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Panax notoginseng

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https://www.readbyqxmd.com/read/28778038/application-of-magnetically-immobilized-edible-fungus-for-the-biotransformation-of-panax-notoginseng-saponin-rb1-to-rd-and-rg3
#1
Yuping Zang, Na Guo, Jiao Jiao, Xiqing Wang, Qingyan Gai, Wenjing Xu, Yujie Fu
In this study, we developed a new magnetically immobilized edible fungus for the biotransformation of panax notoginseng saponins Rb1 to Rd and Rg3. The optimum biotransformation conditions were as follows: temperature 32°C, pH 6.5, time 48h and liquid-solid ratio 25:1(mL/g). The yields of Rd and Rg3 reached 41.35±0.12mg/g and 6.35±0.08mg/g which increased 6.97-fold and 3.23-fold to that of untreated control, respectively. Additionally, SEM demonstrated that vestured pits and cell walls of samples were destroyed obviously which was beneficial to the Rb1 biotransformation and target Rd and Rg3 release...
July 27, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28758911/molecular-cloning-and-characterization-of-pnbhlh1-transcription-factor-in-panax-notoginseng
#2
Xiang Zhang, Feng Ge, Bing Deng, Taif Shah, Zhuangjia Huang, Diqiu Liu, Chaoyin Chen
Panax notoginseng has been extensively used as a traditional Chinese medicine. In the current study, molecular cloning and characterization of PnbHLH1 transcription factor were explored in Panax notoginseng. The full length of the PnbHLH1 gene obtained by splicing was 1430 bp, encoding 321 amino acids. Prokaryotic expression vector pET-28a-PnbHLH1 was constructed and transferred into the BL21 prokaryotic expression strain. An electrophoretic mobility shift assay of PnbHLH1 protein binding to E-box cis-acting elements verified that PnbHLH1 belonged to the bHLH class transcription factor which could interact with the promoter region of the E-box core sequence...
July 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28758425/new-triterpenoid-saponins-from-the-steaming-treated-roots-of-panax-notoginseng
#3
Cheng-Zhen Gu, Yi-Jun Qiao, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Min Xu, Ying-Jun Zhang
Further phytochemical investigation of the steaming treated roots of Panax notoginseng (Araliaceae) led to the identification of two new dammarane-type triterpenoid saponins, notoginsenoside SP20 (1) and SP21 (2). In addition, a pair of new phenolic glycosides (3a and 3b) was also isolated together with two known compounds. Their structures were elucidated by HRESIMS, 1D- and 2D-NMR spectra. Compounds 1 and 2 showed no in vitro cytotoxicity against five human cancer cell lines (HL-60, SMMC-7712, A-549, MCF-9 and SW480)...
July 31, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28730971/apoptosis-and-anti-cancer-drug-discovery-the-power-of-medicinal-fungi-and-plants
#4
Jack Ho Wong, Stephen Cho Wing Sze, Tzi Bun Ng, Randy Chi Fai Cheung, Chit Tam, Kalin Yanbo Zhang, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye, Hexiang Wang, Fang Liu, David Wai Chan, Hextan Yuen Sheung Ngan, Ou Sha, Guohui Li, Ryan Tse, Tak Fu Tse, Helen Chan
The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus , Dendrobium spp,Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28701877/endophytic-fungi-harbored-in-panax-notoginseng-diversity-and-potential-as-biological-control-agents-against-host-plant-pathogens-of%C3%A2-root-rot-disease
#5
You-Kun Zheng, Cui-Ping Miao, Hua-Hong Chen, Fang-Fang Huang, Yu-Mei Xia, You-Wei Chen, Li-Xing Zhao
BACKGROUND: Endophytic fungi play an important role in balancing the ecosystem and boosting host growth. In the present study, we investigated the endophytic fungal diversity of healthy Panax notoginseng and evaluated its potential antimicrobial activity against five major phytopathogens causing root-rot of P. notoginseng. METHODS: A culture-dependent technique, combining morphological and molecular methods, was used to analyze endophytic fungal diversity. A double-layer agar technique was used to challenge the phytopathogens of P...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28687778/evolution-of-the-araliaceae-family-inferred-from-complete-chloroplast-genomes-and-45s-nrdnas-of-10-panax-related-species
#6
Kyunghee Kim, Van Binh Nguyen, Jingzhou Dong, Ying Wang, Jee Young Park, Sang-Choon Lee, Tae-Jin Yang
We produced complete sequences and conducted comparative analysis of the maternally inherited chloroplast (cp) genomes and bi-parentally inherited 45S nuclear ribosomal RNA genes (nrDNA) from ten Araliaceae species to elucidate the genetic diversity and evolution in that family. The cp genomes ranged from 155,993 bp to 156,730 bp with 97.1-99.6% similarity. Complete 45S nrDNA units were about 11 kb including a 5.8-kb 45S cistron. Among 79 cp protein-coding genes, 74 showed nucleotide variations among ten species, of which infA, rpl22, rps19 and ndhE genes showed the highest Ks values and atpF, atpE, ycf2 and rps15 genes showed the highest Ka/Ks values...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28632266/proteomic-analysis-reveals-xuesaitong-injection-attenuates-myocardial-ischemia-reperfusion-injury-by-elevating-pyruvate-dehydrogenase-mediated-aerobic-metabolism
#7
Xiaoping Zhao, Feng Zhang, Yi Wang
Xuesaitong injection (XST), which mainly consists of Panax notoginseng saponins, has been widely used for treating cardio-cerebral vascular diseases. However, the underlying mechanisms of XST associated with its cardioprotective effects are still unclear. To identify the potential target proteins of XST, two-dimensional gel electrophoresis (2-DE)-based proteomics was utilized to analyze the protein profile of myocardium in rats with myocardial ischemia/reperfusion (I/R) injury. The differentially expressed proteins were identified by matrix assisted laser desorption/ionization time-of-flight mass spectrometry...
