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At the crossroads

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https://www.readbyqxmd.com/read/29773710/arginine-methylation-is-required-for-canonical-wnt-signaling-and-endolysosomal-trafficking
#1
Lauren V Albrecht, Diego Ploper, Nydia Tejeda-Muñoz, Edward M De Robertis
Arginine methylation has emerged as a widespread and reversible protein modification with the potential to regulate a multitude of cellular processes, but its function is poorly understood. Endolysosomes play an important role in Wnt signaling, in which glycogen synthase kinase 3 (GSK3) becomes sequestered inside multivesicular bodies (MVBs) by the process known as microautophagy, causing the stabilization of many proteins. Up to 20% of cellular proteins contain three or more consecutive putative GSK3 sites, and of these 33% also contain methylarginine (meArg) modifications...
May 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29772730/at-the-crossroads-of-clinical-and-preclinical-research-for-muscular-dystrophy-are-we-closer-to-effective-treatment-for-patients
#2
REVIEW
Kinga I Gawlik
Among diseases affecting skeletal muscle, muscular dystrophy is one of the most devastating and complex disorders. The term 'muscular dystrophy' refers to a heterogeneous group of genetic diseases associated with a primary muscle defect that leads to progressive muscle wasting and consequent loss of muscle function. Muscular dystrophies are accompanied by numerous clinical complications and abnormalities in other tissues that cause extreme discomfort in everyday life. The fact that muscular dystrophy often takes its toll on babies and small children, and that many patients die at a young age, adds to the cruel character of the disease...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29771299/at-the-crossroads-of-fate-somatic-cell-lineage-specification-in-the-fetal-gonad
#3
Emmi Rotgers, Anne Jørgensen, Humphrey Hung-Chang Yao
The reproductive endocrine systems are vastly different between male and female. This sexual dimorphism of endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. The majority of gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the gonadal somatic cells initiate sex-specific differentiation during gonadal sex determination with the specification of the supporting cell lineages: Sertoli cells in the testis vs...
May 15, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29764521/amino-acid-transporter-slc7a11-xct-at-the-crossroads-of-regulating-redox-homeostasis-and-nutrient-dependency-of-cancer
#4
REVIEW
Pranavi Koppula, Yilei Zhang, Li Zhuang, Boyi Gan
Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT). SLC7A11 promotes cystine uptake and glutathione biosynthesis, resulting in protection from oxidative stress and ferroptotic cell death. Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells...
April 25, 2018: Cancer communications
https://www.readbyqxmd.com/read/29752438/role-of-fgfr2b-expression-and-signaling-in-keratinocyte-differentiation-sequential-involvement-of-pkc%C3%AE-and-pkc%C3%AE
#5
Benedetta Rosato, Danilo Ranieri, Monica Nanni, Maria Rosaria Torrisi, Francesca Belleudi
The tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular contexts, including keratinocytes. Therefore, in this paper we propose to clarify if FGFR2b could play a role also in the late steps of keratinocyte differentiation and to assess if this receptor-induced process would sequentially involve PKCδ and PKCα isoforms. Immunofluorescence, biochemical, and molecular approaches, performed on 2D cultures or 3D organotypic rafts of human keratinocytes overexpressing FGFR2b by stable transduction, showed that receptor signaling induced the precocious onset and an accelerated progression of keratinocyte differentiation, indicating that FGFR2b is a crucial regulator of the entire program of keratinocyte differentiation...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29740787/healthcare-at-the-crossroads-the-need-to-shape-an-organizational-culture-of-humanistic-teaching-and-practice
#6
Elizabeth A Rider, MaryAnn C Gilligan, Lars G Osterberg, Debra K Litzelman, Margaret Plews-Ogan, Amy B Weil, Dana W Dunne, Janet P Hafler, Natalie B May, Arthur R Derse, Richard M Frankel, William T Branch
BACKGROUND: Changes in the organization of medical practice have impeded humanistic practice and resulted in widespread physician burnout and dissatisfaction. OBJECTIVE: To identify organizational factors that promote or inhibit humanistic practice of medicine by faculty physicians. DESIGN: From January 1, 2015, through December 31, 2016, faculty from eight US medical schools were asked to write reflectively on two open-ended questions regarding institutional-level motivators and impediments to humanistic practice and teaching within their organizations...
