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multiple myeloma fracture

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https://www.readbyqxmd.com/read/27888274/percutaneous-sacroplasty-for-the-management-of-painful-pathologic-fracture-in-a-multiple-myeloma-patient-case-report-and-review-of-the-literature
#1
A A Dmytriw, K Talla, R Smith
Percutaneous kyphoplasty has a well-established role in the treatment of pathologic fractures in patients with multiple myeloma. Despite this, there is a scarcity of literature surrounding its use and efficacy in the sacrum. We present a case of successful symptom resolution in a patient with painful sacral fracture following sacroplasty, and review the existing literature.An 81-year-man with multiple myeloma presented to the hematology/oncology clinic with a history of excruciating pain while seated. The impact of this pain on his quality of life subjectively was rated to be particularly high...
November 25, 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27863287/bone-health-in-the-elderly-cancer-patient-a-siog-position-paper
#2
REVIEW
J J Body, E Terpos, B Tombal, P Hadji, A Arif, A Young, M Aapro, R Coleman
More than a third of cancers are diagnosed in people over the age of 75. Androgen deprivation for prostate cancer and aromatase inhibitors in breast cancer accelerate age-related bone loss and increase fracture rates. BMD should be checked by dual energy X-ray absorptiometry at baseline and, dependent on risk, every 12-24months. Sufficient calcium, vitamin D and exercise are part of primary fracture prevention. Resistance exercise in particular may improve functional activity and bone density. In men at increased fracture risk and women with postmenopausal early breast cancer, antiresorptive treatment is warranted to reduce fracture rate and to increase overall survival in breast cancer...
December 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27809247/assessing-heterogeneity-of-osteolytic-lesions-in-multiple-myeloma-by-%C3%A2-h-hr-mas-nmr-metabolomics
#3
Laurette Tavel, Francesca Fontana, Josè Manuel Garcia Manteiga, Silvia Mari, Elisabetta Mariani, Enrico Caneva, Roberto Sitia, Francesco Camnasio, Magda Marcatti, Simone Cenci, Giovanna Musco
Multiple myeloma (MM) is a malignancy of plasma cells characterized by multifocal osteolytic bone lesions. Macroscopic and genetic heterogeneity has been documented within MM lesions. Understanding the bases of such heterogeneity may unveil relevant features of MM pathobiology. To this aim, we deployed unbiased ¹H high-resolution magic-angle spinning (HR-MAS) nuclear magnetic resonance (NMR) metabolomics to analyze multiple biopsy specimens of osteolytic lesions from one case of pathological fracture caused by MM...
October 31, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27791828/spine-stereotactic-radiosurgery-for-the-treatment-of-multiple-myeloma
#4
Jacob A Miller, Ehsan H Balagamwala, Samuel T Chao, Todd Emch, John H Suh, Toufik Djemil, Lilyana Angelov
OBJECTIVE The objective of this study was to define symptomatic and radiographic outcomes following spine stereotactic radiosurgery (SRS) for the treatment of multiple myeloma. METHODS All patients with pathological diagnoses of myeloma undergoing spine SRS at a single institution were included. Patients with less than 1 month of follow-up were excluded. The primary outcome measure was the cumulative incidence of pain relief after spine SRS, while secondary outcomes included the cumulative incidences of radiographic failure and vertebral fracture...
October 28, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27783835/percutaneous-acetabuloplasty-for-metastatic-lesions-to-the-pelvis
#5
Ryan A Durfee, Scott A Sabo, G Douglas Letson, Odion Binitie, David Cheong
Metastatic lesions of the acetabulum can be painful and debilitating. First-line treatment is multimodal and consists of disease-specific chemotherapy, osteoclastic inhibitors, analgesics, and radiation therapy. When these therapies fail, surgical intervention usually is indicated and varies from regional defect stabilization to large periacetabular reconstructions that are demanding procedures with high rates of complications. Percutaneous cement augmentation (acetabuloplasty) of lesions in selected patients has been explored as a less invasive method of lesional control...
October 25, 2016: Orthopedics
https://www.readbyqxmd.com/read/27758772/effect-of-systemic-therapies-on-outcomes-following-vertebroplasty-among-patients-with-multiple-myeloma
#6
R J McDonald, J S McDonald, D F Kallmes, V T Lehman, F E Diehn, J T Wald, K R Thielen, A Dispenzieri, P H Luetmer
BACKGROUND AND PURPOSE: The role of vertebroplasty in patients with myeloma remains relatively undefined. Accordingly, we sought to better define the efficacy of vertebroplasty for myeloma-associated fractures and determine the effect of procedure timing relative to the initiation of systemic therapy on outcomes and complication rates. MATERIALS AND METHODS: Clinical, laboratory, and medication data were retrieved for 172 patients with multiple myeloma treated with vertebroplasty since October 2000...
