keyword
https://read.qxmd.com/read/38037306/an-incidental-finding-of-pulmonary-cement-embolism-four-weeks-after-vertebroplasty-in-a-50-year-old-man-with-multiple-myeloma
#1
JOURNAL ARTICLE
Ari M Fish, Pradhab Kirupaharan, Michael L Scharf
BACKGROUND Vertebroplasty is a minimally invasive radiological procedure that involves injection of cement to stabilize the fractured vertebra. It has also been increasingly used to relieve pain in patients with bone-incorporated malignancies. The most frequently encountered complication of this procedure is inadvertent cement leakage, which has the potential to embolize. This report presents an incidental finding of cement embolism during fluoroscopy for a peripherally inserted central catheter (PICC) line 4 weeks after vertebroplasty in a 50-year-old man with multiple myeloma...
December 1, 2023: American Journal of Case Reports
https://read.qxmd.com/read/38022027/a-case-report-of-plasmacytoma-in-a-28-year-old-patient-bridging-the-age-gap-in-a-rare-presentation
#2
Naveen Kizhakkayil Tency, Julieanna A Camarena, Archa Roy, Mini Pradeep
Plasmacytoma, an uncommon malignancy originating from plasma cells, predominantly manifests in the elderly demographic. However, its incidence among young adults remains infrequent. Herein, we present a case involving a 28-year-old young adult diagnosed with solitary bone plasmacytoma. The patient presented with acute exacerbation of chronic lower back pain of two years, which, upon hospitalization, was attributed to a lumbar spine compression fracture. Comprehensive blood analysis, imaging studies, and pathology assessments suggested the likelihood of solitary plasmacytoma, devoid of indicators characteristic of multiple myeloma (MM)...
October 2023: Curēus
https://read.qxmd.com/read/37456925/two-cases-of-low-back-pain-of-unknown-etiology-diagnosed-as-multiple-myeloma
#3
Keiji Akao, Yusuke Ishida, Saki Kamada, Shusuke Sekine, Kiyoshige Ohseto
We report two cases of patients complaining of lumbar back pain of unknown etiology which were finally diagnosed as multiple myeloma. The first case was a woman in her 80s with a chief complaint of lumbar back pain. The second case was a male in his 70s. He also consulted our institution because his pain did not subside despite receiving increased doses of oral medication and nerve blocks from his previous doctor. Both patients presented with compression fractures on plain radiography, and additionally with cytopenia, hyperproteinemia, and hypoalbuminemia in blood tests...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/36987921/multi-targeting-dkk1-and-lrp6-prevents-bone-loss-and-improves-fracture-resistance-in-multiple-myeloma
#4
JOURNAL ARTICLE
Marija K Simic, Sindhu T Mohanty, Ya Xiao, Tegan L Cheng, Victoria E Taylor, Olga Charlat, Michael Daley, Peter I Croucher, Michelle M McDonald
An imbalance between bone resorption and bone formation underlies the devastating osteolytic lesions and subsequent fractures seen in more than 90% of multiple myeloma (MM) patients. Currently, Wnt-targeted therapeutic agents that prevent soluble antagonists of the Wnt signaling pathway, sclerostin (SOST) and dickkopf-1 (DKK1), have been shown to prevent bone loss and improve bone strength in pre-clinical models of MM. In this study, we show increasing Wnt signaling via a novel anti-LRP6 antibody, which potentiates Wnt1-class ligand signaling through binding the Wnt receptor LRP6, prevented the development of myeloma-induced bone loss primarily through preventing bone resorption...
March 29, 2023: Journal of Bone and Mineral Research
https://read.qxmd.com/read/34626259/clonazepam-for-pain-due-to-muscle-spasm-in-a-patient-with-vertebral-compression-fractures-caused-by-multiple-myeloma-a-case-report
#5
JOURNAL ARTICLE
Kazuki Akita, Yasutomo Kumakura, Emi Nakajima, Hiroki Ishiguro, Tetsuya Iijima
BACKGROUND: Vertebral compression fractures can cause severe back pain. Although many types of analgesics and interventional treatments are available, they are sometimes ineffective in mitigating the pain. We encountered a case where clonazepam was effective for the management of severe low back pain caused by lumbar vertebral compression fractures. CASE PRESENTATION: A 44-year-old male was diagnosed with multiple myeloma and had vertebral compression fractures of the first and second lumbar vertebrae...
