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Pancreas MR

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https://www.readbyqxmd.com/read/28306727/biodistribution-and-pet-imaging-of-pharmacokinetics-of-manganese-in-mice-using-manganese-52
#1
A Lake Wooten, Tolulope A Aweda, Benjamin C Lewis, Rebecca B Gross, Suzanne E Lapi
Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide 52Mn (t1/2 = 5.6 d) by proton bombardment (Ep<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28280965/radiosynthesis-and-first-in-human-pet-mri-evaluation-with-clinical-grade-18-f-ftc-146
#2
Bin Shen, Jun Hyung Park, Trine Hjørnevik, Peter W Cipriano, Daehyun Yoon, Praveen K Gulaka, Dawn Holly, Deepak Behera, Bonnie A Avery, Sanjiv S Gambhir, Christopher R McCurdy, Sandip Biswal, Frederick T Chin
PURPOSE: Sigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our previously reported S1R radioligand, [(18)F]FTC-146, demonstrated high affinity for the S1R (K i = 0.0025 nM) and excellent selectivity for the S1R over the sigma-2 receptor (S2Rs; K i = 364 nM) across several species (from mouse to non-human primate)...
March 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28188872/pre-transplantation-31-p-magnetic-resonance-spectroscopy-for-quality-assessment-of-human-pancreatic-grafts-a-feasibility-study
#3
Lina Carlbom, Jan Weis, Lars Johansson, Olle Korsgren, Håkan Ahlström
OBJECTIVE: To investigate the feasibility of using (31)P-MRS for objective non-invasive quality assessment of human pancreas grafts prior to transplantation or islet isolation. MATERIALS AND METHODS: Pancreata from 5 human donors, 3 males and 2 females, aged 49-78years, with body mass index (BMI) 22-31kg/m(2), were included. Pancreata were perfused with histidine-tryptophan-ketoglutarate solution during procurement and stored in hypothermic condition (4°C) for 21-44h...
February 8, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28121369/four-dimensional-diffusion-weighted-mr-imaging-4d-dwi-a-feasibility-study
#4
Yilin Liu, Xiaodong Zhong, Brian G Czito, Manisha Palta, Mustafa R Bashir, Brian M Dale, Fang-Fang Yin, Jing Cai
PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI) for imaging respiratory motion for radiation therapy applications. MATERIALS/METHODS: Image acquisition was performed by repeatedly imaging a volume of interest (VOI) using an interleaved multislice single-shot echo-planar imaging (EPI) 2D-DWI sequence in the axial plane...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28120404/functional-mri-of-human-pancreas-using-bold-contrast-responses-following-glucose-ingestion
#5
Bozhu Chen, Weibo Chen, Queenie Chan, Nan Zhou, Jian He, Zhengyang Zhou
PURPOSE: To evaluate the response of the pancreas to glucose ingestion in healthy volunteers by blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). MATERIALS AND METHODS: This study was approved by the local Ethics Committee, and informed consent was obtained from all subjects. A multiple gradient recalled echo (mGRE) sequence was performed on a 3.0T MR scanner in 12 healthy volunteers before and after glucose or water ingestion. Pancreatic T2* values were calculated from it at each timepoint, and changes following stimulation were analyzed using summary measures...
January 24, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28099362/laparoscopic-pancreaticoduodenectomy-in-a-92-older-chinese-patient-for-cancer-of-head-of-the-pancreas-a-case-report
#6
Jiayu Zhou, Chang Xin, Tao Xia, Yiping Mou, Xiaowu Xu, Renchao Zhang, Yucheng Zhou, Weiwei Jin, Chao Lu
INTRODUCTION: Laparoscopic pancreaticoduodenectomy (LPD) is one of the most complex gastrointestinal procedures performed in laparoscopic abdominal surgery. However, the concern for elderly undergoing LPD remains. To the best of our knowledge, there are no reports describing LPD for A-92-older patient. This study aimed to share the experience of a tertiary pancreatic center and confirm the safety, feasibility of LPD for the elderly. METHOD: The patient had complained of 6-months history of abdominal discomfort and progressive jaundice...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28091744/prediction-of-pancreatic-fistula-after-distal-pancreatectomy-based-on-cross-sectional-images
#7
Ye Rim Chang, Jae Seung Kang, Jin-Young Jang, Woo Hyun Jung, Mee Joo Kang, Kyung Bun Lee, Sun-Whe Kim
BACKGROUND: Postoperative pancreatic fistula (POPF) is one of the most common and clinically relevant complications after distal pancreatectomy (DP), occurring in 5-40% of patients. Determining risk factors for this complication may aid in its prevention. This study sought to predict the development of POPF after DP preoperatively and objectively based on radiologic findings. METHODS: This study included 60 patients who underwent DP using a stapler for pancreatic division between June 2011 and January 2013...
