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https://www.readbyqxmd.com/read/28212334/transfer-of-anti-rotavirus-antibodies-during-pregnancy-and-in-milk-following-maternal-vaccination-with-a-herpes-simplex-virus-type-1-amplicon-vector
#1
Anita F Meier, Mark Suter, Elisabeth M Schraner, Bruno M Humbel, Kurt Tobler, Mathias Ackermann, Andrea S Laimbacher
Rotaviruses (RVs) are important enteric pathogens of newborn humans and animals, causing diarrhea and in rare cases death, especially in very young individuals. Rotavirus vaccines presently used are modified live vaccines that lack complete biological safety. Previous work from our laboratory suggested that vaccines based on in situ produced, non-infectious rotavirus-like particles (RVLPs) are efficient while being entirely safe. However, using either vaccine, active mucosal immunization cannot induce protective immunity in newborns due to their immature immune system...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28202762/maternal-binding-and-neutralizing-igg-responses-targeting-the-c-terminal-region-of-the-v3-loop-are-predictive-of-reduced-peripartum-hiv-1-transmission-risk
#2
David R Martinez, Nathan Vandergrift, Ayooluwa O Douglas, Erin McGuire, John Bainbridge, Nathan I Nicely, David C Montefiori, Georgia D Tomaras, Genevieve G Fouda, Sallie R Permar
The development of an effective maternal HIV-1 vaccine that could synergize with antiretroviral therapy (ART) to eliminate pediatric HIV-1 infection will require the characterization of maternal immune responses capable of blocking transmission of autologous HIV viruses to the infant. We previously identified that maternal plasma antibody binding to linear epitopes within the variable loop 3 (V3) region of HIV envelope (Env) and neutralizing responses against easy to neutralize tier 1 viruses were associated with reduced risk of peripartum HIV infection in the historic U...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28190746/birth-outcomes-for-australian-mother-infant-pairs-who-received-an-influenza-vaccine-during-pregnancy-2012-2014-the-flumum-study
#3
Lisa McHugh, Ross M Andrews, Stephen B Lambert, Kerri A Viney, Nicholas Wood, Kirsten P Perrett, Helen S Marshall, Peter Richmond, Kerry-Ann F O'Grady
INTRODUCTION: In Australia, influenza vaccination is recommended for all women who will be pregnant during the influenza season. Vaccine safety and effectiveness are key concerns and influencers of uptake for both vaccine providers and families. We assessed the safety of receiving an influenza vaccination during any trimester of pregnancy with respect to preterm births and infant birthweight. METHODS: We conducted a nested retrospective cohort study of 'FluMum' participants (2012-2014)...
February 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28170416/cost-effectiveness-of-maternal-influenza-immunization-in-bamako-mali-a-decision-analysis
#4
Evan W Orenstein, Lauren A V Orenstein, Kounandji Diarra, Mahamane Djiteye, Diakaridia Sidibé, Fadima C Haidara, Moussa F Doumbia, Fatoumata Diallo, Flanon Coulibaly, Adama M Keita, Uma Onwuchekwa, Ibrahima Teguete, Milagritos D Tapia, Samba O Sow, Myron M Levine, Richard Rheingans
BACKGROUND: Maternal influenza immunization has gained traction as a strategy to diminish maternal and neonatal mortality. However, efforts to vaccinate pregnant women against influenza in developing countries will require substantial investment. We present cost-effectiveness estimates of maternal influenza immunization based on clinical trial data from Bamako, Mali. METHODS: We parameterized a decision-tree model using prospectively collected trial data on influenza incidence, vaccine efficacy, and direct and indirect influenza-related healthcare expenditures...
2017: PloS One
https://www.readbyqxmd.com/read/28167667/the-protective-role-of-passively-transferred-maternal-cytokines-against-bordetella-pertussis-infection-in-newborn-piglets
#5
Shokrollah Elahi, David R Thompson, Jill Van Kessel, Lorne A Babiuk, Volker Gerdts
Maternal vaccination represents a potential strategy to protect both the mother and the offspring against life threatening infections. This protective role has mainly been associated with antibodies but the role of cell mediated immunity in particular passively transferred cytokines is not well understood. Herein, using a pertussis model we have demonstrated that immunization of pregnant sows with heat-inactivated bacteria leads to induction of a wide range of cytokines (e.g. TNF-α, IFN-γ, IL-6, IL-8 and IL-12/IL-23p40) in addition to pertussis-specific antibodies...