July 25, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28597423/illumina-based-transcriptomic-profiling-of-panax-notoginseng-in-response-to-arsenic-stress
#8
Yanfang Liu, Yanhua Mi, Jianhua Zhang, Qiwan Li, Lu Chen
BACKGROUND: Panax notoginseng, a famous herbal medicine, has recently attracted great attention on its safety and quality since P. notoginseng can accumulate and tolerate As from growing environment. For the purpose of understanding As damage to the quality of P. notoginseng as well as corresponding tolerance mechanisms, genes involved in As stress response were identified using Illumina sequencing. RESULTS: Totally 91,979,946 clean reads were generated and were de novo assembled into 172,355 unigenes...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28530408/authentication-markers-for-five-major-panax-species-developed-via-comparative-analysis-of-complete-chloroplast-genome-sequences
#9
Van Binh Nguyen, Hyun-Seung Park, Sang-Choon Lee, Junki Lee, Jee Young Park, Tae-Jin Yang
Ginseng represents a set of high-value medicinal plants of different species: Panax ginseng (Asian ginseng), Panax quinquefolius (American ginseng), Panax notoginseng (Chinese ginseng), Panax japonicus (Bamboo ginseng), and Panax vietnamensis (Vietnamese ginseng). Each species is pharmacologically and economically important, with differences in efficacy and price. Accordingly, an authentication system is needed to combat economically motivated adulteration of Panax products. We conducted comparative analysis of the chloroplast genome sequences of these five species, identifying 34-124 InDels and 141-560 SNPs...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28425043/innovative-development-path-of-ethnomedicines-a-case-study
#10
Zhaoyun Zhu, Yali Gui, Li Wang, Ting Wang, Yang Yang, Yunzhuang Niu, Dehuan Fu, Jingkun Wang, Tao Cui
Innovative development extends the vitality of ethnomedicines. Developing ethnomedicines is not only beneficial to the public but also to the related industry and transforms economic growth, driving local social and economic development further. Its economic benefit can be used to optimize and promote the hardware and software of the platform, as well as support the sustainable development of ethnomedicines. Apart from research and discussion on the innovative development of ethnomedicines on the basis of theory and regulations, this series of articles also summarizes cases that are conducive to the overall understanding of the necessity and feasibility of the innovative development...
April 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28397534/a-new-polyketide-glycoside-from-the-rhizospheric-clonostachys-rogersoniana-associated-with-panax-notoginseng
#11
Tian-Peng Yin, Yun Xing, Le Cai, Jing Yu, Ping Luo, Zhong-Tao Ding
A new polyketide glycoside rogerson A (1), along with two known compounds, rogerson B (2) and (22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (3), was obtained from the solid fermentation of Clonostachys rogersoniana, which was isolated from the rhizosphere soil of Panax notoginseng. Rogerson B (2) was isolated for the first time from a natural source. Their structure was determined by extensive analyses of NMR and MS studies. Compounds 1 and 2 were tested for its cytotoxicity against five human cancer cell lines...
April 11, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28379198/strengthening-triterpene-saponins-biosynthesis-by-over-expression-of-farnesyl-pyrophosphate-synthase-gene-and-rna-interference-of-cycloartenol-synthase-gene-in-panax-notoginseng-cells
#12
Yan Yang, Feng Ge, Ying Sun, Diqiu Liu, Chaoyin Chen
To conform to the multiple regulations of triterpene biosynthesis, the gene encoding farnesyl pyrophosphate synthase (FPS) was transformed into Panax notoginseng (P. notoginseng) cells in which RNA interference (RNAi) of the cycloartenol synthase (CAS) gene had been accomplished. Transgenic cell lines showed both higher expression levels of FPS and lower expression levels of CAS compared to the wild-type (WT) cells. In the triterpene and phytosterol analysis, transgenic cell lines provided a higher accumulation of total triterpene saponins, and a lower amount of phytosterols in comparison with the WT cells...
