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https://www.readbyqxmd.com/read/28733324/nadph-oxidase-2-derived-superoxide-drives-mitochondrial-transfer-from-bone-marrow-stromal-cells-to-leukemic-blasts
#1
Christopher R Marlein, Lyubov Zaitseva, Rachel E Piddock, Stephen Robinson, Dylan Edwards, Manar S Shafat, Zhigang Zhou, Matthew Lawes, Kristian M Bowles, Stuart A Rushworth
Improvements in the understanding of the metabolic cross-talk between cancer and its micro-environment are expected to lead to novel therapeutic approaches. Acute myeloid leukemia (AML) cells have increased mitochondria compared to non-malignant CD34+ hematopoietic progenitor cells. Furthermore, contrary to the Warburg hypothesis, (AML) relies on oxidative phosphorylation to generate ATP. Here we report that in human AML, NOX2 generates superoxide which stimulates bone marrow stromal cells (BMSC) to AML blast transfer of mitochondria through AML derived tunnelling nanotubes...
July 21, 2017: Blood
https://www.readbyqxmd.com/read/28731844/outcome-by-gender-in-the-veterans-health-administration-motivating-overweight-obese-veterans-everywhere-weight-management-program
#2
Bryan C Batch, Karen Goldstein, William S Yancy, Linda L Sanders, Susanne Danus, Steven C Grambow, Hayden B Bosworth
BACKGROUND: Few evaluations of the Veterans Health Administration Motivating Overweight/Obese Veterans Everywhere (MOVE!) weight management program have assessed 6-month weight change or factors associated with weight change by gender. MATERIALS AND METHODS: Analysis of administrative data from a national sample of veterans in the VA MOVE! PROGRAM: HASH(0x541ef90) RESULTS: A total of 62,882 participants were included, 14...
July 21, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28726331/novel-fluid-shear-based-dissociation-device-for-improved-single-cell-dissociation-of-spheroids-and-cell-aggregates
#3
Ursula L Triantafillu, Jaron N Nix, Yonghyun Kim
Biological industries commonly rely on bioreactor systems for the large-scale production of cells. Cell aggregation, clumping, and spheroid morphology of certain suspension cells make their large-scale culture challenging. Growing stem cells as spheroids is indispensable to retain their stemness, but large spheroids (>500 µm diameter) suffer from poor oxygen and nutrient diffusion, ultimately resulting in premature cell death in the centers of the spheroids. Despite this, most large-scale bioprocesses do not have an efficient method for dissociating cells into single cells, but rely on costly enzymatic dissociation techniques...
July 20, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28725883/efficient-learning-of-classification-models-from-soft-label-information-by-binning-and-ranking
#4
Yanbing Xue, Milos Hauskrecht
Construction of classification models from data in practice often requires additional human effort to annotate (label) observed data instances. However, this annotation effort may often be too costly and only a limited number of data instances may be feasibly labeled. The challenge is to find methods that let us reduce the number of the labeled instances but at the same time preserve the quality of the learned models. In this paper we study the idea of learning classification from soft label information in which each instance is associated with a soft-label further refining its class label...
May 2017: Proceedings of the ... International Florida AI Research Society Conference
https://www.readbyqxmd.com/read/28725373/high-resolution-photo-mosaic-time-series-imagery-for-monitoring-human-use-of-an-artificial-reef
#5
Georgina Wood, Tim P Lynch, Carlie Devine, Krystle Keller, Will Figueira
Successful marine management relies on understanding patterns of human use. However, obtaining data can be difficult and expensive given the widespread and variable nature of activities conducted. Remote camera systems are increasingly used to overcome cost limitations of conventional labour-intensive methods. Still, most systems face trade-offs between the spatial extent and resolution over which data are obtained, limiting their application. We trialed a novel methodology, CSIRO Ruggedized Autonomous Gigapixel System (CRAGS), for time series of high-resolution photo-mosaic (HRPM) imagery to estimate fine-scale metrics of human activity at an artificial reef located 1...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28724392/a-prospective-study-assessing-agreement-and-reliability-of-a-geriatric-evaluation
#6
Isabella Locatelli, Stéfanie Monod, Jacques Cornuz, Christophe J Büla, Nicolas Senn
BACKGROUND: The present study takes place within a geriatric program, aiming at improving the diagnosis and management of geriatric syndromes in primary care. Within this program it was of prime importance to be able to rely on a robust and reproducible geriatric consultation to use as a gold standard for evaluating a primary care brief assessment tool. The specific objective of the present study was thus assessing the agreement and reliability of a comprehensive geriatric consultation...
July 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28717392/the-power-of-evolutionary-rescue-is-constrained-by-genetic-load
#7
Gavin S Stewart, Madeline R Morris, Allison B Genis, Marianna Szűcs, Brett A Melbourne, Simon J Tavener, Ruth A Hufbauer
The risk of extinction faced by small isolated populations in changing environments can be reduced by rapid adaptation and subsequent growth to larger, less vulnerable sizes. Whether this process, called evolutionary rescue, is able to reduce extinction risk and sustain population growth over multiple generations is largely unknown. To understand the consequences of adaptive evolution as well as maladaptive processes in small isolated populations, we subjected experimental Tribolium castaneum populations founded with 10 or 40 individuals to novel environments, one more favorable, and one resource poor, and either allowed evolution, or constrained it by replacing individuals one-for-one each generation with those from a large population maintained in the natal environment...
