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sheehan syndrome

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https://www.readbyqxmd.com/read/27896263/complete-vaginal-outlet-stenosis-in-a-patient-with-sheehan-s-syndrome
#1
Minji Choo, Hana Park, Kyong Wook Yi
We present a case of complete vaginal stenosis in a woman diagnosed with Sheehan's syndrome. The patient delivered at full-term 5 months prior, and experienced massive postpartum bleeding at that time. During evaluation of persistent amenorrhea, we found that her vaginal orifice was completely adhesive and obstructed. Prior to corrective surgery, we managed the patient with an oral contraceptive to induce uterine bleeding into the vaginal outflow tract. After three cycles of an oral contraceptive, we could confirm that there was no stenotic lesion in the vaginal cavity as a hematocolpos was created...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27867901/sheehan-s-syndrome-in-two-generations
#2
Bashir Ahmad Laway, Mahroosa Ramzan, Shahnaz Ahmad Mir
No abstract text is available yet for this article.
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27854159/sheehan-s-syndrome-and-sickle-cell-disease-the-story-of-natasha
#3
Barbara A Wilson, Anita Rose, Gerhard Florschutz
Sheehan's syndrome (SS) is one of the pituitary disorders caused by severe blood loss during childbirth leading to necrosis of the pituitary gland. Diagnosis is made following severe haemorrhage, failure to produce milk and failure to menstruate. Rare in countries with good obstetric care, SS is still frequent in those countries with poor healthcare services. The majority of papers published on SS do not mention psychological or neuropsychological sequelae. Of those that do, mood disorders are sometimes reported and occasionally cognitive problems are noted, typically attention, memory or executive deficits...
November 17, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27831835/imaging-of-neurologic-conditions-in-pregnant-patients
#4
Sangam Kanekar, Shante Bennett
A number of physiologic, hormonal, immunologic, and hemodynamic changes take place in the maternal body during pregnancy. The majority of these changes are essential for maintaining the normal course of pregnancy. However, these changes may also cause acute or chronic conditions that affect various biologic systems in the mother. In addition, conditions of the central and peripheral nervous systems can cause a variety of neurologic symptoms and complications. Neurologic signs and symptoms in pregnant and postpartum women may be due to the exacerbation of a preexisting medical condition, the initial manifestation of a primary central nervous system-related problem, or a neurologic problem unique to pregnancy and the postpartum period...
November 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27789188/efficacy-and-safety-of-the-glycine-transporter-type-1-inhibitor-amg-747-for-the-treatment-of-negative-symptoms-associated-with-schizophrenia
#5
Eduardo Dunayevich, Robert W Buchanan, Chao-Yin Chen, Jun Yang, Jon Nilsen, Julie M Dietrich, Hong Sun, Stephen Marder
OBJECTIVE: To determine the safety and efficacy of AMG 747, an oral inhibitor of glycine transporter type-1 (GlyT1), as an add-on to antipsychotic therapy in clinically stable people with schizophrenia with enduring negative symptoms. METHOD: Analysis of pooled data from two phase 2 studies. Adults diagnosed with schizophrenia stabilized on antipsychotic medication randomized (2:2:2:3) to orally receive daily AMG 747 (5mg, 15mg, or 40mg) or placebo. Primary endpoint was Negative Symptom Assessment (NSA)-16 total score change from baseline to week 12...
October 24, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27780154/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabour-rupture-of-membranes-before-viability
#6
Winnie Huiyan Sim, Edward Araujo Júnior, Fabricio Da Silva Costa, Penelope Marie Sheehan
AIM: To assess the contemporary maternal and neonatal outcomes following expectant management of preterm premature rupture of membranes (PPROM) prior to 24 weeks' gestation and to identify prognostic indicators of this morbid presentation. METHODS: We performed a systematic review in the Pubmed and EMBASE databases to identify the primary (perinatal mortality, severe neonatal morbidity and serious maternal morbidity) and secondary (neonatal survival and morbidity) outcomes following expectant management of previable PPROM...
