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At the crossroads

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https://www.readbyqxmd.com/read/27890214/-pathology-of-the-triangular-fibrocartilaginous-complex-in-distal-radius-fractures
#1
D Fontès
Distal radius fracture is actually quite rarely isolated and triangular fibrocartilaginous complex (TFCC) is often involved with the same mechanism of injury. A contemporary management of the treatment of the initial fracture is ideal and so benefits from a routine arthroscopic management. Nevertheless, in the absence of diagnosis and therefore early treatment, the symptoms may be located at the ulnar crossroads and justify specific treatment of TFCC. It is generally conducted after an accurate arthroscopic lesion classification guiding a procedure, depending on the lesion vascularization as well as its possible destabilization potential (debridement, capsular suture or foveal reattachment)...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27886796/adult-onset-still-s-disease-advances-in-the-treatment
#2
REVIEW
Santos Castañeda, Ricardo Blanco, Miguel A González-Gay
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder mainly characterized by persistent high spiking fevers, evanescent rash, and joint involvement. The pathogenesis of AOSD is only partially known, but pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, IL-18, and IFN-γ seem to play a major role in this disorder. AOSD is at the crossroad of auto-inflammatory syndromes and autoimmune diseases. It is diagnosed by exclusion to determine the presence of high serum ferritin levels, which is usually >1000 μg/L...
April 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27883186/lactate-at-the-crossroads-of-metabolism-inflammation-and-autoimmunity
#3
Valentina Pucino, Michele Bombardieri, Costantino Pitzalis, Claudio Mauro
For a long time after its discovery at the beginning of the 20th century, lactate was considered a waste product of cellular metabolism. Starting in the early '90s, however, lactate has begun to be recognised as an active molecule capable of modulating the immune response. Inflammatory sites, including in rheumatoid arthritis synovitis, are characterised by the accumulation of lactate, which is partly responsible for the establishment of an acidic environment. We have recently reported that T cells sense lactate via the expression of specific transporters, leading to inhibition of their motility...
November 24, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27881712/astrocytic-tlr4-at-the-crossroads-of-inflammation-and-seizure-susceptibility
#4
Christian Henneberger, Christian Steinhäuser
Astrocytes have been implicated in epilepsy development, but their contribution is under debate. In this issue, Shen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605046) demonstrate that early postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and promote excitatory synaptogenesis, thereby increasing seizure susceptibility in young and adult mice.
November 23, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27873025/the-relativity-of-age-or-geriatric-medicine-at-the-crossroads
#5
EDITORIAL
Gorazd Voga, Dragan Kovačić
No abstract text is available yet for this article.
November 21, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27863257/unraveling-the-chip-hsp70-complex-as-an-information-processor-for-protein-quality-control
#6
REVIEW
Jamie VanPelt, Richard C Page
The CHIP:Hsp70 complex stands at the crossroads of the cellular protein quality control system. Hsp70 facilitates active refolding of misfolded client proteins, while CHIP directs ubiquitination of misfolded client proteins bound to Hsp70. The direct competition between CHIP and Hsp70 for the fate of misfolded proteins leads to the question: how does the CHIP:Hsp70 complex execute triage decisions that direct misfolded proteins for either refolding or degradation? The current body of literature points toward action of the CHIP:Hsp70 complex as an information processor that takes inputs in the form of client folding state, dynamics, and posttranslational modifications, then outputs either refolded or ubiquitinated client proteins...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27859149/psyche-and-culture-perspectives-based-on-the-contributions-and-limits-of-ethnopsychiatry
#7
Rajaa Stitou
