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https://www.readbyqxmd.com/read/29325007/rifampicin-treatment-of-blattella-germanica-evidences-a-fecal-transmission-route-of-their-gut-microbiota
#1
Tania Rosas, Carlos García-Ferris, Rebeca Domínguez-Santos, Pablo Llop, Amparo Latorre, Andrés Moya
Eukaryotes have established symbiotic relationship with microorganisms, which enables them to accomplish functions that they cannot perform alone. In the German cockroach Blattella germanica, the obligate endosymbiont Blattabacterium coexists with a rich gut microbiota. The transmission of Blattabacterium is vertical but little is known about how the gut microbiota colonizes newborn individuals. In this study, we treated B. germanica populations with rifampicin, a broad-spectrum antibiotic, during two generations and analyzed gut bacterial composition and the Blattabacterium load in control and rifampicin-treated populations...
January 9, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29321101/bioremediation-and-detoxification-of-industrial-wastes-by-earthworms-vermicompost-as-powerful-crop-nutrient-in-sustainable-agriculture
#2
REVIEW
Sartaj Ahmad Bhat, Sharanpreet Singh, Jaswinder Singh, Sunil Kumar, Bhawana, Adarsh Pal Vig
Vermicompost is the final product of the vermicomposting process involving the collective action of earthworms and microbes. During this process, the waste is converted into useful manure by reducing the harmful effects of waste. Toxicity of industrial wastes is evaluated by plant bioassays viz. Allium cepa and Vicia faba test. These bioassays are sensitive and cost-effective for the monitoring of environmental contamination. The valorization potential of earthworms and their ability to detoxify heavy metals in industrial wastes is because of their strong metabolic system and involvement of earthworm gut microbes and chloragocyte cells...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29318631/early-life-gut-microbiome-and-egg-allergy
#3
Mina Fazlollahi, Yoojin Chun, Alexander Grishin, Robert A Wood, A Wesley Burks, Peter Dawson, Stacie M Jones, Donald Y M Leung, Hugh A Sampson, Scott H Sicherer, Supinda Bunyavanich
BACKGROUND: Gut microbiota may play a role in egg allergy. We sought to examine the association between early-life gut microbiota and egg allergy. METHODS: We studied 141 children with egg allergy and controls from the multi-center Consortium of Food Allergy Research study. At enrollment (age 3 to 16 months), fecal samples were collected and clinical evaluation, egg specific IgE measurement, and egg skin prick test were performed. Gut microbiome was profiled by 16S rRNA sequencing...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29318122/the-resistance-to-plague-infection-among-meriones-persicus-from-endemic-and-non-endemic-regions-in-iran-the-role-of-gut-microbiota
#4
Mehdi Assmar, Marjan Keypour, Mehdi Rohani, Ehsan Mostafavi, Dariush Daneshvar Farhud
Background: The present study was conducted approximately 40 years ago, but its results have not been released. At the time of this study, the importance of the gut microbiota was not fully understood. Methods: Meriones persicus rodents, as one of the major reservoirs of Yersinia pestis bacterium in Iran, were compared in a disease endemic area (Akanlu, Hamadan, western Iran) and a non-endemic zone (Telo, Tehran, Iran) from 1977 to 1981. Results: This study was able to transmit the resistance to Y...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29316965/decreased-microglial-activation-through-gut-brain-axis-by-prebiotics-probiotics-or-synbiotics-effectively-restored-cognitive-function-in-obese-insulin-resistant-rats
#5
Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C Chattipakorn
BACKGROUND: Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics and probiotics improved obese-insulin resistance. However, the effects of prebiotics, probiotics, and synbiotics on cognition and microglial activity in an obese-insulin resistant condition have not yet been investigated. We aimed to evaluate the effect of prebiotic (Xyloolidosaccharide), probiotic (Lactobacillus paracasei HII01), or synbiotics in male obese-insulin resistant rats induced by a HFD...
