tumour rupture is a life-threatening complication of hepatocellular carcinoma (HCC), staged hepatectomy for HCC controlled after transcatheter arterial embolization (TAE) could provide a better prognosis. Laparoscopic liver resection (LLR) has been accepted worldwide and has been expanded from minor resection to anatomical major resection. We herein report the first case of pure laparoscopic left hepatectomy for ruptured HCC controlled after TAE. CASE REPORT: A 66-year-old man was transferred to our Institute because of abdominal pain and decreased consciousness...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29691651/long-term-results-of-laparoscopic-liver-resection-for-the-primary-treatment-of-hepatocellular-carcinoma-role-of-the-surgeon-in-anatomical-resection
#19
Woo-Hyoung Kang, Ki-Hun Kim, Dong-Hwan Jung, Gil-Chun Park, Seok-Hwan Kim, Hwui-Dong Cho, Sung-Gyu Lee
BACKGROUND: Liver resection is a potentially curative therapy for hepatocellular carcinoma (HCC). LLR is a newly developed and safe technique associated with shorter hospital stay, less pain, better cosmetic outcomes, and similar complication rates as open surgery; however, data on its long-term outcomes remain scarce. METHODS: We retrospectively examined the clinical and follow-up data of 234 patients who underwent LLR (performed by a single surgeon in all cases) for the primary treatment of HCC between July 2007 and December 2015 at Asan Medical Center...
April 24, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29689643/il-17a-promotes-the-invasion-metastasis-cascade-via-the-akt-pathway-in-hepatocellular-carcinoma
#20
Qing-Guo Xu, Jian Yu, Xing-Gang Guo, Guo-Jun Hou, Sheng-Xian Yuan, Yuan Yang, Yun Yang, Hui Liu, Ze-Ya Pan, Fu Yang, Fang-Ming Gu, Wei-Ping Zhou
We previously demonstrated that interleukin-17A (IL-17A) is associated with the progression of hepatocellular carcinoma (HCC). However, its role in the invasion-metastasis cascade of HCC and the efficacy of IL-17A-targeting therapeutics in HCC remain largely unknown. In this study, we found that IL-17A promoted intrahepatic and pulmonary metastasis of HCC cells in an orthotopic implant model. Moreover, our results showed that IL-17A induced epithelial-mesenchymal transition (EMT) and promoted HCC cell colonization in vitro and in vivo, and the role of IL-17A in invasion-metastasis was dependent on activation of the AKT pathway...
April 24, 2018: Molecular Oncology
keyword
keyword
66273
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"