Michael D Chuong, Percy Lee, Daniel A Low, Joshua Kim, Kathryn E Mittauer, Michael F Bassetti, Carri K Glide-Hurst, Ann C Raldow, Yingli Yang, Lorraine Portelance, Kyle R Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren E Henke, Alex T Price, Joseph D Mancias, Christopher L Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam C Mueller, Karen E Mooney, Patrick Kelly, Amish P Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh
BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8...
December 20, 2023: Radiotherapy and Oncology