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Panax notoginseng

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https://www.readbyqxmd.com/read/27900468/complete-genome-sequence-of-a-variant-of-maize-associated-totivirus-from-ecuador
#1
Robert A Alvarez-Quinto, Rodrigo F Espinoza-Lozano, Carlos A Mora-Pinargote, Diego F Quito-Avila
The complete genomic sequence of a variant of the recently reported maize-associated totivirus (MATV) from China was obtained from commercial maize in Ecuador. The genome of MATV-Ec (Ecuador) (4,998 bp) is considerably longer than that of MATV-Ch (China) (3,956 bp), the main difference due to a ≈ 1-kb-long capsid-protein-encoding fragment that is completely absent from the Chinese genome. Sequence alignments between MATV-Ec and MATV-Ch showed an overall identity of 82% at the nucleotide level, whereas at the amino acid level, the viruses exhibited 95% and 94% identity for the putative capsid protein and the RNA-dependent RNA polymerase (RdRp), respectively...
November 30, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27884675/molecular-cloning-and-functional-analysis-of-squalene-synthase-ss-in-panax-notoginseng
#2
Dan Jiang, Qixian Rong, Yijun Chen, Qingjun Yuan, Ye Shen, Juan Guo, Yirui Yang, Liangping Zha, Huixiao Wu, Luqi Huang, Chunsheng Liu
Panax notoginseng (Burk.) F. H. Chen, which is a used traditional Chinese medicine known as Sanqi or Tianqi in China, is widely studied for its ability to accumulate the triterpene saponins. Squalene synthase (SS: EC 2.5.1.21) catalyzes the first enzymatic step from the central isoprenoid pathway toward sterol and triterpenoid biosynthesis. In this study, SS from P. notoginseng was cloned and investigated followed by its recombinant expression and preliminary enzyme activity. The nucleotide sequence of the ORF contains 1 248 nucleotides and encodes 415 amino acid residues with molecular weight of 47...
November 21, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27846268/application-of-rad-sequencing-for-evaluating-the-genetic-diversity-of-domesticated-panax-notoginseng-araliaceae
#3
Yuezhi Pan, Xueqin Wang, Guiling Sun, Fusheng Li, Xun Gong
Panax notoginseng, a traditional Chinese medicinal plant, has been cultivated and domesticated for approximately 400 years, mainly in Yunnan and Guangxi, two provinces in southwest China. This species was named according to cultivated rather than wild individuals, and no wild populations had been found until now. The genetic resources available on farms are important for both breeding practices and resource conservation. In the present study, the recently developed technology RADseq, which is based on next-generation sequencing, was used to analyze the genetic variation and differentiation of P...
2016: PloS One
https://www.readbyqxmd.com/read/27843725/development-of-highly-transferable-microsatellites-for-panax-ginseng-araliaceae-using-whole-genome-data
#4
Peng Jiang, Feng-Xue Shi, Ya-Ling Li, Bao Liu, Lin-Feng Li
PREMISE OF THE STUDY: Highly transferable expressed sequence tag (EST) microsatellites were developed for Panax ginseng (Araliaceae), one of the most celebrated traditional Chinese medicines and an endangered species in East Asia, using whole-genome data. METHODS AND RESULTS: Twenty-one EST microsatellites were characterized from next-generation sequencing and were composed of di- and trinucleotide repeats. Polymorphisms and genetic diversity were evaluated for 45 accessions of three ginseng landraces...
November 2016: Applications in Plant Sciences
https://www.readbyqxmd.com/read/27827951/soil-plant-metal-relations-in-panax-notoginseng-an-ecosystem-health-risk-assessment
#5
Xiaohong Ou, Li Wang, Lanping Guo, Xiuming Cui, Dahui Liu, Ye Yang
This study features a survey of the content of heavy metals (Pb, Cd, Cr, As, Hg and Cu) in root and cultivation soils of Panax notoginseng (P. notoginseng), carried out in China's Yunnan Province. The average contents of Pb, Cd, Cr, As, Hg, and Cu in the soil were 61.6, 0.4, 102.4, 57.1, 0.3, and 35.1 mg·kg(-1), respectively. The heavy metals' pollution indexes can be ranked as follows: As > Cd > Hg > Cu > Cr > Pb. The proportion of soil samples at slight, middle, strong, very strong, and extremely strong levels of potential environmental risk had values of 5...
