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https://www.readbyqxmd.com/read/29771574/is-adding-maternal-vaccination-to-prevent-whooping-cough-cost-effective-in-australia
#1
Laure-Anne Van Bellinghen, Alex Dimitroff, Michael Haberl, Xiao Li, Andrew Manton, Karen Moeremans, Nadia Demarteau
Pertussis or whooping cough, a highly infectious respiratory infection, causes significant morbidity and mortality in infants. In adolescents and adults, pertussis presents with atypical symptoms often resulting in under-diagnosis and under-reporting, increasing the risk of transmission to more vulnerable groups. Maternal vaccination against pertussis protects mothers and newborns. This evaluation assessed the cost-effectiveness of adding maternal dTpa (reduced antigen diphtheria, Tetanus, acellular pertussis) vaccination to the 2016 nationally-funded pertussis program (DTPa [Diphtheria, Tetanus, acellular Pertussis] at 2, 4, 6, 18 months, 4 years and dTpa at 12-13 years) in Australia...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29753607/maternal-immunization-with-a-dna-vaccine-candidate-elicits-specific-passive-protection-against-post-natal-zika-virus-infection-in-immunocompetent-balb-c-mice
#2
Ran Wang, Xianzheng Liao, Dongying Fan, Lei Wang, Ji Song, Kaihao Feng, Mingyuan Li, Peigang Wang, Hui Chen, Jing An
Zika virus (ZIKV) infection is closely associated in the fetus with microcephaly and in the adults with Guillain-Barré syndrome and even male infertility. It is an urgent international priority to develop a safe and effective vaccine that offers protection to both women of childbearing age and their children. In this study, female immunocompetent BALB/c mice were immunized with a DNA-based vaccine candidate, pVAX1-ZME, expressing the prM/E protein of ZIKV, and the immunogenicity for maternal mice and the post-natal protection for suckling mice were evaluated...
May 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29693575/maternal-vaccination-as-an-essential-component-of-life-course-immunization-and-its-contribution-to-preventive-neonatology
#3
REVIEW
Naomi Bergin, Janice Murtagh, Roy K Philip
Maternal immunisation schedules are increasingly coming under the spotlight as part of the development of lifetime immunisation programmes for the role that they play in improving maternal, foetal, and neonatal health. Maternally-acquired antibodies are critical in protecting infants during the first months of their lives. Maternal immunisation was previously overlooked owing to concerns regarding vaccinations in this untested and high-risk population but is now acknowledged for its potential impact on the outcomes in many domains of foetal and neonatal health, aside from its maternal benefits...
April 25, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29627238/coverage-of-recommended-vaccines-during-pregnancy-in-flanders-belgium-fairly-good-but-can-we-do-better
#4
Kirsten Maertens, Tessa Braeckman, Stéphanie Blaizot, Heidi Theeten, Mathieu Roelants, Karel Hoppenbrouwers, Elke Leuridan, Pierre Van Damme, Corinne Vandermeulen
BACKGROUND: In Flanders, Belgium, pertussis vaccination is recommended since 2013 and available free-of-charge in every pregnancy between 24 and 32 weeks of gestation. Influenza vaccination is recommended for more than 10 years with a co-payment system in the second or third trimester of pregnancy, when pregnancy coincides with the influenza season. This study aims to estimate the coverage of pertussis and influenza vaccination during pregnancy in 2016 and to determine predictors for missing vaccination...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29625766/a-follow-up-comparative-safety-analysis-of-pandemic-h1n1-vaccination-during-pregnancy-and-risk-of-infant-birth-defects-among-u-s-military-mothers
#5
Ava Marie S Conlin, Anna T Bukowinski, Jordan A Levine, Zeina G Khodr, Navjot Kaur, Susan C Farrish, Carter J Sevick
OBJECTIVE: To update a previous assessment of birth defects among infants born to active duty U.S. military mothers who received the 2009-2010 pandemic H1N1 vaccine, in comparison to the 2008-2009 seasonal influenza vaccine, during pregnancy. Here, we updated the previous comparative analyses with a more refined definition for birth defects using an additional year of follow-up data from both inpatient and outpatient medical encounters. METHODS: The study population included 15,510 live born infants born to active duty mothers vaccinated during pregnancy with either the 2009-2010 pandemic H1N1 vaccine (n = 9033) or the 2008-2009 seasonal influenza vaccine (n = 6477)...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29559801/vertical-transmission-of-group-b-streptococcus-and-associated-factors-among-pregnant-women-a-cross-sectional-study-eastern-ethiopia