The unconscious often appears in the form of a question or answer to the difficult relationship between the psyche and culture, a difficulty that becomes exacerbated when we are dealing with cultural difference. This difficulty, evidenced for example by Freud's thoughts on Islam, reappears, albeit in a very different way, in ethnopsychiatric theory. The author discusses the blind spots of the binary logic of the unconscious present in the work of George Devereux, a logic that eventually leads him into the same trap he had himself criticized...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27857040/effect-of-stress-on-structural-brain-asymmetry
#8
(no author information available yet)
There is a growing body of evidence that stressful events may affect the brain not only as a whole, but also in multiple laterality aspects. The present review is aimed at discussing the effect of stress and stress hormones on structural brain asymmetry. Differences and crossroads of functional and structural asymmetry are briefly mentioned throughout the document. The first part of this review summarizes major findings in the field of structural brain asymmetries in animals and humans from the evolutionary perspective...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27855321/plasmacytoid-dendritic-cells-in-autoimmunity
#9
REVIEW
Santosh K Panda, Roland Kolbeck, Miguel A Sanjuan
Plasmacytoid dendritic cells (pDC) is a unique cell population that produces large amounts of type I interferon upon recognition of nucleic acids placing them at the crossroad of both innate and adaptive immunity. Their ability to produce interferon makes them central to anti-viral responses. They are also responsive to circulating autoantibodies bound to nuclear antigens and in that scenario the release of interferons initiate self-directed immune responses. There are now a growing number of autoimmune disorders where unabated activation of pDC is suspected to be pathogenic...
November 14, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27852640/janus-at-the-crossroads-perspectives-on-long-term-care-trajectories-for-older-women-with-dementia-in-a-canadian-context
#10
Denise S Cloutier, Margaret J Penning
PURPOSE OF THE STUDY: Janus, the two-faced, Roman god of beginnings and transitions, is used as a metaphor to explore our personal narratives and our quantitative research on the experiences of older women with dementia in long-term care (LTC). Two research questions are addressed: (a) How do our quantitative data map onto our mothers' experiences? (b) What lessons do our mothers' experiences offer for the care of older women with dementia? DESIGN AND METHODS: Informed by a life-course perspective, we triangulate administrative data on 3,717 women with dementia receiving LTC in British Columbia, Canada, with personal narratives-the stories of our mothers who made the transition from home care into residential (nursing home) care...
November 16, 2016: Gerontologist
https://www.readbyqxmd.com/read/27843224/vision-restoration-in-glaucoma-nihilism-and-optimism-at-the-crossroads
#11
EDITORIAL
Muneeb A Faiq
No abstract text is available yet for this article.
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27830380/recovery-of-pan-genotypic-and-genotype-specific-amino-acid-alterations-in-chronic-hepatitis-c-after-viral-clearance-transition-at-the-crossroad-of-metabolism-and-immunity
#12
Ming-Ling Chang, Mei-Ling Cheng, Su-Wei Chang, Hsiang-Yu Tang, Cheng-Tang Chiu, Chau-Ting Yeh, Ming-Shi Shiao
Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched male genotype 1 (G1) and G2 patients underwent paired serum metabolomics analyses with liquid chromatography-tandem mass spectrometry to examine AAs before and 24 weeks after anti-HCV therapy. Before anti-HCV therapy, G1 patients had a higher HCV RNA level than G2 patients...
November 10, 2016: Amino Acids
https://www.readbyqxmd.com/read/27829173/multiple-pathways-of-sirt6-at-the-crossroads-in-the-control-of-longevity-cancer-and-cardiovascular-diseases
#13
REVIEW
Milena Vitiello, Alberto Zullo, Luigi Servillo, Francesco Paolo Mancini, Adriana Borriello, Alfonso Giovane, Fulvio Della Ragione, Nunzia D'Onofrio, Maria Luisa Balestrieri
Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD(+)-dependent deacetylases with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its complex and opposite functional roles, this sirtuin is considered a two-edged sword in health and disease. Indeed, SIRT6 improves longevity, similarly to the founding yeast member, silent information regulator-2 (Sir2), and modulates genome stability, telomere integrity, transcription, and DNA repair. Its deficiency is associated with chronic inflammation, diabetes, cardiac hypertrophy, obesity, liver dysfunction, muscle/adipocyte disorders, and cancer...