February 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28103212/coverage-with-tetanus-diphtheria-and-acellular-pertussis-vaccine-and-influenza-vaccine-among-pregnant-women-minnesota-march-2013-december-2014
#6
Alexandra Barber, Miriam Halstead Muscoplat, Anna Fedorowicz
Pertussis and influenza infections can result in severe disease in infants. The diphtheria, tetanus, acellular pertussis (DTaP) vaccine is recommended for infants beginning at age 2 months, and influenza vaccine is recommended for infants aged ≥6 months. Vaccination of pregnant women induces the production of antibodies that are transferred across the placenta to the fetus and provide passive protection until infants are old enough to receive DTaP and influenza vaccines (1-3). To protect young infants before they are age-eligible for vaccination, the Advisory Committee on Immunization Practices (ACIP) has recommended since 2004 that all women who are or will be pregnant during influenza season receive inactivated influenza vaccine (1), and since 2013 that all pregnant women receive the tetanus, diphtheria, acellular pertussis (Tdap) vaccine (3)...
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28073985/population-based-pertussis-incidence-and-risk-factors-in-infants-less-than-6-months-in-nepal
#7
Michelle M Hughes, Janet A Englund, Jane Kuypers, James M Tielsch, Subarna K Khatry, Laxman Shrestha, Steven C LeClerq, Mark Steinhoff, Joanne Katz
BACKGROUND: Pertussis is estimated to cause 2 percent of childhood deaths globally and is a growing public health problem in developed countries despite high vaccination coverage. Infants are at greatest risk of morbidity and mortality. Maternal vaccination during pregnancy may be effective to prevent pertussis in young infants, but population-based estimates of disease burden in infants are lacking, particularly in low-income countries. The objective of this study was to estimate the incidence of pertussis in infants less than 6 months of age in Sarlahi District, Nepal...
January 10, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28054412/identifying-birth-defects-in-automated-data-sources-in-the-vaccine-safety-datalink
#8
Elyse Olshen Kharbanda, Gabriela Vazquez-Benitez, Paul A Romitti, Allison L Naleway, T Craig Cheetham, Heather S Lipkind, Shanthi Sivanandam, Nicola P Klein, Grace M Lee, Michael L Jackson, Simon J Hambidge, Avalow Olsen, Natalie McCarthy, Frank DeStefano, James D Nordin
PURPOSE: The Vaccine Safety Datalink (VSD), a collaboration between the Centers for Disease Control and Prevention and several large healthcare organizations, aims to monitor safety of vaccines administered in the USA. We present definitions and prevalence estimates for major structural birth defects to be used in studies of maternal vaccine safety. METHODS: In this observational study, we created and refined algorithms for identifying major structural birth defects from electronic healthcare data, conducted formal chart reviews for severe cardiac defects, and conducted limited chart validation for other defects...
January 4, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27832811/farm-characteristics-and-management-routines-related-to-neonatal-porcine-diarrhoea-a-survey-among-swedish-piglet-producers
#9
Jenny Larsson, Nils Fall, Maria Lindberg, Magdalena Jacobson
BACKGROUND: In recent years reports from a number of countries, including Sweden, describe problems with diarrhoea in newborn piglets despite the use of previously effective preventive measures. This seemingly altered disease pattern of neonatal porcine diarrhoea (NPD) warrants investigations on the magnitude and manifestation of the problem. The aim of the present study was to investigate the herd-level prevalence of NPD in Sweden and to describe disease characteristics and intervention strategies used in affected herds...
November 10, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27773474/knowledge-attitudes-and-practices-of-healthcare-providers-in-the-country-of-georgia-regarding-influenza-vaccinations-for-pregnant-women
#10
Mariam Dvalishvili, Darejan Mesxishvili, Maia Butsashvili, George Kamkamidze, Deborah McFarland, Robert A Bednarczyk
OBJECTIVE: To document knowledge, attitudes, and practices of Georgian obstetrician-gynecologists concerning influenza infection and vaccination during pregnancy. METHODS: We conducted a cross-sectional study of obstetrician-gynecologists in 8 cities in the country of Georgian, from June to July, 2015, using an anonymous, self-administered, written survey. Collected data included demographics; knowledge, attitudes, and practices related to influenza vaccination during pregnancy; perceptions of influenza infection in pregnancy; perceived barriers to influenza vaccination during pregnancy; and willingness to receive education about influenza infection and vaccination during pregnancy...