October 6, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27716740/high-levels-of-periostin-correlate-with-increased-fracture-rate-diffuse-mri-pattern-abnormal-bone-remodeling-and-advanced-disease-stage-in-patients-with-newly-diagnosed-symptomatic-multiple-myeloma
#7
E Terpos, D Christoulas, E Kastritis, T Bagratuni, M Gavriatopoulou, M Roussou, A Papatheodorou, E Eleutherakis-Papaiakovou, N Kanellias, C Liakou, I Panagiotidis, M Migkou, P Kokkoris, L A Moulopoulos, M A Dimopoulos
Periostin is an extracellular matrix protein that is implicated in the biology of normal bone remodeling and in different cancer cell growth and metastasis. However, there is no information on the role of periostin in multiple myeloma (MM). Thus, we evaluated periostin in six myeloma cell lines in vitro; in the bone marrow plasma and serum of 105 newly diagnosed symptomatic MM (NDMM) patients and in the serum of 23 monoclonal gammopathy of undetermined significance (MGUS), 33 smoldering MM (SMM) patients, 30 patients at the plateau phase post-first-line therapy, 30 patients at first relapse and 30 healthy controls...
October 7, 2016: Blood Cancer Journal
https://www.readbyqxmd.com/read/27696267/bone-disease-in-multiple-myeloma
#8
Homare Eda, Loredana Santo, G David Roodman, Noopur Raje
Bone involvement represented by osteolytic bone disease (OBD) or osteopenia is one of the pathognomonic and defining characteristics of multiple myeloma (MM). Nearly 90 % of patients with MM develop osteolytic bone lesions, frequently complicated by skeletal-related events (SRE) such as severe bone pain, pathological fractures, vertebral collapse, hypercalcemia, and spinal cord compression. All of these not only result in a negative impact on quality of life but also adversely impact overall survival. OBD is a consequence of increased osteoclast (OC) activation along with osteoblast (OB) inhibition, resulting in altered bone remodeling...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/27660156/pathological-fracture-in-odontoid-process-in-multiple-myeloma
#9
Ufuk Demirci
No abstract text is available yet for this article.
September 23, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27636578/bisphosphonates-inhibit-pain-bone-loss-and-inflammation-in-a-rat-tibia-fracture-model-of-complex-regional-pain-syndrome
#10
Liping Wang, Tian-Zhi Guo, Tzuping Wei, Wen-Wu Li, Xiaoyou Shi, J David Clark, Wade S Kingery
BACKGROUND: Bisphosphonates are used to prevent the bone loss and fractures associated with osteoporosis, bone metastases, multiple myeloma, and osteogenesis deformans. Distal limb fractures cause regional bone loss with cutaneous inflammation and pain in the injured limb that can develop into complex regional pain syndrome (CRPS). Clinical trials have reported that antiresorptive bisphosphonates can prevent fracture-induced bone loss, inhibit serum inflammatory cytokine levels, and alleviate CRPS pain...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27630477/vertebral-augmentation-by-kyphoplasty-and-vertebroplasty-8-years-experience-outcomes-and-complications
#11
Kaan Yaltirik, Ahmed M Ashour, Conner R Reis, Selçuk Özdoğan, Başar Atalay
BACKGROUND AND CONTEXT: Minimally invasive percutaneous vertebral augmentation techniques; vertebroplasty, and kyphoplasty have been treatment choices for vertebral compression fractures (VCFs). The purpose of this study is to evaluate the outcomes of the patients who underwent vertebroplasty or kyphoplasty regarding complications, correction of vertebral body height, kyphosis angle and pain relief assessment using visual analog score (VAS) for pain. MATERIALS AND METHODS: A retrospective review of the hospital records for 100 consecutive patients treated with kyphoplasty or vertebroplasty in our department database...
July 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27627707/consensus-on-surgical-management-of-myeloma-bone-disease
#12
(no author information available yet)
Myeloma bone disease (MBD), the skeletal lesions caused by multiple myeloma, is also known as skeletal related events and includes bone pain, osteoporosis, pathological fractures, osteolytic bone lesions, spinal instability, spinal cord and nerve root compression and extramedullary plasmacytoma. It is now generally accepted that patients with these complications usually require surgical management and that such treatment is safe and effective. The aims of surgical interventions are to alleviate pain, improve quality of life, treat potential or existing pathological fractures, decompress the spinal cord and nerve roots, and reestablish bone continuity...
August 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/27587526/the-relationship-between-spinopelvic-measurements-and-patient-reported-outcome-scores-in-patients-with-multiple-myeloma-of-the-spine
#13
H M Yu, K Malhotra, J S Butler, A Patel, M D Sewell, Y Z Li, S Molloy
AIMS: Patients with multiple myeloma (MM) develop deposits in the spine which may lead to vertebral compression fractures (VCFs). Our aim was to establish which spinopelvic parameters are associated with the greatest disability in patients with spinal myeloma and VCFs. PATIENTS AND METHODS: We performed a retrospective cross-sectional review of 148 consecutive patients (87 male, 61 female) with spinal myeloma and analysed correlations between spinopelvic parameters and patient-reported outcome scores...
