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https://www.readbyqxmd.com/read/28651593/maternal-antibodies-protect-offspring-from-severe-influenza-infection-and-do-not-lead-to-detectable-interference-with-subsequent-offspring-immunization
#1
Joan E M van der Lubbe, Jessica Vreugdenhil, Sarra Damman, Joost Vaneman, Jaco Klap, Jaap Goudsmit, Katarina Radošević, Ramon Roozendaal
BACKGROUND: Various studies have shown that infants under the age of 6 months are especially vulnerable for complications due to influenza. Currently there are no vaccines licensed for use in this age group. Vaccination of pregnant women during the last trimester, recommended by the WHO as protective measure for this vulnerable female population, may provide protection of newborns at this early age. Although it has been observed that maternal vaccination can passively transfer protection, maternal antibodies could possibly also interfere with subsequent active vaccination of the offspring...
June 26, 2017: Virology Journal
https://www.readbyqxmd.com/read/28624306/preclinical-assessment-of-safety-of-maternal-vaccination-against-respiratory-syncytial-virus-rsv-in-cotton-rats
#2
Jorge C G Blanco, Lioubov M Pletneva, Raymonde O Otoa, Mira C Patel, Stefanie N Vogel, Marina S Boukhvalova
Maternal immunization directed to control RSV infection in newborns and infants is an appealing vaccination strategy currently under development. In this work we have modeled maternal vaccination against RSV in cotton rats (CR) to answer two fundamental questions on maternal vaccine safety. We tested (i), whether a known, unsafe RSV vaccine (i.e., FI-RSV Lot 100 vaccine) induces vaccine enhanced disease in the presence of passively transferred, RSV maternal immunity, and (ii) whether the same FI-RSV vaccine could induce vaccine enhanced disease in CR litters when used to immunize their RSV-primed mothers...
July 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28598324/a-case-control-study-to-assess-the-effectiveness-of-pertussis-vaccination-during-pregnancy-on-newborns-valencian-community-spain-1-march-2015-to-29-february-2016
#3
Juan Bellido-Blasco, Silvia Guiral-Rodrigo, Ana Míguez-Santiyán, Antonio Salazar-Cifre, Francisco González-Morán
In the Valencian Community (Spain), the programme of maternal pertussis vaccination during pregnancy started in January 2015. The objective of this study was to estimate in this region the vaccine effectiveness (VE) in protecting newborns against laboratory-confirmed pertussis infection. A matched case-control study was undertaken in the period between 1 March 2015 and 29 February 2016. Twenty-two cases and 66 controls (+/- 15 days of age difference) were included in the study. Cases were non-vaccinated infants < 3 months of age at disease onset testing positive for pertussis by real-time PCR...
June 1, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28582556/serious-bacterial-infections-in-neonates-improving-reporting-and-case-definitions
#4
Stefania Vergnano, Anna C Seale, Elizabeth J A Fitchett, Mike Sharland, Paul T Heath
Neonatal infections affect about 7 million neonates causing over 600 000 deaths every year. Estimating the burden is challenging as there are multiple reporting criteria and definitions for serious bacterial infections in neonates. Essential criteria for reporting serious neonatal bacterial infections have recently been published as the STROBE-NI checklist and, in the context of maternal vaccination, definitions have been published by the Brighton Collaboration Global Alignment of Immunization safety Assessment in pregnancy (GAIA) project...
May 1, 2017: International Health
https://www.readbyqxmd.com/read/28578723/pertussis-diagnosis-in-belgium-results-of-the-national-reference-centre-for-bordetella-anno-2015
#5
H Martini, C Rodeghiero, C VAN DEN Poel, M Vincent, D Pierard, K Huygen
In 2015, the Belgian National Reference Centre for Bordetella analyzed 4110 respiratory samples by qPCR and 4877 serum samples by serology. Whereas about 50% of respiratory samples were from infants and children below the age of five, serum samples were distributed among all age categories. A total of 394 (9·6%) cases was diagnosed as positive for Bordetella pertussis by qPCR and 844 (17·3%) cases were diagnosed as acute infection by serology (anti-pertussis toxin (PT) IgG > 125 IU/ml). Another 1042 (21·4%) sera had anti-PT IgG between 55 and 125 IU/ml reflecting a vaccination or pertussis infection during the last 1-2 years...
