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GLM or (general linear model)

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https://www.readbyqxmd.com/read/27923164/thinking-anxious-feeling-anxious-or-both-cognitive-bias-moderates-the-relationship-between-anxiety-disorder-status-and-sympathetic-arousal-in-youth
#1
Michelle Rozenman, Allison Vreeland, John Piacentini
Cognitive bias and physiological arousal are two putative markers that may underlie youth anxiety. However, data on relationships between cognitive bias and arousal are limited, and typically do not include behavioral measurement of these constructs in order to tap real-time processes. We aimed to examine the relationship between performance-based cognitive bias and sympathetic arousal during stress in clinically anxious and typically-developing youth. The sample included children and adolescents ages 9 to 17 (Mean age=13...
November 17, 2016: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/27922940/impact-of-menopausal-status-on-negative-mood-and-depressive-symptoms-in-a-longitudinal-sample-spanning-20-years
#2
Katherine E Campbell, Lorraine Dennerstein, Sue Finch, Cassandra E Szoeke
OBJECTIVE: Studies examining depressive symptoms and negative mood across the postmenopause are lacking, particularly those that examine prevalence in early and late postmenopause. This study examines negative mood and depressive occurrence in the menopausal stages to provide a better understanding of prevalence of mood disturbance during this period. METHODS: This study was a longitudinal assessment of variables drawn from an epidemiological prospective study of women's healthy aging...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922826/phenotypic-spandrel-absolute-discrimination-and-ligand-antagonism
#3
Paul François, Mathieu Hemery, Kyle A Johnson, Laura N Saunders
We consider the general problem of sensitive and specific discrimination between biochemical species. An important instance is immune discrimination between self and not-self, where it is also observed experimentally that ligands just below the discrimination threshold negatively impact response, a phenomenon called antagonism. We characterize mathematically the generic properties of such discrimination, first relating it to biochemical adaptation. Then, based on basic biochemical rules, we establish that, surprisingly, antagonism is a generic consequence of any strictly specific discrimination made independently from ligand concentration...
December 6, 2016: Physical Biology
https://www.readbyqxmd.com/read/27922762/nonchemotherapy-drug-induced-agranulocytosis-in-children-detected-by-a-prospective-pharmacovigilance-program
#4
Nicolás Medrano-Casique, Hoi Y Tong, Alberto M Borobia, Antonio J Carcas, Jesús Frías, Elena Ramírez
OBJECTIVES: A prospective evaluation of nonchemotherapy drug-induced agranulocytosis (DIA) cases, which are infrequent in the pediatric population. We characterize agranulocytosis cases and assess lab test differences between drug- and nondrug-induced agranulocytosis. METHODS: Through our Prospective Pharmacovigilance Program from Laboratory Signals at Hospital we detected pediatric agranulocytosis cases from July 2007 to December 2010. This program estimates the incidence, drug causality, clinical features, outcomes of DIA pediatric cases, and assesses laboratory differences with respect to non-DIA...
December 6, 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27922533/a-propensity-score-based-fine-stratification-approach-for-confounding-adjustment-when-exposure-is-infrequent
#5
Rishi J Desai, Kenneth J Rothman, Brian T Bateman, Sonia Hernandez-Diaz, Krista F Huybrechts
BACKGROUND: When exposure is infrequent, propensity score matching results in reduced precision because it discards a large proportion of unexposed patients. To our knowledge, the relative performance of propensity score stratification in these circumstances has not been examined. METHODS: Using an empirical example of the association of first-trimester statin exposure (prevalence=0.04%) with risk of congenital malformations and 1,000 simulated cohorts (n=20,000) with eight combinations of exposure prevalence (0...
November 29, 2016: Epidemiology
https://www.readbyqxmd.com/read/27921367/dietary-patterns-in-liberian-refugees-in-buduburam-ghana
#6
Wilhelmenia L Ross, Daniel F Gallego-Pérez, Anna Lartey, Adam Sandow, Rafael Pérez-Escamilla, Amber Hromi-Fiedler
Previous research suggests that acculturation (i.e., exposure and assimilation to local culture) is associated with changes in dietary patterns among immigrants. This study investigates this association in a refugee population using time in refugee settlement as a proxy for acculturation. A cross-sectional survey was conducted among a systematic sample to (a) identify dietary patterns in Liberian refugees and Ghanaians living in or near a refugee settlement, (b) compare adherence to these dietary patterns between groups, and (c) investigate the association between acculturation and dietary patterns in Liberian refugees...