October 9, 2021: JA Clinical Reports
https://read.qxmd.com/read/34499848/non-secretory-multiple-myeloma-with-patchy-marrow-involvement-and-aberrant-cytokeratin-expression
#6
JOURNAL ARTICLE
Miguel Silva, Joana Martins, João Pinto, Teresina Amaro
Non-secretory multiple myeloma is a rare form of the disease that presents a diagnostic challenge. A 69-year-old woman presented to the emergency department with a pathological fracture of the right clavicle, along with a history of asthenia and middle back pain in the preceding three months. Workup revealed multiple focal lytic bone lesions in the clavicles, ribs, skull and thoracic- lumbar-sacral spine, without evidence of anemia, hypercalcemia or renal failure, with no abnormal immunofixation in the serum or urine and with normal serum free light chain ratios...
November 2, 2021: Acta Médica Portuguesa
https://read.qxmd.com/read/33668980/spinal-cord-compression-as-a-consequence-of-spinal-plasmacytoma-in-a-patient-with-multiple-myeloma-a-case-report
#7
Rishi Jayesh Trivedi
Multiple myeloma (MM) is a B cell malignancy resulting in osteolytic lesions. Pathological fracture of the vertebral body resulting in spinal cord compression is a common complication and accounts for approximately 5% of patients with MM. To date, there are no definitive guidelines for the treatment of spinal cord compression as a consequence of MM. Radiotherapy has frequently been the preferred form of treatment. Some surgeons, however, feel that spinal lesions in multiple myeloma should be treated in the same manner as spinal metastases from solid organs...
February 25, 2021: Clinics and Practice
https://read.qxmd.com/read/33651768/can-a-deep-learning-model-for-the-automated-detection-of-vertebral-fractures-approach-the-performance-level-of-human-subspecialists
#8
JOURNAL ARTICLE
Yi-Chu Li, Hung-Hsun Chen, Henry Horng-Shing Lu, Hung-Ta Hondar Wu, Ming-Chau Chang, Po-Hsin Chou
BACKGROUND: Vertebral fractures are the most common osteoporotic fractures in older individuals. Recent studies suggest that the performance of artificial intelligence is equal to humans in detecting osteoporotic fractures, such as fractures of the hip, distal radius, and proximal humerus. However, whether artificial intelligence performs as well in the detection of vertebral fractures on plain lateral spine radiographs has not yet been reported. QUESTIONS/PURPOSES: (1) What is the accuracy, sensitivity, specificity, and interobserver reliability (kappa value) of an artificial intelligence model in detecting vertebral fractures, based on Genant fracture grades, using plain lateral spine radiographs compared with values obtained by human observers? (2) Do patients' clinical data, including the anatomic location of the fracture (thoracic or lumbar spine), T-score on dual-energy x-ray absorptiometry, or fracture grade severity, affect the performance of an artificial intelligence model? (3) How does the artificial intelligence model perform on external validation? METHODS: Between 2016 and 2018, 1019 patients older than 60 years were treated for vertebral fractures in our institution...
February 26, 2021: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/33123386/ultrasound-guided-interscalene-brachial-plexus-block-for-pathological-humerus-fracture-due-to-multiple-myeloma-with-systemic-manifestation-useful-option-for-management-in-low-income-countries
#9
Pawan Kumar Hamal, Bibena Lamichhane, Nabin Pokhrel, Janith Singh, Rupesh Kumar Yadav
Anesthetic management of pathological fracture due to multiple myeloma with systemic manifestation poses a perioperative challenge especially in low-resource setups like Nepal. Regional anesthesia using ultrasound-guided block can improve the accuracy, reduce complications, and improve overall perioperative management of pathological fractures due to malignancy with systemic spread in resource-deprived setups. We present a case of a 53-year-old lady with pathological fracture of left humerus shaft, a diagnosed case of multiple myeloma with compression fracture of multiple lumbar spine with chest wall metastasis with resolving acute kidney injury with chest infections...
2020: Case Reports in Anesthesiology
https://read.qxmd.com/read/32986578/paraplegia-secondary-to-plasmacytoma-of-the-lumbar-spine
#10
JOURNAL ARTICLE
K C Eseonu, S D Middleton, A S Subramanian
BACKGROUND: Solitary plasmacytoma of bone has a predilection for the axial skeleton, most commonly affecting the thoracic spine. We report the case of a patient who presented with acute on chronic back pain and developed severe neurologic deficits within several hours of admission secondary to a pathologic fracture of L1. METHODS: The patient underwent an urgent magnetic resonance imaging scan followed by T12 to L2 posterior decompression and T11 to L3 posterior instrumented stabilization...
