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https://www.readbyqxmd.com/read/28109841/disruption-of-aromatase-homeostasis-as-the-cause-of-a-multiplicity-of-ailments-a-comprehensive-review
#1
REVIEW
Seema Patel
Human health is beset with a legion of ailments, which is exacerbated by the lifestyle errors. Out of the numerous enzymes in human body, aromatase, a cytochromes P450 enzyme is particularly very critical. Occurring at the crossroads of multiple signalling pathways, its homeostasis is vital. Unfortunately, medications, hormone therapy, chemical additives in food, and endocrine-disrupting personal care products are oscillating the aromatase concentration beyond the permissible level. As this enzyme converts androgens (C19) into estrogens (C18), its agitation has different outcomes in different genders and age groups...
January 18, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28105491/the-multi-faceted-role-of-retinoid-x-receptor-in-bone-remodeling
#2
REVIEW
María P Menéndez-Gutiérrez, Mercedes Ricote
Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization...
January 19, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28100637/a-zip3-like-protein-plays-a-role-in-crossover-formation-in-the-sc-less-meiosis-of-the-protist-tetrahymena
#3
Anura Shodhan, Kensuke Kataoka, Kazufumi Mochizuki, Maria Novatchkova, Josef Loidl
When programmed meiotic DNA double-strand breaks (DSBs) undergo recombinational repair, genetic crossovers (COs) may be formed. A certain level of these are required for the faithful segregation of chromosomes, but the majority of DSBs are processed toward a safer alternative, namely non-crossovers (NCOs), via non-reciprocal DNA exchange. At the crossroads between these two DSB fates are the Msh4-Msh5 (MutSγ) complex, which stabilizes CO-destined recombination intermediates, and members of the Zip3/RNF212 family of RING finger proteins, which in turn stabilize MutSγ...
January 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28096743/meeting-at-the-crossroads-collaboration-between-information-technology-departments-and-health-sciences-libraries
#4
Samuel King, Erica Cataldi-Roberts, Erin Wentz
OBJECTIVE: The purposes of this survey were to determine the nature and extent of collaboration between health sciences libraries and their information technology (IT) departments, to identify strengths and issues connected to this relationship, and to provide examples demonstrating exceptional collaborative success. METHODS: A fourteen-question survey was sent to a broad selection of health care and academic libraries through a variety of email discussion lists and was limited to one response per institution...
January 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28090531/at-the-crossroads-from-bench-to-bedside-luteolin-is-a-promising-pharmacological-agent-against-myocardial-ischemia-reperfusion-injury
#5
COMMENT
Defeng Pan, Dongye Li
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28089817/patient-centered-specialty-practice-defining-the-role-of-specialists-in-value-based-healthcare
#6
REVIEW
Lawrence Ward, Rhea E Powell, Michael L Scharf, Andrew Chapman, Mani Kavuru
Healthcare is at a crossroads, under pressure to add value by improving patient experience and health outcomes and reducing costs to the system. Efforts to improve the care model in primary care, such as the patient-centered medical home, have enjoyed some success. Yet primary care accounts for only a small portion of total healthcare spending, and there is a need for policies and frameworks to support high quality, cost-efficient care in specialty practices of the "medical neighborhood". The Patient-Centered Specialty Practice (PCSP) model offers ambulatory-based specialty practices one such framework, supported by a formal recognition program through the National Committee for Quality Assurance...
January 13, 2017: Chest
https://www.readbyqxmd.com/read/28078585/cd95-mediated-proton-regulation
#7
Auréa Cophignon, Mallorie Poët, Michael Monet, Michel Tauc, Laurent Counillon
The Na(+)/H(+) exchanger NHE1 is at the crossroads of a large diversity of signaling pathways, whose activation modifies the cooperative response of the transporter to intracellular H(+) ions. Here we show how the activation of the Na(+)/H(+) exchanger NHE1 by the cleaved ligand of CD95 can be measured. We demonstrate two different methods designed to set intracellular pH at precise values. Then we show how these can be coupled to fast kinetics of lithium transport, which will enable to measure the NHE1 activity like for an enzyme, because they will yield rates of transport...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28074546/-hypoxia-and-cellular-metabolism-in-tumour-pathophysiology
#8
Scott K Parks, Yann Cormerais, Jacques Pouysségur
Cancer cells are optimized for growth and survival via an ability to outcompete normal cells in their microenvironment. Many of these advantageous cellular adaptations are promoted by the pathophysiological hypoxia that arises in solid tumours due to incomplete vascularisation. Tumour cells are thus faced with the challenge of an increased need for nutrients to support the drive for proliferation in the face of a diminished extracellular supply. Among the many modifications occurring in tumour cells, Hypoxia Inducible Factors (HIFs) act as essential drivers of key pro-survival pathways via the promotion of numerous membrane and cytosolic proteins...