December 5, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27921185/hand-bone-loss-in-early-rheumatoid-arthritis-during-a-methotrexate-based-treat-to-target-strategy-with-or-without-adalimumab-a-substudy-of-the-optimized-treatment-algorithm-in-early-ra-opera-trial
#7
L M Ørnbjerg, M Østergaard, T Jensen, K Hørslev-Petersen, K Stengaard-Pedersen, P Junker, T Ellingsen, P Ahlquist, H Lindegaard, A Linauskas, A Schlemmer, M Y Dam, I Hansen, T Lottenburger, C G Ammitzbøll, A Jørgensen, S B Krintel, J Raun, M L Hetland, Ole Slot, Lars Kjær Nielsen, Henrik Skjødt, Ole Majgaard, Tove Lorenzen, Hans Christian Horn, Marcin Kowalski, Inger Lauge Johansen, Peter Mosborg Pedersen, Natalia Manilo, Henning Bliddal
This study aims to investigate 1-year hand bone loss (HBL1-year) in early rheumatoid arthritis (RA) patients treated with a methotrexate (MTX) and intra-articular triamcinolone treat-to-target strategy +/- adalimumab and to determine if HBL6months is associated with radiographic progression after 2 years. In a clinical trial (OPERA) of 180 treatment-naive early RA patients, bone mineral density (BMD) was estimated from hand radiographs with digital X-ray radiogrammetry (DXR) at baseline, after 6 (n = 90) and 12 months (n = 70) of follow-up...
December 5, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27919777/statistical-models-for-the-analysis-of-zero-inflated-pain-intensity-numeric-rating-scale-data
#8
Joseph L Goulet, Eugenia Buta, Harini Bathulapalli, Ralitza Gueorguieva, Cynthia A Brandt
: Pain intensity is often measured in clinical and research settings using the 0 to 10 numeric rating scale (NRS). NRS scores are recorded as discrete values, and in some samples they may display a high proportion of zeroes and a right-skewed distribution. Despite this, statistical methods for normally distributed data are frequently used in the analysis of NRS data. We present results from an observational cross-sectional study examining the association of NRS scores with patient characteristics using data collected from a large cohort of 18,935 Veterans in VA care diagnosed with a potentially painful musculoskeletal disorder...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919334/ionizing-radiation-induced-cataracts-recent-biological-and-mechanistic-developments-and-perspectives-for-future-research
#9
Elizabeth A Ainsbury, Stephen Barnard, Scott Bright, Claudia Dalke, Miguel Jarrin, Sarah Kunze, Rick Tanner, Joseph R Dynlacht, Roy A Quinlan, Jochen Graw, Munira Kadhim, Nobuyuki Hamada
The lens of the eye has long been considered as a radiosensitive tissue, but recent research has suggested that the radiosensitivity is even greater than previously thought. The 2012 recommendation of the International Commission on Radiological Protection (ICRP) to substantially reduce the annual occupational equivalent dose limit for the ocular lens has now been adopted in the European Union and is under consideration around the rest of the world. However, ICRP clearly states that the recommendations are chiefly based on epidemiological evidence because there are a very small number of studies that provide explicit biological, mechanistic evidence at doses <2Gy...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27919313/population-dynamics-of-rice-planthoppers-nilaparvata-lugens-and-sogatella-furcifera-hemiptera-delphacidae-in-central-vietnam-and-its-effects-on-their-spring-migration-to-china
#10
G Hu, M-H Lu, H A Tuan, W-C Liu, M-C Xie, C E McInerney, B-P Zhai
Rice planthopper (RPH) populations of Nilaparvata lugens and Sogatella furcifera periodically have erupted across Asia. Predicting RPH population dynamics and identifying their source areas are crucial for the management of these migratory pests in China, but the origins of the migrants to temperate and subtropical regions in China remains unclear. In particular, their early migration to China in March and April have not yet been explored due to a lack of research data available from potential source areas, Central Vietnam and Laos...
