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https://www.readbyqxmd.com/read/28922794/genome-wide-variation-patterns-uncover-the-origin-and-selection-in-cultivated-ginseng-panax-ginseng-meyer
#1
Ming-Rui Li, Feng-Xue Shi, Ya-Ling Li, Peng Jiang, Lili Jiao, Bao Liu, Lin-Feng Li
Chinese ginseng (Panax ginseng Meyer) is a medicinally important herb and plays crucial roles in traditional Chinese medicine. Pharmacological analyses identified diverse bioactive components from Chinese ginseng. However, basic biological attributes including domestication and selection of the ginseng plant remain under-investigated. Here, we presented a genome-wide view of the domestication and selection of cultivated ginseng based on the whole genome data. A total of 8,660 protein-coding genes were selected for genome-wide scanning of the 30 wild and cultivated ginseng accessions...
September 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28916980/pharmacokinetics-of-panax-notoginseng-saponins-in-adhesive-and-normal-preparation-of-fufang-danshen
#2
Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng
BACKGROUND AND OBJECTIVE: Fufang Danshen formula, a famous Chinese patent medicine containing Salvia miltiorrhiza, Panax notoginseng and borneol, has been widely used in the treatment of coronary heart disease. The application is restricted by low bioavailability partly due to Panax notoginseng saponins (PNS) instability and low in vivo absorption. Thus, adhesive pellets were developed to improve bioavailability. The objectives of the present study were to evaluate the adhesive preparation by describing PNS's plasma pharmacokinetics in vivo and compare adhesive micro pills with normal preparation...
September 15, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28915465/traditional-chinese-medicinal-herbs-as-potential-ache-inhibitors-for-anti-alzheimer-s-disease-a-review
#3
REVIEW
Yingying Jiang, Hongwei Gao, Gulmira Turdu
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 25 million people worldwide, and cholinergic hypothesis is considered as an important hypotheses in the processes of improving cognitive function and recognition skills in recent years. For the long-term treatment of AD, traditional Chinese medicine are particularly suitable for drug discovery. In this review, we sum up six traditional Chinese medicinal herbs concerned with development of AChEIs, including Herba Epimedii, Coptis Chinensis Franch, Rhizoma Curcumae Longae, Green tea, Ganoderma, Panax Ginseng...
September 6, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28914759/isoform-sequencing-provides-a-more-comprehensive-view-of-the-panax-ginseng-transcriptome
#4
Ick-Hyun Jo, Jinsu Lee, Chi Eun Hong, Dong Jin Lee, Wonsil Bae, Sin-Gi Park, Yong Ju Ahn, Young Chang Kim, Jang Uk Kim, Jung Woo Lee, Dong Yun Hyun, Sung-Keun Rhee, Chang Pyo Hong, Kyong Hwan Bang, Hojin Ryu
Korean ginseng (Panax ginseng C.A. Meyer) has been widely used for medicinal purposes and contains potent plant secondary metabolites, including ginsenosides. To obtain transcriptomic data that offers a more comprehensive view of functional genomics in P. ginseng, we generated genome-wide transcriptome data from four different P. ginseng tissues using PacBio isoform sequencing (Iso-Seq) technology. A total of 135,317 assembled transcripts were generated with an average length of 3.2 kb and high assembly completeness...