September 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27566020/predictors-of-survival-in-patients-with-surgical-spine-multiple-myeloma-metastases
#14
Aymeric Amelot, Alexis Moles, Joseph Cristini, Celine Salaud, Cyrille Touzeau, Olivier Hamel, Eric Bord, Kevin Buffenoir
BACKGROUND: Multiple myeloma (MM) is the most common primary malignant tumor of the spine and bone. Spinal metastases are part of the evolution and progression of the MM disease. Therefore, this study aims at investigating prognostic factors associated with overall survival (OS) in patients with symptomatic spine MM metastases. METHODS: Consecutive spine surgery procedures were performed in the largest series reported to date and comprising 51 patients with osteolytic vertebral compression fractures resulting from MM, diagnosed by either bone marrow or tumor biopsy...
September 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27551575/patients-with-multiple-myeloma-have-more-complications-after-surgical-treatment-of-hip-fracture
#15
Kwan Jun Park, Mariano E Menendez, Simon C Mears, C Lowry Barnes
OBJECTIVES: Bone lesions from multiple myeloma may lead to pathological fracture of the proximal femur, requiring either fixation or arthroplasty. Little is known about the impact of multiple myeloma on hip fracture care. We investigated whether the patients with multiple myeloma undergoing surgical treatment of hip fractures would be at increased risk for adverse outcomes versus patients who sustain a hip fracture without multiple myeloma. METHODS: Using discharge records from the Nationwide Inpatient Sample (2002-2011), we identified 2 440 513 patients older than 50 years of age with surgically treated hip fractures...
September 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27536655/amyloid-arthropathy-of-the-hip-joint-associated-with-multiple-myeloma-a-case-report
#16
Yoon Je Cho, Young Soo Chun, Kee Hyung Rhyu, Yong Koo Park, Kyung Nam Ryu, Ji Seon Park, Huo Liang, Gwang Young Jung, Won Ju Shin
Amyloidosis is a disease characterized by the deposition of non-soluble fibrous protein in multiple tissues with a number of possible causes. This protein deposition can occur in any tissue, yet is most commonly seen in kidneys, heart, and gastrointestinal tracts. However, invasion to bone tissues is not often reported. The deposition of amyloid proteins in bone tissues may result in joint pain and pathological fractures; it is important to elucidate the causes and detect early to determine prognosis and treat optimally...
June 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/27507543/surgical-management-of-spinal-fractures-and-neurological-involvement-in-patients-with-myeloma
#17
Vincenzo Denaro, Luca Denaro, Erika Albo, Nicola Papapietro, Andrea Piccioli, Alberto Di Martino
INTRODUCTION: Multiple Myeloma (MM) typically involves the spine and causes bone pain, pathological fractures and spinal cord compression with possible consequent neurological deficits. This retrospective study reports the results of surgery on a selected population of patients who underwent surgery for symptomatic spinal myeloma. MATERIALS AND METHODS: A total of 26 patients who underwent surgery for spinal myeloma with neurological involvement were studied retrospectively...
August 6, 2016: Injury
https://www.readbyqxmd.com/read/27454865/assessment-of-bone-fragility-in-patients-with-multiple-myeloma-using-qct-based-finite-element-modelling
#18
G M Campbell, J Peńa, S Giravent, F Thomsen, T Damm, C-C Glüer, J Borggrefe
Multiple myeloma (MM) is a malignant plasma cell disease associated with severe bone destruction. Surgical intervention is often required to prevent vertebral body collapse and resulting neurological complications; however, its necessity is determined by measuring lesion size or number, without considering bone biomechanics. Finite element (FE) modelling, which simulates the physiological loading, may improve the prediction of fragility. To test this, we developed a quantitative computed tomography (QCT)-based FE model of the vertebra and applied it to a dataset of MM patients with and without prevalent fracture...
July 25, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27435440/fentanyl-in-a-pectin-gel-treating-breakthrough-pain-in-vertebral-compression-fracture-due-to-multiple-myeloma-a-descriptive-study-of-three-cases
#19
Borja Mugabure Bujedo, Brynjar Karlsson
Breakthrough pain (BTP) currently represents a challenge for health professionals dedicated to the treatment of pain. In this descriptive 1-year follow-up study on three patients with BTP from vertebral crush, in the context of multiple myeloma, the authors have observed the great either efficacy or tolerability profile of fentanyl pectin nasal spray. The most relevant findings in this study were better adherence to treatment compared to previously opioids and also great personal satisfaction. Because of common pathophysiological mechanism for noncancerous pain of bone origin, these good results could open the door to investigation of the use of this drug in this patient's group...
May 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27401073/spinal-disease-in-myeloma-cohort-analysis-at-a-specialist-spinal-surgery-centre-indicates-benefit-of-early-surgical-augmentation-or-bracing
#20
Karan Malhotra, Joseph S Butler, Hai Ming Yu, Susanne Selvadurai, Shirley D'Sa, Neil Rabin, Charalampia Kyriakou, Kwee Yong, Sean Molloy
BACKGROUND: Multiple myeloma osteolytic disease affecting the spine results in vertebral compression fractures. These are painful, result in kyphosis, and impact respiratory function and quality of life. We explore the impact of time to presentation on the efficacy of spinal treatment modalities. METHODS: We retrospectively reviewed 183 patients with spinal myeloma presenting to our service over a 2 year period. RESULTS: Median time from multiple myeloma diagnosis to presentation at our centre was 195 days...
2016: BMC Cancer
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