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Nci community oncology research program

Richard F Dunne, Karen M Mustian, Jose M Garcia, William Dale, Reid Hayward, Breton Roussel, Mary M Buschmann, Bette J Caan, Calvin L Cole, Fergal J Fleming, Joe V Chakkalakal, David C Linehan, Aram F Hezel, Supriya G Mohile
PURPOSE OF REVIEW: Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP Research Base led a Symposium on Cancer Cachexia and Sarcopenia with goals of reviewing the state of the science, identifying knowledge gaps, and formulating research priorities in cancer cachexia through active discussion and consensus...
December 2017: Current Opinion in Supportive and Palliative Care
Connie M Szczepanek, Patricia Hurley, Marjorie J Good, Andrea Denicoff, Kelly Willenberg, Casey Dawson, Dax Kurbegov
PURPOSE: Clinical trial billing compliance is a challenge that is faced by overburdened clinical trials sites. The requirements place institutions and research sites at increased potential for financial risk. To reduce their risk, sites develop a coverage analysis (CA) before opening each trial. For multisite trials, this translates into system-wide redundancies, inconsistencies, trial delays, and potential costs to sites and patients. These factors exacerbate low accrual rates to cancer clinical trials...
June 2017: Journal of Oncology Practice
Sushil Beriwal, Hans Benson, Zach Lorinc, Amanda Barry, Kathleen Lokay
148 Background: UPMC CancerCenter and the University of Pittsburgh Cancer Institute (UPMC) created a radiation oncology CP program (now incorporated separately as Via Pathways) in 2003 to standardize care at 19 radiation sites. The program exists to ensure consistency and rapid adoption of best evidence-based care in a large, integrated NCI-designated comprehensive cancer center. METHODS: The web-based CP portal integrates with electronic medical records to provide point-of-care patient-specific decision support...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Worta McCaskill-Stevens, Deborah C Pearson, Barnett S Kramer, Leslie G Ford, Scott M Lippman
In late 2015, the NCI Division of Cancer Prevention convened cancer prevention research experts and stakeholders to discuss the current state of cancer prevention research, identify key prevention research priorities for the NCI, and identify studies that could be conducted within the NCI Community Oncology Research Program. Goals included identifying cancer prevention research opportunities offering the highest return on investment, exploring the concept of precision prevention and what is needed to advance this area of research, and identifying possible targets for prevention...
February 2017: Cancer Prevention Research
Michael E Roth, Ann M O'Mara, Nita L Seibel, David S Dickens, Anne-Marie Langevin, Brad H Pollock, David R Freyer
PURPOSE: Stagnant outcomes for adolescents and young adults (AYAs; 15 to 39 years old) with cancer are partly attributed to poor enrollment onto clinical trials. The National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) was developed to improve clinical trial participation in the community setting, where AYAs are most often treated. Further, many CCOP sites had pediatric and medical oncologists with collaborative potential for AYA recruitment and care. For these reasons, we hypothesized that CCOP sites enrolled proportionately more AYAs than non-CCOP sites onto Children's Oncology Group (COG) trials...
April 2016: Journal of Oncology Practice
Hillary Topazian, Mishka Cira, Sanford M Dawsey, Joseph Kibachio, Lillian Kocholla, Mary Wangai, Jack Welch, Makeda J Williams, Kalina Duncan, Annette Galassi
BACKGROUND: Cancer is the third leading cause of mortality in Kenya, accounting for 7% of annual deaths. The Kenyan Ministry of Health (MOH) is committed to reducing cancer mortality, as evidenced by policies such as the National Cancer Control Strategy (2011-2016). There are many Kenyan and international organizations devoted to this task; however, coordination is lacking among stakeholders, resulting in inefficient and overlapping expenditure of resources. METHODS: The MOH and the NCI Center for Global Health collaboratively executed a two day workshop to improve coordination among government, NGO, and private organizations...
March 1, 2016: Journal of Cancer Policy
Melody Besharati, Teresa Woodruff, David Victorson
PURPOSE: This qualitative study aims to characterize the factors that influence access to fertility preservation (FP) resources and services after cancer diagnosis at NCI Community Oncology Research Program (NCORP) minority/underserved community sites, which serve patient populations comprising at least 30% racial/ethnic minorities or rural residents. METHODS: Phone interviews were conducted from 2014 to 2015 with interested and knowledgeable healthcare providers practicing at NCORP minority/underserved community sites, using a semi-structured interview guide...
