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Panax notoginseng

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https://www.readbyqxmd.com/read/28315720/the-protective-effect-of-the-active-components-of-erpc-on-diabetic-peripheral-neuropathy-in-rats
#1
Gai-Mei Hao, Yong-Gang Liu, Yan Wu, Wei Xing, Shu-Zhen Guo, Yong Wang, Zheng-Lin Wang, Chun Li, Tian-Tian Lv, Hong-Liang Wang, Tian-Jiao Shi, Wei Wang, Jing Han
ETHNOPHARMACOLOGICAL RELEVANCE: Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY: The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis (cERPC) on diabetic peripheral neuropathy in the rats and explore the underlying mechanism involved...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28299913/endophytic-fungi-harbored-in-the-root-of-sophora-tonkinensis-gapnep-diversity-and-biocontrol-potential-against-phytopathogens
#2
Yu Qun Yao, Fang Lan, Yun Ming Qiao, Ji Guang Wei, Rong Shao Huang, Liang Bo Li
This work, for the first time, investigated the diversity of endophytic fungi harbored in the xylem and phloem of the root of Sophora tonkinensis Gapnep from three geographic localities with emphasis on the influence of the tissue type and geographic locality on endophytic fungal communities and their potential as biocontrol agents against phytopathogens of Panax notoginseng. A total of 655 fungal strains representing 47 taxa were isolated. Forty-two taxa (89.4%) were identified but not five taxa (10.6%) according to morphology and molecular phylogenetics...
March 15, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28296594/vasodilatory-effects-of-combined-traditional-chinese-medicinal-herbs-in-optimized-ratio
#3
Yean Chun Loh, Chu Shan Tan, Yung Sing Ch'ng, Mariam Ahmad, Mohd Zaini Asmawi, Mun Fei Yam
Recently, a new syndromic disease combination theory of traditional Chinese medicine (TCM) for hypertensive treatment has been introduced. In the wake of this new concept, a new science-based TCM formula that counteracts various syndromes is needed. The objective of this study was to develop such a formula. Five of the most clinically prescribed TCM herbs that work on different syndromes, namely Gastrodia elata, Uncaria rhynchophylla, Pueraria thomsonii, Panax notoginseng, and Alisma orientale, were selected for this study...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28285072/purity-assessment-of-ginsenoside-rg1-using-quantitative-1-h-nuclear-magnetic-resonance
#4
Bao-Ming Huang, Sheng-Yuan Xiao, Ting-Bo Chen, Ying Xie, Pei Luo, Liang Liu, Hua Zhou
Ginseng herbs comprise a group of the most popular herbs, including Panax ginseng, P. notoginseng and P. quinquefolius (Family Araliaceae), which are used as traditional Chinese medicine (TCM) and are some of the best-selling natural products in the world. The accurate quantification of ginsenoside Rg1 is one of the major aspects of its quality control. However, the purity of the commercial Rg1 chemical reference substance (CRS) is often measured with high-performance chromatography coupled with an ultraviolet detector (HPLC-UV), which is a selective detector with unequal responses to different compounds; thus, this detector introduces probable error to purity assessments...