May 8, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29730736/are-we-at-a-crossroads-or-a-plateau-radiomics-and-machine-learning-in-abdominal-oncology-imaging
#7
Ronald M Summers
Advances in radiomics and machine learning have driven a technology boom in the automated analysis of radiology images. For the past several years, expectations have been nearly boundless for these new technologies to revolutionize radiology image analysis and interpretation. In this editorial, I compare the expectations with the realities with particular attention to applications in abdominal oncology imaging. I explore whether these technologies will leave us at a crossroads to an exciting future or to a sustained plateau and disillusionment...
May 5, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29720143/integrating-student-feedback-during-dental-curriculum-hack-a-thon
#8
Shawheen S Saffari, R Frederick Lambert, Lucy Dang, Sarah Pagni, Irina F Dragan
BACKGROUND: The future of dental education is at crossroads. This study used the parameter of the 2016 Dental Curriculum Hack-a-Thon to assess intra- and inter-institutional agreement between student and faculty views regarding dental curriculums to determine if there is an impact in student perceptions towards dental education from before and after the event. METHODS: This exploratory, cross-sectional study involved two surveys, with Survey 1 being distributed among four faculty-student pairs of the four participating dental schools answering 14 questions...
May 2, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29717057/to-be-or-not-to-be-secreted-as-exosomes-a-balance-finely-tuned-by-the-mechanisms-of-biogenesis
#9
REVIEW
Roberta Palmulli, Guillaume van Niel
The release of extracellular vesicles such as exosomes provides an attractive intercellular communication pathway. Exosomes are 30- to 150-nm membrane vesicles that are generated in endosomal compartment and act as intercellular mediators in both physiological and pathological context. Despite the growing interest in exosome functions, the mechanisms responsible for their biogenesis and secretion are still not completely understood. Knowledge about these mechanisms is important because they control the composition, and hence the function and secretion, of exosomes...
May 1, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29714627/fibroblast-matrix-cross-talk-in-idiopathic-pulmonary-fibrosis-cross-links-at-the-crossroads
#10
Peter Bitterman
No abstract text is available yet for this article.
May 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29666465/molecular-epidemiology-of-lung-cancer-in-iran-implications-for-drug-development-and-cancer-prevention
#11
REVIEW
Zahra Fathi, Nicholas L Syn, Jian-Guo Zhou, Raheleh Roudi
Epidemiological studies undertaken over the past decades reveal a gradual but progressive increase in the incidence and mortality attributable to lung cancer in the Islamic Republic of Iran, a sovereign state geographically situated at the crossroads of Central Eurasia and Western Asia. We identified references published in English and Persian through searches of PubMed, EMBASE, Web of Science, Scopus, and the Scientific Information Database (SID)-a specialized Iranian database, which indexes Iranian scientific journals-between inception and 15 September 2017...
April 18, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29665968/vorticity-at-the-crossroads-of-coronary-biomechanics-and-physiology
#12
EDITORIAL
Juan Luis Gutiérrez-Chico, Shijia Zhao, Yiannis S Chatzizisis
No abstract text is available yet for this article.
April 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29623777/what-keeps-maya-from-eating-a-case-study-of-disordered-eating-from-north-india
#13
Tanja Ahlin
Anthropologists have paid much attention to food and eating practices in India, but surprisingly few scholars in any discipline have examined eating disorders. This article presents an ethnographic case study of disordered eating, based on a story of a young female pharmacist from one of the Northern Indian states. Advocating ethnography as an essential method to uncovering the multiple facets of "not eating," I first show how this phenomenon may reflect resistance to Brahmanical patriarchy, especially the institution of arranged marriage...
