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Atopic dermatitis epidemiology

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https://www.readbyqxmd.com/read/28210979/the-skin-as-a-route-of-allergen-exposure-part-ii-allergens-and-role-of-the-microbiome-and-environmental-exposures
#1
REVIEW
George Knaysi, Anna R Smith, Jeffrey M Wilson, Julia A Wisniewski
PURPOSE OF REVIEW: This second part of the article aims to highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen. RECENT FINDINGS: Several properties of allergens facilitate barrier disruption and cutaneous sensitization. There is a strong epidemiologic relationship between the microbiome, both the gut and skin, and atopic dermatitis (AD). The mechanisms connecting these two entities remain enigmatic; however, recent murine models show that commensal skin bacteria play an active role in supporting skin barrier homeostasis and defense against microbial penetration...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28182031/allergies-in-urban-versus-countryside-settings-in-poland-as-part-of-the-epidemiology-of-the-allergic-diseases-in-poland-ecap-study-challenge-the-early-differential-diagnosis
#2
Edyta Krzych-Fałta, Konrad Furmańczyk, Barbara Piekarska, Aneta Tomaszewska, Adam Sybilski, Bolesław K Samoliński
INTRODUCTION: The incidence of allergies depends on a number of factors, including adopting an urban "western" lifestyle, genetic predispositions, and different regions of residence. AIM: To compare the prevalence of allergic conditions (seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR), bronchial asthma (BA), atopic dermatitis (AD)) in a group of countryside versus urban residents in Poland. MATERIAL AND METHODS: The prevalence of allergic conditions in urban versus countryside settings was assessed using the translated and approved questionnaire developed for international ECRHS II and ISAAC studies...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28168422/contact-allergy-to-preservatives-in-patients-with-occupational-contact-dermatitis-and-exposure-analysis-of-preservatives-in-registered-chemical-products-for-occupational-use
#3
Jakob Ferløv Schwensen, Ulrik Fischer Friis, Torkil Menné, Mari-Ann Flyvholm, Jeanne Duus Johansen
PURPOSE: The aim of the study is to investigate risk factors for sensitization to preservatives and to examine to which extent different preservatives are registered in chemical products for occupational use in Denmark. METHODS: A retrospective epidemiological observational analysis of data from a university hospital was conducted. All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5-year period: 2009-2013...
February 6, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28126434/adult-atopic-dermatitis-and-exposure-to-air-pollutants-a-nationwide-population-based-study
#4
Kuo-Tung Tang, Kai-Chen Ku, Der-Yuan Chen, Ching-Heng Lin, Ben-Jei Tsuang, Yi-Hsing Chen
BACKGROUND: There is a trend toward an increased worldwide prevalence of allergic diseases. It is speculated that industrialization with resultant air pollution plays a role. However, there are sparse epidemiologic data on the relation between air pollution and atopic dermatitis (AD) in adults. OBJECTIVE: To investigate the relation between exposure to air pollutants and adult AD in a cross-sectional study based on data from the National Health Insurance Research Database in Taiwan...
January 23, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28124649/dry-eye-disease-and-allergic-conditions-a-korean-nationwide-population-based-study
#5
Minkyeong Kim, Jong-Hyun Oh, Choul Yong Park, Sang Wha Lee
BACKGROUND: Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface. No epidemiologic reports have yet been published about the relationship between DED and allergic rhinitis or sensitization to allergens. OBJECTIVE: To investigate the association between DED and allergic conditions in the general adult Korean population. METHODS: This population-based cross-sectional study included 17,542 individuals (ages ≥ 19 years) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28052804/prevalence-of-dermatologic-diseases-among-patients-with-selective-immunoglobulin-a-deficiency
#6
Eli Magen, Atheer Masalha, Dan Andrei Waitman, Natan Kahan, Igor Viner, Leonora Klassov, Daniel Vardy
BACKGROUND: There are no published large-scale epidemiologic studies regarding the prevalence of skin diseases in patients with selective immunoglobulin A (IgA) deficiency (sIgAD). The purpose of this study was to investigate the prevalence of dermatological diseases in patients with sIgAD. METHODS: This retrospective matched case-control study was based on data from the Leumit Healthcare Services data base (approximately 725,000 residents of Israel), which was searched for all subjects aged ≥12 years who had undergone serum total IgA measurements during 2004-14 for any reason...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28011146/association-of-atopic-dermatitis-with-cardiovascular-risk-factors-and-diseases
#7
Marie Standl, Falko Tesch, Hansjörg Baurecht, Elke Rodríguez, Martina Müller-Nurasyid, Christian Gieger, Annette Peters, Rui Wang-Sattler, Cornelia Prehn, Jerzy Adamski, Florian Kronenberg, Holger Schulz, Sibylle Koletzko, Tamara Schikowski, Andrea von Berg, Irina Lehmann, Dietrich Berdel, Joachim Heinrich, Jochen Schmitt, Stephan Weidinger
Epidemiological studies suggested an association between atopic dermatitis (AD) and cardiovascular disease (CVD). Therefore, we investigate associations and potential underlying pathways of AD and CVD in large cohort studies: the AOK PLUS cohort (n=1.2Mio), the GINIplus/LISAplus birth cohorts (n=2286), and the KORA F4 cohort (n=2990). Additionally, metabolomics in KORA F4 and established cardiovascular risk loci in genome-wide data on 10,788 AD cases and 30,047 controls were analyzed. Longitudinal analysis of AD patients in AOK PLUS showed slightly increased risk for incident angina pectoris (AP) (adjusted risk ratio 1...