August 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28715998/detection-of-active-transposable-elements-in-arabidopsis-thaliana-using-oxford-nanopore-sequencing-technology
#8
Emilie Debladis, Christel Llauro, Marie-Christine Carpentier, Marie Mirouze, Olivier Panaud
BACKGROUND: Transposables elements (TEs) contribute to both structural and functional dynamics of most eukaryotic genomes. Because of their propensity to densely populate plant and animal genomes, the precise estimation of the impact of transposition on genomic diversity has been considered as one of the main challenges of today's genomics. The recent development of NGS (next generation sequencing) technologies has open new perspectives in population genomics by providing new methods for high throughput detection of Transposable Elements-associated Structural Variants (TEASV)...
July 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28715755/adsorption-of-mercury-ii-from-aqueous-solutions-using-fes-and-pyrite-a-comparative-study
#9
Yue Sun, Dan Lv, Jiasheng Zhou, Xiaoxin Zhou, Zimo Lou, Shams Ali Baig, Xinhua Xu
In this study, a comparative evaluation of synthetic FeS and natural pyrite was performed to investigate their adsorptive potentials toward Hg(II) in aqueous system. Characterization analyses such as BET, SEM and TEM suggested that FeS had porous structures with abundant active sites, while pyrite with a hard and smooth surface relied mainly on surface adsorption to immobilize Hg(II). Results of batch tests revealed that FeS offered much greater Hg(II) maximum adsorption capacity (769.2 mg/g) as compared to pyrite (9...
July 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28715327/joint-statistical-iterative-material-image-reconstruction-for-spectral-computed-tomography-using-a-semi-empirical-forward-model
#10
Korbinian Mechlem, Sebastian Ehn, Thorsten Sellerer, Eva Braig, Daniela Munzel, Franz Pfeiffer, Peter B Noel
By acquiring tomographic measurements with several distinct photon energy spectra, spectral computed tomography (spectral CT) is able to provide additional material-specific information compared to conventional CT. This information enables the generation of material selective images, which have found various applications in medical imaging. However, material decomposition typically leads to noise amplification and a degradation of the signal-to-noise ratio. This is still a fundamental problem of spectral CT, especially for low-dose medical applications...
July 13, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28711427/temporal-remodeling-of-the-cell-cycle-accompanies-differentiation-in-the-drosophila-germline
#11
Taylor D Hinnant, Arturo A Alvarez, Elizabeth T Ables
Development of multicellular organisms relies upon the coordinated regulation of cellular differentiation and proliferation. Growing evidence suggests that some molecular regulatory pathways associated with the cell cycle machinery also dictate cell fate; however, it remains largely unclear how the cell cycle is remodeled in concert with cell differentiation. During Drosophila oogenesis, mature oocytes are created through a series of precisely controlled division and differentiation steps, originating from a single tissue-specific stem cell...
July 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28704390/inter-rater-reliability-of-categorical-versus-continuous-scoring-of-fish-vitality-does-it-affect-the-utility-of-the-reflex-action-mortality-predictor-ramp-approach
#12
Pieter Meeremans, Noëlle Yochum, Marc Kochzius, Bart Ampe, Frank A M Tuyttens, Sven Sebastian Uhlmann
Scoring reflex responsiveness and injury of aquatic organisms has gained popularity as predictors of discard survival. Given this method relies upon the individual interpretation of scoring criteria, an evaluation of its robustness is done here to test whether protocol-instructed, multiple raters with diverse backgrounds (research scientist, technician, and student) are able to produce similar or the same reflex and injury score for one of the same flatfish (European plaice, Pleuronectes platessa) after experiencing commercial fishing stressors...
2017: PloS One
https://www.readbyqxmd.com/read/28704063/evaluation-of-accuracy-of-six-blood-glucose-monitoring-systems-and-modeling-of-possibly-related-insulin-dosing-errors
#13
Annette Baumstark, Nina Jendrike, Stefan Pleus, Cornelia Haug, Guido Freckmann
OBJECTIVE: Self-monitoring of blood glucose (BG) is an essential part of diabetes therapy. Accurate and reliable results from BG monitoring systems (BGMS) are important especially when they are used to calculate insulin doses. This study aimed at assessing system accuracy of BGMS and possibly related insulin dosing errors. RESEARCH DESIGN AND METHODS: System accuracy of six different BGMS (Accu-Chek(®) Aviva Nano, Accu-Chek Mobile, Accu-Chek Performa Nano, CONTOUR(®) NEXT LINK 2...