June 2016: Journal of Adolescent and Young Adult Oncology
Eileen P Dimond, Robin T Zon, Bryan J Weiner, Diane St Germain, Andrea M Denicoff, Kandie Dempsey, Angela C Carrigan, Randall W Teal, Marjorie J Good, Worta McCaskill-Stevens, Stephen S Grubbs, Eileen P Dimond, Robin T Zon, Bryan J Weiner, Diane St Germain, Andrea M Denicoff, Kandie Dempsey, Angela C Carrigan, Randall W Teal, Marjorie J Good, Worta McCaskill-Stevens, Stephen S Grubbs
PURPOSE: Several publications have described minimum standards and exemplary attributes for clinical trial sites to improve research quality. The National Cancer Institute (NCI) Community Cancer Centers Program (NCCCP) developed the clinical trial Best Practice Matrix tool to facilitate research program improvements through annual self-assessments and benchmarking. The tool identified nine attributes, each with three progressive levels, to score clinical trial infrastructural elements from less to more exemplary...
January 2016: Journal of Oncology Practice
James Lloyd Wade, Nicholas J Petrelli, Worta McCaskill-Stevens
Over the last 40 years the National Cancer Institute (NCI) has created a vibrant public-private partnership for the implementation of NCI-sponsored cooperative group (Network) clinical trials throughout the United States and Canada. Over these four decades, the cancer clinical trials process has become more complex more precise and more resource intensive. During this same time period, financial resources to support the NCI community research initiative have become more constrained. The newest manifestation of NCI-sponsored community based cancer clinical trial research, known as the National Community Oncology Research Program (NCORP) began initial operation August 1, 2014...
October 2015: Seminars in Oncology
Carrie Printz
No abstract text is available yet for this article.
October 15, 2014: Cancer
Robin T Zon
Community research has been an integral and influential component of the National Research Program since the late 1970s. Institutionalization of community research in the Community Clinical Oncology Program (CCOP) has resulted in successful collaborations, meaningful accrual, achievement of quality standards, and translation of research into clinical practice. Although the national clinical trial system is undergoing modernization and improvement, the success of the CCOP and minority-based CCOP in cancer treatment, prevention, and control research is being extended to include cancer care delivery research in the newly created National Cancer Institute (NCI) Community Oncology Research Program...
2014: American Society of Clinical Oncology Educational Book
Sara R Jacobs, Bryan J Weiner, Alicia C Bunger
BACKGROUND: It has been noted that implementation climate is positively associated with implementation effectiveness. However, issues surrounding the measurement of implementation climate, or the extent to which organizational members perceive that innovation use is expected, supported and rewarded by their organization remain. Specifically, it is unclear whether implementation climate can be measured as a global construct, whether individual or group-referenced items should be used, and whether implementation climate can be assessed at the group or organizational level...
2014: Implementation Science: IS
Kathy Klinger, Cesar Figueras, Kathleen M Beney, Jane M Armer, Sharon Levy
OBJECTIVES: To describe the Community Clinical Oncology Programs (CCOPs), identify the roles and functions of CCOP nurses in clinical trials, and discuss the future contributions of nurses in the National Cancer Institute (NCI) Community Oncology Research Program. DATA SOURCES: Research and review articles, Web sites, and government reports. CONCLUSION: The contribution of nurses in the community clinical research setting has not been defined or quantified; however, examination of the literature reveals substantial contributions from nurses in the conduct and dissemination of oncology research...
February 2014: Seminars in Oncology Nursing
Tali M Johnson, Matthew J Boron
BACKGROUND: The National Cancer Institute's (NCI) Division of Cancer Treatment and Diagnosis (DCTD), as an investigational new drug sponsor, may provide early access to investigational agents for treatment use. Until recently, the NCI had 3 protocol mechanisms for distributing investigational agents through the Treatment Referral Center (TRC), a service provided by the Pharmaceutical Management Branch (PMB) within the Cancer Therapy Evaluation Program of the NCI's DCTD. The first mechanism is the Group C protocol, the second mechanism is the TRC protocol, and the third, and most common, mechanism is the Special Exception protocol...
