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https://www.readbyqxmd.com/read/29684324/taxonomic-distribution-structure-function-relationship-and-metabolic-context-of-the-two-families-of-sulfide-dehydrogenases-sqr-and-fcsd
#1
Filipe M Sousa, Juliana G Pereira, Bruno C Marreiros, Manuela M Pereira
Hydrogen sulfide (H2 S) is a versatile molecule with different functions in living organisms: it can work as a metabolite of sulfur and energetic metabolism or as a signaling molecule in higher Eukaryotes. H2 S is also highly toxic since it is able to inhibit heme cooper oxygen reductases, preventing oxidative phosphorylation. Due to the fact that it can both inhibit and feed the respiratory chain, the immediate role of H2 S on energy metabolism crucially relies on its bioavailability, meaning that studying the central players involved in the H2 S homeostasis is key for understanding sulfide metabolism...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29682323/granulocyte-macrophage-colony-stimulating-factor-negatively-regulates-early-il-10-mediated-responses
#2
Ruud Hp Wilbers, Lotte B Westerhof, Debbie R van Raaij, Jaap Bakker, Geert Smant, Arjen Schots
Aim: Treatment of inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. IL-10 is a cytokine with therapeutic potential, but until now has not been as successful as previously anticipated. A reason for this may be that IL-10 responsiveness depends on the environment of the inflamed tissue. In this study we investigated whether GM-CSF is able to influence IL-10-mediated responses. Methodology: Dendritic cells and macrophages were differentiated from mouse bone marrow and treated or depleted from GM-CSF prior to analyze their response to IL-10...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29682315/insulin-therapy-for-type-2-diabetes-are-we-there-yet-the-d-nav%C3%A2-story
#3
I Hodish
Insulin replacement therapy is mostly used by patients with type 2 diabetes who become insulin deficient and have failed other therapeutic options. They comprise about a quarter of those with diabetes, endures the majority of the complications and consumes the majority of the resources. Adequate insulin replacement therapy can prevent complications and reduce expenses, as long as therapy goals are achieved and maintained. Sadly, these therapy goals are seldom achieved and outcomes have not improved for decades despite advances in pharmacotherapy and technology...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29676439/oral-and-sublingual-immunotherapy-for-egg-allergy
#4
REVIEW
Olga Romantsik, Maria Angela Tosca, Simona Zappettini, Maria Grazia Calevo
BACKGROUND: Clinical egg allergy is a common food allergy. Current management relies upon strict allergen avoidance. Oral immunotherapy might be an optional treatment, through desensitization to egg allergen. OBJECTIVES: To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with immunoglobulin E (IgE)-mediated egg allergy as compared to a placebo treatment or an avoidance strategy. SEARCH METHODS: We searched 13 databases for journal articles, conference proceedings, theses and trials registers using a combination of subject headings and text words (last search 31 March 2017)...
April 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29676063/development-and-internal-validation-of-a-side-specific-multiparametric-mri-based-nomogram-for-the-prediction-of-extracapsular-extension-of-prostate-cancer
#5
Alberto Martini, Akriti Gupta, Sara C Lewis, Shivaram Cumarasamy, Kenneth G Haines, Alberto Briganti, Francesco Montorsi, Ash K Tewari
OBJECTIVES: To develop a nomogram for predicting side-specific extracapsular extension (ECE) for planning nerve sparing radical prostatectomy (NSRP). MATERIALS AND METHODS: We retrospectively analyzed data from 561 patients who underwent robot-assisted radical prostatectomy between February 2014 and October 2015. To develop a side-specific predictive model, we considered the prostatic lobes separately. Four variables were included: PSA, highest ipsilateral biopsy Gleason grade, highest ipsilateral percentage core involvement and ECE on multiparametric MRI (mpMRI)...
April 19, 2018: BJU International
https://www.readbyqxmd.com/read/29674784/bat-wing-biometrics-using-collagen-elastin-bundles-in-bat-wings-as-a-unique-individual-identifier
#6
Sybill K Amelon, Sarah E Hooper, Kathryn M Womack
The ability to recognize individuals within an animal population is fundamental to conservation and management. Identification of individual bats has relied on artificial marking techniques that may negatively affect the survival and alter the behavior of individuals. Biometric systems use biological characteristics to identify individuals. The field of animal biometrics has expanded to include recognition of individuals based upon various morphologies and phenotypic variations including pelage patterns, tail flukes, and whisker arrangement...
May 29, 2017: Journal of Mammalogy
https://www.readbyqxmd.com/read/29671722/the-complete-replicons-of-16-ensifer-meliloti-strains-offer-insights-into-intra-and-inter-replicon-gene-transfer-transposon-associated-loci-and-repeat-elements
#7
Matthew Nelson, Joseph Guhlin, Brendan Epstein, Peter Tiffin, Michael J Sadowsky
Ensifer meliloti (formerly Rhizobium meliloti and Sinorhizobium meliloti) is a model bacterium for understanding legume-rhizobial symbioses. The tripartite genome of E. meliloti consists of a chromosome, pSymA and pSymB, and in some instances strain-specific accessory plasmids. The majority of previous sequencing studies have relied on the use of assemblies generated from short read sequencing, which leads to gaps and assembly errors. Here we used PacBio-based, long-read assemblies and were able to assemble, de novo, complete circular replicons...