October 25, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27734221/educational-and-psychosocial-support-needs-in-lynch-syndrome-implementation-and-assessment-of-an-educational-workshop-and-support-group
#7
Marina J Corines, Jada G Hamilton, Emily Glogowski, Chris A Anrig, Rachael Goldberg, Kate Niehaus, Erin Salo-Mullen, Megan Harlan, Margaret R Sheehan, Magan Trottier, Asad Ahsraf, Christina Tran, Lauren Jacobs, Rohini Rau-Murthy, Anne G Lincoln, Mark E Robson, Jose G Guillem, Arnold J Markowitz, Kenneth Offit, Zsofia K Stadler
Few reports of educational and counseling support resources exist for Lynch syndrome (LS), a disorder requiring multi-organ cancer screening and specialized medical care throughout adult life. Here we describe the development and efficacy of two resources designed to address this need, the Memorial Sloan Kettering Cancer Center Clinical Genetics Service annual Lynch Syndrome Educational Workshop (LSEW), and a quarterly Lynch Syndrome Patient Advocacy Network (LSPAN) support group. The LSEW and LSPAN were implemented beginning in 2012...
October 12, 2016: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/27728203/recurrent-hypoglycemia-and-hyponatremia-an-unusual-presentation-of-sheehan-s-syndrome
#8
Abhimanyu Uppal
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728175/delayed-presentation-of-sheehans-syndrome-a-case-report
#9
Griger Cherry Williams, V A Kothiwale
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727691/sheehan-syndrome-presenting-as-pancytopenia-divendu-bhushan
#10
Divendu Bhushan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27636931/-evaluation-of-the-therapeutic-efficacy-and-safety-of-the-selective-anxiolytic-afobazole-in-generalized-anxiety-disorder-and-adjustment-disorders-results-of-a-multicenter-randomized-comparative-study-of-diazepam
#11
T S Syunyakov, G G Neznamov
AIM: to summarize the previously published results of a multicenter randomized clinical research phase III study trial of afobazole (INN: fabomotizole) versus diazepam in the treatment of patients with generalized anxiety disorder (GAD) and adjustment disorders (AD). SUBJECTS AND METHODS: Five investigating centers included 150 patients aged 18 to 60 years (60 patients with GAD and 90 with AD) a simple structure of anxiety disorders without concurrent mental, neurological or somatic disorders...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27425780/genetic-expressions-of-thrombophilic-factors-in-patients-with-sheehan-s-syndrome
#12
Fahri Bayram, Halit Diri, Elif Funda Sener, Munis Dundar, Yasin Simsek
PURPOSE: The aim of this study was to evaluate the roles of factors associated with coagulation in the etiology and pathogenesis of Sheehan's syndrome (SS) which is a frequent cause of hypopituitarism in underdeveloped and developing regions of the world. METHODS: Mean prothrombin time (PT), activated partial thromboplastin time (APTT) and expression levels of genes, which included methylenetetrahydrofolate reductase (MTHFR), angiotensin I converting enzyme (ACE), coagulation factor V (FV), FVII, FVIII and FIX in 44 patients with SS were compared with 43 healthy subjects...
July 16, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27405776/a-primer-on-pituitary-injury-for-the-obstetrician-gynecologist-simmonds-disease-sheehan-s-syndrome-traumatic-injury-dahan-s-syndrome-pituitary-apoplexy-and-lymphocytic-hypophysitis
#13
Michael H Dahan, SeangLin Tan
The pituitary gland plays a critical role in reproduction. In response to the hypothalamus the anterior pituitary secretes prolactin, thyroid stimulating hormone (TSH), Adreno corticotropic hormone (ACTH), follicle stimulating hormone (FSH), luteinizing hormone (LH) and growth hormone. Dysregulation in these hormones often lead to reproductive failure. Multiple mechanisms of pituitary injury exist. Simmond's disease is atrophy or destruction of the anterior lobe of the pituitary gland resulting in hypopitiutaryism...
July 13, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27359291/cardiac-structural-and-functional-abnormalities-in-females-with-untreated-hypopituitarism-due-to-sheehan-syndrome-response-to-hormone-replacement-therapy
#14
Bashir Ahmad Laway, Mahroosa Ramzan, Mohd Sultan Allai, Arshad Iqbal Wani, Raiz Ahmad Misgar
OBJECTIVE: Data on cardiac abnormalities in females with untreated hypopituitarism are limited. We investigated echocardiographic abnormalities in females with untreated hypopituitarism and their response to treatment. METHODS: Twenty-three females with treatment-naïve hypopituitarism and 30 matched healthy controls were evaluated for cardiac structure and function. Echocardiographic evaluation was done at presentation and after achieving a euthyroid and eucortisol state...