January 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28048275/su-f-j-168-dosimetric-impact-of-mr-image-distortion-in-treatment-planning
#8
Y Yan, J Yang, S Beddar, G Ibbott, P Balter, R Kudchadker, S Krishnan, C Fuller, J Wang
PURPOSE: To evaluate the dosimetric impact of MR image distortion in treatment planning. METHODS: Based on the realistic MRI distortion measurement data from an integrated MRI-Linac system, we created a generalized distortion model and applied it to CT images to simulate distorted MRI images. Ten patients with IMRT plans generated in Pinnacle treatment planning system in 5 anatomical cancer sites (lung, prostate, spinal cord, liver, and pancreas) were retrospectively selected for the simulation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047704/su-g-jep2-05-dose-effects-of-a-1-5t-magnetic-field-on-air-tissue-and-lung-tissue-interfaces-in-mri-guided-radiotherapy
#9
Xinfeng Chen, Phillip Prior, Guangpei Chen, Christopher Schultz, X Allen Li
PURPOSE: The purpose of the study is to investigate the dose effects of electron-return-effect (ERE) at air-tissue and lung-tissue interfaces under a 1.5T transverse-magnetic-field (TMF). METHODS: IMRT and VMAT plans for representative pancreas, lung, breast and head & neck (H&N) cases were generated following clinical dose volume (DV) criteria. The air-cavity walls, as well as the lung wall, were delineated to examine the ERE. In each case, the original plan generated without TMF is compared with the reconstructed plan (generated by recalculating the original plan with the presence of TMF) and the optimized plan (generated by a full optimization with TMF), using a variety of DV parameters, including V100%, D95% and dose heterogeneity index for PTV, Dmax, and D1cc for OARs (organs at risk) and tissue interface...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047289/tu-ab-bra-11-indications-for-online-adaptive-radiotherapy-based-on-dosimetric-consequences-of-interfractional-pancreas-to-duodenum-motion-in-mri-guided-pancreatic-radiotherapy
#10
K Mittauer, S Rosenberg, M Geurts, M Bassetti, I Chen, L Henke, J Olsen, R Kashani, A Wojcieszynski, P Harari, Z Labby, P Hill, B Paliwal, P Parikh, J Bayouth
PURPOSE: Dose limiting structures, such as the duodenum, render the treatment of pancreatic cancer challenging. In this multi-institutional study, we assess dosimetric differences caused by interfraction pancreas-to-duodenum motion using MR-IGRT to determine the potential impact of adaptive replanning. METHODS: Ten patients from two institutions undergoing MRI-guided radiotherapy with conventional fractionation (n=5) or SBRT (n=5) for pancreatic cancer were included...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047210/th-ab-bra-07-penelope-based-gpu-accelerated-dose-calculation-system-applied-to-mri-guided-radiation-therapy
#11
Y Wang, T Mazur, O Green, Y Hu, H Li, V Rodriguez, H Wooten, D Yang, T Zhao, S Mutic, H Li
PURPOSE: The clinical commissioning of IMRT subject to a magnetic field is challenging. The purpose of this work is to develop a GPU-accelerated Monte Carlo dose calculation platform based on PENELOPE and then use the platform to validate a vendor-provided MRIdian head model toward quality assurance of clinical IMRT treatment plans subject to a 0.35 T magnetic field. METHODS: We first translated PENELOPE from FORTRAN to C++ and validated that the translation produced equivalent results...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046990/su-d-202-03-statistical-segmentation-on-quantitative-ct-for-assessing-spatial-tumor-response-during-radiation-therapy-delivery
#12
D Schott, T Schmidt, X Chen, S Klawikowski, G Noid, E Dalah, X Li
PURPOSE: Develop a method to segment regions of interest (ROIs) in tumor with statistically similar Hounsfield unit (HU) values and/or HU changes during chemoradiation therapy (CRT) delivery, to assess spatial tumor treatment response based on daily CTs during CRT delivery. METHODS: Generate a three region map of ROIs with differential HUs, by sampling neighboring voxels around a selected voxel and comparing to the mean of the entire ROI using a t-test. The cumulative distribution function, P, is calculated from the t-test...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046785/su-f-j-173-online-replanning-for-dose-painting-based-on-changing-adc-map-of-pancreas-cancer
#13
O Ates, E Ahunbay, B Erickson, X Li
PURPOSE: The introduction of MR-guided radiation therapy (RT), e.g., MR-Linac, would allow dose painting to adapt spatial RT response revealed from MRI data during the RT delivery. The purpose of this study is to investigate the use of an online replanning method to adapt dose painting from the MRI Apparent Diffusion Coefficient (ADC) map acquired during the delivery of RT for pancreatic cancers. METHODS: Original dose painting plans were created based on multi-parametric simulation MRI including T1, T2 and ADC, using a treatment planning system (MONACO, Elekta) equipped with an online replanning algorithm (WSO, warm start optimization)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027747/imaging-findings-of-kaposiform-hemangioendothelioma-in-children
#14
Young Jin Ryu, Young Hun Choi, Jung-Eun Cheon, Woo Sun Kim, In-One Kim, Ji Eun Park, Yu Jin Kim