January 10, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28067072/drug-target-identification-at-the-crossroad-of-neuronal-apoptosis-and-survival
#9
Barbara Maino, Simona Paparone, Cinzia Severini, Maria Teresa Ciotti, Velia D'Agata, Pietro Calissano, Sebastiano Cavallaro
Inappropriate activation of apoptosis may contribute to neurodegeneration, a multifaceted process that results in various chronic disorders, including Alzheimer's and Parkinson's diseases. Several in vitro and in vivo studies demonstrated that neuronal apoptosis is a multi-pathway cell-death program that requires RNA synthesis. Thus, transcriptionally activated genes whose products induce cell death can be triggered by different stimuli and antagonized by neurotrophic factors. Systems biology is now unveiling the series of intracellular signaling pathways and key drug targets at the intersection of neuronal apoptosis and survival...
January 8, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28063230/pcsk9-at-the-crossroad-of-cholesterol-metabolism-and-immune-function-during-infections
#10
REVIEW
Francesco Paciullo, Francesca Fallarino, Vanessa Bianconi, Massimo R Mannarino, Amirhossein Sahebkar, Matteo Pirro
Sepsis, a complex and dynamic syndrome resulting from microbial invasion and immune system dysregulation, is associated with an increased mortality, reaching up to 35% worldwide. Cholesterol metabolism is often disturbed during sepsis, with low plasma cholesterol levels being associated with poor prognosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of the low-density lipoprotein receptor (LDLR), thus regulating intracellular and plasma cholesterol levels. PCSK9 is often upregulated during sepsis and might have a detrimental effect on immune host response and survival...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28061689/mitochondrial-mechanisms-of-neuronal-cell-death-potential-therapeutics
#11
Ted M Dawson, Valina L Dawson
Mitochondria lie at the crossroads of neuronal survival and cell death. They play important roles in cellular bioenergetics, control intracellular Ca(2+) homeostasis, and participate in key metabolic pathways. Mutations in genes involved in mitochondrial quality control cause a myriad of neurodegenerative diseases. Mitochondria have evolved strategies to kill cells when they are not able to continue their vital functions. This review provides an overview of the role of mitochondria in neurologic disease and the cell death pathways that are mediated through mitochondria, including their role in accidental cell death, the regulated cell death pathways of apoptosis and parthanatos, and programmed cell death...
January 6, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28039486/cd147-a-small-molecule-transporter-ancillary-protein-at-the-crossroad-of-multiple-hallmarks-of-cancer-and-metabolic-reprogramming
#12
Agnieszka A Kendrick, Johnathon Schafer, Monika Dzieciatkowska, Travis Nemkov, Angelo D Alessandro, Deepika Neelakantan, Heide L Ford, Chad G Pearson, Colin D Weekes, Kirk C Hansen, Elan Z Eisenmesser
Increased expression of CD147 in pancreatic cancer has been proposed to play a critical role in cancer progression via CD147 chaperone function for lactate monocarboxylate transporters (MCTs). Here, we show for the first time that CD147 interacts with membrane transporters beyond MCTs and exhibits a protective role for several of its interacting partners. CD147 prevents its interacting partner's proteasome-dependent degradation and correct plasma membrane localization through CD147 transmembrane (TM) region...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031322/extranuclear-partners-of-androgen-receptor-at-the-crossroads-of-proliferation-migration-and-neuritogenesis
#13
REVIEW
Gabriella Castoria, Ferdinando Auricchio, Antimo Migliaccio
In this review, we focus on the role played by the protein partners of ligand-activated extranuclear androgen receptor (AR) in the final effects of hormone action, such as proliferation, migration and neuritogenesis. The choice of AR partner, at least in part, depends on cell type. Androgen-activated receptor directly associates with cytoplasmic Src tyrosine kinase in epithelial cells, whereas in mesenchymal and neuronal cells, it prevalently interacts with filamin A. In the former, proliferation represents the final hormonal outcome, whereas in the latter, either migration or neuritogenesis, respectively, occur...