October 20, 2016: Vaccine
https://www.readbyqxmd.com/read/27742214/maternal-pertussis-and-influenza-immunization-coverage-and-attitude-of-health-care-workers-towards-these-recommendations-in-flanders-belgium
#11
Kirsten Maertens, Tessa Braeckman, Geert Top, Pierre Van Damme, Elke Leuridan
In Belgium, pertussis vaccination is recommended for all pregnant women in every pregnancy. Adults in close contact with young infants are equally advised to receive a pertussis containing booster dose. Maternal influenza vaccination is likewise recommended in Belgium in the second or third trimester of pregnancy, within the influenza season. A quantitative multicenter survey study has been performed between October 2014 and May 2015 in both postpartum women (N=823, response rate=89.2%) and health care workers (HCWs) (N=261) to assess the coverage of both vaccines during pregnancy along with the coverage of the pertussis cocoon strategy, and to evaluate the knowledge and recommending attitude of HCWs towards the maternal vaccination strategies and the cocoon strategy among surveyed women and HCWs...
October 11, 2016: Vaccine
https://www.readbyqxmd.com/read/27633910/strengthening-the-reporting-of-observational-studies-in-epidemiology-for-newborn-infection-strobe-ni-an-extension-of-the-strobe-statement-for-neonatal-infection-research
#12
REVIEW
Elizabeth J A Fitchett, Anna C Seale, Stefania Vergnano, Michael Sharland, Paul T Heath, Samir K Saha, Ramesh Agarwal, Adejumoke I Ayede, Zulfiqar A Bhutta, Robert Black, Kalifa Bojang, Harry Campbell, Simon Cousens, Gary L Darmstadt, Shabir A Madhi, Ajoke Sobanjo-Ter Meulen, Neena Modi, Janna Patterson, Shamim Qazi, Stephanie J Schrag, Barbara J Stoll, Stephen N Wall, Robinson D Wammanda, Joy E Lawn
Neonatal infections are estimated to account for a quarter of the 2·8 million annual neonatal deaths, as well as approximately 3% of all disability-adjusted life-years. Despite this burden, few data are available on incidence, aetiology, and outcomes, particularly regarding impairment. We aimed to develop guidelines for improved scientific reporting of observational neonatal infection studies, to increase comparability and to strengthen research in this area. This checklist, Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE- NI), is an extension of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement...
October 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27603545/the-effects-of-influenza-vaccination-during-pregnancy-on-birth-outcomes-a-systematic-review-and-meta-analysis
#13
Marta C Nunes, Anushka R Aqil, Saad B Omer, Shabir A Madhi
Objective Numerous observational studies have evaluated the relationship between influenza vaccination during pregnancy and birth outcomes. The number of studies on this subject has increased, especially after the 2009 A/H1N1 pandemic (A/H1N1pdm09). This meta-analysis aims to determine the impact of maternal vaccination with either seasonal trivalent inactivated influenza vaccines (IIV) or A/H1N1pdm09 monovalent vaccines on the rates of preterm (PTB), small for gestational age (SGA), and low birth weight (LBW) births...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27541370/the-safety-of-maternal-immunization
#14
Annette K Regan
Maternal vaccination offers the opportunity to protect pregnant women and their infants against potentially serious disease. As both pregnant women and their newborns are vulnerable to severe illness, the potential public health impact of mass maternal vaccination programs is remarkable. Several high-income countries recommend seasonal influenza and acellular pertussis vaccines, and many developing countries recommend immunization against tetanus during pregnancy. There is a significant amount of literature supporting the safety of vaccination during pregnancy...
December 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27530965/neonatal-invasive-pneumococcal-disease-new-zealand-experience-in-the-era-of-pneumococcal-vaccination
#15
Vicki Mount, Cameron Burton, Catherine Jackson, Helen Heffernan, Emma Best
BACKGROUND: Invasive pneumococcal disease (IPD) became a notifiable disease in New Zealand in 2008, and in the same year pneumococcal conjugate vaccine (PCV) was added to the childhood immunisation schedule. DESIGN: This was a retrospective study of IPD in infants aged <90 days reported to the national notifiable disease database, EpiSurv, from 1 January 2009 to 31 December 2013. All cases had Streptococcus pneumoniae isolated from a normally sterile site. MAIN OUTCOME MEASURES: IPD incidence was calculated for babies aged <90 and <30 days using the number of national IPD cases with a denominator of annual infant live births...