December 6, 2016: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/27919305/a-new-model-for-parent-of-origin-effect-analyses-applied-to-brown-swiss-cattle-slaughterhouse-data
#11
I Blunk, M Mayer, H Hamann, N Reinsch
Genomic imprinting is a phenomenon that arises when the expression of genes depends on the parental origin of alleles. Epigenetic mechanisms may induce the full or partial suppression of maternal or paternal alleles, thereby leading to different types of imprinting. However, imprinting effects have received little consideration in animal breeding programmes, although their relevance to some agricultural important traits has been demonstrated. A recently proposed model (imprinting model) with two path-of-transmission (male and female)-specific breeding values for each animal accounts for all types of imprinting simultaneously (paternal, maternal, full and partial)...
December 6, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27919177/economic-burden-of-inadequate-symptom-control-among-us-commercially-insured-irritable-bowel-syndrome-patients-with-diarrhea
#12
Jessica L Buono, Kush Mathur, Amelia J Averitt, David A Andrae
AIMS: To assess healthcare resource use and costs among irritable bowel syndrome (IBS) with diarrhea (IBS-D) patients with and without evidence of inadequate symptom control on current prescription therapies and estimate incremental all-cause costs associated with inadequate symptom control. METHODS: IBS-D patients aged ≥18 years with ≥1 medical claim for IBS (ICD-9-CM 564.1x) and either ≥2 claims for diarrhea (ICD-9-CM 787.91, 564.5x), or ≥1 claim for diarrhea plus ≥1 claim for abdominal pain (ICD-9-CM 789...
December 6, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27918668/the-influence-of-changes-in-acute-training-load-on-daily-sensitivity-of-morning-measured-fatigue-variables-in-elite-soccer-players
#13
Robin T Thorpe, Anthony J Strudwick, Martin Buchheit, Greg Atkinson, Barry Drust, Warren Gregson
PURPOSE: To determine the sensitivity of a range of potential fatigue measures to daily training load accumulated over the previous two, three and four days during a short in-season competitive period in elite senior soccer players (n=10). METHODS: Total high-speed running distance, perceived ratings of wellness (fatigue, muscle soreness, sleep quality), counter-movement jump height (CMJ), submaximal heart rate (HRex), post-exercise heart rate recovery (HRR) and heart rate variability (HRV: Ln rMSSD) were analysed during an in-season competitive period (17 days)...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918659/importance-of-various-training-load-measures-on-injury-incidence-of-professional-rugby-league-athletes
#14
Heidi R Thornton, Jace A Delaney, Grant M Duthie, Ben J Dascombe
PURPOSE: To investigate the ability of various internal and external training load (TL) monitoring measures to predict injury incidence amongst positional groups within professional rugby league athletes. METHODS: TL and injury data were collected across 3 seasons (2013-2015) from twenty-five players competing in the National Rugby League competition. Daily TL data were included in the analysis, including session rating of perceived exertion (sRPE-TL), total distance (TD), high-speed running distance (HSD; >5m·s(-1)) and high-metabolic power distance (HPD; >20 W·kg(-1))...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918612/generalized-semiparametric-varying-coefficient-model-for-longitudinal-data-with-applications-to-adaptive-treatment-randomizations
#15
Li Qi, Yanqing Sun, Peter B Gilbert
This article investigates a generalized semiparametric varying-coefficient model for longitudinal data that can flexibly model three types of covariate effects: time-constant effects, time-varying effects, and covariate-varying effects. Different link functions can be selected to provide a rich family of models for longitudinal data. The model assumes that the time-varying effects are unspecified functions of time and the covariate-varying effects are parametric functions of an exposure variable specified up to a finite number of unknown parameters...
