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https://www.readbyqxmd.com/read/28427234/diversity-of-the-association-of-serum-levels-and-genetic-variants-of-mhc-class-i-polypeptide-related-chain-a-with-liver-fibrosis-in-chronic-hepatitis-c
#1
Chung-Feng Huang, Ching-I Huang, Ming-Lun Yeh, Shu-Chi Wang, Kuan-Yu Chen, Yu-Min Ko, Ching-Chih Lin, Yi-Shan Tsai, Pei-Chien Tsai, Zu-Yau Lin, Shinn-Cherng Chen, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND/AIMS: Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma. The linkage between serum MICA (sMICA) and liver fibrosis in chronic hepatitis C is elusive. RESULTS: Linear regression analysis revealed that sMICA were independently correlated to α-fetoprotein (β: 0.149; 95% confidence interval [CI]: 0.001, 0.003; P = 0.007)and MICA rs2596542 GG genotype (β: 0.209; 95% CI: 0.153, 0...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425917/tapbpr-bridges-udp-glucose-glycoprotein-glucosyltransferase-1-onto-mhc-class-i-to-provide-quality-control-in-the-antigen-presentation-pathway
#2
Andreas Neerincx, Clemens Hermann, Robin Antrobus, Andy van Hateren, Huan Cao, Nico Trautwein, Stefan Stevanović, Tim Elliott, Janet E Deane, Louise H Boyle
Recently we revealed that TAPBPR is a peptide exchange catalyst important for optimal peptide selection by MHC class I molecules. Here we asked if any other co-factors associate with TAPBPR which would explain its effect on peptide selection. We identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a folding sensor in the calnexin/calreticulin quality control cycle known to regenerate the Glc1Man9GlcNAc2 moiety on glycoproteins. Our results suggest the formation of a multimeric complex, dependent on a conserved cysteine at position 94 in TAPBPR, in which TAPBPR promotes the association of UGT1 with peptide-receptive class I molecules...
April 20, 2017: ELife
https://www.readbyqxmd.com/read/28425436/corrigendum-mhc-dependent-inhibition-of-uterine-nk-cells-impedes-fetal-growth-and-decidual-vascular-remodeling
#3
Jens Kieckbusch, Louise M Gaynor, Ashley Moffett, Francesco Colucci
No abstract text is available yet for this article.
April 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28421994/reply-to-beh%C3%A3-et-s-disease-an-mhc-i-opathy
#4
Dennis McGonagle, Sibel Zehra Aydin, Ahmet Gül, Alfred Mahr, Haner Direskeneli
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April 14, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28420000/-epicatechin-suppresses-angiotensin-ii-induced-cardiac-hypertrophy-via-the-activation-of-the-sp1-sirt1-signaling-pathway
#5
Zeng-Xiang Dong, Lin Wan, Ren-Jun Wang, Yuan-Qi Shi, Guang-Zhong Liu, Si-Jia Zheng, Hui-Ling Hou, Wei Han, Xin Hai
BACKGROUND/AIMS: Flavonol (-)-epicatechin (EPI) is present in high amounts in cocoa and tea products, and has been shown to exert beneficial effects on the cardiovascular system. However, the precise mechanism of EPI on cardiomyocyte hypertrophy has not yet been determined. In this study, we examined whether EPI could inhibit cardiac hypertrophy. METHODS: We utilised cultured neonatal mouse cardiomyocytes and mice for immunofluorescence, immunochemistry, qRT-PCR, and western blot analyses...
April 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28419545/intermolecular-interactions-between-dm%C3%AE-and-dm%C3%AE-proteins-in-bula-dm-complex-of-water-buffalo-bubalus-bubalis
#6
Leena Rawal, Deepak Panwar, Sher Ali
The major histocompatibility complex (MHC) with its 3 classes represents a cluster of tightly linked genes with defined immunological and non-immunological functions. The DM, a MHC class II molecule is formed by the non-covalent association of DMα and DMβ chains. It binds with the processed peptide antigens and presents them to T lymphocytes, thereby triggering the immune responses. Startlingly, the expression pattern and structural organization of DMα and DMβ proteins in buffalo remains undefined. We isolated and purified the DMα and DMβ proteins from Bubalus bubalis using gel filtration chromatography...