PURPOSE: Kaposiform hemangioendothelioma (KHE) is a rare, aggressive vascular tumor that typically occurs during infancy or early childhood. Though several case reports have discussed the imaging findings of KHE, larger comprehensive studies are lacking. The purpose of this study was to evaluate the imaging findings of KHE in children. MATERIALS AND METHODS: A total of twelve cases of pathologically proven KHE were collected by searching our institution's pathology database for children diagnosed between January 2004 and April 2016 (6 male, 6 female; median age: 3 months; age range 7days - 18 years)...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27898201/diffusion-weighted-imaging-of-the-abdomen-impact-of-b-values-on-texture-analysis-features
#15
Anton S Becker, Matthias W Wagner, Moritz C Wurnig, Andreas Boss
The purpose of this work was to systematically assess the impact of the b-value on texture analysis in MR diffusion-weighted imaging (DWI) of the abdomen. In eight healthy male volunteers, echo-planar DWI sequences at 16 b-values ranging between 0 and 1000 s/mm(2) were acquired at 3 T. Three different apparent diffusion coefficient (ADC) maps were computed (0, 750/100, 390, 750 s/mm(2) /all b-values). Texture analysis of rectangular regions of interest in the liver, kidney, spleen, pancreas, paraspinal muscle and subcutaneous fat was performed on DW images and the ADC maps, applying 19 features computed from the histogram, grey-level co-occurrence matrix (GLCM) and grey-level run-length matrix (GLRLM)...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27868105/feasibility-of-automated-3-dimensional-magnetic-resonance-imaging-pancreas-segmentation
#16
Shuiping Gou, Percy Lee, Peng Hu, Jean-Claude Rwigema, Ke Sheng
PURPOSE: With the advent of MR guided radiotherapy, internal organ motion can be imaged simultaneously during treatment. In this study, we evaluate the feasibility of pancreas MRI segmentation using state-of-the-art segmentation methods. METHODS AND MATERIAL: T2 weighted HASTE and T1 weighted VIBE images were acquired on 3 patients and 2 healthy volunteers for a total of 12 imaging volumes. A novel dictionary learning (DL) method was used to segment the pancreas and compared to t mean-shift merging (MSM), distance regularized level set (DRLS), graph cuts (GC) and the segmentation results were compared to manual contours using Dice's index (DI), Hausdorff distance and shift of the-center-of-the-organ (SHIFT)...
July 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/27832518/expanding-the-scope-of-an-automated-radiology-recommendation-tracking-engine-initial-experiences-and-lessons-learned
#17
Mindy Y Licurse, Darco Lalevic, Hanna M Zafar, Mitchell D Schnall, Tessa S Cook
An automated radiology recommendation-tracking engine for incidental focal masses in the liver, pancreas, kidneys, and adrenal glands was launched within our institution in July 2013. For 2 years, the majority of CT, MR, and US examination reports generated within our health system were mined by the engine. However, the need to expand the system beyond the initial four organs was soon identified. In July 2015, the second phase of the system was implemented and expanded to include additional anatomic structures in the abdomen and pelvis, as well as to provide non-radiology and non-imaging options for follow-up...
April 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27760203/correction-preliminary-study-of-mr-diffusion-tensor-imaging-of-pancreas-for-the-diagnosis-of-acute-pancreatitis
#18
Xinghui Li, Ling Zhuang, Xiaoming Zhang, Jian Wang, Tianwu Chen, Liangjun Li, Emmanuel Ajedichiga Aduah, Jiani Hu
[This corrects the article DOI: 10.1371/journal.pone.0160115.].
2016: PloS One
https://www.readbyqxmd.com/read/27699875/tomoelastography-of-the-abdomen-tissue-mechanical-properties-of-the-liver-spleen-kidney-and-pancreas-from-single-mr-elastography-scans-at-different-hydration-states
#19
Florian Dittmann, Heiko Tzschätzsch, Sebastian Hirsch, Eric Barnhill, Jürgen Braun, Ingolf Sack, Jing Guo
PURPOSE: To develop a compact magnetic resonance elastography (MRE) protocol for abdomen and to investigate the effect of water uptake on tissue stiffness in the liver, spleen, kidney, and pancreas. METHODS: Nine asymptomatic volunteers were investigated by MRE before and after 1 liter water uptake. Shear-wave excitation at four frequencies was transferred to the abdomen from anterior and posterior directions using pressurized air drivers. Tomographic representations of shear-wave speed were produced by analysis of multifrequency wave numbers in axial and coronal images acquired within four breath-holds or under free breathing, respectively...
October 3, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27660281/detection-of-exocrine-dysfunction-by-mri-in-patients-with-early-chronic-pancreatitis
#20
Temel Tirkes, Evan L Fogel, Stuart Sherman, Chen Lin, Jordan Swensson, Fatih Akisik, Kumaresan Sandrasegaran
PURPOSE: To determine if T1-weighted MR signal of the pancreas can be used to detect early CP. METHODS: A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST...
September 23, 2016: Abdominal Radiology
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