Richard M Reznick, Haihong Zong, Ji Li, Katsutaro Morino, Irene K Moore, Hannah J Yu, Zhen-Xiang Liu, Jianying Dong, Kirsty J Mustard, Simon A Hawley, Douglas Befroy, Marc Pypaert, D Grahame Hardie, Lawrence H Young, Gerald I Shulman
Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats...
February 2007: Cell Metabolism