Read by QxMD icon Read

rely able

Johanna Block, Hannes Witt, Andrea Candelli, Jordi Cabanas Danes, Erwin J G Peterman, Gijs J L Wuite, Andreas Janshoff, Sarah Köster
Structure and dynamics of living matter rely on design principles fundamentally different from concepts of traditional material science. Specialized intracellular filaments in the cytoskeleton permit living systems to divide, migrate, and grow with a high degree of variability and durability. Among the three filament systems, microfilaments, microtubules, and intermediate filaments (IFs), the physical properties of IFs and their role in cellular mechanics are the least well understood. We use optical trapping of individual vimentin filaments to investigate energy dissipation, strain history dependence, and creep behavior of stretched filaments...
June 2018: Science Advances
Patrick Fernandes Rodrigues, Llucia Alberti-Servera, Anna Eremin, Gary E Grajales-Reyes, Robert Ivanek, Roxane Tussiwand
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R+ lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch...
June 20, 2018: Nature Immunology
Pierre E Galand, Olivier Pereira, Corentin Hochart, Jean Christophe Auguet, Didier Debroas
Marine microbes have tremendous diversity, but a fundamental question remains unanswered: why are there so many microbial species in the sea? The idea of functional redundancy for microbial communities has long been assumed, so that the high level of richness is often explained by the presence of different taxa that are able to conduct the exact same set of metabolic processes and that can readily replace each other. Here, we refute the hypothesis of functional redundancy for marine microbial communities by showing that a shift in the community composition altered the overall functional attributes of communities across different temporal and spatial scales...
June 20, 2018: ISME Journal
Troy David Loeffler, Henry Chan, Badri Narayanan, Mathew J Cherukara, Stephen K Gray, Subramanian K R S Sankaranarayanan
Coarse-grained molecular dynamics (MD) simulations represent a powerful approach to simulate longer time scale and larger length scale phenomena than those accessible to all-atom models. The gain in efficiency, however, comes at the cost of atomistic details. The reverse transformation, also known as back-mapping, of coarse grained beads into their atomistic constituents represents a major challenge. Most existing approaches are limited to specific molecules or specific force-fields and often rely on running a long time atomistic MD of the back-mapped configuration to arrive at an optimal solution...
June 20, 2018: Journal of Physical Chemistry. B
Thierry Nazzi, Linda Polka
The current study used an object manipulation task to explore whether infants rely more on consonant information than on vowel information when learning new words even when the words start with a vowel. Canadian French-learning 20-month-olds, who were taught pairs of new vowel-initial words contrasted either on their initial vowel (opsi/eupsi) or following consonant (oupsa/outsa), were found to have learned the words only in the consonant condition and performed significantly better in the consonant condition than in the vowel condition...
June 16, 2018: Journal of Experimental Child Psychology
Thomas Pirzer, Kira-Sophie Becher, Marcel Rieker, Tobias Meckel, Henning D Mootz, Harald Kolmar
Cell targeting protein toxins have gained increasing interest for cancer therapy, aimed at increasing the therapeutic window and to reduce systemic toxicity. Since recombinant expression of immunotoxins consisting of a receptor-binding and a cell-killing moiety is hampered by their high toxicity in an eukaryotic production host, most applications rely on recombinant production of fusion proteins consisting of an antibody fragment and a protein toxin in bacterial hosts such as Escherichia coli (E. coli). These fusions often lack beneficial properties of whole antibodies like extended serum half-life or efficient endocytic uptake via receptor clustering...
June 19, 2018: ACS Chemical Biology
Marta Ponari, Courtenay Frazier Norbury, Armand Rotaru, Alessandro Lenci, Gabriella Vigliocco
Some explanations of abstract word learning suggest that these words are learnt primarily from the linguistic input, using statistical co-occurrences of words in language, whereas concrete words can also rely on non-linguistic, experiential information. According to this hypothesis, we expect that, if the learner is not able to fully exploit the information in the linguistic input, abstract words should be affected more than concrete ones. Embodied approaches instead argue that both abstract and concrete words can rely on experiential information and, therefore, there might not be any linguistic primacy...