August 2020: International Journal of Spine Surgery
https://read.qxmd.com/read/32904950/diagnostic-yield-and-technical-aspects-of-fluoroscopy-guided-percutaneous-transpedicular-biopsy-of-the-spine-a-single-center-retrospective-analysis-of-outcomes-and-review-of-the-literature
#11
JOURNAL ARTICLE
Reddy Ravikanth
BACKGROUND: The technique of a percutaneous transpedicular biopsy of spinal lesions has been shown to be a useful alternative to paraspinal biopsy for vertebral body lesions in the thoracic and lumbosacral spine. Percutaneous vertebral biopsy is less invasive, cost-effective, and is suitable for patients with intractable back pain and vertebral body lesions that are detected with noninvasive imaging modalities. OBJECTIVE: The purpose of this study was to establish the diagnostic utility and spectrum of fluoroscopy-guided percutaneous transpedicular biopsies of the thoracolumbar spine performed at our institution...
April 2020: Journal of Craniovertebral Junction and Spine
https://read.qxmd.com/read/32888349/evaluation-of-sarcopenia-with-f-18-fdg-pet-ct-and-relation-with-disease-outcomes-in-patients-with-multiple-myeloma
#12
JOURNAL ARTICLE
Elif G Umit, Ulku Korkmaz, Mehmet Baysal, Sedanur Karaman Gulsaran, Volkan Bas, Ufuk Demirci, Hakki Onur Kirkizlar, Gulay Durmus Altun, Ahmet Muzaffer Demir
INTRODUCTION: Multiple myeloma (MM) is a potentially incurable haematological malignancy with devastating manifestations including lytic bone lesions leading to fractures and renal insufficiency. As a disease of patients with a mean age of 66 years, both the disease and the continuous efforts of treatments lead to frailty and devastation. From this stand point, we aimed to evaluate the development of muscle loss in MM patients and also with a new method of sarcopenia evaluation, F-18 FDG PET/CT...
November 2020: European Journal of Cancer Care
https://read.qxmd.com/read/31772434/an-unusual-case-of-solitary-spinal-intradural-plasmacytoma-the-unforeseen-challenge
#13
Suyash Singh, Ashutosh Kumar, Kamlesh Singh Bhaisora, Arun Kumar Srivastava, Sanjay Behari
Localized proliferation of atypical plasma cells, either at bony or extramedullary, forms a rare subset of multiple myeloma (MM) disorders. The patients usually present with intractable pain and pathological fractures and respond well to radiotherapy. The clinical presentation is variable and radiologically is nonspecific. The spinal location is rare, and the solitary plasmacytoma in the intradural extramedullary (IDEM) region is unusual. Herein, we report the second case of solitary plasmacytoma at the lumbar IDEM region...
July 2019: Journal of Craniovertebral Junction and Spine
https://read.qxmd.com/read/31528488/minimally-invasive-lateral-transpsoas-approach-for-lumbar-corpectomy-and-stabilization
#14
Umesh Srikantha, Yadhu Kasetti Lokanath, Akshay Hari, S Nirmala, Ravi Gopal Varma
BACKGROUND: Here, we present our experience with the minimally invasive (MI) transpsoas approach for lumbar corpectomy and stabilization. Transpsoas approach accesses the lumbar spine and includes both the direct lateral interbody fusion and extreme lateral interbody fusion techniques. Both procedures utilize a tubular retractor system which facilitates adequate retraction and direct visualization of the target, while supposedly reducing soft tissue trauma. CASE DESCRIPTION: We evaluated two patients, one with a traumatic L2 wedge compression fracture and the other with an L3 pathological compression fracture due to multiple myeloma...
2019: Surgical Neurology International
https://read.qxmd.com/read/30973772/digital-tomosynthesis-and-fractal-analysis-predict-prevalent-vertebral-fractures-in-patients-with-multiple-myeloma-a-preliminary-in-vivo-study
#15
JOURNAL ARTICLE
Daniel Oravec, Omar Yaldo, Carrie Bolton, Michael J Flynn, Marnix van Holsbeeck, Yener N Yeni
OBJECTIVE. The objective of this study was to investigate the association of fractal-derived bone microstructural parameters with vertebral fracture status using in vivo digital tomosynthesis images of the spine. MATERIALS AND METHODS. Digital tomosynthesis images of the thoracic and lumbar spine from T1 to L5 were acquired from 36 patients with newly diagnosed multiple myeloma or monoclonal gammopathy of uncertain significance (age range, 39-85 years old). Scans were performed with patients in the supine position with reconstructed planes formed in the coronal direction...
