keyword
MENU ▼
Read by QxMD icon Read
search

Panax notoginseng

keyword
https://www.readbyqxmd.com/read/29329646/effects-of-gardenia-jasminoides-extracts-on-cognition-and-innate-immune-response-in-an-adult-drosophila-model-of-alzheimer-s-disease
#1
Wei-Wei Ma, Ye Tao, Yan-Ying Wang, I-Feng Peng
Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329092/effect-of-aspirin-on-the-pharmacokinetics-and-absorption-of-panax-notoginseng-saponins
#2
Zhihao Tian, Huanhuan Pang, Qiang Zhang, Shouying Du, Yang Lu, Lin Zhang, Jie Bai, Pengyue Li, Danqi Li, Mengdi Zhao, Xiaonan Chen
BACKGROUND: Panax notoginseng saponins, a traditional Chinese medicine extraction, and aspirin are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved, when Panax notoginseng saponins was taken together with aspirin. METHODS: To investigate the interaction of the two drugs in vivo, the concentration of notoginsenoside R1, ginsenoside Rg1, Rb1, Re and Rd. in blood were simultaneously measured by UPLC/MS/MS...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29321807/different-modulation-of-panax-notoginseng-on-the-absorption-profiling-of-triptolide-and-tripterine-from-tripterygium-wilfordii-in-rat-intestine
#3
Yiqun Li, Huiting Cao, Mengzhu Liu, Benyong Zhang, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu, Qichun Zhang
Background: Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney. Methods: The absorption of triptolide, triptonide, wilforlide and tripterine from monomer, TW, TW-PN, TW-Caulis Sinomenii (TW-CS) and Qing-Luo Tong-Bi were analyzed in duodenum, jejunum, ileum and colon of rat via single-pass intestinal perfusion model...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29318835/-study-on-extraction-method-of-panax-notoginseng-plots-in-wenshan-of-yunnan-province-based-on-decision-tree-model
#4
Ting-Ting Shi, Xiao-Bo Zhang, Lan-Ping Guo, Lu-Qi Huang
The herbs used as the material for traditional Chinese medicine are always planted in the mountainous area where the natural environment is suitable. As the mountain terrain is complex and the distribution of planting plots is scattered, the traditional survey method is difficult to obtain accurate planting area. It is of great significance to provide decision support for the conservation and utilization of traditional Chinese medicine resources by studying the method of extraction of Chinese herbal medicine planting area based on remote sensing and realizing the dynamic monitoring and reserve estimation of Chinese herbal medicines...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29312623/notoginsenoside-r7-suppresses-cervical-cancer-via-pi3k-pten-akt-mtor-signaling
#5
Li Li, Jin-Xia Sun, Xiao-Qi Wang, Xiao-Kai Liu, Xian-Xiong Chen, Bo Zhang, Zhen-Dan He, Dong-Zhou Liu, Li-Xin Chen, Li-Wei Wang, Zhong Huang
Notoginsenoside R7 was isolated from Panax notoginseng, a plant used commonly in traditional Chinese medicine. We investigated the anti-cancer effects of R7 in HeLa cells in vitro and in vivo, and explored the underlying mechanisms of action. R7 dose-dependently inhibited HeLa cell proliferation and induced apoptosis in vitro, In silico docking-based screening assays showed that R7 can directly bind Akt. Pretreatment with the Akt inhibitor LY294002 synergistically enhanced the R7 anti-proliferation and anti-apoptosis effects in HeLa cells, confirming that R7 acts through the PI3K/Akt pathway...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29280337/analysis-of-bioactive-components-and-multi-component-pharmacokinetics-of-saponins-from-leaves-of-panax-notoginseng-in-rat-plasma-after-oral-administration-by-lc-ms-ms
#6
Zhengcai Ju, Jia Li, Han Han, Li Yang, Zhengtao Wang
In this study, simple ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass tandem mass spectrometry was used to characterize the absorbed components in rat plasma after the oral administration of saponins from leaves of Panax notoginseng. Seventeen prototype compounds were structurally characterized. Furthermore, a simple and sensitive liquid chromatography with tandem mass spectrometry method was also used for the simultaneous determination of notoginsenoside Fc, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rb3, ginsenoside Rd and notoginsenoside Fe in rat plasma within 5 min...