January 9, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29315632/food-allergen-sensitized-ccr9-lymphocytes-enhance-airways-allergic-inflammation-in-mice
#6
Laure Castan, Marie-Aude Cheminant, Luc Colas, Sophie Brouard, Antoine Magnan, Grégory Bouchaud
BACKGROUND: The mechanisms of the atopic march, characterized by a natural progression from food and cutaneous allergies to rhinitis and asthma, are still unknown. However, as several organs can be involved, chemokines and their receptors might be implicated in this process and may be instrumental factors. OBJECTIVES: We hypothesized that the T-cell gut-homing receptor CCR9 could be implicated in the evolution of allergic diseases. METHODS: We characterized the immune response and the role of CCR9 in a murine model combining food allergy to wheat gliadin and a model of acute airways inflammation in response to house dust mite...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29307992/fructo-oligosaccharide-intensifies-visceral-hypersensitivity-and-intestinal-inflammation-in-a-stress-induced-irritable-bowel-syndrome-mouse-model
#7
Bin-Rui Chen, Li-Jun Du, Hui-Qin He, John J Kim, Yan Zhao, Ya-Wen Zhang, Liang Luo, Ning Dai
AIM: To determine whether fructo-oligosaccharide (FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids (SCFA) in an irritable bowel syndrome (IBS) mouse model. METHODS: Mice were randomly assigned to daily oral gavage of saline solution with or without FOS (8 g/kg body weight) for 14 d. Mice were further assigned to receive either daily one-hour water avoidance stress (WAS) or sham-WAS for the first 10 d. After 2 wk, visceral sensitivity was measured by abdominal withdrawal reflex in response to colorectal distension and mucosal inflammation was evaluated...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29306503/a-mouse-model-with-age-dependent-immune-response-and-immune-tolerance-for-hbv-infection
#8
Xuerui Yi, Youcheng Yuan, Na Li, Lu Yi, Cuiling Wang, Ying Qi, Liang Gong, Guangze Liu, Xiangping Kong
BACKGROUND: Viral clearance of human HBV infection largely depends on the age of exposure. Thus, a mouse model with age-dependent immune response and immune-tolerance for HBV infection was established. METHODS: HBVRag1 mice were generated by crossing Rag1-/- mice with HBV-Tg mice. Following adoptive transfer of splenocytes adult (8-9 weeks old) and young (3 weeks old) HBVRag1 mice were named as HBVRag-ReA and HBVRag-ReY mice respectively. The biochemical parameters that were associated with viral load and immune function, as well as the histological evaluation of the liver tissues between the two mouse models were detected...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29305401/changes-in-gut-microbiota-related-metabolites-and-long-term-successful-weight-loss-in-response-to-weight-loss-diets-the-pounds-lost-trial
#9
Yoriko Heianza, Dianjianyi Sun, Steven R Smith, George A Bray, Frank M Sacks, Lu Qi
OBJECTIVE: Adiposity and the gut microbiota are both related to the risk of type 2 diabetes. We aimed to comprehensively examine how changes induced by a weight-loss diet intervention in gut microbiota-related metabolites, such as trimethylamine N-oxide (TMAO) and its precursors (choline and l-carnitine), were associated with improvements in adiposity and regional fat deposition. RESEARCH DESIGN AND METHODS: This study included 510 overweight and obese individuals who were randomly assigned one of four diets varying in macronutrient intake...
January 5, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29304144/a-clinically-parameterized-mathematical-model-of-shigella-immunity-to-inform-vaccine-design
#10
Courtney L Davis, Rezwanul Wahid, Franklin R Toapanta, Jakub K Simon, Marcelo B Sztein
We refine and clinically parameterize a mathematical model of the humoral immune response against Shigella, a diarrheal bacteria that infects 80-165 million people and kills an estimated 600,000 people worldwide each year. Using Latin hypercube sampling and Monte Carlo simulations for parameter estimation, we fit our model to human immune data from two Shigella EcSf2a-2 vaccine trials and a rechallenge study in which antibody and B-cell responses against Shigella's lipopolysaccharide (LPS) and O-membrane proteins (OMP) were recorded...