July 13, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28699904/the-anti-apoptotic-bag3-protein-is-involved-in-braf-inhibitor-resistance-in-melanoma-cells
#14
Luana Guerriero, Giuseppe Palmieri, Margot De Marco, Antonio Cossu, Paolo Remondelli, Mario Capunzo, Maria Caterina Turco, Alessandra Rosati
BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumour types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating crucial events such as apoptosis, differentiation, cell motility, and autophagy. In human melanomas, BAG3 positivity is correlated with the aggressiveness of the tumour cells and can sustain IKK-γ levels, allowing a sustained activation of NF-κB. Furthermore, BAG3 is able to modulate BRAFV600E levels and activity in thyroid carcinomas...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697731/texture-analysis-of-pulmonary-parenchymateous-changes-related-to-pulmonary-thromboembolism-in-dogs-a-novel-approach-using-quantitative-methods
#15
C B Marschner, M Kokla, J M Amigo, E A Rozanski, B Wiinberg, F J McEvoy
BACKGROUND: Diagnosis of pulmonary thromboembolism (PTE) in dogs relies on computed tomography pulmonary angiography (CTPA), but detailed interpretation of CTPA images is demanding for the radiologist and only large vessels may be evaluated. New approaches for better detection of smaller thrombi include dual energy computed tomography (DECT) as well as computer assisted diagnosis (CAD) techniques. The purpose of this study was to investigate the performance of quantitative texture analysis for detecting dogs with PTE using grey-level co-occurrence matrices (GLCM) and multivariate statistical classification analyses...
July 11, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28694699/antitumor-hpv-e7-specific-ctl-activity-elicited-by-in-vivo-engineered-exosomes-produced-through-dna-inoculation
#16
Paola Di Bonito, Chiara Chiozzini, Claudia Arenaccio, Simona Anticoli, Francesco Manfredi, Eleonora Olivetta, Flavia Ferrantelli, Emiliana Falcone, Anna Ruggieri, Maurizio Federico
We recently proved that exosomes engineered in vitro to deliver high amounts of HPV E7 upon fusion with the Nef(mut) exosome-anchoring protein elicit an efficient anti-E7 cytotoxic T lymphocyte immune response. However, in view of a potential clinic application of this finding, our exosome-based immunization strategy was faced with possible technical difficulties including industrial manufacturing, cost of production, and storage. To overcome these hurdles, we designed an as yet unproven exosome-based immunization strategy relying on delivery by intramuscular inoculation of a DNA vector expressing Nef(mut) fused with HPV E7...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28692831/children-s-quantitative-bayesian-inferences-from-natural-frequencies-and-number-of-chances
#17
Stefania Pighin, Vittorio Girotto, Katya Tentori
Zhu and Gigerenzer (2006) showed that an appreciable number of Chinese children aged between 9 and 12years old made correct quantitative Bayesian inferences requiring the integration of priors and likelihoods as long as they were presented with numerical information phrased in terms of natural frequencies. In this study, we sought to replicate this finding and extend the investigation of children's Bayesian reasoning to a different numerical format (chances) and other probability questions (distributive and relative)...
July 7, 2017: Cognition
https://www.readbyqxmd.com/read/28682248/fused-estimation-of-sparse-connectivity-patterns-from-rest-fmri-application-to-comparison-of-children-and-adult-brains
#18
Pascal Zille, Vince D Calhoun, Julia M Stephen, Tony W Wilson, Yu-Ping Wang
In this work, we consider the problem of estimating multiple sparse, co-activated brain regions from functional magnetic resonance imaging (fMRI) observations belonging to different classes. More precisely, we propose a method to analyze similarities and differences in functional connectivity between children and young adults. Often, analysis is conducted on each class separately, and differences across classes are identified with an additional postprocessing step using adequate statistical tools. Here, we propose to rely on a generalized fused Lasso penalty, which allows us to make use of the entire dataset in order to estimate connectivity patterns that are either shared across classes, or specific to a given group...
June 29, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28681721/dot-map-cartograms-for-detection-of-infectious-disease-outbreaks-an-application-to-q-fever-the-netherlands-and-pertussis-germany
#19
Loes Soetens, Susan Hahné, Jacco Wallinga
Geographical mapping of infectious diseases is an important tool for detecting and characterising outbreaks. Two common mapping methods, dot maps and incidence maps, have important shortcomings. The former does not represent population density and can compromise case privacy, and the latter relies on pre-defined administrative boundaries. We propose a method that overcomes these limitations: dot map cartograms. These create a point pattern of cases while reshaping spatial units, such that spatial area becomes proportional to population size...
June 29, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28679684/study-of-the-plasma-membrane-proteome-dynamics-reveals-novel-targets-of-nitrogen-regulation-in-yeast
#20
Jennifer Villers, Jérôme Savocco, Aleksandra Szopinska, Hervé Degand, Sylvain Nootens, Pierre Morsomme
Yeast cells, to be able to grow on a wide variety of nitrogen sources, regulate the set of nitrogen transporters present at their plasma membrane. Such regulation relies on both transcriptional and post-translational events. While microarray studies have identified most nitrogen-sensitive genes, nitrogen-induced post-translational regulation has only been studied for very few proteins among which the general amino acid permease Gap1. Adding a preferred nitrogen source to proline-grown cells triggers Gap1 endocytosis and vacuolar degradation in an Rsp5-Bul1/2-dependent manner...
July 5, 2017: Molecular & Cellular Proteomics: MCP
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