March 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28284427/pharmacokinetics-and-correlation-between-in-vitro-release-and-in-vivo-absorption-of-bio-adhesive-pellets-of-panax-notoginseng-saponins
#5
Ying Li, Yun Zhang, Chun-Yan Zhu
The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins (PNS) with hydroxy propyl methyl cellulose (HPMC), chitosan, and chitosan : carbomer, explore the influence of different bio-adhesive materials on pharmacokinetics behaviors of PNSbio-adhesive pellets, and evaluate the correlation between in vivo absorption and in vitro release (IVIVC). In order to predict the in vivo concentration-time profile by the in vitro release data of bio-adhesive pellets, the release experiment was performed using the rotating basket method in pH 6...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28278662/antimicrobial-activity-of-saponins-produced-by-two-novel-endophytic-fungi-from-panax-notoginseng
#6
Zhaoxia Jin, Lin Gao, Lin Zhang, Tianyi Liu, Fang Yu, Zongshen Zhang, Qiong Guo, Biying Wang
Endophytes in plants may be co-producer of the bioactive compounds of their hosts. We conducted a study to bioprospect for saponin-producing endophytic fungi from Panax notoginseng and evaluate the antimicrobial activity of saponins. Two novel fungal endophytes, Fusarium sp. PN8 and Aspergillus sp. PN17, were isolated from traditional Chinese medicinal herb P. notoginseng. After eight days of fermentation, the total saponins produced in the culture broth of PN8 and PN17 were 1.061 and 0.583 mg mL(-1), respectively...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#7
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28250796/neuroprotective-properties-of-panax-notoginseng-saponins-via-preventing-oxidative-stress-injury-in-samp8-mice
#8
Jin-Lan Huang, Xin Jing, Xin Tian, Mei-Chun Qin, Zhe-Hao Xu, Deng-Pan Wu, Zhen-Guo Zhong
Inhibiting oxidative damage in early stage of Alzheimer's disease (AD) is considered as a strategy for AD treatment. Our previous study has shown that Panax notoginseng saponins (PNS) have an antiaging action by increasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of aged rats. In this study, we aimed to investigate the effects of PNS on antioxidant enzymes and uncoupling proteins (UCPs) involved in oxidative stress in AD mice. The results showed that PNS prevented neuronal loss in hippocampal CA1 region and alleviated pathomorphological change of neurons in CA1 region...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28238184/biodegradation-of-pentachloronitrobenzene-by-cupriavidus-sp-yns-85-and-its-potential-for-remediation-of-contaminated-soils
#9
Ying Teng, Xiaomi Wang, Ye Zhu, Wei Chen, Peter Christie, Zhengao Li, Yongming Luo
Pentachloronitrobenzene (PCNB) is a toxic chlorinated nitroaromatic compound. However, only a few bacteria have been reported to be able to utilize PCNB. In the present study, one pentachloronitrobenzene (PCNB)-degrading bacterium, Cupriavidus sp. YNS-85, was isolated from a contaminated Panax notoginseng plantation. The strain co-metabolized 200 mg L(-1) PCNB in aqueous solution with a removal rate of 73.8% after 5 days. The bacterium also degraded PCNB effectively under acid conditions (pH 4-6) and showed resistance to toxic trace elements (arsenic, copper, and cadmium)...
February 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28164352/simultaneous-determination-of-tanshinol-protocatechuic-aldehyde-protocatechuic-acid-notoginsenoside-r1-ginsenoside-rg1-and-rb1-in-rat-plasma-by-lc-ms-ms-and-its-application
#10
Tingyang Li, Yang Chu, Kaijing Yan, Shuming Li, Xiangyang Wang, Ying Wang, Wei Li, Xiaohui Ma, Jin Yang, Changxiao Liu
Dantonic pill, consisting of Salviae miltiorrhize, Panax notoginseng and Borneol, is a widely used compound Chinese medicine for preventing and treating ischemic cardiovascular diseases in China. In the present study, an original and sensitive method for simultaneous determination of tanshinol (i.e. danshensu), protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 in rat plasma by liquid chromatography-tandem mass spectrometry operated in positive/negative ion switching mode was established and validated...
November 7, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28114983/panaxatriol-saponins-promotes-angiogenesis-and-enhances-cerebral-perfusion-after-ischemic-stroke-in-rats
#11
Zhen Hui, Du-Juan Sha, Su-Lei Wang, Chao-Sheng Li, Jian Qian, Jing-Qing Wang, Yang Zhao, Jing-Hua Zhang, Hong-Yu Cheng, Hui Yang, Lin-Jie Yu, Yun Xu
BACKGROUND: Panaxatriol saponins (PTS), an extract from the traditional Chinese herb Panax notoginseng, which has been used to treat ischemic stroke for many years in China. However, the mechanism underlying the effects of PTS remains unclear. This study aimed to determine whether PTS can protect against ischemic brain injury by promoting angiogenesis and to explore the possible mechanism by which it promotes angiogenesis. METHODS: Middle cerebral artery occlusion (MCAO) was induced in rats, and neurological deficit scores and brain infarct volumes were assessed...
