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Atopic dermatitis epidemiology

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https://www.readbyqxmd.com/read/28052804/prevalence-of-dermatologic-diseases-among-patients-with-selective-immunoglobulin-a-deficiency
#1
Eli Magen, Atheer Masalha, Dan Andrei Waitman, Natan Kahan, Igor Viner, Leonora Klassov, Daniel Vardy
BACKGROUND: There are no published large-scale epidemiologic studies regarding the prevalence of skin diseases in patients with selective immunoglobulin A (IgA) deficiency (sIgAD). The purpose of this study was to investigate the prevalence of dermatological diseases in patients with sIgAD. METHODS: This retrospective matched case-control study was based on data from the Leumit Healthcare Services data base (approximately 725,000 residents of Israel), which was searched for all subjects aged ≥12 years who had undergone serum total IgA measurements during 2004-14 for any reason...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28011146/association-of-atopic-dermatitis-with-cardiovascular-risk-factors-and-diseases
#2
Marie Standl, Falko Tesch, Hansjörg Baurecht, Elke Rodríguez, Martina Müller-Nurasyid, Christian Gieger, Annette Peters, Rui Wang-Sattler, Cornelia Prehn, Jerzy Adamski, Florian Kronenberg, Holger Schulz, Sibylle Koletzko, Tamara Schikowski, Andrea von Berg, Irina Lehmann, Dietrich Berdel, Joachim Heinrich, Jochen Schmitt, Stephan Weidinger
Epidemiological studies suggested an association between atopic dermatitis (AD) and cardiovascular disease (CVD). Therefore, we investigate associations and potential underlying pathways of AD and CVD in large cohort studies: the AOK PLUS cohort (n=1.2Mio), the GINIplus/LISAplus birth cohorts (n=2286), and the KORA F4 cohort (n=2990). Additionally, metabolomics in KORA F4 and established cardiovascular risk loci in genome-wide data on 10,788 AD cases and 30,047 controls were analyzed. Longitudinal analysis of AD patients in AOK PLUS showed slightly increased risk for incident angina pectoris (AP) (adjusted risk ratio 1...
December 20, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27997983/validation-of-international-classification-of-disease-ninth-revision-codes-for-atopic-dermatitis
#3
Derek Y Hsu, Prarthana Dalal, Kimberly A Sable, Nihal Voruganti, Beatrice Nardone, Dennis West, Jonathan I Silverberg
BACKGROUND: Evaluation of large-scale data sets is needed to better understand the epidemiology, cost and burden of atopic dermatitis (AD). We sought to validate the use of ICD-9-CM codes for identifying AD. METHODS: Patients from a large metropolitan quaternary care medical center with a diagnostic code of either 691.8 (AD) or 692.9 (eczema and contact dermatitis) were queried. Medical records were reviewed for demographics, Hanifin & Rajka (H&R) and United Kingdom Working Party (UKWP) criteria...