September 15, 2017: Genes
https://www.readbyqxmd.com/read/28903427/ginsenoside-rg1-attenuates-adjuvant-induced-arthritis-in-rats-via-modulation-of-ppar-%C3%AE-nf-%C3%AE%C2%BAb-signal-pathway
#5
Leiming Zhang, Maojing Zhu, Minmin Li, Yuan Du, Sijin Duan, Yanan Huang, Yongying Lu, Jianqiao Zhang, Tian Wang, Fenghua Fu
Ginsenoside Rg1, the main active compound in Panax ginseng, has already been shown to have anti-inflammatory effects. However, the protective effects of Rg1 on rheumatoid arthritis (RA) remain unclear. The aim of the present study was to investigate the effects and mechanisms of Rg1 on adjuvant-induced arthritis (AIA) in rats. AIA rats were given Rg1 at doses of 5, 10, and 20 mg/kg intraperitoneally for 14 days to observe the anti-arthritic effects. The results showed that Rg1 significantly alleviated joint swelling and injuries...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900617/serum-and-brain-metabolomic-variations-reveal-perturbation-of-sleep-deprivation-on-rats-and-ameliorate-effect-of-total-ginsenoside-treatment
#6
Xiao-Jun Gou, Fang Cen, Zi-Quan Fan, Ying Xu, Hong-Yi Shen, Ming-Mei Zhou
Sleep loss or sleep deprivation (SD) refers to shorter sleep than average baseline need, and SD has been a serious problem of modern societies which affects health and well-being. Panax ginseng is a well-known traditional Chinese medicine (TCM). Our previous study has demonstrated that total ginsenosides (GS), the extracts from Panax ginseng, could effectively improve cognition and behavior on SD rats. However, little is known about its metabolomic study. In this study, serum and brain metabolomic method based on gas chromatography coupled with mass spectrometry (GC/MS) was employed to evaluate the efficacy and study the mechanism of GS on a rat model of SD...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28892002/state-of-panax-ginseng-research-a-global-analysis
#7
REVIEW
Wanqi Xu, Hyung-Kyoon Choi, Linfang Huang
This article aims to understand the global and longitudinal trends of research on Panax ginseng. We used bibliometrics to analyze 3974 papers collected from the Web of Science(TM) Core Collection database during 1959-2016. The number of publications showed a steady growth before 2000 and exponentially increased in stage III (2000-2016, about 86% of the papers were published). Research on P. ginseng was conducted in 64 countries, mainly in Asia; in particular, 41% and 28% of the publications were from South Korea and China, respectively...
September 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28891956/panax-ginseng-leaf-extracts-exert-anti-obesity-effects-in-high-fat-diet-induced-obese-rats
#8
Seul-Gi Lee, Yoon-Jeong Lee, Myeong-Hwan Jang, Tae-Ryong Kwon, Ju-Ock Nam
Recent studies have reported that the aerial parts of ginseng contain various saponins, which have anti-oxidative, anti-inflammatory, and anti-obesity properties similar to those of ginseng root. However, the leaf extracts of Korean ginseng have not yet been investigated. In this study, we demonstrate the anti-obesity effects of green leaf and dried leaf extracts (GL and DL, respectively) of ginseng in high-fat diet (HFD)-induced obese rats. The administration of GL and DL to HFD-induced obese rats significantly decreased body weight (by 96...
September 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28884396/ginsenoside-re-protects-trimethyltin-induced-neurotoxicity-via-activation-of-il-6-mediated-phosphoinositol-3-kinase-akt-signaling-in-mice
#9
Thu-Hien Thi Tu, Naveen Sharma, Eun-Joo Shin, Hai-Quyen Tran, Yu Jeung Lee, Ji Hoon Jeong, Jung Hwan Jeong, Seung Yeol Nah, Hoang-Yen Phi Tran, Jae Kyung Byun, Sung Kwon Ko, Hyoung-Chun Kim
Ginseng (Panax ginseng), an herbal medicine, has been used to prevent neurodegenerative disorders. Ginsenosides (e.g., Re, Rb1, or Rg1) were obtained from Korean mountain cultivated ginseng. The anticonvulsant activity of ginsenoside Re (20 mg/kg/day × 3) against trimethyltin (TMT) insult was the most pronounced out of ginsenosides (e.g., Re, Rb1, and Rg1). Re itself did not significantly alter tumor necrosis factor-α (TNF-α), interferon-ϒ (IFN-ϒ), and interleukin-1β (IL-1β) expression, however, it significantly increases the interleukin-6 (IL-6) expression...
