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Hepatectomy for hepatocellular carcinoma

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https://www.readbyqxmd.com/read/29348394/hoxc6-predicts-invasion-and-poor-survival-in-hepatocellular-carcinoma-by-driving-epithelial-mesenchymal-transition
#1
Pin-Dong Li, Peng Chen, Xin Peng, Charlie Ma, Wen-Jie Zhang, Xiao-Fang Dai
Aberrant expression of HOXC6 has been reported in several malignant tumors, yet little is known about the value of HOXC6 in invasion and prognosis of hepatocellular carcinoma (HCC). HOXC6 expression was positively correlated with high AFP level, liver cirrhosis, larger tumor, vascular invasion and BCLC stage. Kaplan-Meier analysis revealed that HOXC6 was an independent predictor for overall survival (OS) and time to recurrence (TTR). In addition, HOXC6 status could act as prognostic predictor in different risk subgroups...
January 15, 2018: Aging
https://www.readbyqxmd.com/read/29344784/the-feasibility-and-efficacy-of-pure-laparoscopic-repeat-hepatectomy
#2
Yusuke Ome, Kazuki Hashida, Mitsuru Yokota, Yoshio Nagahisa, Kazushige Yamaguchi, Michio Okabe, Kazuyuki Kawamoto
BACKGROUND: Repeat hepatectomy is often required for hepatocellular carcinoma and metastatic tumors. However, this procedure is technically challenging, so laparoscopic repeat hepatectomy (LRH) has not been widely adopted. The aim of this study was to evaluate the feasibility and efficacy of LRH compared with open repeat hepatectomy (ORH) and laparoscopic primary hepatectomy (LPH). METHODS: We introduced laparoscopic hepatectomy at our institution in April 2014...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29344514/portal-vein-embolization-history-and-current-indications
#3
REVIEW
Hiroji Shinkawa, Shigekazu Takemura, Shogo Tanaka, Shoji Kubo
Portal vein embolization (PVE) was first adapted for patients undergoing major hepatectomy for hepatocellular carcinoma (HCC). In these patients, PVE caused hypertrophy of the unaffected liver and increased the volumetric ratio of future liver remnant (FLR) to total liver volume. 99mTechnetium-galactosyl human serum albumin (99mTc-GSA) scintigraphy revealed that PVE also induced a shift in hepatic function from the embolized part to the nonembolized part of the liver. Various hepatobiliary malignancies can be treated using PVE, and PVE is increasingly being used to expand the indication for major hepatectomy in patients with initially insufficient FLR volume or function...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29340728/indocyanine-green-retention-rates-at-15%C3%A2-min-predicted-hepatic-decompensation-in-a-western-population
#4
Bertrand Le Roy, Emilie Grégoire, Cyril Cossé, Badr Serji, Nicolas Golse, René Adam, Daniel Cherqui, Jean-Yves Mabrut, Yves-Patrice Le Treut, Eric Vibert
BACKGROUND: ICGR15 is widely used in Asia to evaluate the liver reserve before hepatectomy, but not in Western countries where patients are selected using the MELD score and/or platelet count. Postoperative liver failure is rare nowadays, but hepatic decompensation (HD), defined by 3-month postoperative ascites, impairs quality of life and survival. The aim of this study was to evaluate the relevance of indocyanine green retention rate at 15 min (ICGR15) before liver resection in Western countries, in order to predict HD...
January 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29330919/meta-analysis-of-laparoscopic-versus-open-liver-resection-for-hepatocellular-carcinoma
#5
Bin Jiang, Xiufang Yan, Jian-Huai Zhang
OBJECTIVE: To evaluate surgical safety and effectiveness of laparoscopic hepatectomy(LH) in short- and long-term outcomes compared to open hepatectomy(OH) in patients operated for hepatocellular carcinoma (HCC). METHODS: An electronic search until August 2017 was conducted to identify comparative studies evaluating laparoscopic versus open liver resection for HCC. RESULTS: A total of 5889 patients (2421 underwent LH, and 3468 with OH) were included in our meta-analysis from 47 studies...
January 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29327594/liver-resection-and-surgical-strategies-for-management-of-primary-liver-cancer
#6
Sonia T Orcutt, Daniel A Anaya
Primary liver cancer-including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC)-incidence is increasing and is an important source of cancer-related mortality worldwide. Management of these cancers, even when localized, is challenging due to the association with underlying liver disease and the complex anatomy of the liver. Although for ICC, surgical resection provides the only potential cure, for HCC, the risks and benefits of the multiple curative intent options must be considered to individualize treatment based upon tumor factors, baseline liver function, and the functional status of the patient...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29324802/prognostic-value-of-liver-stiffness-measurement-for-the-liver-related-surgical-outcomes-of-patients-under-hepatic-resection-a-meta-analysis
#7
Zitong Huang, Jingjing Huang, Tianran Zhou, Hongying Cao, Bo Tan
BACKGROUND: Previous studies have discussed the liver stiffness measurement (LSM) performance on predicting liver-related surgical outcomes for patients of hepatocellular carcinoma (HCC) under hepatic resection, yet there is much variation in reporting and consistency of findings. Therefore, we report a meta-analysis on this issue. METHODS: We comprehensively searched PubMed, Embase, and Web of science to find the eligible cohort studies. The pooled Odds Ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate effect...