2018: PloS One
https://www.readbyqxmd.com/read/29298861/hypersensitive-assessment-of-aryl-hydrocarbon-receptor-transcriptional-activity-using-a-novel-truncated-cyp1a-promoter-in-zebrafish
#11
Juan-Juan Luo, Dong-Sheng Su, Shao-Lin Xie, Yi Liu, Pei Liu, Xiao-Jun Yang, De-Sheng Pei
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent organic pollutant (POP), an unintentional byproduct of various industrial processes, and a human carcinogen. The expression of the cytochrome P450 1A (cyp1a) gene is upregulated in the presence of TCDD through activating the aryl hydrocarbon receptor pathway in a dose-dependent manner. Several essential response elements, including the 8 potential xenobiotic response elements in the cyp1a promoter region, have been identified to be the main functional parts for the response to TCDD...
January 3, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29281815/the-nlr-protein-nlrp6-does-not-impact-gut-microbiota-composition
#12
Paul Lemire, Susan J Robertson, Heather Maughan, Ivan Tattoli, Catherine J Streutker, Jaye M Platnich, Daniel A Muruve, Dana J Philpott, Stephen E Girardin
NLRP6 is a Nod-like receptor expressed in the intestinal epithelium. Previous studies reported a protective role for NLRP6 against intestinal injury and colitis-associated carcinogenesis via the regulation and establishment of a healthy microbiota. However, these results were not obtained using littermate animals, leaving the possibility that the pro-colitogenic microbiota phenotype associated with knockout (KO) mice was stochastically acquired and genotype independent. Here, we analyzed the microbiota at three intestinal locations from Nlrp6-/- and wild-type (WT) littermates, either co-caged or individually caged after weaning...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29274915/differences-in-fecal-microbial-metabolites-and-microbiota-of-children-with-autism-spectrum-disorders
#13
Dae-Wook Kang, Zehra Esra Ilhan, Nancy G Isern, David W Hoyt, Daniel P Howsmon, Michael Shaffer, Catherine A Lozupone, Juergen Hahn, James B Adams, Rosa Krajmalnik-Brown
Evidence supporting that gut problems are linked to ASD symptoms has been accumulating both in humans and animal models of ASD. Gut microbes and their metabolites may be linked not only to GI problems but also to ASD behavior symptoms. Despite this high interest, most previous studies have looked mainly at microbial structure, and studies on fecal metabolites are rare in the context of ASD. Thus, we aimed to detect fecal metabolites that may be present at significantly different concentrations between 21 children with ASD and 23 neurotypical children and to investigate its possible link to human gut microbiome...
December 21, 2017: Anaerobe
https://www.readbyqxmd.com/read/29274892/role-of-resistant-starch-on-diabetes-risk-factors-in-people-with-prediabetes-design-conduct-and-baseline-results-of-the-starch-trial
#14
Kara L Marlatt, Ursula A White, Robbie A Beyl, Courtney M Peterson, Corby K Martin, Maria L Marco, Michael J Keenan, Roy J Martin, Kayanush J Aryana, Eric Ravussin
Dietary resistant starch (RS) might alter gastrointestinal tract function in a manner that improves human health, particularly among adults at risk for diabetes. Here, we report the design and baseline results (with emphasis on race differences) from the STARCH trial, the first comprehensive metabolic phenotyping of people with prediabetes enrolled in a randomized clinical trial testing the effect of RS on risk factors for diabetes. Overweight/obese participants (BMI≥27kg/m2 and weight≤143kg), age 35-75y, with confirmed prediabetes were eligible...
December 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29260432/extracellular-expression-of-a-novel-%C3%AE-agarase-from-microbulbifer-sp-q7-isolated-from-the-gut-of-sea-cucumber
#15
Qian Su, Tianyi Jin, Yuan Yu, Min Yang, Haijin Mou, Li Li
A novel endo-type β-agarase was cloned from an agar-degrading bacterium, Microbulbifer sp. Q7 (CGMCC No. 14061), that was isolated from sea cucumber gut. The agarase-encoding gene, ID2563, consisted of 1800 bp that encoded a 599-residue protein with a signal peptide of 19 amino acids. Sequence analysis suggested that the agarase belongs to the GH16 family. The agarase was expressed in Escherichia coli with a total activity of 4.99 U/mL in fermentation medium. The extracellular enzyme activity accounted for 65...
