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At the crossroads

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https://www.readbyqxmd.com/read/28815712/psychoanalytic-education-at-the-crossroads-reformation-change-and-the-future-of-psychoanalytic-training-by-otto-friedmann-kernberg
#1
Lee Jaffe
No abstract text is available yet for this article.
July 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28802165/the-world-according-to-garp-transcription-factors
#2
REVIEW
Alaeddine Safi, Anna Medici, Wojciech Szponarski, Sandrine Ruffel, Benoît Lacombe, Gabriel Krouk
Plant specific GARP transcription factor family (made of ARR-B and G2-like) contains genes with very diverse in planta functions: nutrient sensing, root and shoot development, floral transition, chloroplast development, circadian clock oscillation maintenance, hormonal transport and signaling. In this work we review: first, their structural but distant relationships with MYB transcription factors, second, their role in planta, third, the diversity of their Cis-regulatory elements, fourth, their potential protein partners...
August 10, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28802039/circadian-reprogramming-in-the-liver-identifies-metabolic-pathways-of-aging
#3
Shogo Sato, Guiomar Solanas, Francisca Oliveira Peixoto, Leonardo Bee, Aikaterini Symeonidi, Mark S Schmidt, Charles Brenner, Selma Masri, Salvador Aznar Benitah, Paolo Sassone-Corsi
The process of aging and circadian rhythms are intimately intertwined, but how peripheral clocks involved in metabolic homeostasis contribute to aging remains unknown. Importantly, caloric restriction (CR) extends lifespan in several organisms and rewires circadian metabolism. Using young versus old mice, fed ad libitum or under CR, we reveal reprogramming of the circadian transcriptome in the liver. These age-dependent changes occur in a highly tissue-specific manner, as demonstrated by comparing circadian gene expression in the liver versus epidermal and skeletal muscle stem cells...
August 10, 2017: Cell
https://www.readbyqxmd.com/read/28798693/phosphorylation-modulates-ameloblastin-self-assembly-and-ca-2-binding
#4
Øystein Stakkestad, Ståle P Lyngstadaas, Bernd Thiede, Jiri Vondrasek, Bjørn S Skålhegg, Janne E Reseland
Ameloblastin (AMBN), an important component of the self-assembled enamel extra cellular matrix, contains several in silico predicted phosphorylation sites. However, to what extent these sites actually are phosphorylated and the possible effects of such post-translational modifications are still largely unknown. Here we report on in vitro experiments aimed at investigating what sites in AMBN are phosphorylated by casein kinase 2 (CK2) and protein kinase A (PKA) and the impact such phosphorylation has on self-assembly and calcium binding...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28782645/marfan-syndrome-a-connective-tissue-disease-at-the-crossroads-of-mechanotransduction-tgf%C3%AE-signaling-and-cell-stemness
#5
REVIEW
Francesco Ramirez, Cristina Caescu, Elisabeth Wondimu, Josephine Galatioto
Mutations in fibrillin-1 cause Marfan syndrome (MFS), the most common heritable disorder of connective tissue. Fibrillin-1 assemblies (microfibrils and elastic fibers) represent a unique dual-function component of the architectural matrix. The first role is structural for they endow tissues with tensile strength and elasticity, transmit forces across them and demarcate functionally discrete areas within them. The second role is instructive in that these macroaggregates modulate a large variety of sub-cellular processes by interacting with mechanosensors, and integrin and syndecan receptors, and by modulating the bioavailability of local TGFβ signals...
August 4, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28781758/diagnostic-approach-to-pleural-diseases-new-tricks-for-an-old-trade
#6
REVIEW
Fabien Maldonado, Robert J Lentz, Richard W Light
The burden of pleural diseases has substantially increased in the past decade because of a rise in the incidence of pleural space infections and pleural malignancies in a patient population that is older and more immunocompromised and has more comorbidities. This complexity increasingly requires minimally invasive diagnostic options and tailored management. Implications for patients are such that the limitations of current diagnostic methods need to be addressed by multidisciplinary teams of investigators from the fields of imaging, biology, and engineering...