#6
Tesfaye Assebe Yadeta, Alemayehu Worku, Gudina Egata, Berhanu Seyoum, Dadi Marami, Yemane Berhane
Background: Vertically transmitted group B Streptococcus (GBS) causes fetal and neonatal infections. However, there is limited information on the vertical transmission of GBS in low-income countries. This study, therefore, aimed to determine the rate of vertical transmission of GBS and associated factors among pregnant women in Eastern Ethiopia. Subjects and methods: A cross-sectional, facility-based study was conducted among pregnant women in Harar town, Eastern Ethiopia, from June to October, 2016...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29534683/challenges-of-interpreting-epidemiologic-surveillance-pertussis-data-with-changing-diagnostic-and-immunization-practices-the-case-of-the-state-of-s%C3%A3-o-paulo-brazil
#7
Eder Gatti Fernandes, Ana Marli Christovam Sartori, Patrícia Coelho de Soárez, Telma Regina M P Carvalhanas, Marcela Rodrigues, Hillegonda Maria Dutilh Novaes
BACKGROUND: A significant increase in pertussis incidence occurred in Brazil, from 2011 to 2014, despite high coverage of childhood immunization with whole-cell-pertussis (wP) containing vaccines. This study presents pertussis surveillance data from São Paulo state and discusses the challenges to interpret them considering pertussis cyclic epidemic behavior, the introduction of new diagnostic techniques and new vaccination strategies, and enhanced disease awareness during epidemics. METHODS: Observational study including pertussis cases reported to the Surveillance System in São Paulo state, from January 2001 to December 2015...
March 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29501321/effectiveness-of-maternal-pertussis-vaccination-in-preventing-infection-and-disease-in-infants-the-nsw-public-health-network-case-control-study
#8
Nathan Saul, Kevin Wang, Shopna Bag, Heather Baldwin, Kate Alexander, Meena Chandra, Jane Thomas, Helen Quinn, Vicky Sheppeard, Stephen Conaty
BACKGROUND: Infants are at the highest risk of severe complications - including death - as a result of pertussis infection. Controlling pertussis in this group has been challenging, particularly in those too young to be vaccinated. Following revised national recommendations in March 2015, the state of New South Wales, Australia, introduced a funded maternal vaccination campaign at 28 - 32 weeks of gestation using a 3-component tetanus-diphtheria-acellular pertussis vaccine (dTpa; Boostrix, GSK)...
March 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29494274/understanding-the-barriers-to-uptake-of-antenatal-vaccination-by-women-from-culturally-and-linguistically-diverse-backgrounds-a-cross-sectional-study
#9
Sushena Krishnaswamy, Allen C Cheng, Euan M Wallace, Jim Buttery, Michelle L Giles
The role of maternal vaccination in reducing neonatal morbidity and mortality is expanding but uptake remains suboptimal. While the barriers to uptake have been well described, women from minority groups have not been well represented in previous studies. In this study we examine the facilitators and barriers to uptake of antenatal vaccination by women from culturally and linguistically diverse backgrounds in Melbourne, Australia. 537 women attending antenatal care completed a survey; 69% were born overseas...
March 1, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29474132/who-s-the-target-mother-or-baby
#10
Alisa Kachikis, Linda O Eckert, Janet Englund
Maternal immunization for prevention of morbidity and mortality of pregnant women and their neonates due to infectious diseases is ongoing worldwide. The complexity of vaccine research and development in this population is challenging. Not only do vaccines for pregnant women require evidence of immunogenicity, potency, stability, and limited reactogenicity, they must also provide efficacy in decreasing morbidity for the pregnant woman, her fetus, and the neonate, demonstrate safety or lack of evidence of harm, and offer benefit or potential benefit of vaccination during pregnancy...