December 20, 2016: Allergy
https://www.readbyqxmd.com/read/27979023/rate-of-recurrent-anaphylaxis-and-associated-risk-factors-among-olmsted-county-minnesota-residents-a-population-based-study
#4
Sangil Lee, Curtis Bashore, Christine M Lohse, M Fernanda Bellolio, Alanna Chamberlain, Kumi Yuki, Erik P Hess, Ronna L Campbell
BACKGROUND: The rate and risk factors for recurrence of anaphylaxis are not well known. OBJECTIVE: To measure the rate and risk factors for recurrent anaphylaxis in a population-based cohort in Olmsted County, Minnesota. METHODS: We conducted a population-based cohort study using the Rochester Epidemiology Project, a comprehensive medical records linkage system, to obtain records of patients who presented to medical centers within the Olmsted County area with anaphylaxis from January 1, 2001, through December 31, 2010...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27957490/prevalence-and-clinical-features-of-atopic-dermatitis-in-china
#5
Xin Wang, Lin-Feng Li, Da-Yu Zhao, Yi-Wei Shen
Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified. Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients. Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 tertiary hospitals in 15 provinces. Results. This study included 682 patients diagnosed with AD, with the mean age of 28.8 ± 20.1 years and the median course of 5.3 ± 6.9 years. AD patients had more severe itching (30...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27931536/advances-in-atopic-dermatitis-in-2015
#6
REVIEW
Takashi Nomura, Kenji Kabashima
This review aims to highlight recently published articles on atopic dermatitis (AD). Updated are the insights into epidemiology, pathology, diagnostics, and therapy. Epidemiologic studies have revealed a positive correlation between AD and systemic conditions, such as rheumatoid arthritis, inflammatory bowel disease, and neonatal adiposity. Pathologic findings highlight the involvement of novel barrier factors (desmoplakin and claudin), novel immune cell subsets (pathogenic effector TH2 cells and group 2 innate lymphoid cells), and differential skewing of helper T cells (eg, TH17 dominance in Asians with AD)...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27882588/clinical-and-epidemiological-analysis-in-149-cases-of-rhododendrol-induced-leukoderma
#7
Momoko Yoshikawa, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kimi Kase, Yasue Ishii-Osai, Junji Kato, Yuji Kan, Shiori Kamiya, Yuki Sato, Toshiharu Yamashita
Rhododendrol-induced leukoderma is an acquired depigmentation that develops mainly at the contact site after repeated use of skin-whitening cosmetics containing rhododendrol. In most cases, cessation of further depigmentation or occurrence of repigmentation is observed after discontinuing the use of cosmetics. However, some patients develop vitiligo vulgaris through the spread of depigmentation into the non-exposed areas. Our study aims to investigate the patient-specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27677381/prevalence-and-risk-factors-for-asthma-among-children-aged-0-14-years-in-hangzhou-a-cross-sectional-survey
#8
Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao
BACKGROUND: Asthma is a global problem. Prevalence varies among different countries and cities. We aimed to obtain the prevalence, describe the characteristics, and discover factors that may relate to asthma in Hangzhou. METHODS: This cross-sectional study was conducted in Hangzhou. The subjects were children aged 14 years and younger. A control group of non-asthma children that matched in age and sex with each asthmatic patient was also randomly selected and interviewed...
September 27, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27663502/ld-hub-a-centralized-database-and-web-interface-to-perform-ld-score-regression-that-maximizes-the-potential-of-summary-level-gwas-data-for-snp-heritability-and-genetic-correlation-analysis
#9
Jie Zheng, A Mesut Erzurumluoglu, Benjamin L Elsworth, John P Kemp, Laurence Howe, Philip C Haycock, Gibran Hemani, Katherine Tansey, Charles Laurin, Beate St Pourcain, Nicole M Warrington, Hilary K Finucane, Alkes L Price, Brendan K Bulik-Sullivan, Verneri Anttila, Lavinia Paternoster, Tom R Gaunt, David M Evans, Benjamin M Neale
MOTIVATION: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correlation between different phenotypes. Because the method relies on summary level results data, LD score regression is computationally tractable even for very large sample sizes. However, publicly available GWAS summary-level data are typically stored in different databases and have different formats, making it difficult to apply LD score regression to estimate genetic correlations across many different traits simultaneously...
September 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27639188/skin-absorption-through-atopic-dermatitis-skin-a-systematic-review
#10
A-S Halling-Overgaard, S Kezic, I Jakasa, K A Engebretsen, H Maibach, J P Thyssen
Patients with atopic dermatitis have skin barrier impairment in both lesional and non-lesional skin. They are typically exposed to emollients daily and topical anti-inflammatory medicaments intermittently, hereby increasing the risk of developing contact allergy and systemic exposed to chemicals ingredients found in these topical preparations. We systematically searched for studies that investigated skin absorption of various penetrants, including medicaments, in atopic dermatitis patients, but also animals with experimentally induced dermatitis...