January 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28112228/hormetic-effect-of-panaxatriol-saponins-confers-neuroprotection-in-pc12-cells-and-zebrafish-through-pi3k-akt-mtor-and-ampk-sirt1-foxo3-pathways
#12
Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Lijuan Ma, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Meiwan Chen, Peng Li, Huanxing Su, Simon Ming Yuen Lee, Kechun Liu, Jian-Bo Wan, Chengwei He
Hormesis is an adaptive response of living organisms to a moderate stress. However, its biomedical implication and molecular mechanisms remain to be intensively investigated. Panaxatriol saponins (PTS) is the major bioactive components extracted from Panax notoginseng, a widely used herbal medicine for cerebrovascular diseases. This study aims to examine the hormetic and neuroprotective effects of PTS in PC12 cells and zebrafish Parkinson's disease (PD) models. Our results demonstrated that PTS stimulated PC12 cell growth by about 30% at low doses, while PTS at high doses inhibited cell growth, which is a typical hormetic effect...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106137/ameliorative-effects-of-compound-k-and-ginsenoside-rh1-on-non-alcoholic-fatty-liver-disease-in-rats
#13
Xu-Jia Chen, Wen-Jing Liu, Meng-Liang Wen, Hong Liang, Shao-Mei Wu, Yun-Zhen Zhu, Jiang-Yuan Zhao, Xiang-Qian Dong, Ming-Gang Li, Li Bian, Cheng-Gang Zou, Lan-Qing Ma
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease, which has no standard treatment available. Panax notoginseng saponines (PNS) have recently been reported to protect liver against hepatocyte injury induced by ethanol or high fat diet (HFD) in rats. Compound K and ginsenoside Rh1 are the main metabolites of PNS. In this study, we evaluated the effects of CK and Rh1 on NAFLD. Rats fed HFD showed significant elevations in liver function markers, lipids, glucose tolerance, and insulin resistance...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101178/endothelium-dependent-vasodilation-effects-of-panax-notoginseng-and-its-main-components-are-mediated-by-nitric-oxide-and-cyclooxygenase-pathways
#14
Yanyan Wang, Yu Ren, Leilei Xing, Xiangdong Dai, Sheng Liu, Bin Yu, Yi Wang
Panax notoginseng, a traditional Chinese herbal medicine, has been used for the treatment of cardiovascular diseases. The main bioactive components of this species are Panax notoginseng saponins (PNS). The present study aimed to investigate the effects of PNS and five of its main components (ginsenosides Rg1, Re, Rb1 and Rd, and notoginsenoside R1) on rat aorta rings pre-contracted with norepinephrine (NE) and to determine the underlying mechanism of action. Isolated aorta rings (with or without intact endothelium) from adult male Wistar rats were stimulated with NE to induce vasoconstriction, and subsequently treated with different concentrations of PNS and its five main components (Rg1, Re, Rb1, R1 and Rd) separately...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28065779/effects-of-panax-notoginseng-ginsenoside-rb1-on-abnormal-hippocampal-microenvironment-in-rats
#15
Shiyun Wang, Minghong Li, Ying Guo, Chen Li, Lanou Wu, Xin-Fu Zhou, Yaohui Luo, Dong An, Shude Li, Haiyun Luo, Lijin Pu
Cerebral ischemia damages central neurons, and abnormal microenvironment in ischemic condition is the key factor to the damages. The increase of local concentration of glutamic acid, the overload of Ca(2+), and the mitochondrial stress caused by release of cytochrome C are important factors of abnormal microenvironment in cerebral ischemia. In this study ginsenoside Rb1, a compound from Panax Notoginseng, was used to intervene abnormal environment of neurons in the hippocampal CA1 region in two animal models (microperfusion model and photothrombosis model)...