December 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29277608/triptolide-induced-hepatotoxicity-can-be-alleviated-when-combined-with-panax-notoginseng-saponins-and-catapol
#7
Lingling Zhou, Cong Zhou, Zhe Feng, Zhangpu Liu, Huaxu Zhu, Xueping Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: The hepatotoxicity of Tripterygium wilfordii Hook. f. (TW), due to the presence of triptolide (TP), limits its therapeutic potential. Based on the traditional Chinese medicine theory, the theory of "Yi lei xiang zhi" was proposed that Chinese herbs with different efficacy can restrict each other to achieve the least adverse reactions. AIM OF THE STUDY: To observe the effects of Catapol (CAT) and Panax notoginseng saponins (PNS), active ingredients in Rehmannia glutinosa (RG) and Panax notoginseng (PN) respectively, on reducing TP-induced hepatotoxicity, and further to explore the mechanisms...
December 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29245089/metabolic-analysis-of-panax-notoginseng-saponins-with-gut-microbiota-mediated-biotransformation-by-hplc-dad-q-tof-ms-ms
#8
Man-Yun Chen, Li Shao, Wei Zhang, Chong-Zhi Wang, Hong-Hao Zhou, Wei-Hua Huang, Chun-Su Yuan
Saponins such as notoginsenosides and ginsenosides from Panax notoginseng are responsible for the herb's clinical applications. Unfortunately, there is poor oral bioavailability of saponins. However, gut microbiota can transform saponins to yield the metabolites that are potential bioactive substances. In this study, we aimed to characterize the metabolic profiles of P. notoginseng saponins (PNS) by incubating them with human gut microbiota. The notoginsenosides, ginsenosides and related metabolites were separated and identified using a highly sensitive and selective high-performance liquid chromatography coupled with diode array detection/quadrupole tandem time-of-flight mass spectrometry (HPLC-DAD-Q-TOF-MS/MS)...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29243439/-identification-of-saponins-from-panax-notoginseng-in-metabolites-of-rats
#9
Wen-Wen Shen, Yin Zhang, Shou-Bei Qiu, Fen-Xia Zhu, Xiao-Bin Jia, Dao-Quan Tang, Bin Chen
UPLC-QTOF-MS/MS was used to identify metabolites in rat blood, urine and feces after the administration of n-butanol extract derived from steamed notoginseng. The metabolic process of saponins came from steamed notoginseng was analyzed. The metabolites were processed by PeakView software, and identified according to the structural characteristics of prototype compounds and the accurate qualitative and quantitative changes of common metabolic pathways. Four saponins metabolites were identified based on MS/MS information of metabolites, namely ginsenoside Rh₄, Rk₃, Rk₁, Rg₅,and their 15 metabolites were verified...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235296/-effect-of-astragaloside-%C3%A2-combined-with-panax-notoginseng-saponins-on-cerebral-ischemia-reperfusion-injury-and-study-of-pharmacokinetics-in-rats
#10
Jing-Xian Li, Xiao-Qian Yang, Biao Tang, Xiao-Dan Liu, Ying-Hong Tang, Chang-Qing Deng, Xiao-Ping Huang
The aim is to study the effect of astragaloside Ⅳ (AST Ⅳ) combined with Panax notoginseng saponins (PNS) on cerebral ischemia-reperfusion injury, and to probe the synergistic mechanism through the pharmacokinetics of the four major components such as AST Ⅳ, ginsenoside Rg₁ (Rg₁), ginsenoside Rb₁ (Rb₁), notoginsenoside R₁ (R₁) in cerebral ischemia-reperfusion rats. Following the establishment of cerebral ischemia/reperfusion model in rats by modified suture method, neurological function score, cerebral infarction area and pathomorphology were used to evaluate the pharmacological effect that the combination of AST Ⅳ and PNS antagonized cerebral ischemia-reperfusion injury; the contents of AST Ⅳ, Rg₁, Rb₁, R₁ in rat plasma of different time points were determined with ultra performance liquid chromatography tandem massspectrometry (UPLC-MS/MS), pharmacokinetic parameters were calculated and pharmacokinetics changes of the main effective components were analyzed...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29225132/ginsenoside-rh4-induces-apoptosis-and-autophagic-cell-death-through-activation-of-the-ros-jnk-p53-pathway-in-colorectal-cancer-cells
#11
Qian Wu, Jianjun Deng, Daidi Fan, Zhiguang Duan, Chenhui Zhu, Rongzhan Fu, Shanshan Wang
The use of ginsenosides in cancer therapy has been intensively investigated. The ginsenoside Rh4 (Rh4), a rare saponin obtained from Panax notoginseng, dissolves in water more readily than total saponins, making this compound easier to use in anti-cancer pharmaceutics. Here, we investigated the antiproliferative activity and mechanisms of Rh4 in colorectal cancer, both in vivo and in vitro. A colorectal cancer xenograft model showed that Rh4 significantly inhibited tumor growth with few side effects. CCK-8 assays, flow cytometric analysis, Western blotting and immunohistochemistry revealed that Rh4 effectively suppressed colorectal cancer cell proliferation via inducing G0/G1 phase arrest, caspase-dependent apoptosis and autophagic cell death but was not significantly cytotoxic to normal colon epithelial cells...