August 17, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27507412/-infection-prevention-in-newborns-through-maternal-vaccination-current-insights-and-developments
#16
N A T van der Maas, K van Aerde, L J Bont, M N Bekker, N Rots, H E de Melker
- In the first few months of life, newborns are vulnerable to infections.- Vaccination of the pregnant mother leads to transplacental antibody transfer, resulting in the best possible protection of the newborn.- Maternal vaccination has long been given for the prevention of tetanus in developing countries, and for the prevention of pertussis and influenza in developed countries, such as the United States, England and Belgium. These vaccinations give newborns good protection and, to date, no adverse effects are known for the foetus or the pregnancy...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27494630/influenza-immunization-during-pregnancy-benefits-for-mother-and-infant
#17
Isaac G Sakala, Yoshikazu Honda-Okubo, Johnson Fung, Nikolai Petrovsky
The serious consequences of influenza infection during pregnancy have been recognized for almost a century. In this article, we reviewed the evidence on the immunogenicity, safety and impact of maternal influenza immunization for both mother and child. After vaccination, pregnant women have similar protective titers of anti-influenza antibodies as non-pregnant women, demonstrating that pregnancy does not alter the trivalent inactivated influenza vaccine immune response. Studies from the United States, Europe and resource-constrained regions demonstrate that maternal vaccination is associated with increased anti-influenza antibody concentrations and protection in the newborn child as well as the immunized mother...
December 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27491687/neonatal-infections-case-definition-and-guidelines-for-data-collection-analysis-and-presentation-of-immunisation-safety-data
#18
Stefania Vergnano, Jim Buttery, Ben Cailes, Ravichandran Chandrasekaran, Elena Chiappini, Ebiere Clark, Clare Cutland, Solange Dourado de Andrade, Alejandra Esteves-Jaramillo, Javier Ruiz Guinazu, Chrissie Jones, Beate Kampmann, Jay King, Sonali Kochhar, Noni Macdonald, Alexandra Mangili, Reinaldo de Menezes Martins, César Velasco Muñoz, Michael Padula, Flor M Muñoz, James Oleske, Melvin Sanicas, Elizabeth Schlaudecker, Hans Spiegel, Maja Subelj, Lakshmi Sukumaran, Beckie N Tagbo, Karina A Top, Dat Tran, Paul T Heath
Maternal vaccination is an important area of research and requires appropriate and internationally comparable definitions and safety standards. The GAIA group, part of the Brighton Collaboration was created with the mandate of proposing standardised definitions applicable to maternal vaccine research. This study proposes international definitions for neonatal infections. The neonatal infections GAIA working group performed a literature review using Medline, EMBASE and the Cochrane collaboration and collected definitions in use in neonatal and public health networks...
December 1, 2016: Vaccine
https://www.readbyqxmd.com/read/27467322/-novel-approaches-to-control-the-rise-in-pertussis-cases
#19
J Machač, R Chlíbek, S Plíšek
UNLABELLED: Pertussis is a respiratory disease caused by the Gram-negative encapsulated bacterium Bordetella pertussis. Despite the high vaccination coverage rate and addition of new booster doses to the immunisation scheme (in response to the epidemiological situation), pertussis is on the rise not only in the Czech Republic but also in many other countries. The age groups at highest risk are infants and, to a lower extent, newborns who can get infected before receiving the first dose of vaccine and develop a severe course of the disease, often requiring admission to hospital...
December 0: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/27449414/risk-of-preterm-or-small-for-gestational-age-birth-after-influenza-vaccination-during-pregnancy-caveats-when-conducting-retrospective-observational-studies
#20
Gabriela Vazquez-Benitez, Elyse O Kharbanda, Allison L Naleway, Heather Lipkind, Lakshmi Sukumaran, Natalie L McCarthy, Saad B Omer, Lei Qian, Stanley Xu, Michael L Jackson, Vinutha Vijayadev, Nicola P Klein, James D Nordin
Vaccines are increasingly targeted toward women of reproductive age, and vaccines to prevent influenza and pertussis are recommended during pregnancy. Prelicensure clinical trials typically have not included pregnant women, and when they are included, trials cannot detect rare events. Thus, postmarketing vaccine safety assessments are necessary. However, analysis of observational data requires detailed assessment of potential biases. Using data from 8 Vaccine Safety Datalink sites in the United States, we analyzed the association of monovalent H1N1 influenza vaccine (MIV) during pregnancy with preterm birth (<37 weeks) and small-for-gestational-age birth (birth weight < 10th percentile)...
August 1, 2016: American Journal of Epidemiology
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