December 2012: Journal of Hematology Oncology Pharmacy
Stephen S Grubbs
The National Cancer Institute (NCI) Cooperative Group Program has been reviewed by three published studies in the last 7 years evaluating the efficiency and effectiveness of this national oncology clinical trials system. The recommendations for improvement from these reports have prompted NCI to transform the Cooperative Group Program into a new NCI National Clinical Trials Network (NCTN) to improve the efficiency of large clinical trials and increase the speed of cancer translational research. The new NCTN offers community-based clinical investigators new opportunities to advance cancer research in their community setting but also presents challenges in promoting community-based research...
2012: American Society of Clinical Oncology Educational Book
Anne-Marie Meyer, Katherine E Reeder-Hayes, Huan Liu, Stephanie B Wheeler, Dolly Penn, Bryan J Weiner, William R Carpenter
BACKGROUND: Practice-based research networks (PBRNs) are promising for accelerating not only research, but also dissemination of research-based evidence into broader community practice. Sentinel lymph node biopsy (SLNB) is an innovation in breast cancer care associated with equivalent survival and lower morbidity, as compared with standard axillary lymph node dissection. We examined the diffusion of SLNB into practice and whether affiliation with the Community Clinical Oncology Program (CCOP), a cancer-focused PBRN, was associated with more rapid uptake of SLNB...
September 2013: Medical Care
Worta McCaskill-Stevens, Alan P Lyss, Marge Good, Thomas Marsland, Rogerio Lilenbaum
Research in the community setting is essential for the translation of advances in cancer research into practice and improving cancer care for all populations. The National Cancer Institute is proposing a new community-based program, NCI Community Oncology Research Program (NCORP), which is the alignment of two existing programs, the Community Clinical Oncology Program, Minority-Based Community Clinical Oncology Program, and their Research Bases, and the National Cancer Institute's Community Cancer Centers Program...
2013: American Society of Clinical Oncology Educational Book
Bryan J Weiner, Sara R Jacobs, Lori M Minasian, Marjorie J Good
PURPOSE: To examine the organizational design features that were consistently associated in 2010 with high levels of patient enrollment onto National Cancer Institute (NCI) cancer treatment trials among the oncology practices and hospitals participating in the NCI Community Clinical Oncology Program (CCOP). METHODS: Fuzzy-set qualitative comparative analysis was used to identify the recipes (ie, combinations of organizational design features) that CCOPs used to achieve high levels of patient enrollment onto NCI treatment trials in 2010...
September 2012: Journal of Oncology Practice
William R Carpenter, Seth Tyree, Yang Wu, Anne-Marie Meyer, Lisa DiMartino, Leah Zullig, Paul A Godley
BACKGROUND: The Institute of Medicine (IOM) has recommended that each person with cancer should have access to clinical trials, which have been associated with improving care quality and disparities. With no effective enrollment monitoring system, patterns of trial enrollment remain unclear. PURPOSE: We developed a population-based, statewide system designed to facilitate monitoring of cancer trial enrollment and targeting of future interventions to improve it. METHODS: Person-level cancer incidence data from the North Carolina Central Cancer Registry (NCCCR), person-level treatment trial accrual data from the National Cancer Institute (NCI), and county-level Area Resource Files (ARF) measures for 12 years, 1996-2007, were studied...
August 2012: Clinical Trials: Journal of the Society for Clinical Trials
Shellie D Ellis, William R Carpenter, Lori M Minasian, Bryan J Weiner
Thirty-five U.S. states and territories have implemented policies requiring insurers to cover patient care costs in the context of cancer clinical trials; however, evidence of the effectiveness of these policies is limited. This study assesses the impact of state insurance mandates on clinical trial accrual among community-based practices participating in the NCI Community Clinical Oncology Program (CCOP), which enrolls approximately one-third of all NCI cancer trial participants. We analyzed CCOP clinical trial enrollment over 17 years in 37 states, 14 of which implemented coverage policies, using fixed effects least squares regression to estimate the effect of state policies on trial accrual among community providers, controlling for state and CCOP differences in capacity to recruit...
September 2012: Contemporary Clinical Trials
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