December 20, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27997983/validation-of-international-classification-of-disease-ninth-revision-codes-for-atopic-dermatitis
#8
Derek Y Hsu, Prarthana Dalal, Kimberly A Sable, Nihal Voruganti, Beatrice Nardone, Dennis West, Jonathan I Silverberg
BACKGROUND: Evaluation of large-scale data sets is needed to better understand the epidemiology, cost and burden of atopic dermatitis (AD). We sought to validate the use of ICD-9-CM codes for identifying AD. METHODS: Patients from a large metropolitan quaternary care medical center with a diagnostic code of either 691.8 (AD) or 692.9 (eczema and contact dermatitis) were queried. Medical records were reviewed for demographics, Hanifin & Rajka (H&R) and United Kingdom Working Party (UKWP) criteria...
December 20, 2016: Allergy
https://www.readbyqxmd.com/read/27979023/rate-of-recurrent-anaphylaxis-and-associated-risk-factors-among-olmsted-county-minnesota-residents-a-population-based-study
#9
Sangil Lee, Curtis Bashore, Christine M Lohse, M Fernanda Bellolio, Alanna Chamberlain, Kumi Yuki, Erik P Hess, Ronna L Campbell
BACKGROUND: The rate and risk factors for recurrence of anaphylaxis are not well known. OBJECTIVE: To measure the rate and risk factors for recurrent anaphylaxis in a population-based cohort in Olmsted County, Minnesota. METHODS: We conducted a population-based cohort study using the Rochester Epidemiology Project, a comprehensive medical records linkage system, to obtain records of patients who presented to medical centers within the Olmsted County area with anaphylaxis from January 1, 2001, through December 31, 2010...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27957490/prevalence-and-clinical-features-of-atopic-dermatitis-in-china
#10
Xin Wang, Lin-Feng Li, Da-Yu Zhao, Yi-Wei Shen
Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified. Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients. Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 tertiary hospitals in 15 provinces. Results. This study included 682 patients diagnosed with AD, with the mean age of 28.8 ± 20.1 years and the median course of 5.3 ± 6.9 years. AD patients had more severe itching (30...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27931536/advances-in-atopic-dermatitis-in-2015
#11
REVIEW
Takashi Nomura, Kenji Kabashima
This review aims to highlight recently published articles on atopic dermatitis (AD). Updated are the insights into epidemiology, pathology, diagnostics, and therapy. Epidemiologic studies have revealed a positive correlation between AD and systemic conditions, such as rheumatoid arthritis, inflammatory bowel disease, and neonatal adiposity. Pathologic findings highlight the involvement of novel barrier factors (desmoplakin and claudin), novel immune cell subsets (pathogenic effector TH2 cells and group 2 innate lymphoid cells), and differential skewing of helper T cells (eg, TH17 dominance in Asians with AD)...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27882588/clinical-and-epidemiological-analysis-in-149-cases-of-rhododendrol-induced-leukoderma
#12
Momoko Yoshikawa, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kimi Kase, Yasue Ishii-Osai, Junji Kato, Yuji Kan, Shiori Kamiya, Yuki Sato, Toshiharu Yamashita
Rhododendrol-induced leukoderma is an acquired depigmentation that develops mainly at the contact site after repeated use of skin-whitening cosmetics containing rhododendrol. In most cases, cessation of further depigmentation or occurrence of repigmentation is observed after discontinuing the use of cosmetics. However, some patients develop vitiligo vulgaris through the spread of depigmentation into the non-exposed areas. Our study aims to investigate the patient-specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris...
November 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27677381/prevalence-and-risk-factors-for-asthma-among-children-aged-0-14-years-in-hangzhou-a-cross-sectional-survey
#13
Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao
BACKGROUND: Asthma is a global problem. Prevalence varies among different countries and cities. We aimed to obtain the prevalence, describe the characteristics, and discover factors that may relate to asthma in Hangzhou. METHODS: This cross-sectional study was conducted in Hangzhou. The subjects were children aged 14 years and younger. A control group of non-asthma children that matched in age and sex with each asthmatic patient was also randomly selected and interviewed...
