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Hepatectomy for hepatocellular carcinoma

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https://www.readbyqxmd.com/read/28639044/short-term-surgical-outcomes-of-minimally-invasive-repeat-hepatectomy-for-recurrent-liver-cancer
#1
Takehiro Noda, Hidetoshi Eguchi, Hiroshi Wada, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Kunihito Gotoh, Koichi Kawamoto, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori
BACKGROUND: Repeat liver resection is an effective treatment, with long-term surgical outcomes for recurrent hepatocellular carcinoma and colorectal liver metastasis. However, the efficacy of a minimally invasive surgical approach for recurrent liver cancer is not yet confirmed. The purpose of this study is to examine the efficacy of minimally invasive repeat liver resection (MISRLR) compared with open repeat liver resection (ORLR) for primary and metastatic liver cancer. Here, we retrospectively analyzed the clinicopathological features and short-term surgical outcomes of patients undergoing MISRLR and ORLR...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28637037/surgical-site-infection-after-hepatectomy-for-hepatocellular-carcinoma
#2
Chikara Shirata, Kiyoshi Hasegawa, Takashi Kokudo, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Masatoshi Makuuchi, Norihiro Kokudo
AIMS: To clarify the clinical impact, risk factors, and preventive methods for surgical site infection (SSI) after hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 879 consecutive patients who underwent hepatectomy for HCC between 2002 and 2011. Univariate and multivariate analyses were conducted to identify the risk factors for incisional and organ/space SSIs. ORs and 95% CIs are reported. RESULTS: The incidences of incisional and organ/space SSIs were 24 (2...
June 21, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28630395/cerebral-infarction-by-paradoxical-gas-embolism-during-laparoscopic-liver-resection-with-injury-of-the-hepatic-vessels-in-a-patient-without-a-right-to-left-systemic-shunt
#3
Toshiyasu Kawahara, Masahiro Hagiwara, Hiroyuki Takahashi, Mariko Tanaka, Koji Imai, Jun Sawada, Takayuki Kunisawa, Hiroyuki Furukawa
BACKGROUND Carbon dioxide (CO2) is believed to be the safest gas for laparoscopic surgery, which is a standard procedure. We experienced severe cerebral infarction caused by paradoxical CO2 embolism during laparoscopic liver resection with injury of the hepatic vessels despite the absence of a right-to-left systemic shunt. CASE REPORT A 60-year-old man was diagnosed with hepatocellular carcinoma in the right hepatic lobe secondary to alcoholic liver disease. We planned the laparoscopy-assisted liver resection...
June 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28628947/meta-analysis-of-determinants-of-survival-following-treatment-of-recurrent-hepatocellular-carcinoma
#4
REVIEW
S Erridge, P H Pucher, S R Markar, G Malietzis, T Athanasiou, A Darzi, M H Sodergren, L R Jiao
BACKGROUND: Intrahepatic recurrence of hepatocellular carcinoma (HCC) following resection is common. However, no current consensus guidelines exist to inform management decisions in these patients. Systematic review and meta-analysis of survival following different treatment modalities may allow improved treatment selection. This review aimed to identify the optimum treatment strategies for HCC recurrence. METHODS: A systematic review, up to September 2016, was conducted in accordance with MOOSE guidelines...
June 19, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28628229/troxerutin-with-copper-generates-oxidative-stress-in-cancer-cells-its-possible-chemotherapeutic-mechanism-against-hepatocellular-carcinoma
#5
A Subastri, A Suyavaran, Preedia Babu E, Nithyananthan S, R Bharathidasan, C Thirunavukkarasu
Troxerutin (TXER) a rutin derivative is known for its anticancer effect against hepatocellular carcinoma (HCC). As part of large study, recently we have shown TXER interact with genetic material and its anti-mutagenic property. In the present study we have explored its possible mode of action in HCC. Since TXER alone did not show significant anticancer effect on Huh-7 cells, in vitro biochemical assays were performed for determining anticancer efficacy of TXER + metal complex using transition metals such as Cu, Zn & Fe...