November 5, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27825116/ginsenoside-rb1-targets-chemotherapy-resistant-ovarian-cancer-stem-cells-via-simultaneous-inhibition-of-wnt-%C3%AE-catenin-signaling-and-epithelial-to-mesenchymal-transition
#6
Shan Deng, Chris Kong Chu Wong, Hung-Cheng Lai, Alice Sze Tsai Wong
Chemoresistance is a major clinical problem compromising the successful treatment of cancer. One exciting approach is the eradication of cancer stem/tumor-initiating cells (jointly CSCs), which account for tumor initiation, progression, and drug resistance. Here we show for the first time, with mechanism-based evidence, that ginsenoside-Rb1, a natural saponin isolated from the rhizome of Panax quinquefolius and notoginseng, exhibits potent cytotoxicity on CSCs. Rb1 and its metabolite compound K could effectively suppress CSC self-renewal without regrowth...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27818924/identification-and-differentiation-of-panax-ginseng-panax-quinquefolium-and-panax-notoginseng-by-monitoring-multiple-diagnostic-chemical-markers
#7
Wenzhi Yang, Xue Qiao, Kai Li, Jingran Fan, Tao Bo, De-An Guo, Min Ye
To differentiate traditional Chinese medicines (TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG), Panax quinquefolium (PQ) and Panax notoginseng (PN) are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations...
November 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27803670/poria-attenuates-idiosyncratic-liver-injury-induced-by-polygoni-multiflori-radix-praeparata
#8
Dan Gao, Jing-Yao Pang, Cong-En Zhang, Chun-Yu Li, Can Tu, Hai-Zhu Zhang, Ming Niu, Yin Xiong, Xiao-He Xiao, Kui-Jun Zhao, Wei-Wei Gao, Jia-Bo Wang
The hepatotoxicity induced by Polygoni Multiflori Radix Praeparata (PM) has aroused great concern throughout the world. Hence, it is worthwhile to perform studies on the detoxification with the combined use of medicinal herbs based on the compatibility theory of traditional Chinese medicine. In this work, the rat model of PM/LPS-induced idiosyncratic liver injury was used. The effects of Poria, Licorice, and Panax notoginseng on rats of PM/LPS-induced liver injury were investigated respectively, hoping to find the most effective herbal medicine to reduce the hepatotoxicity...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27771987/dammarane-type-triterpene-extracts-of-panax-notoginseng-root-ameliorates-hyperglycemia-and-insulin-sensitivity-by-enhancing-glucose-uptake-in-skeletal-muscle
#9
Kumiko Kitamura, Yusuke Takamura, Taku Iwamoto, Mitsuru Nomura, Hideaki Iwasaki, Motoyasu Ohdera, Michiaki Murakoshi, Keikichi Sugiyama, Kazuki Matsuyama, Yasuko Manabe, Nobuharu L Fujii, Tohru Fushiki
Skeletal muscle is an important organ for controlling the development of type 2 diabetes. We discovered Panax notoginseng roots as a candidate to improve hyperglycemia through in vitro muscle cells screening test. Saponins are considered as the active ingredients of ginseng. However, in the body, saponins are converted to dammarane-type triterpenes, which may account for the anti-hyperglycemic activity. We developed a method for producing a dammarane-type triterpene extract (DTE) from Panax notoginseng roots and investigated the extract's potential anti-hyperglycemic activity...
October 24, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27746683/endophytic-trichoderma-gamsii-yim-ph30019-a-promising-biocontrol-agent-with-hyperosmolar-mycoparasitism-and-antagonistic-activities-of-induced-volatile-organic-compounds-on-root-rot-pathogenic-fungi-of-panax-notoginseng
#10
Jin-Lian Chen, Shi-Zhong Sun, Cui-Ping Miao, Kai Wu, You-Wei Chen, Li-Hua Xu, Hui-Lin Guan, Li-Xing Zhao
BACKGROUND: Biocontrol agents are regarded as promising and environmental friendly approaches as agrochemicals for phytodiseases that cause serious environmental and health problems. Trichoderma species have been widely used in suppression of soil-borne pathogens. In this study, an endophytic fungus, Trichoderma gamsii YIM PH30019, from healthy Panax notoginseng root was investigated for its biocontrol potential. METHODS: In vitro detached healthy roots, and pot and field experiments were used to investigate the pathogenicity and biocontrol efficacy of T...