September 27, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27663502/ld-hub-a-centralized-database-and-web-interface-to-perform-ld-score-regression-that-maximizes-the-potential-of-summary-level-gwas-data-for-snp-heritability-and-genetic-correlation-analysis
#14
Jie Zheng, A Mesut Erzurumluoglu, Benjamin L Elsworth, John P Kemp, Laurence Howe, Philip C Haycock, Gibran Hemani, Katherine Tansey, Charles Laurin, Beate St Pourcain, Nicole M Warrington, Hilary K Finucane, Alkes L Price, Brendan K Bulik-Sullivan, Verneri Anttila, Lavinia Paternoster, Tom R Gaunt, David M Evans, Benjamin M Neale
MOTIVATION: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correlation between different phenotypes. Because the method relies on summary level results data, LD score regression is computationally tractable even for very large sample sizes. However, publicly available GWAS summary-level data are typically stored in different databases and have different formats, making it difficult to apply LD score regression to estimate genetic correlations across many different traits simultaneously...
September 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27639188/skin-absorption-through-atopic-dermatitis-skin-a-systematic-review
#15
A-S Halling-Overgaard, S Kezic, I Jakasa, K A Engebretsen, H Maibach, J P Thyssen
Patients with atopic dermatitis have skin barrier impairment in both lesional and non-lesional skin. They are typically exposed to emollients daily and topical anti-inflammatory medicaments intermittently, hereby increasing the risk of developing contact allergy and systemic exposed to chemicals ingredients found in these topical preparations. We systematically searched for studies that investigated skin absorption of various penetrants, including medicaments, in atopic dermatitis patients, but also animals with experimentally induced dermatitis...
September 17, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27562258/whole-metagenome-profiling-reveals-skin-microbiome-dependent-susceptibility-to-atopic-dermatitis-flare
#16
Kern Rei Chng, Angeline Su Ling Tay, Chenhao Li, Amanda Hui Qi Ng, Jingjing Wang, Bani Kaur Suri, Sri Anusha Matta, Naomi McGovern, Baptiste Janela, Xuan Fei Colin C Wong, Yang Yie Sio, Bijin Veonice Au, Andreas Wilm, Paola Florez De Sessions, Thiam Chye Lim, Mark Boon Yang Tang, Florent Ginhoux, John E Connolly, E Birgitte Lane, Fook Tim Chew, John E A Common, Niranjan Nagarajan
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases, but issues of cost, robustness and sampling efficacy have limited its application. Here, we have established an alternative, clinically practical and robust metagenomic analysis protocol and applied it to 80 skin microbiome samples epidemiologically stratified for atopic dermatitis (AD). We have identified distinct non-flare, baseline skin microbiome signatures enriched for Streptococcus and Gemella but depleted for Dermacoccus in AD-prone versus normal healthy skin...
2016: Nature Microbiology
https://www.readbyqxmd.com/read/27525380/update-on-epidemiology-diagnosis-and-disease-course-of-atopic-dermatitis
#17
REVIEW
Eric L Simpson, Alan D Irvine, Lawrence F Eichenfield, Sheila F Friedlander
Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life...
June 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27499642/stigmatization-and-self-perception-in-children-with-atopic-dermatitis
#18
REVIEW
Pavel V Chernyshov
Atopic dermatitis (AD) is one of the most common skin diseases. Prevalence of AD is highest in childhood. Because of chronicity and often visible lesions, AD may lead to stigmatization and problems with self-perception. However, problems of self-perception and stigmatization in AD children are poorly studied. Literature data on general tendencies of children's development, clinical course, and epidemiologic tendencies of AD in different age groups make it possible to highlight three main periods in the formation of self-perception and stigmatization...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27461758/atopic-dermatitis-naevi-count-and-skin-cancer-risk-a-meta-analysis
#19
Sara Gandini, Ignazio Stanganelli, Domenico Palli, Vincenzo De Giorgi, Giovanna Masala, Saverio Caini
BACKGROUND: The risk of skin malignancy among atopic dermatitis (AD) patients is not well established. OBJECTIVE: We reviewed the epidemiological evidence on the association between AD, naevi count, and the risk of cutaneous melanoma and keratinocyte skin cancer (KSC). METHODS: We included all studies that compared the naevi count and the risk of skin cancer (melanoma and/or KSC) between AD patients and unaffected individuals. We calculated summary relative risks (SRRs) and 95% confidence intervals (CI) through random effects models; explored correlates of between-studies heterogeneity using sub-group and sensitivity analysis; and assessed publication bias using a funnel-plot-based approach...
November 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27459457/epidemiological-assessments-of-skin-outcomes-in-the-nurses-health-studies
#20
Wen-Qing Li, Eunyoung Cho, Martin A Weinstock, Hasan Mashfiq, Abrar A Qureshi
OBJECTIVES: To review the contribution of the Nurses' Health Studies (NHSs) to identifying epidemiological factors associated with multiple skin diseases, including skin cancer, psoriasis, and other inflammatory and autoimmune skin diseases. METHODS: We carried out a narrative review of NHS articles published between 1976 and 2016. RESULTS: The NHSs have identified environmental and lifestyle factors related to psoriasis, supporting obesity and smoking as psoriasis risk factors; associations between psoriasis and diabetes, myocardial infarction, and Crohn's disease, supporting psoriasis as a systemic disorder; and associations of pigmentary traits, ultraviolet radiation, and lifestyle factors such as citrus consumption with risk of skin cancer...
September 2016: American Journal of Public Health
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