September 17, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27562258/whole-metagenome-profiling-reveals-skin-microbiome-dependent-susceptibility-to-atopic-dermatitis-flare
#11
Kern Rei Chng, Angeline Su Ling Tay, Chenhao Li, Amanda Hui Qi Ng, Jingjing Wang, Bani Kaur Suri, Sri Anusha Matta, Naomi McGovern, Baptiste Janela, Xuan Fei Colin C Wong, Yang Yie Sio, Bijin Veonice Au, Andreas Wilm, Paola Florez De Sessions, Thiam Chye Lim, Mark Boon Yang Tang, Florent Ginhoux, John E Connolly, E Birgitte Lane, Fook Tim Chew, John E A Common, Niranjan Nagarajan
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases, but issues of cost, robustness and sampling efficacy have limited its application. Here, we have established an alternative, clinically practical and robust metagenomic analysis protocol and applied it to 80 skin microbiome samples epidemiologically stratified for atopic dermatitis (AD). We have identified distinct non-flare, baseline skin microbiome signatures enriched for Streptococcus and Gemella but depleted for Dermacoccus in AD-prone versus normal healthy skin...
2016: Nature Microbiology
https://www.readbyqxmd.com/read/27525380/update-on-epidemiology-diagnosis-and-disease-course-of-atopic-dermatitis
#12
REVIEW
Eric L Simpson, Alan D Irvine, Lawrence F Eichenfield, Sheila F Friedlander
Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life...
June 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27499642/stigmatization-and-self-perception-in-children-with-atopic-dermatitis
#13
REVIEW
Pavel V Chernyshov
Atopic dermatitis (AD) is one of the most common skin diseases. Prevalence of AD is highest in childhood. Because of chronicity and often visible lesions, AD may lead to stigmatization and problems with self-perception. However, problems of self-perception and stigmatization in AD children are poorly studied. Literature data on general tendencies of children's development, clinical course, and epidemiologic tendencies of AD in different age groups make it possible to highlight three main periods in the formation of self-perception and stigmatization...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27461758/atopic-dermatitis-naevi-count-and-skin-cancer-risk-a-meta-analysis
#14
Sara Gandini, Ignazio Stanganelli, Domenico Palli, Vincenzo De Giorgi, Giovanna Masala, Saverio Caini
BACKGROUND: The risk of skin malignancy among atopic dermatitis (AD) patients is not well established. OBJECTIVE: We reviewed the epidemiological evidence on the association between AD, naevi count, and the risk of cutaneous melanoma and keratinocyte skin cancer (KSC). METHODS: We included all studies that compared the naevi count and the risk of skin cancer (melanoma and/or KSC) between AD patients and unaffected individuals. We calculated summary relative risks (SRRs) and 95% confidence intervals (CI) through random effects models; explored correlates of between-studies heterogeneity using sub-group and sensitivity analysis; and assessed publication bias using a funnel-plot-based approach...
November 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27459457/epidemiological-assessments-of-skin-outcomes-in-the-nurses-health-studies
#15
Wen-Qing Li, Eunyoung Cho, Martin A Weinstock, Hasan Mashfiq, Abrar A Qureshi
OBJECTIVES: To review the contribution of the Nurses' Health Studies (NHSs) to identifying epidemiological factors associated with multiple skin diseases, including skin cancer, psoriasis, and other inflammatory and autoimmune skin diseases. METHODS: We carried out a narrative review of NHS articles published between 1976 and 2016. RESULTS: The NHSs have identified environmental and lifestyle factors related to psoriasis, supporting obesity and smoking as psoriasis risk factors; associations between psoriasis and diabetes, myocardial infarction, and Crohn's disease, supporting psoriasis as a systemic disorder; and associations of pigmentary traits, ultraviolet radiation, and lifestyle factors such as citrus consumption with risk of skin cancer...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27438199/profile-of-patients-admitted-to-a-triage-dermatology-clinic-at-a-tertiary-hospital-in-s%C3%A3-o-paulo-brazil
#16
Fernanda Bertanha, Erica Judite Pimentel Nelumba, Alyne Korukian Freiberg, Luciana Paula Samorano, Cyro Festa
BACKGROUND: Knowledge of epidemiological data on skin diseases is important in planning preventive strategies in healthcare services. OBJECTIVE: To assess data from patients admitted to a triage dermatology clinic. METHODS: A retrospective study was performed of patients admitted over a one-year period to the Triage Dermatology Clinic at the Hospital das Clínicas of the University of São Paulo Medical School. Data were obtained from record books...
