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Atopic dermatitis epidemiology

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https://www.readbyqxmd.com/read/29319189/epidemiology-of-atopic-dermatitis-in-adults-results-from-an-international-survey
#1
S Barbarot, S Auziere, A Gadkari, G Girolomoni, L Puig, E L Simpson, D J Margolis, M de Bruin-Weller, L Eckert
BACKGROUND: There are gaps in our knowledge of the prevalence of adult atopic dermatitis (AD). OBJECTIVE: To estimate prevalence of AD in adults and by disease severity. METHODS: This international, cross-sectional, web-based survey was performed in the United States, Canada, France, Germany, Italy, Spain, United Kingdom, and Japan. Adult members of online respondent panels were sent a questionnaire for AD identification and severity assessment; demographic quotas ensured population representativeness for each country...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29273149/pxr-a-new-player-in-atopic%C3%A2-dermatitis
#2
Landon K Oetjen, Anna M Trier, Brian S Kim
Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking. Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis. These observations provide new insight into how environmental insults may predispose individuals to atopic dermatitis.
January 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29246346/peanut-allergy-an-epidemiologic-analysis-of-a-large-database
#3
Frederick E Leickly, Kirsten M Kloepfer, James E Slaven, Girish Vitalpur
OBJECTIVE: To confirm new observations on peanut allergy and answer current concerns that families and healthcare providers have about peanut allergy. STUDY DESIGN: Children who presented with a story of peanut allergy or peanut sensitization were asked to participate in a registry, which allowed an analysis focused on questions that a food allergy support group had about children with peanut allergy or sensitization. RESULTS: A total of 1070 children were entered into the registry over 5 years...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29238123/epidemiology-triggers-and-severity-of-childhood-asthma-in-ilesa-nigeria-implications-for-management-and-control
#4
Bankole Peter Kuti, Kehinde Oluyori Omole
Background: Knowledge about childhood asthma in a locality will assist clinicians to adequately manage the condition. This study set out to report the epidemiology, triggers of exacerbation, comorbid conditions, and severity of childhood asthma at a tertiary health facility in Nigeria and the implication of these, in management and symptoms control. Methods: Over a 15-month study period, children (aged <15 years) with physician-diagnosed asthma were consecutively recruited at the pediatric chest clinic of the hospital...
January 2017: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/29233462/recent-advancement-to-prevent-the-development-of-allergy-and-allergic-diseases-and-therapeutic-strategy-in-the-perspective-of-barrier-dysfunction
#5
REVIEW
Osamu Natsume, Yukihiro Ohya
Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march...
December 7, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29214323/economic-value-of-using-partially-hydrolysed-infant-formula-for-risk-reduction-of-atopic-dermatitis-in-high-risk-infants-not-exclusively-breastfed-in-singapore
#6
Marc F Botteman, Abhijeet J Bhanegaonkar, Erica G Horodniceanu, Xiang Ji, Bee Wah Lee, Lynette P Shek, Hugo Ps Van Bever, Patrick Detzel
INTRODUCTION: Previous trials have demonstrated reductions in atopic dermatitis (AD) incidence when healthy, high-risk, non-exclusively breastfed infants were fed until four months of age with 100% whey-based partially hydrolysed formula (PHF-W) versus standard cow's milk formula (CMF). We assessed this intervention's cost-effectiveness in Singapore. METHODS: Modelling techniques were used to simulate, from birth to Month 30, the incidence, and clinical and economic burden of AD in high-risk, non-exclusively breastfed infants fed with PHF-W or CMF for up to four months...
December 7, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29163443/parasite-derived-proteins-for-the-treatment-of-allergies-and-autoimmune-diseases
#7
REVIEW
Zhenyu Wu, Lifu Wang, Yanlai Tang, Xi Sun
The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29150853/poor-agreement-in-questionnaire-based-diagnostic-criteria-for-adult-atopic-dermatitis-is-a-challenge-when-examining-cardiovascular-comorbidity
#8
Yuki M F Andersen, Alexander Egeberg, Carsten R Hamann, Lone Skov, Gunnar H Gislason, Tea Skaaby, Allan Linneberg, Jacob P Thyssen
BACKGROUND: The association between atopic dermatitis (AD) and cardio-metabolic risk factors is not yet established. Furthermore, no validated questionnaire-based method of identifying adults with AD is currently available. OBJECTIVES: To assess the cardio-metabolic risk in adults with a history of AD by using three different questionnaire-based diagnostic criteria. METHODS: We utilized data from a general population study including questionnaire data and objective measurements of 9,656 Danish adults...