December 28, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28007918/arf1-at-the-crossroads-of-podosome-construction-and-function
#14
Elisabeth Genot
Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605104) reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation, maintenance, and function.
January 2, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28003374/effects-of-calorie-restriction-in-obese-older-adults-the-crossroads-randomized-controlled-trial
#15
Jamy D Ard, Barbara Gower, Gary Hunter, Christine S Ritchie, David L Roth, Amy Goss, Brooks C Wingo, Eric V Bodner, Cynthia J Brown, David Bryan, David R Buys, Marilyn C Haas, Akilah Dulin Keita, Lee Anne Flagg, Courtney P Williams, Julie L Locher
BACKGROUND: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. METHODS: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss)...
December 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27992964/pkr-signalling-and-paradigms-of-cardiometabolic-syndrome
#16
REVIEW
Jaspreet Kalra, Arti Dhar
Metabolic syndrome (Met S) is a collection of the most severe cardio-metabolic risk factors that encompasses raised fasting plasma glucose, dyslipidemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its etiology. Recently, double stranded RNA dependent protein kinase has been found to intersect at the crossroad of oxidative stress, inflammation and apoptosis in several metabolic diseases...
December 19, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27978999/editorial-overview-biofuels-at-the-crossroads
#17
EDITORIAL
David Savage, Wenjun Zhang
No abstract text is available yet for this article.
December 2016: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/27974671/p62-at-the-crossroad-of-the-ubiquitin-proteasome-system-and-autophagy
#18
EDITORIAL
Victoria Cohen-Kaplan, Aaron Ciechanover, Ido Livneh
No abstract text is available yet for this article.
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27929542/autophagy-and-epithelial-mesenchymal-transition-an-intricate-interplay-in-cancer
#19
REVIEW
Mila Gugnoni, Valentina Sancisi, Gloria Manzotti, Greta Gandolfi, Alessia Ciarrocchi
Autophagy and epithelial to mesenchymal transition (EMT) are major biological processes in cancer. Autophagy is a catabolic pathway that aids cancer cells to overcome intracellular or environmental stress, including nutrient deprivation, hypoxia and drugs effect. EMT is a complex transdifferentiation through which cancer cells acquire mesenchymal features, including motility and metastatic potential. Recent observations indicate that these two processes are linked in a complex relationship. On the one side, cells that underwent EMT require autophagy activation to survive during the metastatic spreading...
December 8, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27920298/malate-synthase-and-%C3%AE-methylmalyl-coa-lyase-reactions-in-the-methylaspartate-cycle-in-haloarcula-hispanica
#20
Farshad Borjian, Jing Han, Jing Hou, Hua Xiang, Jan Zarzycki, Ivan A Berg
: Haloarchaea are extremely halophilic heterotrophic microorganisms belonging to the class Halobacteria (Euryarchaeota). Almost half of the haloarchaea possesses the genes coding for enzymes of the methylaspartate cycle, a recently discovered anaplerotic acetate assimilation pathway. In this cycle, the enzymes of the tricarboxylic acid cycle together with the dedicated enzymes of the methylaspartate cycle convert two acetyl-CoA molecules to malate. The methylaspartate cycle involves two reactions catalyzed by homologous enzymes belonging to the CitE-like enzyme superfamily, the malyl-CoA lyase/thioesterase (haloarchaeal malate synthase, hMS, Hah_2476 in Haloarcula hispanica) and the β-methylmalyl-CoA lyase (hMCL, Hah_1341)...
December 5, 2016: Journal of Bacteriology
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