September 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27252045/four-decades-without-diagnosis-sheehan-s-syndrome-a-retrospective-analysis
#15
Deniz Gokalp, Gulistan Alpagat, Alpaslan Tuzcu, Mithat Bahceci, Sadiye Tuzcu, Fatime Yakut, Azad Yildirim
AIM: Sheehan's syndrome (SS) remains a frequent cause of hypopituitarism in undeveloped and developing countries, but due to improvements in obstetric care, it is rare in developed countries. We aimed to share the results of a retrospective study analyzing the demographic, clinical, imaging, and hormonal characteristics of a large group of patients with SS, and also increase awareness of this syndrome especially in developed countries. METHODS: The medical records of 124 patients with SS patients who were followed up in the Endocrinology Department of Dicle University between 1995 and 2015 were assessed retrospectively...
June 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27227993/analysis-of-the-in-vivo-turnover-of-cd4-t-cell-subsets-in-chronically-siv-infected-sooty-mangabeys
#16
Alexandra M Ortiz, Diane G Carnathan, Joana Yu, Katherine M Sheehan, Peter Kim, Arnold Reynaldi, Thomas H Vanderford, Nichole R Klatt, Jason M Brenchley, Miles P Davenport, Guido Silvestri
Aberrant turnover of memory CD4+ T-cells is central to Acquired Immunodeficiency Syndrome (AIDS) progression. Understanding the relationship between the turnover of CD4+ subsets and immunological homeostasis during simian immunodeficiency virus (SIV) infection in natural hosts may provide insight into mechanisms of immune regulation that may serve as models for therapeutic intervention in Human Immunodeficiency Virus (HIV)-infected persons. Sooty mangabeys (SMs) have naturally evolved with SIV to avoid AIDS progression while maintaining healthy peripheral CD4+ T-cell counts and thus represent a model by which therapeutic interventions for AIDS progression might be elucidated...
2016: PloS One
https://www.readbyqxmd.com/read/27207403/restless-legs-syndrome-following-lung-transplantation-prevalence-and-relationship-with-tacrolimus-exposure
#17
Nathan J Menninga, Kalynn A Rohde, Zachary W Schlei, Krista M Katers, Ashley K Weber, Marissa M Brokhof, Donald S Hawes, Kelly L Radford, Mary L Francois, Richard D Cornwell, Ruth Benca, Mary S Hayney, John M Dopp
CONTEXT: Complications following lung transplantation are common and significantly reduce quality of life, and increase morbidity and mortality. Increasing evidence suggests sleep disorders are prevalent following lung transplantation, but factors associated with their development are not known. OBJECTIVES: We sought to evaluate the prevalence of restless legs syndrome (RLS) in a lung transplant population and determine if a relationship exists between RLS and exposure to immunosuppressant medications...
June 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27173501/quinine-and-the-abcs-of-long-qt-a-patient-s-misfortune-with-arthritis-alcoholic-beverages-and-cramps
#18
Elyce T Sheehan, Jarrod D Frizzell, Jude Gabaldon, Michael B West
A 91-year-old woman presented to the emergency department by ambulance after her family found her minimally responsive. Telemetry monitoring demonstrated episodes of non-sustained polymorphic ventricular tachycardia (PMVT) associated with significantly prolonged repolarization. Her medical history revealed that she was taking quinine or a derivative in three different forms: hydroxychloroquine, quinine sulfate (for leg cramps), and her gin mixed with tonic water (containing quinine). The present case is illustrative of classic etiologies and findings of acquired long QT syndrome, and serves as an important reminder for providers to take a complete medication history, including use of duplicative and alternative medicines and type of alcohol consumption...
October 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27114684/even-very-low-dose-hydrocortisone-might-precipitate-psychosis-in-sheehan-s-syndrome-a-need-for-caution
#19
Seshadri Sekhar Chatterjee, Sayantanava Mitra, Nitu Mallik, Malay Ghosal
No abstract text is available yet for this article.
April 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27034575/the-price-of-a-15-year-delay-in-diagnosis-of-sheehan-s-syndrome
#20
Rohan Parikh, Varun Buch, Mitesh Makwana, Harit N Buch
We describe a case of a 48-year-old woman who presented with a 15-year history of recurrent episodes of hypoglycemia and hyponatremia leading to altered behavior and generalized seizures. She underwent full clinical assessment, endocrine tests, and a pituitary magnetic resonance scan that showed pananterior hypopituitarism secondary to postpartum pituitary necrosis (Sheehan's syndrome). She was commenced on appropriate hormone replacement therapy, which led to significant improvement in lethargy, anorexia, muscle weakness, and episodes of hypoglycemia...
April 2016: Proceedings of the Baylor University Medical Center
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