August 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28575286/efficacy-of-maternal-influenza-vaccination-against-all-cause-lower-respiratory-tract-infection-hospitalizations-in-young-infants-results-from-a-randomized-controlled-trial
#6
Marta C Nunes, Clare L Cutland, Stephanie Jones, Sarah Downs, Adriana Weinberg, Justin R Ortiz, Kathleen M Neuzil, Eric A F Simões, Keith P Klugman, Shabir A Madhi
Background: Influenza immunization of pregnant women protects their young infants against laboratory-confirmed influenza infection. Influenza infection might predispose to subsequent bacterial infections that cause severe pneumonia. In a secondary analysis of a randomized clinical trial (RCT), we evaluated the effect of maternal vaccination on infant hospitalizations for all-cause acute lower respiratory tract infection (ALRI). Methods: Infants born to women who participated in a double-blind placebo-controlled RCT in 2011 and 2012 on the efficacy of trivalent inactivated influenza vaccine (IIV) during pregnancy were followed during the first 6 months of life...
May 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28520789/antigen-specific-immunoglobulin-variable-region-sequencing-measures-humoral-immune-response-to-vaccination-in-the-equine-neonate
#7
Rebecca L Tallmadge, Steven C Miller, Stephen A Parry, Maria Julia B Felippe
The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth. Taken our previous studies on equine B cell ontogeny, we hypothesized that the equine neonate generates a diverse immunoglobulin repertoire in response to vaccination, independently of circulating maternal antibodies. In this study, equine neonates were vaccinated with 3 doses of keyhole limpet hemocyanin (KLH) or equine influenza vaccine, and humoral immune responses were assessed using antigen-specific serum antibodies and B cell Ig variable region sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28510067/immunization-during-pregnancy-impact-on-the-infant
#8
REVIEW
Kirsten P Perrett, Terry M Nolan
Maternal immunization has undergone a paradigm shift in recent years, as women and healthcare providers accept and recognize the benefits of this strategy not only for the pregnant woman but also for the developing fetus and young infant. This article reviews the evidence for active immunization during pregnancy, with an emphasis on perinatal and infant outcomes. Current recommendations for immunization during pregnancy are presented, with particular focus on the routinely recommended vaccines during pregnancy: influenza and Tdap (tetanus, diphtheria, and pertussis)...
August 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28495223/feasibility-of-text-message-influenza-vaccine-safety-monitoring-during-pregnancy
#9
Melissa S Stockwell, Maria Cano, Kathleen Jakob, Karen R Broder, Cynthia Gyamfi-Bannerman, Paula M Castaño, Paige Lewis, Angela Barrett, Oidda I Museru, Ormarys Castellanos, Philip S LaRussa
INTRODUCTION: The feasibility and accuracy of text messaging to monitor events after influenza vaccination throughout pregnancy and the neonatal period has not been studied, but may be important for seasonal and pandemic influenza vaccines and future maternal vaccines. METHODS: This prospective observational study was conducted during 2013-2014 and analyzed in 2015-2016. Enrolled pregnant women receiving inactivated influenza vaccination at a gestational age <20 weeks were sent text messages intermittently through participant-reported pregnancy end to request fever, health events, and neonatal outcomes...
May 2, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#10
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28468899/maternal-vaccination-against-pertussis-a-systematic-review-of-the-recent-literature
#11
REVIEW
Despoina Gkentzi, Paraskeui Katsakiori, Markos Marangos, Yingfen Hsia, Gayatri Amirthalingam, Paul T Heath, Shamez Ladhani
OBJECTIVE: This study is conducted to summarise and present the current knowledge on antenatal vaccination against pertussis with regard to national recommendations, coverage, immunogenicity, safety and effectiveness of the current available vaccines. METHODS: A systematic review of the literature in English was undertaken from January 2011 to May 2016 with searches in four databases. The review conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
May 3, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28465095/association-of-influenza-vaccination-during-pregnancy-with-birth-outcomes-in-nicaragua
#12
Carmen S Arriola, Nancy Vasconez, Mark G Thompson, Sonja J Olsen, Ann C Moen, Joseph Bresee, Alba María Ropero
BACKGROUND: Studies have shown that influenza vaccination during pregnancy reduces the risk of influenza disease in pregnant women and their offspring. Some have proposed that maternal vaccination may also have beneficial effects on birth outcomes. In 2014, we conducted an observational study to test this hypothesis using data from two large hospitals in Managua, Nicaragua. METHODS: We conducted a retrospective cohort study to evaluate associations between influenza vaccination and birth outcomes...