September 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28881818/20-s-rg3-blocked-epithelial-mesenchymal-transition-through-dnmt3a-mir-145-fscn1-in-ovarian-cancer
#10
Jie Li, Jiaojiao Lu, Zhongxue Ye, Xi Han, Xia Zheng, Huilian Hou, Wei Chen, Xu Li, Le Zhao
Epithelial-mesenchymal transition (EMT) is one of the key mechanisms mediating cancer progression. MicroRNAs (miRs) are essential regulators of gene expression by suppressing translation or causing degradation of target mRNA. Growing evidence illustrates the crucial roles of miRs dysregulation in cancer development and progression. Here, we have found for the first time that the ginsenoside 20(S)-Rg3, a pharmacologically active component of Panax ginseng, potently increases miR-145 expression by downregulating methyltransferase DNMT3A to attenuate the hypermethylation of the promoter region in the miR-145 precursor gene...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28875201/ginseng-panax-ginseng-meyer-oligopeptides-regulate-innate-and-adaptive-immune-responses-in-mice-via-increased-macrophage-phagocytosis-capacity-nk-cell-activity-and-th-cells-secretion
#11
Li-Xia He, Jin-Wei Ren, Rui Liu, Qi-He Chen, Jian Zhao, Xin Wu, Zhao-Feng Zhang, Jun-Bo Wang, Giuseppe Pettinato, Yong Li
Traditionally used as a restorative medicine, ginseng (Panax ginseng Meyer) has been the most widely used and acclaimed herb in Chinese communities for thousands of years. To investigate the immune-modulating activity of ginseng oligopeptides (GOP), 420 healthy female BALB/c mice were intragastrically administered distilled water (control), whey protein (0.15 g per kg body weight (BW)), and GOP 0.0375, 0.075, 0.15, 0.3 and 0.6 g per kg BW for 30 days. Blood samples from mice were collected from the ophthalmic venous plexus and then sacrificed by cervical dislocation...
September 6, 2017: Food & Function
https://www.readbyqxmd.com/read/28874596/a-double-blind-randomized-placebo-controlled-trial-of-panax-ginseng-for-cancer-related-fatigue-in-patients-with-advanced-cancer
#12
Sriram Yennurajalingam, Nizar M Tannir, Janet L Williams, Zhanni Lu, Kenneth R Hess, Susan Frisbee-Hume, Helen L House, Zita Dubauskas Lim, Kyu-Hyoung Lim, Gabriel Lopez, Akhila Reddy, Ahsan Azhar, Angelique Wong, Sunil M Patel, Deborah A Kuban, Ahmed Omar Kaseb, Lorenzo Cohen, Eduardo Bruera
Background: Despite the high frequency, severity, and effects of cancer-related fatigue (CRF) on the quality of life (QoL) of patients with cancer, limited treatment options are available. The primary objective of this study was to compare the effects of oral Panax ginseng extract (PG) and placebo on CRF. Secondary objectives were to determine the effects of PG on QoL, mood, and function. Methods: In this randomized, double-blind, placebo-controlled study, patients with CRF ≥4/10 on the Edmonton Symptom Assessment System (ESAS) were eligible...