June 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28626378/partial-hepatectomy-with-middle-hepatic-vein-reconstruction-using-a-left-inferior-vena-cava-graft
#6
Yusuke Kawamoto, Yusuke Ome, Kazuyuki Kawamoto
Duplicated inferior vena cava (IVC) is a rare congenital anomaly. We describe the utility of a new graft from the left IVC in a patient with duplicated IVC for reconstructing the middle hepatic vein (MHV) after partial hepatectomy with MHV resection. A 67-year-old woman with hepatitis C was found to have a liver tumor. Magnetic resonance imaging confirmed that the tumor, which was attached to the MHV, was hepatocellular carcinoma. Central bisectionectomy (S4, S5, and S8 resection) could not be tolerated because of poor liver function and a low future liver remnant volume...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28621681/overexpression-of-emt-inducing-transcription-factors-as-a-potential-poor-prognostic-factor-for-hepatocellular-carcinoma-in-asian-populations-a-meta-analysis
#7
Tao Wan, Tianwei Zhang, Xiaoying Si, Yanming Zhou
BACKGROUND AND OBJECTIVES: The clinical relevance of epithelial to mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) progression has been highlighted during the last decade. The zinc finger E-box binding homeobox (ZEB) family, the zinc-finger transcriptional repressor (SNAI) family, and the basic helix-loop-helix transcription factor (Twist) family, known as the prominent EMT-inducing transcription factors (EMT-TFs), played a crucial role in the process of EMT. Here, this meta-analysis aimed to evaluate the prognostic value of EMT-TFs high expression in patients with HCC after hepatectomy...
June 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615138/wide-versus-narrow-margins-after-partial-hepatectomy-for-hepatocellular-carcinoma-balancing-recurrence-risk-and-liver-function
#8
Wesley B S Field, Jack W Rostas, Prejesh Philps, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
BACKGROUND: The goal of this study was to compare the outcome after partial hepatectomy for hepatocellular carcinoma (HCC) in which a margin less than or equal to 5 mm or greater than 5 mm was achieved. METHODS: A review of our 3300-patient prospective HPB database was performed from 12/2002 to 4/2015. Patients were stratified into two groups: resection margins ≤5 ("narrow") and >5 mm ("wide") as measured on final pathologic assessment. RESULTS: One-hundred thirty patients were included in the analysis (margin ≤5 mm, n = 41 and margin >5 mm, n = 89)...
June 8, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28611981/the-clinical-significance-of-alpha-fetoprotein-mrnas-in-patients-with-hepatocellular-carcinoma
#9
Shogo Kobayashi, Akira Tomokuni, Hidenori Takahashi, Hirofumi Akita, Keijiro Sugimura, Norikatsu Miyoshi, Jeong Ho Moon, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano, Masato Sakon
BACKGROUND/AIMS: Alpha-fetoprotein (AFP) mRNA-expressing cells are candidates for circulating tumor cells in hepatocellular carcinoma. We analyzed portal vein blood, peripheral blood, and peritoneal lavage samples to detect the presence of AFP mRNA-expressing cells, and explored their relationship with metastasis. METHODS: We measured the AFP mRNA expression in 112 sets of portal vein and peripheral blood samples and 61 peritoneal lavage samples that had been obtained during surgery...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28611283/prognostic-value-of-systemic-inflammation-score-in-patients-with-hepatocellular-carcinoma-after-hepatectomy
#10
Shiming Shi, Qing Chen, Luxi Ye, Dan Yin, Xuedong Li, Zhi Dai, Jian He
Inflammation plays an important role in cancer progression. In this study, we aimed to investigate the prognostic value of the systemic inflammatory biomarkers in hepatocellular carcinoma (HCC) patients undergoing curative resection. Data from 271 HCC patients who underwent curative resection in Zhongshan Hospital between 2008 and 2011 were included. Kaplan-Meier survival analysis showed that gamma-glutamyltransferase (GGT) and lymphocyte-to-monocyte ratio (LMR) were significantly associated with overall survival(OS) and time to recurrence(TTR)...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28606281/-effect-of-different-anesthetic-techniques-on-the-prognosis-of-hepatocellular-carcinoma-after-hepatectomy
#11
T Yan, J J Zhao, X Y Bi, J Q Cai, H Zheng
Objective: To investigate the influence of different anesthetic techniques on the prognosis of hepatocellular carcinoma (HCC)after hepatectomy. Methods: A total of 185 consecutive patients with HCC confirmed underwent surgery in Cancer Hospital, Chinese Academy of Medical Sciences were recruited from January 2006 to January 2008. The patients were assessed as American Society of Anesthesiologists (ASA)Ⅰ-Ⅲ, with body mass index (BMI) (22.8±4.6)kg/m(2). There were 169 males, with an average age of 56 years old and 16 females, with an average age of 53 years old...