May 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28456432/maternal-immune-correlates-of-protection-against-placental-transmission-of-cytomegalovirus
#13
Hannah L Itell, Cody S Nelson, David R Martinez, Sallie R Permar
Human cytomegalovirus (HCMV) is the most common congenitally transmitted pathogen worldwide, impacting an estimated 1 million newborns annually. In a subset of infected infants, congenital HCMV causes severe, long-lasting sequelae, including deafness, microcephaly, neurodevelopmental delay, and even death. Accordingly, a maternal vaccine to prevent congenital HCMV infection continues to be a top public health priority. Nevertheless, all vaccines tested to date have failed to meet clinical trial endpoints. Maternal immunity provides partial protection against congenital HCMV transmission, as vertical transmission from seropositive mothers is relatively rare...
April 20, 2017: Placenta
https://www.readbyqxmd.com/read/28441089/one-size-fits-all-antibody-avidity-measurement-against-multiple-antigens-in-maternal-vaccination-studies
#14
Thomas Rice, Beate Kampmann, Beth Holder
No abstract text is available yet for this article.
April 25, 2017: Virulence
https://www.readbyqxmd.com/read/28434651/neonatal-sepsis
#15
REVIEW
Andi L Shane, Pablo J Sánchez, Barbara J Stoll
Neonatal sepsis is the cause of substantial morbidity and mortality. Precise estimates of neonatal sepsis burden vary by setting. Differing estimates of disease burden have been reported from high-income countries compared with reports from low-income and middle-income countries. The clinical manifestations range from subclinical infection to severe manifestations of focal or systemic disease. The source of the pathogen might be attributed to an in-utero infection, acquisition from maternal flora, or postnatal acquisition from the hospital or community...
April 20, 2017: Lancet
https://www.readbyqxmd.com/read/28398711/major-birth-defects-after-vaccination-reported-to-the-vaccine-adverse-event-reporting-system-vaers-1990-to-2014
#16
Pedro L Moro, Janet Cragan, Paige Lewis, Lakshmi Sukumaran
BACKGROUND: Major birth defects are important infant outcomes that have not been well studied in the postmarketing surveillance of vaccines given to pregnant women. We assessed the presence of major birth defects following vaccination in the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system used to monitor the safety of vaccines in the United States. METHODS: We searched VAERS for reports of major birth defects during January 1, 1990, through December 31, 2014...
April 11, 2017: Birth defects research
https://www.readbyqxmd.com/read/28398678/maternal-immunization
#17
Helen Y Chu, Janet A Englund
Pregnant women, neonates, and infants are at higher risk for severe infections due to vaccine-preventable diseases. Very young infants rarely respond well to vaccination due to poor immunogenicity and interference from maternal antibody. Maternal immunization protects the mother and fetus from disease and protects the infant through transplacental antibody transfer through the first 6 months of life. Currently, immunizations routinely recommended during pregnancy include inactivated influenza, tetanus toxoid, and acellular pertussis vaccines...
March 15, 2017: Birth defects research
https://www.readbyqxmd.com/read/28362650/placental-transfer-of-antibody-and-its-relationship-to-vaccination-in-pregnancy
#18
Anna Calvert, Christine E Jones
PURPOSE OF REVIEW: Vaccination in pregnancy boosts maternal vaccine-specific antibody concentration and therefore increases transplacental transfer of antibody to optimize protection of the infant. The purpose of this review is to describe what is known about placental transfer of antibody in the context of vaccination in pregnancy, focussing on the recent literature and areas of debate, particularly about the timing of vaccination. RECENT FINDINGS: There is a debate about the timing of pertussis vaccination in pregnancy with some studies reporting that vaccination in the third trimester results in higher pertussis antigen-specific IgG concentrations in cord blood and others finding that the concentration is higher following vaccination in the second trimester...
June 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28341114/measuring-maternal-tdap-and-influenza-vaccination-rates-comparison-of-two-population-based-methods
#19
Ruth Koepke, Stephanie L Schauer, Jeffrey P Davis
Pregnant women are routinely recommended to receive Tdap and influenza vaccines to prevent disease and complications among mothers and newborns. Monitoring population trends in maternal vaccination is important in order to evaluate the implementation of these recommendations and to identify pockets of need. We present two methods for measuring maternal vaccination among a state population and discuss the strengths and drawbacks of each method. First, we matched maternal information from records of Wisconsin births during 2013-2015 with maternal vaccination records in the Wisconsin Immunization Registry...
March 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28329335/pertussis-antibody-transfer-to-preterm-neonates-after-second-versus-third-trimester-maternal-immunization
#20
COMPARATIVE STUDY
Christiane S Eberhardt, Geraldine Blanchard-Rohner, Barbara Lemaître, Christophe Combescure, Véronique Othenin-Girard, Antonina Chilin, Jean Petre, Begoña Martinez de Tejada, Claire-Anne Siegrist
Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates.
April 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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