August 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Lorenzo Ugga, Valeria Romeo, Enrico Tedeschi, Arturo Brunetti, Mario Quarantelli
Iron oxide (IO) nanocolloids are being increasingly used to image cellular contribution to neuroinflammation using MRI, as these particles are capable of labeling circulating cells with phagocytic activity, allowing to assess cell trafficking from the blood to neuroinflammation sites. The use of IOs relies on the natural phagocytic properties of immune cells, allowing their labeling either in vitro or directly in vivo, following intravenous injection. Despite concerns on the specificity of the latter approach, the widespread availability and relatively low cost of these techniques, coupled to a sensitivity that allows to reach single cell detection, have promoted their use in several preclinical and clinical studies...
June 15, 2018: Journal of Neuroscience Methods
Simon G Potts, Peter Neumann, Bernard Vaissière, Nicolas J Vereecken
The notion that robotic crop pollination will solve the decline in pollinators has gained wide popularity recently (Fig. 1), and in March 2018 Walmart filed a patent for autonomous robot bees. However, w present six arguments showing that this is a technically and economically inviable 'solution' at present and poses substantial ecological and moral risks: (1) despite recent advances, robotic pollination is far from being able to replace bees to pollinate crops efficiently; (2) using robots is very unlikely to be economically viable; (3) there would be unacceptably high environmental costs; (4) wider ecosystems would be damaged; (5) it would erode the values of biodiversity; and, (6) relying on robotic pollination could actually lead to major food insecurity...
June 14, 2018: Science of the Total Environment
C E Starrett
Modeling high-temperature (tens or hundreds of eV), dense plasmas is challenging due to the multitude of non-negligible physical effects including significant partial ionization and multisite effects. These effects cause the breakdown or intractability of common methods and approximations used at low temperatures, such as pseudopotentials or plane-wave basis sets. Here we explore the Korringa-Kohn-Rostoker Green's function method at these high-temperature conditions. The method is all electron, does not rely on pseudopotentials, and uses a spherical harmonic basis set, and so avoids the aforementioned limitations...
May 2018: Physical Review. E
Katharine J McCarthy, Ann K Blanc, Charlotte E Warren, Brian Mdawida
Background: Despite the concentration of maternal and infant deaths in the early postnatal period, information on the content and quality of postnatal care interventions is not routinely collected in most low and middle-income countries. At present, data on the coverage of postnatal care interventions mostly rely on women's reports collected in household surveys, such as the Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS), which collect limited information...
June 2018: Journal of Global Health
Vladimir Mouraviev, Michael McDonald
INTRODUCTION: The changing face of current infection phenotypes from planktonic to biofilm type has been developed implicating bacterial biofilms in recurrent infection. To date, no specific medical treatment exists to specifically target biofilms in the human host. Similarly, the identification of a biofilm has relied upon the analysis of tissue samples with electron microscopy or DNA identification with polymerase chain reaction (PCR) and sequencing. Standard culture and sensitivity test is not able to detect a presence of biofilms...
June 2018: Canadian Journal of Urology
Chris J Holderman, Daniel R Swale, Jeffery R Bloomquist, Phillip E Kaufman
Horn flies, Haematobia irritans , a major cattle pest in the USA, cause substantial economic losses and current control methods rely heavily on insecticides. Three horn fly populations were evaluated for insecticide susceptibility to permethrin, β-cyfluthrin, and diazinon. Susceptibility was variable by population, with the greatest resistance exhibited by a 66-fold resistance ratio (RR) to permethrin and >14-fold RR to diazinon. Mechanisms of resistance were determined using molecular techniques and enzymatic assays...
June 12, 2018: Insects
Meelad Sayma, George Nowell, Aedamar O'Connor, Gemma Clark, Andrew Gaukroger, Dominic Proctor, Jamie Walsh, Brian Rigney, Storm Norman, Andrew Adedeji, David Wilson, Darren O'hagan, Victoria Cook, Robbie Carrington, Preshgena Sekaran, Maya Wehbe, Duncan Paterson, Sophie Welchman, Jay Over, Sheila Payne
OBJECTIVES: Treatment escalation plans (TEPs) are vital in communicating a ceiling of care. However, many patients still deteriorate and die without a pre-established ceiling of care for attending clinicians to rely on. We aimed to increase the proportion of suitable patients that have TEPs in place in a rural district general hospital. METHODS: We undertook three 'Plan-Do-Study-Act' (PDSA) cycles between 1 December 2016 and 9 June 2017. These cycles aimed to assess the problem, implement a solution and monitor its sustainability...