March 2018: Viral Immunology
https://www.readbyqxmd.com/read/29463582/infant-hospitalizations-and-mortality-after-maternal-vaccination
#11
Lakshmi Sukumaran, Natalie L McCarthy, Elyse O Kharbanda, Gabriela Vazquez-Benitez, Heather S Lipkind, Lisa Jackson, Nicola P Klein, Allison L Naleway, David L McClure, Rulin C Hechter, Alison T Kawai, Jason M Glanz, Eric S Weintraub
BACKGROUND: The Advisory Committee on Immunization Practices currently recommends pregnant women receive influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines. There are limited studies of the long-term safety in infants for vaccines administered during pregnancy. We evaluate whether maternal receipt of influenza and Tdap vaccines increases the risk of infant hospitalization or death in the first 6 months of life. METHODS: We included singleton, live birth pregnancies in the Vaccine Safety Datalink between 2004 and 2014...
February 20, 2018: Pediatrics
https://www.readbyqxmd.com/read/29458448/rubella-antibodies-in-cord-blood-sera-in-portugal-association-with-maternal-age-and-vaccination-status
#12
J Frade, C Nunes, J R Mesquita, M São José Nascimento, G Gonçalves
This study evaluated the impact of maternal vaccination against rubella on the levels of specific rubella IgG (rIgG) in 198 newborn cord sera samples. Detailed maternal vaccination data were available. Specific rIgG was measured using a commercial enzyme immunoassay. Most mothers (78.8%) had been vaccinated against rubella at least once in their lives. In 15 (7.6%) cord sera samples, the concentration of specific rIgG was below 11 IU/ml, which was classified as seronegative. Statistical analysis using multiple logistic regression (n = 198) showed that newborns of mothers born between 1986 and 1995, and those born to unvaccinated mothers, were more likely to be seronegative (odds ratio (ORs) 5...
April 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29445450/prevention-of-influenza-related-illness-in-young-infants-by-maternal-vaccination-during-pregnancy
#13
REVIEW
Marta C Nunes, Shabir A Madhi
The influenza virus circulates yearly and causes global epidemics. Influenza infection affects all age groups and causes mild to severe illness, and young infants are at particular risk for serious disease. The most effective measure to prevent influenza disease is vaccination; however, no vaccine is licensed for use in infants younger than 6 months old. Thus, there is a crucial need for other preventive strategies in this high-risk age group. Influenza vaccination during pregnancy protects both the mothers and the young infants against influenza infection...
2018: F1000Research
https://www.readbyqxmd.com/read/29426660/ped-subunit-vaccine-based-on-coe-domain-replacement-of-flagellin-domain-d3-improved-specific-humoral-and-mucosal-immunity-in-mice
#14
Qianniu Li, Ouyang Peng, Tingting Wu, Zhichao Xu, Licheng Huang, Yun Zhang, Chunyi Xue, Zhifen Wen, Qingfeng Zhou, Yongchang Cao
Porcine epidemic diarrhea (PED) is an important re-emergent infectious disease and inflicts huge economic losses to the swine industry worldwide. To meet the pressing need of developing a safe and cost-efficient PED maternal vaccine, we generated three PED subunit vaccine candidates, using recombined Salmonella flagellin (rSF) as a mucosal molecular adjuvant. Domain D3 in rSF was replaced with COE domain of PEDV to generate rSF-COE-3D. COE fused to the flanking C'/N' terminal of rSF yielded rSF-COE-C and rSF-COE-N...