2018: PloS One
https://www.readbyqxmd.com/read/29323061/accuracy-of-vascular-invasion-reporting-in-hepatocellular-carcinoma-before-and-after-implementation-of-subspecialty-surgical-pathology-sign-out
#8
Aaron R Huber, Raul S Gonzalez, Mark S Orloff, Christopher T Barry, Christa L Whitney-Miller
CONTEXT: Liver cancers (including hepatocellular carcinoma [HCC] and cholangiocarcinoma) are the fifth most common cause of cancer death. The most powerful independent histologic predictor of overall survival after transplantation for HCC is the presence of microscopic vascular invasion (VI). AIMS: Given that VI is known to have somewhat high interobserver variability in both HCC and other tumors, we hypothesized that pathologists with special interest and training in liver pathology would be more likely to identify and report VI in HCC than would general surgical pathologists...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29317157/laparoscopic-liver-resection-for-hepatocellular-carcinoma-in-early-and-advanced-cirrhosis
#9
Rachel E Beard, Yisi Wang, Sidrah Khan, J Wallis Marsh, Allan Tsung, David A Geller
BACKGROUND: Laparoscopic liver resection for hepatocellular carcinoma is well described in early cirrhosis. Less is known regarding outcomes with more advanced cirrhosis, and this study aimed to compare these groups. METHODS: A retrospective review of resections at a high-volume hepatobiliary center over a 15-year period was performed. Primary end-points were 30 and 90-day mortality. Secondary end-points included complications and survival. RESULTS: 80 early (Child's A) were compared to 26 advanced (20 Child's B and 6 Child's C) patients...
January 6, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29316082/minimally-invasive-liver-resection-for-hepatocellular-carcinoma-of-patients-with-liver-damage-b-a-propensity-score-based-analysis
#10
Takehiro Noda, Hidetoshi Eguchi, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Kunihito Gotoh, Koichi Kawamoto, Shogo Kobayashi, Yasuji Hashimoto, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori
AIMS: Minimally invasive liver resection (MILR) is considered as safe and feasible treatment for malignant liver tumors. However, few studies have investigated the surgical outcomes of MILR in patients with impaired liver function. Liver damage is used for consideration of hepatectomy. The aim of this study is to clarify the efficacy of MILR for patients with impaired liver function by using the propensity score matching. METHODS: Ninety nine patients with liver damage B underwent hepatic resection were analyzed...
January 9, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29313290/impact-of-preoperative-hepatitis-b-virus-levels-on-prognosis-after-primary-and-repeat-hepatectomies-for-hepatocellular-carcinoma-patients-a-retrospective-study
#11
Pin-Gao Yan, Ruo-Yu Wang, Jin Zhang, Wen-Ming Cong, Hui Dong, Hong-Yu Yu, Wan Yee Lau, Meng-Chao Wu, Wei-Ping Zhou
BACKGROUND: Chronic HBV plays an important role in hepatocellular carcinoma pathogenesis. Previously, most studies have been focusing on HBV DNA levels before the primary curative hepatectomy. However, the association of virus level before repeat hepatectomy with the degrees of inflammation and fibrosis on histopathology and prognosis has not been surveyed. METHODS: From January 2002 to December 2009, all patients who were seropositive for hepatitis B surface antigen (HBsAg) were enrolled and assigned into four groups based on their HBV DNA levels before the primary and repeat hepatectomies...
January 8, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29312985/superior-oncological-outcome-in-laparoscopic-hepatectomy-for-hepatocellular-carcinoma-hype-or-hope
#12
COMMENT
Tan To Cheung
No abstract text is available yet for this article.
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29311397/short-and-long-term-outcomes-between-young-and-older-hcc-patients-exceeding-the-milan-criteria-after-hepatectomy
#13
Junyi Shen, Chuan Li, Lvnan Yan, Bo Li, Mingqing Xu, Jiayin Yang, Wentao Wang, Tianfu Wen
AIM: The objective of this study was to evaluate short- and long-term survival after surgical treatment between young and older hepatocellular carcinoma (HCC) patients beyond the Milan criteria. MATERIAL AND METHODS: One hundred fifty-seven HCC patients (≤ 55 years old) were categorized into group A, and one hundred fifty-eight HCC patients (> 55 years old) were categorized into group B. Postoperative complications and overall survival were retrospectively analyzed...