January 1, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29608521/-is-there-value-to-seeing-a-transgender-fellowship-trained-surgeon
#14
Christopher J Salgado, Ajani Nugent, Joseph Kuhn
We are presently at a unique crossroad in medicine, where the healthcare field has the opportunity to recognize and treat transgender patients on a scale that was previously unattainable. As more professionals join the effort to treat this increasingly visible population, we have a duty to set standards for training residents and credentialing our colleagues to protect the wellbeing of this already vulnerable group. Fellowship training may be the fundamental answer to surmounting the significant medical, legal, and social complexities entailed with treating this deserving population...
March 22, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29607112/-pnuts-at-the-crossroads-of-tumorigenesis-and-metastasis-formation
#15
EDITORIAL
Nicole Kiweler, Oliver H Krämer
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606701/rbl2-p130-is-a-direct-akt-target-and-is-required-to-induce-apoptosis-upon-akt-inhibition-in-lung-cancer-and-mesothelioma-cell-lines
#16
Francesca Pentimalli, Iris M Forte, Luca Esposito, Paola Indovina, Carmelina A Iannuzzi, Luigi Alfano, Caterina Costa, Daniela Barone, Gaetano Rocco, Antonio Giordano
The retinoblastoma (RB) protein family includes RB1/p105, RBL1/p107, and RBL2/p130, which are key factors in cell-cycle regulation and stand at the crossroads of multiple pathways dictating cell fate decisions. The role of RB proteins in apoptosis is controversial because they can inhibit or promote apoptosis depending on the context, on the apoptotic stimuli and on their intrinsic status, impacting on the response to antitumoral treatments. Here we identified RBL2/p130 as a direct substrate of the AKT kinase, a key antiapoptotic factor hyperactive in multiple cancer types...
April 2, 2018: Oncogene
https://www.readbyqxmd.com/read/29606317/behavioral-disorders-the-blind-spot-of-neurology-and-psychiatry
#17
REVIEW
C Azuar, R Levy
Behavioral disorders occupy the crossroads between neurology and psychiatry, and emerging disorders, such as frontotemporal lobar degeneration of genetic origin and autoimmune encephalitis, can present with both neurological and psychiatric signs. Thus, the primary aim of this introductory article is to review frequently encountered behavioral clinical features, such as apathy and agitation, and their related syndromes, including frontal and anterior temporal syndromes. These behavioral states and their underlying etiologies are also here illustrated with clinical case reports...
March 29, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29605513/pharmacovigilance-in-crisis-drug-safety-at-a-crossroads
#18
John Price
Pharmacovigilance (PV) is under unprecedented stress from fundamental changes in a booming pharmaceutical industry, from the challenges of creating and maintaining an increasingly complex PV system in a globally diverse regulatory environment, and from unpredicted consequences of historical PV cost-reduction strategies. At the same time, talent availability lags demand, and many PV professionals may no longer be finding personal fulfillment in their careers. The situation creates risks for companies. Advantages and disadvantages of potential strategies to address this increasing problem at a corporate and industry level and in collaboration with regulatory agencies are discussed, as well as opportunities to adopt new technologies, including artificial intelligence and machine-learning to automate pharmacovigilance operations...
March 28, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29593731/transcriptional-regulation-of-emergency-granulopoiesis-in-leukemia
#19
REVIEW
Shirin Hasan, Afsar R Naqvi, Asim Rizvi
Neutropenic conditions are prevalent in leukemia patients and are often associated with increased susceptibility to infections. In fact, emergency granulopoiesis (EG), a process regulating neutrophil homeostasis in inflammatory conditions and infections, may occur improperly in leukemic conditions, leading to reduced neutrophil counts. Unfortunately, the mechanisms central to dysfunctional EG remain understudied in both leukemia patients and leukemic mouse models. However, despite no direct studies on EG response in leukemia are reported, recently certain transcription factors (TFs) have been found to function at the crossroads of leukemia and EG...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29584903/multifaceted-cellular-reprogramming-at-the-crossroad-between-plant-development-and-biotic-interactions
#20
Keiko Sugimoto, Lin Xu, Uta Paszkowski, Makoto Hayashi
No abstract text is available yet for this article.
March 22, 2018: Plant & Cell Physiology
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