November 6, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27820607/promotion-of-drugs-for-off-label-uses-the-us-food-and-drug-administration-at-a-crossroads
#14
Jeanie Kim, Amy Kapczynski
No abstract text is available yet for this article.
November 7, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27816488/at-the-crossroads-of-cancer-stem-cells-and-targeted-therapy-resistance
#15
Anbang Wang, Le Qu, Linhui Wang
Small-molecule targeted therapy (TT) has brought great hopes to patients with advanced malignancies. However, most patients suffer from tumor progression and relapse due to drug resistance. Recently, considerable efforts trying to elucidate the underlying mechanisms have focused on the contribution of cancer stem cells (CSCs) to the targeted therapy resistance (TTR). In this article, we provide an overview of the currently available literature on the rising roles of CSCs in TTR, as well as therapeutic opportunities of combining TT and anti-CSC therapy in the treatment of advanced malignancies...
November 2, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27813481/-unlocking-the-full-potential-of-landsp%C3%A3-tali-university-hospital-icelandic-healthcare-at-a-crossroads-an-outsiders-view-from-mckinsey-and-company-editorial
#16
https://www.readbyqxmd.com/read/27810356/protein-trafficking-at-the-crossroads-to-mitochondria
#17
REVIEW
Michal Wasilewski, Katarzyna Chojnacka, Agnieszka Chacinska
Mitochondria are central power stations in the cell, which additionally serve as metabolic hubs for a plethora of anabolic and catabolic processes. The sustained function of mitochondria requires the precisely controlled biogenesis and expression coordination of proteins that originate from the nuclear and mitochondrial genomes. Accuracy of targeting, transport and assembly of mitochondrial proteins is also needed to avoid deleterious effects on protein homeostasis in the cell. Checkpoints of mitochondrial protein transport can serve as signals that provide information about the functional status of the organelles...
October 31, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27808218/russian-science-at-the-crossroads
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2016: Nature
https://www.readbyqxmd.com/read/27808023/searching-for-best-direction-in-healthcare-distilling-opportunities-priorities-and-responsibilities
#19
Terrence Montague, Amédé Gogovor, Lucas Marshall, Bonnie Cochrane, Sara Ahmed, Emily Torr, John Aylen, Joanna Nemis-White
Canada's health and its care are evolving. Evidence from serial Health Care in Canada surveys of the public and health professionals over the last two decades reveal a persistent sense of care quality, despite an aging population, decreasing levels of good and excellent health, increasing prevalence of chronic illnesses; and sub-optimal access to timely and patient-centred care. Stakeholders are, however, somewhat pessimistic and many sense complete rebuilding, or major changes, may be necessary. To improve access, the primary health concern of all Canadians - increasing medical and nursing school enrolment, and requiring professionals to work in teams - have attracted increasingly high support from both the public and professionals...
2016: Healthcare Quarterly
https://www.readbyqxmd.com/read/27803127/phospholipases-at-the-crossroads-of-the-immune-system-and-the-pathogenesis-of-hiv-1-infection
#20
REVIEW
Serena Cecchetti, Francesca Spadaro, Sandra Gessani, Franca Podo, Laura Fantuzzi
Multiple host factors and their interactions with viral proteins contribute to the complexity of HIV-1 pathogenesis and disease progression. The virus exploits the cell-signaling networks to prepare the ground for viral replication, to affect functions of either infected or uninfected bystander cells, and to evade the immune response. These events are hallmarks of HIV-1 pathogenesis that lead toward AIDS. Phospholipases are essential mediators of intracellular and intercellular signaling. They function as phospholipid-hydrolyzing enzymes, generating many bioactive lipid mediators or second messengers, which control multiple cellular functions, thus regulating a variety of physiologic and pathophysiologic processes...
November 1, 2016: Journal of Leukocyte Biology
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