April 19, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29670871/echocardiographic-evaluation-of-ventricular-function-for-the-neonatologist-and-pediatric-intensivist
#8
REVIEW
Cécile Tissot, Yogen Singh, Nicole Sekarski
In the neonatal and pediatric intensive care setting, bedside cardiac ultrasound is often used to assess ventricular dimensions and function. Depending upon the underlying disease process, it is necessary to be able to evaluate the systolic and diastolic function of left and or right ventricles. The systolic function of left ventricle is mostly assessed qualitatively on visual inspection "eye-balling" and quantitatively by measuring circumferential fraction shortening or calculating the ejection fraction by Simpson's planimetry...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29670411/formative-usability-evaluation-of-a-fixed-dose-pen-injector-platform-device
#9
Jakob Lange, Tobias Nemeth
Background: This article for the first time presents a formative usability study of a fixed-dose pen injector platform device used for the subcutaneous delivery of biopharmaceuticals, primarily for self-administration by the patient. The study was conducted with a user population of both naïve and experienced users across a range of ages. The goals of the study were to evaluate whether users could use the devices safely and effectively relying on the instructions for use (IFU) for guidance, as well as to benchmark the device against another similar injector established in the market...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29669461/connected-speech-and-language-in-mild-cognitive-impairment-and-alzheimer-s-disease-a-review-of-picture-description-tasks
#10
Kimberly D Mueller, Bruce Hermann, Jonilda Mecollari, Lyn S Turkstra
INTRODUCTION: The neuropsychological profile of people with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia includes a history of decline in memory and other cognitive domains, including language. While language impairments have been well described in AD dementia, language features of MCI are less well understood. Connected speech and language analysis is the study of an individual's spoken discourse, usually elicited by a target stimulus, the results of which can facilitate understanding of how language deficits typical of MCI and AD dementia manifest in everyday communication...
April 19, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29665110/illusion-thermotics
#11
Run Hu, Shuling Zhou, Ying Li, Dang-Yuan Lei, Xiaobing Luo, Cheng-Wei Qiu
"Fata Morgana" or "Mirage" phenomena have long been captivated as optical illusions, which actually relies on gradient-density air or vapor. Man-made optical illusions have witnessed significant progress by resorting to artificially structured metamaterials. Nevertheless, two long-standing challenges remain formidable: first, exotic parameters (negative or less than unity) become inevitable; second, the signature of original object is altered to that of a virtual counterpart. It is thus not able to address the holy grail of illusion per se, since a single virtual object still exposes the location...
April 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29660052/side-to-side-and-end-to-side-double-anastomosis-using-the-parietal-branch-of-the-superficial-temporal-artery-a-novel-technique-for-extracranial-to-intracranial-bypass-surgery-3-dimensional-operative-video
#12
Gregory D Arnone, Ziad A Hage, Fady T Charbel
In this 3-dimensional video, we perform a side-to-side and end-to-side double anastomosis using the parietal-branch of the superficial temporal artery (STA) to provide flow augmentation in a symptomatic 59-yr-old male with bilateral internal carotid artery occlusion at the origin, and left M1 segment occlusion. The patient suffered multiple left hemispheric strokes despite maximal medical therapy and was found to have poor hemodynamic reserve in the left hemisphere during evaluation with regional and global blood oxygenation level-dependent functional magnetic resonance imaging with CO2-challenge as well as quantitative magnetic resonance angiography and noninvasive optimal vessel analysis pre- and post-acetazolamide challenge...
April 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29653395/learning-physical-parameters-from-dynamic-scenes
#13
Tomer D Ullman, Andreas Stuhlmüller, Noah D Goodman, Joshua B Tenenbaum
Humans acquire their most basic physical concepts early in development, and continue to enrich and expand their intuitive physics throughout life as they are exposed to more and varied dynamical environments. We introduce a hierarchical Bayesian framework to explain how people can learn physical parameters at multiple levels. In contrast to previous Bayesian models of theory acquisition (Tenenbaum, Kemp, Griffiths, & Goodman, 2011), we work with more expressive probabilistic program representations suitable for learning the forces and properties that govern how objects interact in dynamic scenes unfolding over time...
April 10, 2018: Cognitive Psychology
https://www.readbyqxmd.com/read/29649208/assessing-the-durability-and-efficiency-of-landscape-based-strategies-to-deploy-plant-resistance-to-pathogens
#14
Loup Rimbaud, Julien Papaïx, Jean-François Rey, Luke G Barrett, Peter H Thrall
Genetically-controlled plant resistance can reduce the damage caused by pathogens. However, pathogens have the ability to evolve and overcome such resistance. This often occurs quickly after resistance is deployed, resulting in significant crop losses and a continuing need to develop new resistant cultivars. To tackle this issue, several strategies have been proposed to constrain the evolution of pathogen populations and thus increase genetic resistance durability. These strategies mainly rely on varying different combinations of resistance sources across time (crop rotations) and space...