April 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28378572/effect-of-compatible-herbs-on-the-pharmacokinetics-of-effective-components-of-panax-notoginseng-in-fufang-xueshuantong-capsule
#13
Huan-Huan Pang, Meng-Yi Li, Yuan Wang, Min-Ke Tang, Chang-Hua Ma, Jian-Mei Huang
Fufang Xueshuantong (FXT) is a well-known Chinese herbal formula which has been used to treat cardiovascular and ophthalmic diseases, especially diabetic retinopathy. Panax notoginseng (Burkill) F.H. Chen (PN) is the main herb of FXT, whose major bioactive constituents are ginsenosides. However, the scientific basis of the compatibility of FXT is still ambiguous. The present study investigated the scientific basis of the compatibility of FXT by comparing the pharmacokinetics of marker compounds after oral administrations of PN and FXT...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28315720/the-protective-effect-of-the-active-components-of-erpc-on-diabetic-peripheral-neuropathy-in-rats
#14
Gai-Mei Hao, Yong-Gang Liu, Yan Wu, Wei Xing, Shu-Zhen Guo, Yong Wang, Zheng-Lin Wang, Chun Li, Tian-Tian Lv, Hong-Liang Wang, Tian-Jiao Shi, Wei Wang, Jing Han
ETHNOPHARMACOLOGICAL RELEVANCE: Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY: The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis (cERPC) on diabetic peripheral neuropathy in the rats and explore the underlying mechanism involved...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28299913/endophytic-fungi-harbored-in-the-root-of-sophora-tonkinensis-gapnep-diversity-and-biocontrol-potential-against-phytopathogens
#15
Yu Qun Yao, Fang Lan, Yun Ming Qiao, Ji Guang Wei, Rong Shao Huang, Liang Bo Li
This work, for the first time, investigated the diversity of endophytic fungi harbored in the xylem and phloem of the root of Sophora tonkinensis Gapnep from three geographic localities with emphasis on the influence of the tissue type and geographic locality on endophytic fungal communities and their potential as biocontrol agents against phytopathogens of Panax notoginseng. A total of 655 fungal strains representing 47 taxa were isolated. Forty-two taxa (89.4%) were identified but not five taxa (10.6%) according to morphology and molecular phylogenetics...
June 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28296594/vasodilatory-effects-of-combined-traditional-chinese-medicinal-herbs-in-optimized-ratio
#16
Yean Chun Loh, Chu Shan Tan, Yung Sing Ch'ng, Mariam Ahmad, Mohd Zaini Asmawi, Mun Fei Yam
Recently, a new syndromic disease combination theory of traditional Chinese medicine (TCM) for hypertensive treatment has been introduced. In the wake of this new concept, a new science-based TCM formula that counteracts various syndromes is needed. The objective of this study was to develop such a formula. Five of the most clinically prescribed TCM herbs that work on different syndromes, namely Gastrodia elata, Uncaria rhynchophylla, Pueraria thomsonii, Panax notoginseng, and Alisma orientale, were selected for this study...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28285072/purity-assessment-of-ginsenoside-rg1-using-quantitative-1-h-nuclear-magnetic-resonance
#17
Bao-Ming Huang, Sheng-Yuan Xiao, Ting-Bo Chen, Ying Xie, Pei Luo, Liang Liu, Hua Zhou
Ginseng herbs comprise a group of the most popular herbs, including Panax ginseng, P. notoginseng and P. quinquefolius (Family Araliaceae), which are used as traditional Chinese medicine (TCM) and are some of the best-selling natural products in the world. The accurate quantification of ginsenoside Rg1 is one of the major aspects of its quality control. However, the purity of the commercial Rg1 chemical reference substance (CRS) is often measured with high-performance chromatography coupled with an ultraviolet detector (HPLC-UV), which is a selective detector with unequal responses to different compounds; thus, this detector introduces probable error to purity assessments...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28284427/pharmacokinetics-and-correlation-between-in-vitro-release-and-in-vivo-absorption-of-bio-adhesive-pellets-of-panax-notoginseng-saponins
#18
Ying Li, Yun Zhang, Chun-Yan Zhu
The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins (PNS) with hydroxy propyl methyl cellulose (HPMC), chitosan, and chitosan : carbomer, explore the influence of different bio-adhesive materials on pharmacokinetics behaviors of PNSbio-adhesive pellets, and evaluate the correlation between in vivo absorption and in vitro release (IVIVC). In order to predict the in vivo concentration-time profile by the in vitro release data of bio-adhesive pellets, the release experiment was performed using the rotating basket method in pH 6...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28278662/antimicrobial-activity-of-saponins-produced-by-two-novel-endophytic-fungi-from-panax-notoginseng
#19
Zhaoxia Jin, Lin Gao, Lin Zhang, Tianyi Liu, Fang Yu, Zongshen Zhang, Qiong Guo, Biying Wang
Endophytes in plants may be co-producer of the bioactive compounds of their hosts. We conducted a study to bioprospect for saponin-producing endophytic fungi from Panax notoginseng and evaluate the antimicrobial activity of saponins. Two novel fungal endophytes, Fusarium sp. PN8 and Aspergillus sp. PN17, were isolated from traditional Chinese medicinal herb P. notoginseng. After eight days of fermentation, the total saponins produced in the culture broth of PN8 and PN17 were 1.061 and 0.583 mg mL(-1), respectively...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#20
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
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