April 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28419492/expression-and-trafficking-of-mhc-related-protein-1-mr1
#7
REVIEW
R Lamichhane, J E Ussher
MHC related protein 1 (MR1) is a non-polymorphic MHC class IB antigen presenting molecule that is the restricting molecule for mucosal associated invariant T (MAIT) cells, a prominent population of innate-like antibacterial T cells. The MAIT cell-MR1 axis represents a new paradigm in antigen presentation, with the MR1 ligand derived from vitamin B compounds or their metabolic precursors. Many bacteria and some fungi produce the activating ligand for MR1. In evolution, MR1 is highly conserved in most, but not all, mammals...
April 17, 2017: Immunology
https://www.readbyqxmd.com/read/28419176/mica-diversity-and-linkage-disequilibrium-with-hla-b-alleles-in-renal-transplant-candidates-in-southern-brazil
#8
Roger Haruki Yamakawa, Patrícia Keiko Saito, Geórgia Fernanda Gelmini, José Samuel da Silva, Maria da Graça Bicalho, Sueli Donizete Borelli
The major histocompatibility complex (MHC) class I chain-related gene A (MICA) is located centromerically to the human leukocyte antigen (HLA)-B. The short distance between these loci in the MHC indicates the presence of linkage disequilibrium (LD). Similarly to the HLA, the MICA is highly polymorphic, and this polymorphism has not been well documented in different populations. In this study, we estimated the allelic frequencies of MICA and the linkage disequilibrium with HLA-B alleles in 346 renal-transplant candidates in southern Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28419155/culture-expanded-allogenic-adipose-tissue-derived-stem-cells-attenuate-cartilage-degeneration-in-an-experimental-rat-osteoarthritis-model
#9
Li Mei, Bojiang Shen, Peixue Ling, Shaoying Liu, Jiajun Xue, Fuyan Liu, Huarong Shao, Jianying Chen, Aibin Ma, Xia Liu
Mesenchymal stem cell (MSC)-based cell therapy is a promising avenue for osteoarthritis (OA) treatment. In the present study, we evaluated the efficacy of intra-articular injections of culture-expanded allogenic adipose tissue-derived stem cells (ADSCs) for the treatment of anterior cruciate ligament transection (ACLT) induced rat OA model. The paracrine effects of major histocompatibility complex (MHC)-unmatched ADSCs on chondrocytes were investigated in vitro. Rats were divided into an OA group that underwent ACLT surgery and a sham-operated group that did not undergo ACLT surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28418931/socs3-treatment-prevents-the-development-of-alopecia-areata-by-inhibiting-cd8-t-cell-mediated-autoimmune-destruction
#10
Zhen Gao, Yu-Qing Jin, Wei Wu
Alopecia areata is one of the most common autoimmune diseases resulting from T cell-mediated damage of hair follicles. CD8+ T cells infiltrate hair follicles and are responsible for destruction of hair follicles. However the underlying mechanisms for hair loss remain still obscure. In the present study, we identified that suppressor of cytokine signaling-3 (SOCS3), a classical inhibitor of cytokine signaling, significantly inhibits CD8+T cell maturation, interferon-γ (IFN-γ) production and alopecia areata...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417963/loop-diuretics-affect-skeletal-myoblast-differentiation-and-exercise-induced-muscle-hypertrophy
#11
Shintaro Mandai, Susumu Furukawa, Manami Kodaka, Yutaka Hata, Takayasu Mori, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Daiei Takahashi, Yuki Yoshizaki, Yuri Kasagi, Yohei Arai, Emi Sasaki, Sayaka Yoshida, Yasuro Furuichi, Nobuharu L Fujii, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Muscle wasting or sarcopenia contributes to morbidity and mortality in patients with cancer, renal failure, or heart failure, and in elderly individuals. Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is highly expressed in mammalian skeletal muscle, where it contributes to the generation of membrane ion currents and potential. However, the physiologic function of NKCC1 in myogenesis is unclear. We investigated this issue using the NKCC1 inhibitors bumetanide and furosemide, which are commonly used loop diuretics...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417619/human-leukocyte-antigen-hla-class-i-and-ii-polymorphism-in-iranian-healthy-population-from-yazd-province