2017: F1000Research
https://www.readbyqxmd.com/read/28777567/inorganic-nanotubes-and-fullerene-like-nanoparticles-at-the-crossroad-between-solid-state-chemistry-and-nanotechnology
#7
Bojana Višić, Leela S Panchakarla, Reshef Tenne
Inorganic nanotubes and fullerene-like nanoparticles of WS2 were discovered some 25 years ago and are produced now on a commercial scale for various applications. This "Perspective" is dedicated to a brief description of recent progress in this scientific discipline. The conceptual evolution leading to their discovery, is briefly discussed. Subsequently, the recent progress with the synthesis of such nanoparticles from variety of inorganic compounds with layered (2D) structure is described. In particular, the synthesis of nanotubes from chalcogenide- and oxide-based ternary misfit layered compounds is discussed as well as their structure and different growth-mechanisms...
August 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28769537/osteopontin-at-the-crossroads-of-inflammation-and-tumor-progression
#8
REVIEW
Luigi Mario Castello, Davide Raineri, Livia Salmi, Nausicaa Clemente, Rosanna Vaschetto, Marco Quaglia, Massimiliano Garzaro, Sergio Gentilli, Paolo Navalesi, Vincenzo Cantaluppi, Umberto Dianzani, Anna Aspesi, Annalisa Chiocchetti
Complex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the target organs and are capable of surviving and growing at distant sites. In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28765450/the-21-st-century-dental-curriculum-a-framework-for-understanding-current-models
#9
Denise K Kassebaum, Lisa A Tedesco
This article provides an overview of the emergence of professional education and academic dentistry, in particular into the comprehensive research university. The development of academic dentistry as a vital member of the academic health center at the research university and beyond is described. Summaries are provided of major studies and innovations in dental education models and curricula, ranging from the Gies report in 1926 to the 1995 Institute of Medicine study Dental Education at the Crossroads, the U...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28758926/emt-met-at-the-crossroad-of-stemness-regeneration-and-oncogenesis-the-ying-yang-equilibrium-recapitulated-in-cell-spheroids
#10
REVIEW
Elvira Forte, Isotta Chimenti, Paolo Rosa, Francesco Angelini, Francesca Pagano, Antonella Calogero, Alessandro Giacomello, Elisa Messina
The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process, which plays a critical role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. It is the fundamental mechanism by which epithelial cells lose many of their characteristics while acquiring features typical of mesenchymal cells, such as migratory capacity and invasiveness. Depending on the contest, EMT is complemented and balanced by the reverse process, the mesenchymal-to-epithelial transition (MET)...
July 29, 2017: Cancers
https://www.readbyqxmd.com/read/28745594/the-hiv-response-in-ukraine-at-a-crossroads
#11
Andrew Green
No abstract text is available yet for this article.
July 22, 2017: Lancet
https://www.readbyqxmd.com/read/28733254/pre-travel-advice-at-a-crossroad-medical-preparedness-of-travellers-to-south-and-southeast-asia-the-hamburg-airport-survey
#12
Thierry Rolling, Melina Mühlenpfordt, Marylyn M Addo, Jakob P Cramer, Christof D Vinnemeier
BACKGROUND: Specific travel-related recommendations exist for the prevention or self-treatment of infectious diseases contracted by travellers to the tropics. In the current study, we assessed the medical preparedness per these recommendations, focusing on whether travellers carried antidiarrheal and antimalarial medication with them stratified by type of pre-travel advice. METHODS: We surveyed travellers departing from Hamburg International Airport to South or Southeast Asia, using a questionnaire on demographic, medical and travel characteristics...