April 12, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29649149/vehicular-visible-light-networks-for-urban-mobile-crowd-sensing
#15
Barbara M Masini, Alessandro Bazzi, Alberto Zanella
Crowd sensing is a powerful tool to map and predict interests and events. In the future, it could be boosted by an increasing number of connected vehicles sharing information and intentions. This will be made available by on board wireless connected devices able to continuously communicate with other vehicles and with the environment. Among the enabling technologies, visible light communication (VLC) represents a low cost solution in the short term. In spite of the fact that vehicular communications cannot rely on the sole VLC due to the limitation provided by the light which allows communications in visibility only, VLC can however be considered to complement other wireless communication technologies which could be overloaded in dense scenarios...
April 12, 2018: Sensors
https://www.readbyqxmd.com/read/29643135/arthroscopic-reduction-and-fixation-of-a-lateral-inverted-osteochondral-fracture-of-the-talus-lift
#16
Joao Teixeira, Manuel Carvalho, António Torres, Nuno Tavares
Some ankle sprains hide important lesions beyond the classic lateral ligament complex injuries. The lateral inverted osteochondral fracture of the talus (LIFT) represents a rare osteochondral lesion, whose diagnosis relies on a high clinical suspicion followed by correct image study interpretation. We present a successful arthroscopic fixation of a LIFT lesion in a 45-year-old active man. At 8 months follow-up, the patient was pain free and able to return to his daily activities without limitation. The imagiological study showed osteochondral fragment consolidation with no signs of hardware failure...
April 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29628883/achieving-accurate-automatic-sleep-staging-on-manually-pre-processed-eeg-data-through-synchronization-feature-extraction-and-graph-metrics
#17
Panteleimon Chriskos, Christos A Frantzidis, Polyxeni T Gkivogkli, Panagiotis D Bamidis, Chrysoula Kourtidou-Papadeli
Sleep staging, the process of assigning labels to epochs of sleep, depending on the stage of sleep they belong, is an arduous, time consuming and error prone process as the initial recordings are quite often polluted by noise from different sources. To properly analyze such data and extract clinical knowledge, noise components must be removed or alleviated. In this paper a pre-processing and subsequent sleep staging pipeline for the sleep analysis of electroencephalographic signals is described. Two novel methods of functional connectivity estimation (Synchronization Likelihood/SL and Relative Wavelet Entropy/RWE) are comparatively investigated for automatic sleep staging through manually pre-processed electroencephalographic recordings...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29627221/fluorescence-microscopy-of-h-e-stained-cervical-biopsies-to-assist-the-diagnosis-and-grading-of-cin
#18
REVIEW
Mario R Castellanos, Vijeyaluxmy Motilal Nehru, Edyta C Pirog, Lynne Optiz
BACKGROUND: Prevention of cervical cancer is based upon the accurate diagnosis and grading of cervical lesions identified during screening. The pathological classification of cervical intraepithelial neoplasia (CIN) is problematic, as it relies on subjective criteria and is known to have high interobserver variability and low reproducibility. These limitations can result in either over or under treatment of patients. Biomarkers to improve CIN diagnosis have not overcome all these challenges...
March 26, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29618088/cell-wall-synthesis-and-ribosome-maturation-are-co-regulated-by-an-rna-switch-in-mycobacterium-tuberculosis
#19
Stefan Schwenk, Alexandra Moores, Irene Nobeli, Timothy D McHugh, Kristine B Arnvig
The success of Mycobacterium tuberculosis relies on the ability to switch between active growth and non-replicating persistence, associated with latent TB infection. Resuscitation promoting factors (Rpfs) are essential for the transition between these states. Rpf expression is tightly regulated as these enzymes are able to degrade the cell wall, and hence potentially lethal to the bacterium itself. We have identified a regulatory element in the 5' untranslated region (UTR) of rpfB. We demonstrate that this element is a transcriptionally regulated RNA switch/riboswitch candidate, which appears to be restricted to pathogenic mycobacteria, suggesting a role in virulence...
March 29, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29615903/adenosine-a-2a-receptor-blockade-modulates-glucocorticoid-induced-morphological-alterations-in-axons-but-not-in-dendrites-of-hippocampal-neurons
#20
Helena Pinheiro, Rita Gaspar, Filipa I Baptista, Carlos A Fontes-Ribeiro, António F Ambrósio, Catarina A Gomes
The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the susceptibility to neuropsychiatric disorders. Dexamethasone, an exogenous glucocorticoid widely used in pregnant women in risk of preterm delivery, is associated with higher rates of neuropsychiatric conditions throughout life of the descendants. In animal models, prenatal dexamethasone exposure leads to anxious-like behavior and increased susceptibility to depressive-like behavior in adulthood, concomitant with alterations in neuronal morphology in brain regions implicated in the control of emotions and mood...
2018: Frontiers in Pharmacology
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