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28597349/perioperative-allogenic-blood-transfusion-is-a-poor-prognostic-factor-after-hepatocellular-carcinoma-surgery-a-multi-center-analysis
#12
Hiroshi Wada, Hidetoshi Eguchi, Hiroaki Nagano, Shoji Kubo, Takuya Nakai, Masaki Kaibori, Michihiro Hayashi, Shigekazu Takemura, Shogo Tanaka, Yasuyuki Nakata, Kosuke Matsui, Morihiko Ishizaki, Fumitoshi Hirokawa, Koji Komeda, Kazuhisa Uchiyama, Masanori Kon, Yuichiro Doki, Masaki Mori
PURPOSE: The influence of allogenic blood transfusion on the postoperative outcomes of hepatocellular carcinoma (HCC) surgery remains controversial. This study aims to clarify the clinical impacts of perioperative allogenic blood transfusion on liver resection outcome in HCC patients. METHODS: We analyzed data collected over 5 years for 642 patients who underwent hepatectomy for HCC at one of the five university hospitals. We investigated the impact of allogenic blood transfusion on postoperative outcome after surgery in all patients and in 74 matched pairs, using a propensity score...
June 8, 2017: Surgery Today
https://www.readbyqxmd.com/read/28591740/prognostic-value-and-preoperative-predictors-of-microvascular-invasion-in-solitary-hepatocellular-carcinoma-%C3%A2-5-cm-without-macrovascular-invasion
#13
Hui Zhao, Ye Hua, Zhihua Lu, Shen Gu, Laifa Zhu, Yuan Ji, Yudong Qiu, Tu Dai, Huihan Jin
OBJECTIVES: The aim of this study was to investigate the prognostic value and preoperative predictors of microvascular invasion (MVI) in solitary hepatocellular carcinoma (HCC) ≤ 5 cm without macrovascular invasion. METHODS: A total of 233 consecutive HCC patients underwent curative hepatectomy were included in our study. Independent risk factors influencing the prognosis were identified, and preoperative predictors for MVI were determined. RESULTS: Multivariate regression analysis identified ICG-R15, BCLC staging and MVI as independent risk factors for the overall survival rate...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28590929/prognostic-nomogram-for-hepatocellular-carcinoma-in-adolescent-and-young-adult-patients-after-hepatectomy
#14
Wei Zhang, Yifei Tan, Shu Shen, Li Jiang, Lunan Yan, Jiayin Yang, Bo Li, Tianfu Wen, Yong Zeng, Wen Tao Wang, Mingqing Xu
BACKGROUND: Hepatocellular carcinoma (HCC) was rarely discussed in adolescent and young adult (AYA) patients. This study aimed to discuss the character of AYA HCC patients and establish an effective prognostic nomogram for patients after hepatectomy. RESULTS: For all of the patients, the median OS was 57 months with 5-year OS rate 60.4%, and DFS was 48 months with 5-year DFS rate 51.4%. The tumor size, vascular invasion status and the pathological differentiation were the independent predictors for both OS and DFS...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28588794/intrahepatic-biloma-following-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-incidence-imaging-features-and-management
#15
Bo Zhang, Yongjian Guo, Ketong Wu, Hong Shan
Repeat transcatheter arterial chemoembolization (TACE) becomes more challenging for patients with intrahepatic biloma following TACE for hepatocellular carcinoma (HCC). The purpose of this study was to investigate the clinical course, incidence, imaging features and outcome and to explore the reasonable therapy scheme for intrahepatic biloma following TACE for HCC.A total of 4,695 TACE procedures were performed for 1,923 patients with HCC. Twenty patients with intrahepatic biloma following TACE were studied retrospectively...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28583634/texture-analysis-of-baseline-multiphasic-hepatic-computed-tomography-images-for-the-prognosis-of-single-hepatocellular-carcinoma-after-hepatectomy-a-retrospective-pilot-study