June 12, 2018: Postgraduate Medical Journal
Paolo Barsocchi, Antonello Calabrò, Erina Ferro, Claudio Gennaro, Eda Marchetti, Claudio Vairo
Smart Home has gained widespread attention due to its flexible integration into everyday life. Pervasive sensing technologies are used to recognize and track the activities that people perform during the day, and to allow communication and cooperation of physical objects. Usually, the available infrastructures and applications leveraging these smart environments have a critical impact on the overall cost of the Smart Home construction, require to be preferably installed during the home construction and are still not user-centric...
June 8, 2018: Sensors
Luca Canale, Axel Laborieux, Agasthya Aroul Mogane, Laetitia Jubin, Jean Comtet, Antoine Lainé, Lydéric Bocquet, Alessandro Siria, Antoine Niguès
Atomic Force Microscopy (AFM) allows to reconstruct the topography of surfaces with a resolutions in the nanometer range. The exceptional resolution attainable with the AFM makes this instrument a key tool in nanoscience and technology. The core of standard AFM set-up relies on the detection of the change of the mechanical motion of a micro-oscillator when approaching the sample to image. Despite the fact that AFM is nowadays a very common instrument for both fundamental and applied research. The fabrication of the micrometric scale mechanical oscillator is still a very complicated and expensive task requiring dedicated platforms...
June 11, 2018: Nanotechnology
Stephanie Klinghammer, Tino Uhlig, Fabian Patrovsky, Matthias Böhm, Julian Schuett, Nils Pütz, Larysa Baraban, Lukas M Eng, Gianaurelio Cuniberti
Implementing large arrays of gold nanowires as functional elements of a plasmonic biosensor is an important task for future medical diagnostic applications. Here we present a microfluidic-channel-integrated sensor for the label-free detec-tion of biomolecules, relaying on localized surface plasmon resonances. Large arrays (~ 1 cm2) of vertically aligned and densely packed gold nanorods to receive, locally confine and amplify the external optical signal, are used to allow for reli-able biosensing. We accomplish this by monitoring the change of the optical nanostructure resonance upon the presence of biomolecules within the tight focus area above the nanoantennas, combined with a surface treatment of the nanowires for a specific binding of the target molecules...
June 11, 2018: ACS Sensors
S R Sundararajan, Abdul Azeem Badurudeen, R Ramakanth, Shanmuganathan Rajasekaran
Fractures of talar body are uncommon injuries often associated with fractures of other long bones and in polytraumatized patients. The integrity of the talus is essential for the normal function of the ankle, subtalar, and midtarsal joints. The relative infrequency of this injury limits the number of studies available to guide treatment. They occur as a result of high-velocity trauma and are therefore associated with considerable soft tissue damage. Axial compression with supination or pronation is the common mechanism of injury...
May 2018: Indian Journal of Orthopaedics
Laurie Geers, Mauro Pesenti, Michael Andres
How does the eye guide the hand in an ever-changing world? The perception-action model posits that visually-guided actions rely on object size estimates that are computed from an egocentric perspective independently of the visual context. Accordingly, adjusting grip aperture to object size should be resistant to illusions emerging from the contrast between a target and surrounding elements. However, experimental studies gave discrepant results that have remained difficult to explain so far. Visual and proprioceptive information of the acting hand are potential sources of ambiguity in previous studies because the on-line corrections they allow may contribute to masking the illusory effect...
June 5, 2018: Neuropsychologia
Francesca Fulceri, Alessandro Tonacci, Andrea Lucaferro, Fabio Apicella, Antonio Narzisi, Giulia Vincenti, Filippo Muratori, Annarita Contaldo
BACKGROUND: Kinematics plays a key role in action prediction, imitation and joint action coordination. Despite people with autism spectrum disorder (ASD) show a failure to use kinematic cues during observation and imitation, there is a paucity of studies exploring the role of this dysfunction during joint actions in children with ASD. AIM: To evaluate the interpersonal motor coordination of children with ASD and typically developing (TD) children during a joint action task...
June 4, 2018: Research in Developmental Disabilities
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"