May 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27429944/utility-of-the-atopy-patch-test-in-the-diagnosis-of-allergic-rhinitis
#17
REVIEW
Nicola Fuiano, Cristoforo Incorvaia
INTRODUCTION: The diagnostic work-up of allergic rhinitis (AR) is first and foremost based on the combination of clinical history data and results of skin prick tests (SPT). Other tests, including specific IgE measurement, nasal challenge, and, as a third option, component resolved diagnosis or basophil activation test, may be useful when the diagnosis is difficult because of polysensitization or when negative results of SPT are observed despite a suggestive history for allergy. The atopy patch test (APT) that assesses the type 4 delayed hypersensitivity allergy is currently not sufficiently used...
May 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27371104/low-dna-sequence-diversity-of-the-intergenic-spacer-1-region-in-the-human-skin-commensal-fungi-malassezia-sympodialis-and-m-dermatis-isolated-from-patients-with-malassezia-associated-skin-diseases-and-healthy-subjects
#18
Otomi Cho, Takashi Sugita
As DNA sequences of the intergenic spacer (IGS) region in the rRNA gene show remarkable intraspecies diversity compared with the small subunit, large subunit, and internal transcribed spacer region, the IGS region has been used as an epidemiological tool in studies on Malassezia globosa and M. restricta, which are responsible for the exacerbation of atopic dermatitis (AD) and seborrheic dermatitis (SD). However, the IGS regions of M. sympodialis and M. dermatis obtained from the skin of patients with AD and SD, as well as healthy subjects, lacked sequence diversity...
December 2016: Mycopathologia
https://www.readbyqxmd.com/read/27333715/importance-of-educational-intervention-and-parental-knowledge-on-atopic-dermatitis-in-children
#19
Lena Kotrulja, Tina Milavić, Suzana Ožanić Bulić, Natalija Šitum, Ana Bakija Konsuo, Ivanka Muršić, Ines Birkić Belanović, Lidija Dilenardo
Atopic dermatitis (AD) is a chronic relapsing, inflammatory skin disease. Failure to treat AD successfully can often be directly linked to poor treatment adherence as a result of the lack of information about the disease and basic principles of treatment. Several studies have found that making patients active participants in their care through information and education is a successful treatment strategy in AD. The aim of this study was to evaluate parental knowledge on AD and to stress the importance of therapeutic educational program in long-term management and control of the disease...
March 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/27265078/prurigo-pruritic-folliculitis-and-atopic-eruption-of-pregnancy-facts-and-controversies
#20
Maria Magdalena Roth, Patricia Cristodor, George Kroumpouzos
Prurigo (PP) and pruritic folliculitis of pregnancy (PFP) are poorly characterized entities. Traditionally classified under specific dermatoses of pregnancy, they were reclassified under a new umbrella entity, atopic eruption of pregnancy (AEP), which also includes atopic dermatitis (AD) that can worsen or present for the first time in pregnancy. Still, several aspects of AEP have not been adequately elucidated. It needs to be clarified whether it is the intrinsic ("nonallergic" or "atopiform dermatitis") or extrinsic (immunoglobulin E-associated) AD that is affected by pregnancy...
May 2016: Clinics in Dermatology
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