December 5, 2016: Biometrics
https://www.readbyqxmd.com/read/27918586/impact-of-preconception-micronutrient-supplementation-on-anemia-and-iron-status-during-pregnancy-and-postpartum-a-randomized-controlled-trial-in-rural-vietnam
#16
Phuong H Nguyen, Melissa Young, Ines Gonzalez-Casanova, Hoa Q Pham, Hieu Nguyen, Truong V Truong, Son V Nguyen, Kimberly B Harding, Gregory A Reinhart, Reynaldo Martorell, Usha Ramakrishnan
OBJECTIVE: Preconception micronutrient interventions may be a promising approach to reduce anemia and iron deficiency during pregnancy, but currently we have limited data to inform policies. We evaluated whether providing additional pre-pregnancy weekly iron-folic acid (IFA) or multiple micronutrient (MM) supplements compared to only folic acid (FA) improves iron status and anemia during pregnancy and early postpartum. METHODS: We conducted a double blind randomized controlled trial in which 5011 Vietnamese women were provided with weekly supplements containing either only 2800 μg FA (control group), IFA (60 mg Fe and 2800 μg FA) or MM (15 micronutrients with similar amounts of IFA)...
2016: PloS One
https://www.readbyqxmd.com/read/27917882/parity-deformed-jaynes-cummings-model-robust-maximally-entangled-states
#17
A Dehghani, B Mojaveri, S Shirin, S Amiri Faseghandis
The parity-deformations of the quantum harmonic oscillator are used to describe the generalized Jaynes-Cummings model based on the λ-analog of the Heisenberg algebra. The behavior is interestingly that of a coupled system comprising a two-level atom and a cavity field assisted by a continuous external classical field. The dynamical characters of the system is explored under the influence of the external field. In particular, we analytically study the generation of robust and maximally entangled states formed by a two-level atom trapped in a lossy cavity interacting with an external centrifugal field...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917777/the-identification-and-treatment-of-women-with-hyperglycaemia-in-pregnancy-an-analysis-of-individual-participant-data-systematic-reviews-meta-analyses-and-an-economic-evaluation
#18
Diane Farrar, Mark Simmonds, Susan Griffin, Ana Duarte, Debbie A Lawlor, Mark Sculpher, Lesley Fairley, Su Golder, Derek Tuffnell, Martin Bland, Fidelma Dunne, Donald Whitelaw, John Wright, Trevor A Sheldon
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a higher risk of important adverse outcomes. Practice varies and the best strategy for identifying and treating GDM is unclear. AIM: To estimate the clinical effectiveness and cost-effectiveness of strategies for identifying and treating women with GDM. METHODS: We analysed individual participant data (IPD) from birth cohorts and conducted systematic reviews to estimate the association of maternal glucose levels with adverse perinatal outcomes; GDM prevalence; maternal characteristics/risk factors for GDM; and the effectiveness and costs of treatments...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27917528/the-ultimate-signal-to-noise-ratio-in-realistic-body-models
#19
Bastien Guérin, Jorge F Villena, Athanasios G Polimeridis, Elfar Adalsteinsson, Luca Daniel, Jacob K White, Lawrence L Wald
PURPOSE: We compute the ultimate signal-to-noise ratio (uSNR) and G-factor (uGF) in a realistic head model from 0.5 to 21 Tesla. METHODS: We excite the head model and a uniform sphere with a large number of electric and magnetic dipoles placed at 3 cm from the object. The resulting electromagnetic fields are computed using an ultrafast volume integral solver, which are used as basis functions for the uSNR and uGF computations. RESULTS: Our generalized uSNR calculation shows good convergence in the sphere and the head and is in close agreement with the dyadic Green's function approach in the uniform sphere...
December 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27917499/longitudinal-beta-binomial-modeling-using-gee-for-overdispersed-binomial-data
#20
Hongqian Wu, Ying Zhang, Jeffrey D Long
Longitudinal binomial data are frequently generated from multiple questionnaires and assessments in various scientific settings for which the binomial data are often overdispersed. The standard generalized linear mixed effects model may result in severe underestimation of standard errors of estimated regression parameters in such cases and hence potentially bias the statistical inference. In this paper, we propose a longitudinal beta-binomial model for overdispersed binomial data and estimate the regression parameters under a probit model using the generalized estimating equation method...
December 5, 2016: Statistics in Medicine
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