November 18, 2017: Allergy
https://www.readbyqxmd.com/read/28978208/overview-of-atopic-dermatitis
#9
Carmela Avena-Woods
Atopic dermatitis (AD), also known as atopic eczema, is a chronic relapsing inflammatory skin condition. Incidence of AD has increased 2- to 3-fold in industrialized nations, impacting approximately 15% to 20% of children and 1% to 3% of adults worldwide. AD has a wide-ranging impact on a patient's quality of life and the burden from direct and indirect costs (approximately $37.7 billion in out-of-pocket costs) is shared by the families and caregivers of patients with AD. This article reviews the epidemiology, burden of disease, pathophysiology, and diagnostic criteria important for early diagnosis and treatment...
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28975640/increased-attention-deficit-hyperactivity-symptoms-in-atopic-dermatitis-are-associated-with-history-of-antihistamine-use
#10
J Schmitt, A Buske-Kirschbaum, F Tesch, K Trikojat, V Stephan, S Abraham, A Bauer, K Nemat, F Plessow, V Roessner
BACKGROUND: Epidemiologic evidence indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD). Underlying mechanisms and ways to best identify subgroups of AD patients at risk for ADHD are poorly understood. AIMS OF THE STUDY: To compare sociodemographic, clinical and psychosocial characteristics of children with AD, ADHD, comorbid AD/ADHD and age-matched healthy controls and to investigate aspects of AD related to ADHD symptoms...
October 4, 2017: Allergy
https://www.readbyqxmd.com/read/28966512/factors-associated-with-severity-of-alopecia-areata
#11
Hye Rin You, Seong-Jin Kim
BACKGROUND: Alopecia areata is the most common cause of localized, nonscarring alopecia. Unfortunately, there are few data regarding clinical features and epidemiology of alopecia areata in Korean patients, and its clinical course and treatment response rates are unpredictable. OBJECTIVE: This study strived to investigate the differences in clinical profiles according to disease severity and to determine risk factors for severe alopecia areata. METHODS: A total of 1,137 patients from 2006 to 2015 were analyzed retrospectively...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28965102/association-between-eczema-and-major-cardiovascular-outcomes-in-population-based-studies-a-systematic-review-protocol
#12
Anna Ascott, Ashley M Yu, Morten Schmidt, Katrina Abuabara, Liam Smeeth, Sinéad M Langan
INTRODUCTION: Chronic inflammatory diseases such as eczema (also known as atopic dermatitis) have been inconsistently linked to cardiovascular disease and stroke in both mechanistic and epidemiological studies. There is a need to review the existing epidemiological data examining the association between eczema and major cardiovascular outcomes, including angina, myocardial infarction, coronary revascularisation, heart failure, cardiac arrhythmias, stroke and cardiovascular death, in order to improve our understanding of the comorbidities of eczema...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28927889/epidemiology-of-eczema-herpeticum-in-hospitalized-us-children-analysis-of-a-nationwide-cohort
#13
Derek Y Hsu, Kanade Shinkai, Jonathan I Silverberg
Eczema herpeticum (EH) is characterized by viral infection of a preexisting inflammatory dermatosis and is associated with considerable morbidity. In this cross-sectional study, we sought to determine the incidence, risk factors, comorbidities, costs of care, length of stay, and mortality in hospitalized US children with EH. The Nationwide Inpatient Sample 2002-2012, containing a 20% sample of all US hospitalizations, was analyzed. We used a validated approach involving ICD-9-CM codes to identify patients primarily admitted for EH (n=4655 weighted)...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28925103/autoimmune-diseases-involving-skin-and-intestinal-mucosa-are-more-frequent-in-adolescents-and-young-adults-suffering-from-atopic-dermatitis
#14
REVIEW
Francesca Cipriani, Alice Marzatico, Giampaolo Ricci
Evidence has emerged about the relationship between atopic dermatitis (AD) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co-occurrence of AD and autoimmune diseases. Our systematic review included 22 articles from PubMed describing the reciprocal association between AD and autoimmune diseases. Although not all the studies achieved statistically significant results, patients suffering from autoimmune diseases involving skin and intestinal mucosa, such as vitiligo, alopecia areata, celiac disease and inflammatory bowel diseases, showed a higher risk to have AD as comorbidity...