July 2019: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/30915300/delayed-presentation-of-a-symptomatic-psoas-hematoma-following-lumbar-vertebral-kyphoplasty-for-myeloma-a-case-report
#16
Valerio Pace, Dimpu Bhagawati, Chang Park, Sean Molloy
Introduction: The Royal National Orthopaedic Hospital (RNOH) is a tertiary referral center and patients with spinal complications from multiple myeloma are managed here in a multidisciplinary approach. Balloon kyphoplasty(BKP) procedures are routinely performed in such patients when clinically indicated with good results and a low complication rate. There are little data reported in the literature about post-BKP hematoma formation and its management. We present the first known reported case delayed post-operative psoas hematoma in a myeloma patient following a BKP...
November 2018: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/30775546/clinical-significance-of-trabecular-bone-score-for-prediction-of-pathologic-fracture-risk-in-patients-with-multiple-myeloma
#17
JOURNAL ARTICLE
Eun Mi Lee, Bukyung Kim
OBJECTIVES: Osteolytic bone lesions are common complications in multiple myeloma (MM), and can have an impact on quality of life due to the risk of fractures. Trabecular bone score (TBS) is a novel texture index derived from dual energy x-ray absorptiometry (DXA) of lumbar spine (LS) images that provides information about bone microarchitecture. The aim of this study was to evaluate whether TBS is useful in predicting bone fractures in MM patients. METHODS: TBS was calculated retrospectively from existing DXA images of the LS, in 20 patients with newly diagnosed MM...
June 2018: Osteoporosis and Sarcopenia
https://read.qxmd.com/read/30189893/pemphigus-vulgaris-as-the-first-manifestation-of-multiple-myeloma-a-case-report
#18
JOURNAL ARTICLE
Fandresena Arilala Sendrasoa, Irina Mamisoa Ranaivo, Mendrika Fifaliana Rakotoarisaona, Onivola Raharolahy, Naina Harinjara Razanakoto, Malalaniaina Andrianarison, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja
BACKGROUND: The association between pemphigus and malignancy has been well documented for decades but an association between pemphigus vulgaris and multiple myeloma is unusual. We report a case of pemphigus vulgaris revealing multiple myeloma. CASE PRESENTATION: A 55-year-old Malagasy man, with no significant past medical history, presented with bullous and erosive skin lesions involving his trunk and scalp for the last 2 months. He had no mucous membrane involvement...
September 7, 2018: Journal of Medical Case Reports
https://read.qxmd.com/read/28670417/discrimination-between-malignant-and-benign-vertebral-fractures-using-magnetic-resonance-imaging
#19
JOURNAL ARTICLE
Tomoyuki Takigawa, Masato Tanaka, Yoshihisa Sugimoto, Tomoko Tetsunaga, Keiichiro Nishida, Toshifumi Ozaki
STUDY DESIGN: Retrospective analysis using magnetic resonance imaging (MRI). PURPOSE: To identify MRI features that could discriminate benign from malignant vertebral fractures. OVERVIEW OF LITERATURE: Discrimination between benign and malignant vertebral fractures remains challenging, particularly in patients with osteoporosis and cancer. Presently, the most sensitive means of detecting and assessing fracture etiology is MRI. However, published reports have focused on only one or a few discriminators...
June 2017: Asian Spine Journal
https://read.qxmd.com/read/28174184/multiple-myeloma-presenting-with-bilateral-ankle-pain-microangiopathy-and-complicated-by-streptococcal-meningitis-and-pneumocystis-carinii-pneumonia
#20
JOURNAL ARTICLE
Louise Dunphy, Neeraj Singh, Elizabeth Keating
Multiple myeloma is characterised by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. This clone of plasma cells proliferates in the bone marrow, resulting in extensive skeletal destruction with osteolytic lesions, osteopenia and pathological fractures. Additional disease-related complications include hypercalcaemia, renal insufficiency, anaemia and infection. We present the case of a 64-year-old woman presenting with rapid onset, painful distal symmetrical lower limb weakness and an acute kidney injury...
February 7, 2017: BMJ Case Reports
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