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Julie Ryan Wolf, Charles E Heckler, Joseph J Guido, Anita R Peoples, Jennifer S Gewandter, Marilyn Ling, Vincent P Vinciguerra, Thomas Anderson, Lisa Evans, James Wade, Alice P Pentland, Gary R Morrow
PURPOSE: Despite advances in medical technology, radiation dermatitis occurs in 95% of patients receiving radiation therapy (RT) for cancer. Currently, there is no standard and effective treatment for the prevention or control of radiation dermatitis. The goal of the study was to determine the efficacy of oral curcumin, one of the biologically active components in turmeric, at reducing radiation dermatitis severity (RDS) at the end of RT, using the RDS scale, compared to placebo. METHODS: This was a multisite, randomized, double-blinded, placebo-controlled trial of 686 breast cancer patients...
December 1, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ruth C Carlos, JoRean D Sicks, George J Chang, Alan P Lyss, Teresa L Stewart, Lillian Sung, Kathryn E Weaver
PURPOSE: Cancer care spans the spectrum from screening and diagnosis through therapy and into survivorship. Delivering appropriate care requires patient transitions across multiple specialties, such as primary care, radiology, and oncology. From the program's inception, the National Cancer Institute Community Oncology Research Program (NCORP) sites were tasked with conducting cancer care delivery research (CCDR) that evaluates structural, organizational, and social factors, including care transitions that determine patient outcomes...
December 2017: Journal of the American College of Radiology: JACR
Richard F Dunne, Karen M Mustian, Jose M Garcia, William Dale, Reid Hayward, Breton Roussel, Mary M Buschmann, Bette J Caan, Calvin L Cole, Fergal J Fleming, Joe V Chakkalakal, David C Linehan, Aram F Hezel, Supriya G Mohile
PURPOSE OF REVIEW: Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP Research Base led a Symposium on Cancer Cachexia and Sarcopenia with goals of reviewing the state of the science, identifying knowledge gaps, and formulating research priorities in cancer cachexia through active discussion and consensus...
December 2017: Current Opinion in Supportive and Palliative Care
Connie M Szczepanek, Patricia Hurley, Marjorie J Good, Andrea Denicoff, Kelly Willenberg, Casey Dawson, Dax Kurbegov
PURPOSE: Clinical trial billing compliance is a challenge that is faced by overburdened clinical trials sites. The requirements place institutions and research sites at increased potential for financial risk. To reduce their risk, sites develop a coverage analysis (CA) before opening each trial. For multisite trials, this translates into system-wide redundancies, inconsistencies, trial delays, and potential costs to sites and patients. These factors exacerbate low accrual rates to cancer clinical trials...
June 2017: Journal of Oncology Practice
T Giaddui, N Li, K Curry, K Moore, L Mell, C Leath, C Kunos, Y Xiao
PURPOSE: To establish a workflow for NRG-GY006 IMRT pre-treatment reviews, incorporating advanced radiotherapy technologies being evaluated as part of the clinical trial. METHODS: Pre-Treatment reviews are required for every IMRT case as part of NRG-GY006 (a randomized phase II trial of radiation therapy and cisplatin alone or in combination with intravenous triapine in women with newly diagnosed bulky stage I B2, stage II, IIIB, or IVA cancer of the uterine cervix or stage II-IVA vaginal cancer...
June 2016: Medical Physics
Anita R Peoples, Joseph A Roscoe, Robert C Block, Charles E Heckler, Julie L Ryan, Karen M Mustian, Michelle C Janelsins, Luke J Peppone, Dennis F Moore, Charlotte Coles, Karen L Hoelzer, Gary R Morrow, Ann M Dozier
PURPOSE: Cancer-related fatigue (CRF) is a prevalent and distressing side effect of cancer and its treatment that remains inadequately understood and poorly managed. A better understanding of the factors contributing to CRF could result in more effective strategies for the prevention and treatment of CRF. The objectives of this study were to examine the prevalence, severity, and potential predictors for the early onset of CRF after chemotherapy cycle 1 in breast cancer patients. METHODS: We report on a secondary data analysis of 548 female breast cancer patients from a phase III multi-center randomized controlled trial examining antiemetic efficacy...