#12
Behrouz Nikbin, Mohammad Hossein Nicknam, Hossein Hadinedoushan, Bita Ansaripour, Batol Moradi, Mirsaeed Yekaninejad, Mahdi Aminikhah, Mohammad Mehdi Ranjbar, Aliakbar Amirzargar
The major histocompatibility complex (MHC) genes are the most polymorphic loci in the human genome and have been widely studied in various populations and ethnic groups. Investigations into the HLA genes and proteins have been useful tool for anthropological, transplantation and disease association studies. The polymorphism of the HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) genes were investigated in 90 unrelated Iranian individuals from Yazd province located in the center of Iran using sequence-specific primers (PCR-SSP)...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28414303/development-of-potent-class-ii-transactivator-gene-delivery-systems-capable-of-inducing-de-novo-mhc-ii-expression-in-human-cells-in-vitro-and-ex-vivo
#13
M de Lucena Palma, P Duangkhae, B Douradinha, I F T Viana, P O Rigato, R Dhalia, R B Mailliard, S M Barratt-Boyes, E J M do Nascimento, T M Oshiro, A J da Silva Duarte, E T de A Marques
Class II Transactivator (CIITA) induces transcription of MHC II genes and can potentially be used to improve genetic immunotherapies by converting non-immune cells into cells capable of presenting antigens to CD4(+) T cells. However, CIITA expression is tightly controlled and it remains unclear whether distinct non-immune cells differ in this transactivator regulation. Here we describe the development of gene delivery systems capable of promoting the efficient CIITA expression in non-immune cell lines and in primary human cells of an ex vivo skin explant model...
April 17, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28414183/nkg2d-a-versatile-player-in-the-immune-system
#14
REVIEW
Vedrana Jelenčić, Maja Lenartić, Felix M Wensveen, Bojan Polić
NKG2D is known as a potent activating receptor of the immune system. It is expressed on a multitude of immune cells, including NK cells and different subsets of T cells. NKG2D recognizes various MHC I-like ligands that are induced on target cells exposed to stressors such as viral infection, DNA damage and oncological transformation. NKG2D drives or facilitates cytotoxic and cytokine responses towards cells expressing its ligands to eliminate the threat. Therefore, NKG2D is usually classified as a sensor that translates cellular stress into activation signals for immune cells...
April 13, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28412740/combination-epidermal-growth-factor-receptor-variant-iii-peptide-pulsed-dendritic-cell-vaccine-with-mir-326-results-in-enhanced-killing-on-egfrviii-positive-cells
#15
Jianlong Li, Feng Wang, Guangzhi Wang, Ying Sun, Jinquan Cai, Xing Liu, Junhe Zhang, Xiaoyan Lu, Yongli Li, Meng Chen, Lingchao Chen, Chuanlu Jiang
The mutant Type III variant of epidermal growth factor receptor (EGFRvIII) is present in approximately one-third of glioblastoma (GBM) patients. It is never found in normal tissues; therefore, it represents a candidate target for GBM immunotherapy. PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes. Dendritic cells (DCs) have great potential to sensitize CD4+ T and CD8+ T cells to precisely target and eradicate GBM. Here, we show that PEPvIII could be loaded by DCs and presented to T lymphocytes, especially PEPvIII-specific CTLs, to precisely kill U87-EGFRvIII cells...