October 2016: Journal of Ginseng Research
https://www.readbyqxmd.com/read/27723805/quality-assessment-of-panax-notoginseng-from-different-regions-through-the-analysis-of-marker-chemicals-biological-potency-and-ecological-factors
#11
Hai-Zhu Zhang, Da-Hui Liu, Ding-Kun Zhang, Yan-Hui Wang, Gang Li, Gui-Lin Yan, Li-Juan Cao, Xiao-He Xiao, Lu-Qi Huang, Jia-Bo Wang
Panax notoginseng (Burk.) F.H. Chen, called Sanqi in China, is a perennial herb that has been used as a medicinal herb in traditional Chinese medicine for more than 400 years. Because notoginseng is included in many proprietary Chinese medicines, the quality of notoginseng directly affects its efficacy and safety. However, considering the complex and special growth environment requirements of notoginseng, it is insufficient to evaluate its quality based solely on the analysis of marker chemicals. Thus, in this study, we tried to evaluate the quality of notoginseng with integrated indicators: (1) the concentration of five marker chemicals, notoginsenoside R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd; (2) the anticoagulant activity (ACA); and (3) twenty-one ecological factors (e...
2016: PloS One
https://www.readbyqxmd.com/read/27642594/lipid-regulation-effects-of-raw-and-processed-notoginseng-radix-et-rhizome-on-steatotic-hepatocyte-l02-cell
#12
Zhu Chen, Chunmei Li, Caixia Yang, Ronghua Zhao, Xiaojian Mao, Jie Yu
Introduction. Raw and processed Notoginseng Radix Et Rhizome (NRR) have been widely used in treatment of metabolic syndromes and related disease, including nonalcoholic fatty liver disease (NAFLD). This study was designed to investigate lipid regulation effects of raw and processed NRR in steatotic L02 cell. Materials and Methods. Steatotic L02 cells were obtained after being cultured with 5% fat emulsion-10% FBS-RPMI 1640 medium for 48 h. Contents of total cholesterol (TC), triglyceride (TG), free fatty acid (FFA), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in steatotic L02 cells were evaluated after treatment...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27641158/ginsenoside-rd-attenuates-breast-cancer-metastasis-implicating-derepressing-microrna-18a-regulated-smad2-expression
#13
Peiwei Wang, Xiaoye Du, Minqi Xiong, Jingang Cui, Qinbo Yang, Wenjian Wang, Yu Chen, Teng Zhang
Metastasis remains a major cause of mortality and poor prognosis in breast cancer patients. Anti-metastatic therapies are in great need to achieve optimal clinical outcome in breast cancer patients. Panax Notoginseng Saponins (PNS) has previously been shown to inhibit breast cancer metastasis in mouse. Here the potential anti-metastatic effect of one of the chemical compounds of PNS, ginsenoside Rd (Rd), was further evaluated in mouse mammary carcinoma 4T1 cells. The results revealed that Rd treatment dose-dependently suppressed cell migration and invasion in cultured 4T1 cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27637802/qualitatively-and-quantitatively-investigating-the-regulation-of-intestinal-microbiota-on-the-metabolism-of-panax-notoginseng-saponins
#14
Jingcheng Xiao, Huimin Chen, Dian Kang, Yuhao Shao, Boyu Shen, Xinuo Li, Xiaoxi Yin, Zhangpei Zhu, Haofeng Li, Tai Rao, Lin Xie, Guangji Wang, Yan Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Intestinal microflora plays crucial roles in modulating pharmacokinetic characteristics and pharmacological actions of active ingredients in traditional Chinese medicines (TCMs). However, the exact impact of altered intestinal microflora affecting the biotransformation of TCMs remains poorly understood. AIMS OF THE STUDY: This study aimed to reveal the specific enterobacteria which dominate the metabolism of panax notoginseng saponins (PNSs) via exploring the relationship between bacterial community structures and the metabolic profiles of PNSs...