December 19, 2017: AMB Express
https://www.readbyqxmd.com/read/29259559/mechanical-regulation-of-gene-expression-in-gut-smooth-muscle-cells
#16
REVIEW
Xuan-Zheng Shi
Intraluminal contents and their movement along the gastrointestinal tract create shear stress and mechanical stretch on the gut wall. While the shear stress is important in the initiation of immediate physiological responses, the circumferential mechanical stretch, such as that in obstructive bowel disorders, exerts long-lasting impacts on bowel functions by mainly affecting the deeper muscularis externae. Recent studies demonstrate that mechanical stretch alters gene transcription in gut smooth muscle cells (SMC), and the stretch-altered gene expression (mechano-transcription) may play a critical role in pathogenesis of motility dysfunction and abdominal pain in obstruction...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29258553/prenatal-alcohol-exposure-is-a-risk-factor-for-adult-neuropathic-pain-via-aberrant-neuroimmune-function
#17
Joshua J Sanchez, Shahani Noor, Suzy Davies, Daniel Savage, Erin D Milligan
BACKGROUND: Clinical studies show that prenatal alcohol exposure (PAE) results in effects that persist into adulthood. Experimental animal models of moderate PAE demonstrate that young adults with PAE display potentiated sensitivity to light touch, clinically termed allodynia, following sciatic nerve chronic constriction injury (CCI) that coincides with heightened spinal glial, spinal macrophage, and peripheral immune responses. However, basal touch sensitivity and corresponding glial and leukocyte activation are unaltered...
December 19, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29248543/plasma-ghrelin-suppression-as-an-early-predictor-for-postoperative-complications-after-pancreatoduodenectomy
#18
Kazuki Sasaki, Tadafumi Asaoka, Hidetoshi Eguchi, Yasunari Fukuda, Yoshifumi Iwagami, Daisaku Yamada, Yasuhiro Miyazaki, Takehiro Noda, Tsuyoshi Takahashi, Kunihito Gotoh, Koichi Kawamoto, Yukinori Kurokawa, Shogo Kobayashi, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
BACKGROUND/OBJECTIVES: The gut peptide hormone ghrelin induces appetite and exhibits an anti-inflammatory effect. Serial perioperative changes in ghrelin have been examined in several surgical procedures, but few in pancreatectomy. The present study analyzed perioperative changes in plasma ghrelin levels after pancreaduodenectomy (PD). METHODS: The study included 24 patients undergoing PD between May 2015 and January 2016 at Osaka University Hospital. Plasma ghrelin and interleukin-6 (IL-6) levels, as well as white blood cells (WBCs) and C-reactive protein (CRP), were measured preoperatively and on postoperative day (POD) 1, 3, 7, and 14 by enzyme-linked immunosorbent assay...
December 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29245089/metabolic-analysis-of-panax-notoginseng-saponins-with-gut-microbiota-mediated-biotransformation-by-hplc-dad-q-tof-ms-ms
#19
Man-Yun Chen, Li Shao, Wei Zhang, Chong-Zhi Wang, Hong-Hao Zhou, Wei-Hua Huang, Chun-Su Yuan
Saponins such as notoginsenosides and ginsenosides from Panax notoginseng are responsible for the herb's clinical applications. Unfortunately, there is poor oral bioavailability of saponins. However, gut microbiota can transform saponins to yield the metabolites that are potential bioactive substances. In this study, we aimed to characterize the metabolic profiles of P. notoginseng saponins (PNS) by incubating them with human gut microbiota. The notoginsenosides, ginsenosides and related metabolites were separated and identified using a highly sensitive and selective high-performance liquid chromatography coupled with diode array detection/quadrupole tandem time-of-flight mass spectrometry (HPLC-DAD-Q-TOF-MS/MS)...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29241213/antibiotics-induced-obesity-a-mitochondrial-perspective
#20
Melisa J Andrade, Chinchu Jayaprakash, Smitha Bhat, Nikolaos Evangelatos, Angela Brand, Kapaettu Satyamoorthy
Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity...
December 15, 2017: Public Health Genomics
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