February 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412087/pregestational-type-2-diabetes-mellitus-induces-cardiac-hypertrophy-in-the-murine-embryo-through-cardiac-remodeling-and-fibrosis
#16
Xue Lin, Penghua Yang, E Albert Reece, Peixin Yang
BACKGROUND: Cardiac hypertrophy is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Experimental evidence has implied that pregnant women with T2DM and their children are at an increased risk of cardiovascular diseases. Our previous mouse model study has revealed that maternal T2DM induces structural heart defects in their offspring. OBJECTIVE: The present study aims to determine whether maternal T2DM induces embryonic heart hypertrophy in a murine model of diabetic embryopathy...
April 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28410529/ifn%C3%AE-enhances-cytotoxic-efficiency-of-the-cytotoxic-t-lymphocytes-against-human-glioma-cells
#17
Shengwen Shao, Eric Risch, Danielle Burner, Lingeng Lu, Boris Minev, Wenxue Ma
Cytotoxic T lymphocytes (CTLs) are a key player in cancer immunotherapies, and MHC class I molecules on the cell surface are crucial for cellular recognition. However, the aberrant expression of MHC class I molecules is frequently found in various malignancies. IFNγ has dual functions in cancer progression, and its effect on tumor immunity is controversial. To investigate whether IFNγ can enhance cytotoxic efficiency of the tumor antigen-specific CTLs, we generated the CTLs using modified human dendritic cells as antigen presenting cells, then studied the activities of CTLs on human leukocyte antigen (HLA)-A2 positive glioma cells treated with, or without IFNγ...
April 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28408901/serine-rich-repeat-adhesins-contribute-to-streptococcus-gordonii-induced-maturation-of-human-dendritic-cells
#18
Eun Byeol Ko, Sun Kyung Kim, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Dendritic cells (DCs) play a pivotal role in the induction of immunity by recognition, capture, process, and presentation of antigens from infectious microbes. Streptococcus gordonii is able to cause life-threatening systemic diseases such as infective endocarditis. Serine-rich repeat (SRR) glycoproteins of S. gordonii are sialic acid-binding adhesins mediating the bacterial adherence to the host and the development of infective endocarditis. Thus, the SRR adhesins are potentially involved in the bacterial adherence to DCs and the maturation and activation of DCs required for the induction of immunity to S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28408181/peptide-conjugated-nanoparticles-reduce-positive-co-stimulatory-expression-and-t-cell-activity-to-induce-tolerance
#19
Robert Kuo, Eiji Saito, Stephen D Miller, Lonnie D Shea
Targeted approaches to treat autoimmune diseases would improve upon current therapies that broadly suppress the immune system and lead to detrimental side effects. Antigen-specific tolerance was induced using poly(lactide-co-glycolide) nanoparticles conjugated with disease-relevant antigen to treat a model of multiple sclerosis. Increasing the nanoparticle dose and amount of conjugated antigen both resulted in more durable immune tolerance. To identify active tolerance mechanisms, we investigated downstream cellular and molecular events following nanoparticle internalization by antigen-presenting cells...
April 10, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28407117/nnalign-a-platform-to-construct-and-evaluate-artificial-neural-network-models-of-receptor-ligand-interactions
#20
Morten Nielsen, Massimo Andreatta
Peptides are extensively used to characterize functional or (linear) structural aspects of receptor-ligand interactions in biological systems, e.g. SH2, SH3, PDZ peptide-recognition domains, the MHC membrane receptors and enzymes such as kinases and phosphatases. NNAlign is a method for the identification of such linear motifs in biological sequences. The algorithm aligns the amino acid or nucleotide sequences provided as training set, and generates a model of the sequence motif detected in the data. The webserver allows setting up cross-validation experiments to estimate the performance of the model, as well as evaluations on independent data...
April 12, 2017: Nucleic Acids Research
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