April 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Worta McCaskill-Stevens, Deborah C Pearson, Barnett S Kramer, Leslie G Ford, Scott M Lippman
In late 2015, the NCI Division of Cancer Prevention convened cancer prevention research experts and stakeholders to discuss the current state of cancer prevention research, identify key prevention research priorities for the NCI, and identify studies that could be conducted within the NCI Community Oncology Research Program. Goals included identifying cancer prevention research opportunities offering the highest return on investment, exploring the concept of precision prevention and what is needed to advance this area of research, and identifying possible targets for prevention...
February 2017: Cancer Prevention Research
Matthew Asare, Luke J Peppone, Joseph A Roscoe, Ian R Kleckner, Karen M Mustian, Charles E Heckler, Joseph J Guido, Mark Sborov, Peter Bushunow, Adedayo Onitilo, Charles Kamen
Before treatment, cancer patients need information about side effects and prognosis, while after treatment they need information to transition to survivorship. Research documenting these needs is limited, especially among racial and ethnic minorities. This study evaluated cancer patients' needs according to race both before and after treatment. We compared white (nā€‰=ā€‰904) to black (nā€‰=ā€‰52) patients receiving treatment at 17 National Cancer Institute Community Oncology Research Program (NCORP) sites on their cancer-related concerns and need for information before and after cancer treatment...
February 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Michael E Roth, Ann M O'Mara, Nita L Seibel, David S Dickens, Anne-Marie Langevin, Brad H Pollock, David R Freyer
PURPOSE: Stagnant outcomes for adolescents and young adults (AYAs; 15 to 39 years old) with cancer are partly attributed to poor enrollment onto clinical trials. The National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) was developed to improve clinical trial participation in the community setting, where AYAs are most often treated. Further, many CCOP sites had pediatric and medical oncologists with collaborative potential for AYA recruitment and care. For these reasons, we hypothesized that CCOP sites enrolled proportionately more AYAs than non-CCOP sites onto Children's Oncology Group (COG) trials...
April 2016: Journal of Oncology Practice
Melody Besharati, Teresa Woodruff, David Victorson
PURPOSE: This qualitative study aims to characterize the factors that influence access to fertility preservation (FP) resources and services after cancer diagnosis at NCI Community Oncology Research Program (NCORP) minority/underserved community sites, which serve patient populations comprising at least 30% racial/ethnic minorities or rural residents. METHODS: Phone interviews were conducted from 2014 to 2015 with interested and knowledgeable healthcare providers practicing at NCORP minority/underserved community sites, using a semi-structured interview guide...
June 2016: Journal of Adolescent and Young Adult Oncology
James Lloyd Wade, Nicholas J Petrelli, Worta McCaskill-Stevens
Over the last 40 years the National Cancer Institute (NCI) has created a vibrant public-private partnership for the implementation of NCI-sponsored cooperative group (Network) clinical trials throughout the United States and Canada. Over these four decades, the cancer clinical trials process has become more complex more precise and more resource intensive. During this same time period, financial resources to support the NCI community research initiative have become more constrained. The newest manifestation of NCI-sponsored community based cancer clinical trial research, known as the National Community Oncology Research Program (NCORP) began initial operation August 1, 2014...
October 2015: Seminars in Oncology
Carrie Printz
No abstract text is available yet for this article.
October 15, 2014: Cancer
Worta McCaskill-Stevens, Alan P Lyss, Marge Good, Thomas Marsland, Rogerio Lilenbaum
Research in the community setting is essential for the translation of advances in cancer research into practice and improving cancer care for all populations. The National Cancer Institute is proposing a new community-based program, NCI Community Oncology Research Program (NCORP), which is the alignment of two existing programs, the Community Clinical Oncology Program, Minority-Based Community Clinical Oncology Program, and their Research Bases, and the National Cancer Institute's Community Cancer Centers Program...
2013: American Society of Clinical Oncology Educational Book
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