January 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28060404/diversity-and-composition-of-rhizospheric-soil-and-root-endogenous-bacteria-in-panax-notoginseng-during-continuous-cropping-practices
#16
Yong Tan, Yinshan Cui, Haoyu Li, Anxiu Kuang, Xiaoran Li, Yunlin Wei, Xiuling Ji
Rhizobacteria and endophytic bacteria play important roles in protecting host plants from infection by phytopathogens, which cause soil-borne diseases and severely impair plant health. Panax notoginseng is negatively affected by continuous cropping and becomes vulnerable to attack by microbial pathogens. In the present study, culture-independent Illumina MiSeq was used to investigate root-endophytic and rhizospheric bacteria in response to continuous cropping of P. notoginseng. Numbers of rhizospheric bacteria decreased with continuous P...
January 6, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28051353/panax-notoginseng-saponin-controls-il-17-expression-in-helper-t-cells
#17
Jia-Ru Wei, Xiaofeng Wen, Paul W Bible, Zhiyu Li, Robert B Nussenblatt, Lai Wei
PURPOSE: Panax Notoginseng, a traditional Chinese medicine, is known as an anti-inflammatory herb. However, the molecular mechanism by which it controls helper T cell mediated immune responses is largely unknown. METHODS: Naive CD4(+) T cells isolated from healthy donors, patients with Behcet's disease, and C57BL/6 mice were polarized into Th1, Th17, and Treg cells. Proliferation and cytokine expression were measured in these cells with the presence or absence of Panax Notoginseng saponins (PNS)...
January 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28017695/mir-29c-is-implicated-in-the-cardioprotective-activity-of-panax-notoginseng-saponins-against-isoproterenol-induced-myocardial-fibrogenesis
#18
Li Liu, Bingbing Ning, Jingang Cui, Teng Zhang, Yu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Panax notoginseng (Burkill) F.H. Chen (Araliaceae) has a long history of clinical application in China for the treatment of cardiovascular diseases. Panax notoginseng saponins (PNS) have been proven to be the major cardioprotective substances of Panax notoginseng (Burkill) F.H. Chen (Araliaceae). AIM OF THE STUDY: The current study further investigated the molecular mechanisms associated with the cardioprotective effect of PNS. MATERIALS AND METHODS: C57BL/6J mice were subject to isoproterenol (ISO)-induced myocardial injury in the absence or presence of PNS treatment...
December 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28010843/an-in-source-multiple-collision-neutral-loss-filtering-based-nontargeted-metabolomics-approach-for-the-comprehensive-analysis-of-malonyl-ginsenosides-from-panax-ginseng-p-%C3%A2-quinquefolius-and-p-%C3%A2-notoginseng
#19
Xiao-Jian Shi, Wen-Zhi Yang, Shi Qiu, Chang-Liang Yao, Yao Shen, Hui-Qin Pan, Qi-Rui Bi, Min Yang, Wan-Ying Wu, De-An Guo
The simultaneous identification and quantification of target metabolites from herbal medicines are difficult to implement by the full-scan MS based nontargeted metabolomics approaches. Here an in-source multiple collision-neutral loss filtering (IMC-NLF) based nontargeted metabolomics approach is developed and applied to identify and quantify the variations of malonyl-ginsenosides, a common group of acyl saponins with potential anti-diabetic activity, among Panax ginseng, P. quinquefolius, and P. notoginseng...
February 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27978468/effect-of-panax-notoginseng-saponins-on-the-pharmacokinetics-of-aspirin-in-rats
#20
Zhihao Tian, Huanhuan Pang, Shouying Du, Yang Lu, Lin Zhang, Huichao Wu, Shuang Guo, Min Wang, Qiang Zhang
Aspirin (ASA) is widely used to treat fever, pain, inflammation and cerebral infarction in clinic. Panax Notoginseng Saponins (PNS) is the extracts of Panax Notoginseng (PN)-a traditional Chinese medicine extensively used in cardiovascular diseases. Panax notoginseng saponins and ASA are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved when the two drugs were taken together. To investigate the effect of PNS on ASA in vivo, the concentrations of salicylic acid (SA) in blood were measured after oral administration of ASA or ASA combined with PNS by UPLC-MS/MS...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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