December 7, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29181006/protective-effect-of-panax-notoginseng-root-water-extract-against-influenza-a-virus-infection-by-enhancing-antiviral-interferon-mediated-immune-responses-and-natural-killer-cell-activity
#12
Jang-Gi Choi, Young-Hee Jin, Heeeun Lee, Tae Woo Oh, Nam-Hui Yim, Won-Kyung Cho, Jin Yeul Ma
Influenza is an acute respiratory illness caused by the influenza A virus, which causes economic losses and social disruption mainly by increasing hospitalization and mortality rates among the elderly and people with chronic diseases. Influenza vaccines are the most effective means of preventing seasonal influenza, but can be completely ineffective if there is an antigenic mismatch between the seasonal vaccine virus and the virus circulating in the community. In addition, influenza viruses resistant to antiviral drugs are emerging worldwide...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29175746/dna-barcoding-in-concentrated-chinese-medicine-granules-using-adaptor-ligation-mediated-polymerase-chain-reaction
#13
Yat-Tung Lo, Pang-Chui Shaw
The use of DNA barcodes for species identification is a common laboratory practice. However, PCR amplification of full-length DNA barcode in processed material is difficult because of severe DNA fragmentation. In this study, an adaptor ligation-mediated PCR protocol was derived to amplify sets of target DNA fragments isolated from two CCMG products. The specially designed adaptor with asymmetric strands and terminal modification avoids amplification of non-target DNA sequences. DNA extracted from Angelica sinensis and Panax notoginseng CCMG were ligated with the adaptors and amplified by an adaptor primer and a single universal barcode primer to obtain partial ITS2 sequence...
November 21, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29174034/panax-notoginseng-saponins-reduce-high-risk-factors-for-thrombosis-through-peroxisome-proliferator-activated-receptor-%C3%AE-pathway
#14
Qin Shen, Jun Li, Caixin Zhang, Pengbo Wang, Anaz Mohammed, Songshi Ni, Zhiyuan Tang
The classic Virchow theory suggests that blood stasis, hypercoagulability and endothelial dysfunction are three major factors that cause venous thrombosis (VT). It is a complicated biological process involved multi-factors. Platelet plays a central role and participates in multiple links of this process. Panax notoginseng saponins (PNS), the principal constituents derived from panax notoginseng, has been widely described for its anti-platelet activity. However, its potential mechanism against platelet aggregation has not been clarified...