March 7, 2018: Vaccine
https://www.readbyqxmd.com/read/29417364/maternal-care-providers-barriers-regarding-influenza-and-pertussis-vaccination-during-pregnancy-in-catalonia-spain
#15
Luz Maria Vilca, Cristina Martínez, Miriam Burballa, Magda Campins
Objective Maternal care providers (MCPs), obstetrician-gynaecologists and midwives are uniquely placed to increase maternal vaccination acceptance. We aimed to assess their knowledge, attitudes and practices regarding influenza and pertussis vaccination during pregnancy. Methods We conducted an online survey among MCPs working at "Attention to Sexual and Reproductive Health" (ASSIR) Units in Catalonia region. The survey included questions about current recommendations of influenza and pertussis immunization during pregnancy, reasons for not routinely recommending vaccination and several strategies to increase vaccination uptake...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29395531/strategies-to-implement-maternal-vaccination-a-comparison-between-standing-orders-for-midwife-delivery-a-hospital-based-maternal-immunisation-service-and-primary-care
#16
Sushena Krishnaswamy, Euan M Wallace, Jim Buttery, Michelle L Giles
Maternal vaccination is a safe and effective strategy to reduce maternal and neonatal morbidity and mortality from pertussis and influenza. However, despite recommendations for maternal vaccination since 2010, uptake remains suboptimal. Barriers to uptake have been studied widely and include lack of integration of vaccination into routine pregnancy care and access to vaccination services. Standing orders for administration of vaccines without the need for a physician review or prescription have been demonstrated to improve uptake as part of multi-model interventions to increase antenatal influenza and post-partum pertussis vaccination...
March 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29386093/incidence-and-seasonality-of-respiratory-syncytial-virus-hospitalisations-in-young-children-in-denmark-2010-to-2015
#17
Martin T Jepsen, Ramona Trebbien, Hanne Dorthe Emborg, Tyra G Krause, Kristian Schønning, Marianne Voldstedlund, Jens Nielsen, Thea K Fischer
For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010-2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medical-costs of ca EUR 4.1 million per year...
January 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29384237/uptake-of-maternal-vaccinations-by-indigenous-women-in-central-australia
#18
Sushena Krishnaswamy, Shamendri Thalpawila, Megan Halliday, Euan M Wallace, Jim Buttery, Michelle Giles
No abstract text is available yet for this article.
January 31, 2018: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29374589/functional-activity-of-maternal-and-cord-antibodies-elicited-by-an-investigational-group-b-streptococcus-trivalent-glycoconjugate-vaccine-in-pregnant-women
#19
Monica Fabbrini, Fabio Rigat, Giovanna Tuscano, Emiliano Chiarot, Gilbert Donders, Roland Devlieger, Sara Filippini, Elisabetta Frigimelica, Pietro Forte, Frederick Wittke, Scott A Halperin, Karen Slobod, Guido Grandi, Immaculada Margarit
OBJECTIVES: The main aim of this exploratory study was to evaluate functional activity of antibodies elicited by a maternal Group B Streptococcus (GBS) investigational vaccine composed of capsular polysaccharides Ia, Ib, and III conjugated to genetically detoxified Diphtheria toxin CRM197 . The second objective was to investigate the relationship between serotype-specific IgG concentrations and functional activity in maternal and cord sera. METHODS: Maternal and cord sera collected at baseline and at delivery from vaccine and placebo recipients during a double-blind placebo-controlled Phase II study (www...
May 2018: Journal of Infection
https://www.readbyqxmd.com/read/29359183/maternal-hiv-1-env-vaccination-for-systemic-and-breast-milk-immunity-to-prevent-oral-shiv-acquisition-in-infant-macaques
#20
Joshua A Eudailey, Maria L Dennis, Morgan E Parker, Bonnie L Phillips, Tori N Huffman, Camden P Bay, Michael G Hudgens, Roger W Wiseman, Justin J Pollara, Genevieve G Fouda, Guido Ferrari, David J Pickup, Pamela A Kozlowski, Koen K A Van Rompay, Kristina De Paris, Sallie R Permar
Mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) contributes to an estimated 150,000 new infections annually. Maternal vaccination has proven safe and effective at mitigating the impact of other neonatal pathogens and is one avenue toward generating the potentially protective immune responses necessary to inhibit HIV-1 infection of infants through breastfeeding. In the present study, we tested the efficacy of a maternal vaccine regimen consisting of a modified vaccinia virus Ankara (MVA) 1086...
January 2018: MSphere
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