September 13, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27620662/inhibiting-adhesion-events-by-panax-notoginseng-saponins-and-ginsenoside-rb1-protecting-arteries-via-activation-of-nrf2-and-suppression-of-p38-vcam-1-signal-pathway
#15
Jishan Fan, Danning Liu, Cuiyao He, Xiaohui Li, Fengtian He
ETHNOPHARMACOLOGICAL RELEVANCE: Asian countries, such as China, Japan, and Korea, have witnessed a history of more than 1000 years of Panax notoginseng (Burk.) F.H. Chen's application as a famous traditional medicine for cardiovascular diseases (Zhou et al., 2004). The use of Panax notoginseng (Sanqi) was first recorded in "Bencao Gangmu", which was written by Li Shizhen, a Chinese pharmacologist of the MING dynasty, in 1578. It is included in "The Plant List" as one species of genus Panax (family Araliaceae)...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27617577/rn1-a-novel-galectin-3-inhibitor-inhibits-pancreatic-cancer-cell-growth-in-vitro-and-in-vivo-via-blocking-galectin-3-associated-signaling-pathways
#16
L Zhang, P Wang, Y Qin, Q Cong, C Shao, Z Du, X Ni, P Li, K Ding
Galectin-3 (Gal-3) has been implicated in pancreatic ductal adenocarcinoma (PDAC), and its candidacy as a therapeutic target has been evaluated. Gal-3 is widely upregulated in tumors, and its expression is associated with the development and malignancy of PDAC. In the present study, we demonstrate that a polysaccharide, RN1, purified from the flower of Panax notoginseng binds to Gal-3 and suppresses its expression. In addition, RN1 markedly inhibits PDAC cells growth in vitro, in vivo and in patient-derived xenografts...
September 12, 2016: Oncogene
https://www.readbyqxmd.com/read/27589712/panax-notoginseng-saponins-as-a-novel-nature-stabilizer-for-poorly-soluble-drug-nanocrystals-a-case-study-with-baicalein
#17
Yuanbiao Xie, Yueqin Ma, Junnan Xu, Yang Liu, Pengfei Yue, Qin Zheng, Pengyi Hu, Ming Yang
This study is aimed at seeking a nature saponin-based stabilizer for drug nanosuspensions. A poorly soluble drug (baicalein, BCL) was used as a model drug. BCL nanosuspensions with particle size of 156 nm were prepared by means of homogenization and converted into BCL nanocrystals (BCL-NC) stabilized with panax notoginseng saponins (PNS). It was found that PNS was able to prevent the aggregation of BCL-NS during storage and improve the redispersibility of BCL-NC after freeze-drying and spray-drying, compared with polymer stabilizer PVPK30...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27586658/subtractive-transcriptome-analysis-of-leaf-and-rhizome-reveals-differentially-expressed-transcripts-in-panax-sokpayensis
#18
Bhusan Gurung, Pardeep K Bhardwaj, Narayan C Talukdar
In the present study, suppression subtractive hybridization (SSH) strategy was used to identify rare and differentially expressed transcripts in leaf and rhizome tissues of Panax sokpayensis. Out of 1102 randomly picked clones, 513 and 374 high quality expressed sequenced tags (ESTs) were generated from leaf and rhizome subtractive libraries, respectively. Out of them, 64.92 % ESTs from leaf and 69.26 % ESTs from rhizome SSH libraries were assembled into different functional categories, while others were of unknown function...
September 1, 2016: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/27585466/panax-notoginseng-saponins-administration-modulates-pro-anti-inflammatory-factor-expression-and-improves-neurologic-outcome-following-permanent-mcao-in-rats
#19
Xiaowei Shi, Wenjing Yu, Lixing Liu, Wei Liu, Xiaomeng Zhang, Tiantian Yang, Limin Chai, Lixia Lou, Yonghong Gao, Lingqun Zhu
Ischemic stroke, particularly permanent occlusion, accounts for the overwhelming majority of all strokes. In addition to the occlusion of arteries, the inflammatory response plays a pivotal role in the severity of the cerebral injury and its clinical prognosis. Here, panax notoginseng saponins (PNS) extracted from a traditional Chinese herbal medicine was administered following permanent middle cerebral artery occlusion (MCAO) in rats to explore the neuroprotective mechanisms against ischemic injury. The results showed that MCAO surgery was successful in producing an infarct and that PNS and nimodipine could ameliorate the neurological deficits...
September 2, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27566197/panax-notoginseng-saponins-attenuate-lung-cancer-growth-in-part-through-modulating-the-level-of-met-mir-222-axis
#20
Qinbo Yang, Peiwei Wang, Jingang Cui, Wenjian Wang, Yu Chen, Teng Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Panax notoginseng saponins (PNS) are the major chemical constituents of Panax notoginseng (Burkill) F.H. Chen (Araliaceae), a medicinal herb extensively used in China for the treatment of various diseases including cancer. PNS have been reported to contribute to the therapeutic effects of Panax notoginseng in disease conditions including lung cancer. AIM OF THE STUDY: The current study aims to further understand the molecular mechanisms implicated in the pharmacological activities of PNS in attenuating lung cancer growth...
August 23, 2016: Journal of Ethnopharmacology
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