July 18, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28725217/metagenomics-the-next-culture-independent-game-changer
#13
REVIEW
Jessica D Forbes, Natalie C Knox, Jennifer Ronholm, Franco Pagotto, Aleisha Reimer
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories is at a crossroads with the ability of public health agencies to perform their basic mandate of foodborne disease surveillance and response. The implementation of culture-independent diagnostic tests (CIDTs) including nucleic acid and antigen-based assays for acute gastroenteritis is leaving public health agencies without laboratory evidence to link clinical cases to each other and to food or environmental substances...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28718433/mitotic-dna-damage-response-at-the-crossroads-of-structural-and-numerical-cancer-chromosome-instabilities
#14
REVIEW
Samuel F Bakhoum, Lilian Kabeche, Duane A Compton, Simon N Powell, Holger Bastians
DNA double-strand breaks (DSBs) prevent cells from entering mitosis allowing cells to repair their genomic damage. Little is known about the response to DSBs once cells have already committed to mitosis. Here, we review the genome-protective role of the mitotic DNA damage response (DDR) and evidence suggesting that its untimely activation induces chromosome segregation errors and paradoxically undermines genomic integrity. In contrast to normal cells, cancer cells coopt this pathway to propagate structural and numerical chromosomal instabilities...
March 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28704162/thioester-containing-proteins-at-the-crossroads-of-immune-effector-mechanisms
#15
Ulrich Theopold, Martin Schmid
No abstract text is available yet for this article.
July 13, 2017: Virulence
https://www.readbyqxmd.com/read/28691044/rituals-in-gastrointestinal-endoscopy-at-the-crossroads-of-shaman-and-science
#16
Amnon Sonnenberg
BACKGROUND AND AIM:  Over the last decades, the length of time required for endoscopic procedures has greatly expanded. The aim of the present decision analysis is to study the interactions amongst various factors that have caused such delays and to compare the relative magnitude of their influences. METHODS:  Performance of gastrointestinal endoscopy is influenced by the interaction of five domains, that is, (1) patient discomfort and fear; (2) injury, disorder, and disruption; (3) rituals to reduce fear, prevent disruption, and maintain order; (4) administrators or various health providers carrying out a ritual; (5) information, knowledge, and science, which influence fear, prevent disruption, and curtail unnecessary ritualistic behavior...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28687205/oxindole-based-intraocular-pressure-reducing-agents
#17
Ekaterina V Zaryanova, Nataly A Lozinskaya, Olga V Beznos, Maria S Volkova, Nataly B Chesnokova, Nikolay S Zefirov
The study represents the new findings at the crossroads of chemistry and medicine, particularly between medicinal and organic chemistry and ophthalmology. In this work we describe how the chemical reactivity of indolinone scaffold may be used to create small molecule ligands with strong biological response comparable with and larger than that of endogenous hormone. The synthesis of oxindole-based melatonin and 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) analogues was proposed and their ability to influence intraocular pressure (IOP) was studied in vivo...
June 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28677542/sexual-health-and-reproductive-rights-at-a-crossroad
#18
EDITORIAL
The Lancet
No abstract text is available yet for this article.
July 1, 2017: Lancet
https://www.readbyqxmd.com/read/28667566/connecting-gaucher-and-parkinson-disease-considerations-for-clinical-and-research-genetic-counseling-settings
#19
Lola Cook, Jeanine Schulze
There are multiple autosomal recessive disorders in which carriers may be at risk for other diseases. This observation calls into question the previous understanding that carriers of autosomal recessive disorders escape clinical consequences. We also know that childhood genetic conditions may have adult disease counterparts (Zimran et al., The Israel Medical Association Journal: IMAJ, 16(11), 723-724, 2014). Individuals who have Gaucher disease and carriers of the disorder are at increased risk for a seemingly unrelated and complex neurological condition, Parkinson disease...
June 30, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28661111/-at-the-crossroads-the-role-of-laboratory-medicine-in-the-patient-care-process
#20
REVIEW
Yuval Geffen, Itzhak Zaidise
In recent decades, the laboratory medicine profession has undergone significant changes due to both technological developments and economic constraints. Technological innovations support automation, provide faster and more accurate equipment, and allow increased efficiency through the use of commercial test kits. These changes, combined with budgetary constraints, have led to mergers and centralization of medical laboratories to optimize work and cut costs. While this centralization may be a business necessity, it leads to a disconnection between the laboratory and the clinical context...
June 2017: Harefuah
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