December 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28905999/validation-of-patient-reported-global-severity-of-atopic-dermatitis-in-adults
#15
P P Vakharia, R Chopra, R Sacotte, N Patel, S Immaneni, T White, R Kantor, D Y Hsu, J I Silverberg
BACKGROUND: Atopic dermatitis (AD) is associated with a heterogeneous presentation and clinical course. There is a lack of simple and validated severity assessments that are feasible for clinical practice and epidemiological research. OBJECTIVES: We sought to validate patient-reported global AD severity in adults. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 265)...
September 14, 2017: Allergy
https://www.readbyqxmd.com/read/28904961/analysis-of-epidemiology-and-risk-factors-of-atopic-dermatitis-in-korean-children-and-adolescents-from-the-2010-korean-national-health-and-nutrition-examination-survey
#16
Kyung Suk Lee, In-Hwan Oh, Sun Hee Choi, Yeong-Ho Rha
BACKGROUND: Atopic dermatitis (AD) is a common chronic inflammatory skin disease, but only few studies involved samples of children and adolescents that are representative of the entire Korean population. This study aimed to estimate the prevalence and risk factors of AD among children and adolescents in Korea by using nationally representative data. METHODS: We used data from the fifth Korean National Health and Nutrition Examination Survey in 2010 and retrospectively evaluated 2,116 children and adolescents...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28873238/cholinergic-urticaria-patients-of-different-age-groups-have-distinct-features
#17
A Asady, J Ruft, A Ellrich, T Hawro, M Maurer, S Altrichter
BACKGROUND: Cholinergic urticaria (CholU) is a common skin disease characterized by the development of pinpoint-sized weals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. As of now, it is unclear whether patients of different age show differences in the clinical manifestation of CholU, duration of disease, comorbidities or response to treatment. METHODS: Here, we analysed the demographic data and clinical characteristics including disease duration and comorbidities of 200 patients with CholU, 12-76 years of age...
September 5, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28838840/-hand-eczema-in-children-clinical-and-epidemiological-study-of-the-population-referred-to-a-tertiary-hospital
#18
José María Ortiz-Salvador, Daniela Subiabre-Ferrer, Ana García Rabasco, Altea Esteve-Martínez, Violeta Zaragoza-Ninet, Víctor Alegre de Miquel
INTRODUCTION: Hand eczema is a frequent disease in adults. Diagnosing the cause of hand eczema is difficult due to different classifications. There is lack of evidence on hand eczema and its causes in children. MATERIAL AND METHOD: A total of 389 children between 0 and 16 years were identified between 1996 and 2016, from whom 42 (10.8%) with exclusively hand eczema were selected. In all cases a standard battery of epicutaneous patch tests was performed, as well as additional batteries depending on the clinical suspicion...
August 21, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28811862/allergic-profiles-of-mothers-and-fathers-in-the-japan-environment-and-children-s-study-jecs-a-nationwide-birth-cohort-study
#19
Kiwako Yamamoto-Hanada, Limin Yang, Kazue Ishitsuka, Tadayuki Ayabe, Hidetoshi Mezawa, Mizuho Konishi, Testsuo Shoda, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: The Japan Environment and Children's Study (JECS) is a nationwide, multicenter, prospective birth cohort investigation launched by the Ministry of Environment in Japan. The purpose of the JECS is to evaluate the influence of prenatal and postnatal exposures to environmental factors on the postnatal health of the children. In this study, we evaluated the allergic characteristics of parents within the JECS cohort. METHODS: This study covered a wide geographical area and encompassed 15 regional centers...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28730653/dermatitis-of-the-foot-epidemiologic-and-clinical-features-in-389-children
#20
José-María Ortiz-Salvador, Altea Esteve-Martínez, Ana García-Rabasco, Daniela Subiabre-Ferrer, Lorena Martínez-Leboráns, Violeta Zaragoza-Ninet
BACKGROUND/OBJECTIVES: Footwear dermatitis is a form of contact dermatitis resulting from exposure to shoes. There have been only small studies regarding foot contact dermatitis in children. The present study was undertaken to define the prevalence and epidemiologic and clinical features of shoe dermatitis in children. METHODS: A retrospective study was undertaken of all children referred for patch testing between 1996 and 2015. Children with dermatitis limited to the feet were selected...
September 2017: Pediatric Dermatology
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