November 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29171228/-molecular-cloning-bacterial-expression-analysis-and-functional-characterization-of-pathogenesis-related-pr10-2-gene-in-panax-notoginseng
#15
Dan Yang, Yi Bao, Li-Mei Chen, Xiu-Ming Cui, Kun-Zhi Li
Base on the transcriptome analysis and RT-PCR techniques,a pathogenesis-related protein 10 gene was isolated from Panax notoginseng root and named as PnPR10-2. Bioinformatics and phylogenetic trees analysis revealed that open reading frame (ORF) of PnPR10-2 was 465 bp in length,encoding 154 amino acids,containing one typical conserved domain of pathogenesis related protein Bet v I family, and showed high similarity with that from P. ginseng. The recombinant expressed plasmid pET32a(+)-PnPR10-2 was expressed in Escherichia coli BL21...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29156976/two-new-saponins-from-the-leaves-of-panax-notoginseng
#16
Ji-Wu Huang, Fang-You Chen, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Xiao-Guang Chen, Dong-Ming Zhang
Two new saponins, notoginsenosides Ng1 (1) and Ng2 (2), together with seven known compounds (3-9), were isolated from the leaves of Panax notoginseng. Their structures were elucidated by UV, IR, HRESIMS, and NMR experiments. Compounds 6 and 7 showed moderate cytotoxic activities against HCT-116, with IC50 values of 4.98 and 0.64 μmol/L, respectively.
November 20, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29143877/ft-mir-and-nir-spectral-data-fusion-a-synergetic-strategy-for-the-geographical-traceability-of-panax-notoginseng
#17
Yun Li, Jin-Yu Zhang, Yuan-Zhong Wang
Three data fusion strategies (low-llevel, mid-llevel, and high-llevel) combined with a multivariate classification algorithm (random forest, RF) were applied to authenticate the geographical origins of Panax notoginseng collected from five regions of Yunnan province in China. In low-level fusion, the original data from two spectra (Fourier transform mid-IR spectrum and near-IR spectrum) were directly concatenated into a new matrix, which then was applied for the classification. Mid-level fusion was the strategy that inputted variables extracted from the spectral data into an RF classification model...
November 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29130614/panax-notoginseng-saponins-attenuate-cardiomyocyte-apoptosis-through-mitochondrial-pathway-in-natural-aging-rats
#18
Zhiyong Zhou, Jiao Wang, Yanan Song, Yumin He, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Yaoyan Dun, Ding Yuan, Ting Wang
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for the treatment of cardiovascular diseases and stroke in China. In this study, we investigated the anti-apoptotic effect of PNS on cardiomyocytes in the natural aging rat and explored the potential mechanisms regarding oxidative stress and mitochondrial function signaling pathways. Male Sprague-Dawley rats were randomly divided into five groups: adult control (3-month old), aging control (24-month old), and different doses of PNS-treated aging rat groups (10, 30, 60 mg/kg/day, orally)...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29127028/effects-of-dietary-panax-notoginseng-extract-on-growth-performance-fish-composition-immune-responses-intestinal-histology-and-immune-related-genes-expression-of-hybrid-grouper-epinephelus-lanceolatus-%C3%A2-%C3%A3-epinephelus-fuscoguttatus-%C3%A2-fed-high-lipid-diets
#19
Zhenzhu Sun, Xiaohong Tan, Huaqun Ye, Cuiyun Zou, Chaoxia Ye, Anli Wang
Growth, plasma biochemical parameters, fish composition, immune parameters, intestinal histology, and expressions of immune-related genes were examined in hybrid grouper (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀) that fed respectively six diets containing Panax notoginseng extract (PNE) at 0, 0.5, 1, 2, 4, and 10 g kg(-1) after 8 weeks. Results indicated that dietary PNE significantly improved growth, feed efficiency ratio, protein efficiency ratio, and protein deposit rate, and significantly increased crude protein and crude lipid levels of whole body and crude protein level of muscle...
November 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29093679/uncovering-active-constituents-responsible-for-different-activities-of-raw-and-steamed-panax-notoginseng-roots
#20
Yin Xiong, Lijuan Chen, Yupiao Hu, Xiuming Cui
Although Panax notoginseng (PN) roots in raw and steamed forms were historically supposed to be different in the efficacies, the raw materials and steamed ones were often undifferentiated in the use and market circulation, which might bring unstable curative effects or even adverse reactions. To uncover chemical constituents responsible to different activities of raw and steamed PN, chemometrics analyses including partial least squares regression (PLSR) and multi-linear regression analysis (MLRA) were used to establish the relationships between the chromatographic fingerprints and activities of PN samples...
2017: Frontiers in Pharmacology
keyword
keyword
66219
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"