December 27, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29310356/combined-low-mirna-29s-is-an-independent-risk-factor-in-predicting-prognosis-of-patients-with-hepatocellular-carcinoma-after-hepatectomy-a-chinese-population-based-study
#14
Zhen Zhang, Shiqiang Shen
The prediction of prognosis of hepatocellular carcinoma (HCC) following partial hepatectomy is still an unresolved issue. The aim of this study is to identify the association between miRNA-29s family and the prognosis of patients with HCC in a large Asian cohort. We retrospectively reviewed 122 patients with HCC managed in our institution between 2008 and 2015. The expression of miRNA-29s was detected by real-time polymerase chain reaction (PCR). Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29303507/t-cell-immune-regulator-1-enhances-metastasis-in-hepatocellular-carcinoma
#15
Hee Doo Yang, Jung Woo Eun, Kyung-Bun Lee, Qingyu Shen, Hyung Seok Kim, Sang Yean Kim, Dong-Wan Seo, Won Sang Park, Jung Young Lee, Suk Woo Nam
Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative gene expression analysis with recurrent HCC tissues from HCC patients who underwent partial or total hepatectomy and from non-metastatic primary HCC tissues. From this, we were able to identify genes associated with HCC recurrence. TCIRG1 (T-Cell Immune Regulator 1) was one of the aberrantly overexpressed genes in patients with recurrent HCC who had undergone total hepatectomy...
January 5, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29299157/management-of-intrahepatic-recurrence-after-resection-for-hepatocellular-carcinoma-exceeding-the-barcelona-clinic-liver-cancer-criteria
#16
Wei Xu, Rui Guo, Gang Xu, Lejia Sun, Dandan Hu, Haifeng Xu, Huayu Yang, Xinting Sang, Xin Lu, Yilei Mao
Background: Although patients with Barcelona clinic liver cancer stage B or C hepatocellular carcinoma derive survival benefit from hepatectomy, prognostic factors and management after curative resection are unclear. This study aims to evaluate predictive factors, therapy and prognosis of intra-hepatic recurrences after curative resection of Barcelona clinic liver cancer stage B or C hepatocellular carcinoma. Methods: We retrospectively analyzed 397 patients with Barcelona clinic liver cancer stage B or C hepatocellular carcinoma who underwent curative resections from January 1989 to October 2011...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290957/prognostic-nomogram-for-hepatocellular-carcinoma-in-adolescent-and-young-adult-patients-after-hepatectomy
#17
Wei Zhang, Yifei Tan, Shu Shen, Li Jiang, Lunan Yan, Jiayin Yang, Bo Li, Tianfu Wen, Yong Zeng, Wen Tao Wang, Mingqing Xu
Background: Hepatocellular carcinoma (HCC) was rarely discussed in adolescent and young adult (AYA) patients. This study aimed to discuss the character of AYA HCC patients and establish an effective prognostic nomogram for patients after hepatectomy. Results: For all of the patients, the median OS was 57 months with 5-year OS rate 60.4%, and DFS was 48 months with 5-year DFS rate 51.4%. The tumor size, vascular invasion status and the pathological differentiation were the independent predictors for both OS and DFS...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284411/prediction-of-posthepatectomy-liver-failure-using-transient-elastography-in-patients-with-hepatitis-b-related-hepatocellular-carcinoma
#18
Jie-Wen Lei, Xiao-Yu Ji, Jun-Feng Hong, Wan-Bin Li, Yan Chen, Yan Pan, Jia Guo
BACKGROUND: It is essential to accurately predict Postoperative liver failure (PHLF) which is a life-threatening complication. Liver hardness measurement (LSM) is widely used in non-invasive assessment of liver fibrosis. The aims of this study were to explore the application of preoperative liver stiffness measurements (LSM) by transient elastography in predicting postoperative liver failure (PHLF) in patients with hepatitis B related hepatocellular carcinoma. METHODS: The study included 247 consecutive patients with hepatitis B related hepatocellular carcinoma who underwent hepatectomy between May 2015 and September 2015...
December 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29284151/laparoscopic-vs-open-hepatectomy-for-hepatocellular-carcinoma-in-patients-with-cirrhosis-a-meta-analysis-of-the-long-term-survival-outcomes
#19
REVIEW
En Lin Goh, Swathikan Chidambaram, Shaocheng Ma
BACKGROUND: In patients with hepatocellular carcinoma (HCC) and cirrhosis, laparoscopic hepatectomy (LH) confers short-term benefits over open hepatectomy (OH) but the long-term outcomes of this procedure are unclear. This systematic review aims to compare the long-term survival outcomes of LH and OH for patients with HCC and underlying cirrhosis. METHODS: EMBASE, MEDLINE and Scopus databases were searched from date of inception to 7th October 2016. Controlled clinical studies comparing LH to OH for HCC in cirrhotic patients, which reported long-term overall and disease-free survival were included...
December 25, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29279997/outcomes-of-surgery-for-hepatocellular-carcinoma-with-tumor-thrombus-in-the-inferior-vena-cava-or-right-atrium
#20
REVIEW
Kazuhiko Sakamoto, Hiroaki Nagano
The prognosis of hepatocellular carcinoma (HCC) patients with tumor thrombus (TT) in the inferior vena cava (IVC) or right atrium (RA) is extremely poor. We reviewed the recent surgical treatments and outcomes of this form of advanced HCC. TT is classified into three types according to its anatomic location relative to the heart: the inferior hepatic type (type I), where the TT is in the IVC below the diaphragm; the superior hepatic type (type II), where the TT is in the IVC above the diaphragm, but still outside the RA; and the intracardiac type (type III), where the TT is above the diaphragm and has entered the RA...
December 26, 2017: Surgery Today
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