#16
Shuting Chen, Yanjie Zhu, Zaiyi Liu, Changhong Liang
OBJECTIVE: To assess the prognostic value of texture analysis for single hepatocellular carcinomas (HCCs) after hepatectomy. MATERIALS AND METHODS: A total of 61 HCC patients were enrolled in this retrospective study. Textural characteristics of the computed tomography (CT) images were quantified. The differences between the hepatic arterial phase and the portal venous phase were obtained (the Dif.). The receiver operating characteristic (ROC) curves were used for data screening...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28577725/postoperative-liver-volume-was-accurately-predicted-by-a-medical-image-three-dimensional-visualization-system-in-hepatectomy-for-liver-cancer
#17
Wei Cai, Yingfang Fan, Haoyu Hu, Nan Xiang, Chihua Fang, Fucang Jia
BACKGROUND: Liver cancer is the second most common cause of cancer death worldwide. The hepatectomy is the most effective and the only potentially curative treatment for patients with resectable neoplasm. Precisely preoperative assessment of remnant liver volume is essential in preventing postoperative liver failure. The aim of our study is to report our experience of using a medical image three dimensional (3D) visualization system (MI-3DVS), which was developed by our team, in assisting hepatectomy for patients with liver cancer...
June 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28572700/peritumoral-epcam-is-an-independent-prognostic-marker-after-curative-resection-of-hbv-related-hepatocellular-carcinoma
#18
Xiao-Meng Dai, Tao Huang, Sheng-Li Yang, Xiu-Mei Zheng, George G Chen, Tao Zhang
Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) patients. In this study, the expression of EpCAM and CD13 was assessed by immunohistochemistry in peritumoral liver hepatocytes from 106 hepatitis B virus- (HBV-) related HCC patients who had undergone curative hepatectomy...
2017: Disease Markers
https://www.readbyqxmd.com/read/28567071/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-a-surgical-technique-for-liver-resections
#19
Behnam Sanei, Saba Sheikhbahaei, Mohammad Hossein Sanei, Amin Bahreini, Hamid Reza Jafari
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel surgical technique liver resection in traditionally nonresectable primary intrahepatic tumors or colorectal liver metastases. MATERIALS AND METHODS: From June 2013 to March 2014, patients with primary tumor of liver or colorectal tumors with liver metastasis were selected to evaluate whether they met the initial criteria for ALPPS procedure. RESULTS: Nine patients enrolled in the study with primary diagnoses of colon and rectosigmoid cancer, carcinoid tumor, gastrointestinal stromal tumor of small intestine, hepatocellular carcinoma, and pancreatic neuroendocrine tumor (PNET)...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28559922/association-of-hepatitis-status-with-surgical-outcomes-in-patients-with-dual-hepatitis-b-and-c-related-hepatocellular-carcinoma
#20
Xiu-Tao Fu, Ying-Hong Shi, Jian Zhou, Yuan-Fei Peng, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Kang Song, Jia Fan, Zhen-Bin Ding
BACKGROUND: The conception that serological hepatitis markers determined surgical prognosis of hepatocellular carcinoma (HCC) associated with hepatitis B (HBV) or hepatitis C (HCV) has been well defined. However, little is known about the relationship between surgical outcomes and serological hepatitis markers in patients with dual HBV and HCV related HCC. METHODS: A retrospective analysis of the clinical data of 39 HCC patients with HBV-HCV coinfection who underwent curative hepatectomy between 2001 and 2011 was performed...
2017: Infectious Agents and Cancer
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