September 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28873717/herbal-products-containing-hibiscus-sabdariffa-l-crataegus-spp-and-panax-spp-labeling-and-safety-concerns
#13
Maria Antónia Nunes, Francisca Rodrigues, Rita C Alves, Maria Beatriz P P Oliveira
Herbs have been used from ancient times for infusion preparation based on their potential health effects. In particular, the consumption of Hibiscus sabdariffa L., Crataegus spp. and Panax spp. has been largely associated to cardiovascular benefits. In this work, the label information of 52 herbal products for infusion preparation containing the referred herbs was analyzed and discussed, taking into consideration the European Union regulation for herbal products, which intends to protect public health and harmonize the legal framework in Member States...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28866703/clinical-judgement-perplexed-by-initially-undisclosed-use-of-herbal-medicine-and-unexpected-cross-reactivity-of-immunoassay
#14
K T Liu, C W Lee
We report a case of symptomatic bradycardia caused by consumption of a Chinese herbal medicine which was initially undisclosed to the attending emergency physician. The scientific name of the herb is Panax japonicus. Electrocardiogram revealed sinus bradycardia. Laboratory tests were normal except for the detection of a high serum digoxin level. Further interrogation of the patient eventually disclosed ingestion of the herb which, however, did not contain any digoxin. Other active ingredients in the herb include various types of ginsenoside...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28861641/medicinal-plant-extracts-modulate-respiratory-burst-and-proliferation-activity-of-rainbow-trout-oncorhynchus-mykiss-leukocytes
#15
Chiara Bulfon, Marco Galeotti, Donatella Volpatti
The present study was designed to investigate the immunomodulatory effects of Aloe vera, Curcuma longa, Echinacea purpurea, Lavandula officinalis, Origanum vulgare, Panax ginseng, and Rheum officinale extracts on leukocytes purified from rainbow trout (Oncorhynchus mykiss) head kidney. The cells were cultured in a medium containing increasing doses of extracts; afterwards, they were tested for reactive oxygen species production after stimulation with phorbol myristate acetate (PMA) and proliferation in the presence or absence of phytohemagglutinin from Phaseolus vulgaris (PHA-P)...
September 1, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28860064/revalorization-of-selected-municipal-solid-wastes-as-new-precursors-of-green-nanocellulose-via-a-novel-one-pot-isolation-system-a-source-perspective
#16
You Wei Chen, Hwei Voon Lee
In the present work, four types of newly chosen municipal solid wastes (Panax ginseng, spent tea residue, waste cotton cloth, and old corrugated cardboard) were studied as the promising sources for nanocellulose, which has efficiently re-engineered the structure of waste products into highly valuable nanocellulose materials. The nanocellulose was produced directly via a facile one-pot oxidative hydrolysis process by using H2O2/Cr(NO3)3 solution as the bleaching agent and hydrolysis medium under acidic condition...
August 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28855721/composition-diversity-and-bioactivity-of-culturable-bacterial-endophytes-in-mountain-cultivated-ginseng-in-korea
#17
Emran Khan Chowdhury, Junhyun Jeon, Soon Ok Rim, Young-Hwan Park, Seung Kyu Lee, Hanhong Bae
Plants harbor diverse communities of bacterial species in their internal compartments. Here we isolated and identified bacterial endophytes from mountain-cultivated ginseng (MCG, Panax ginseng Meyer) to make working collection of endophytes and exploit their potentially beneficial properties toward plants and human being. A total of 1,886 bacteria were isolated from root, stem and leaf of MCGs grown in 24 different sites across the nation, using culture-dependent approach. Sequencing of 16S rDNA allowed us to classify them into 252 distinct groups...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846648/sensitive-and-selective-detection-of-oxo-form-organophosphorus-pesticides-based-on-cdse-zns-quantum-dots
#18
Jinchao Wei, Jiliang Cao, Hao Hu, Qing Yang, Fengqing Yang, Jianbo Wan, Huanxing Su, Chengwei He, Peng Li, Yitao Wang
A rapid, sensitive and enzyme-based optical biosensor was applied for the determination of seven organophosphorus pesticides (OPPs), including the oxo forms (malaoxon, paraoxon, dibrom, and dichlorvos), the thio forms (malathion and parathion) and the mixed form (demeton) in Panax ginseng. The principal of the proposed method is that the fluorescence quenching effect of quantum dots (QDs) can be observed by enzyme-generated H₂O₂. The active centers of acetylcholinesterase (AChE) could be inhibited in the presence of pesticides, which caused decrease of the generated H₂O₂...
August 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28844680/korean-red-ginseng-panax-ginseng-inhibits-obesity-and-improves-lipid-metabolism-in-high-fat-diet-fed-castrated-mice
#19
Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (Panax ginseng C.A. Meyer, Araliaceae) has been historically used as a traditional drug for the prevention and treatment of most ageing-related diseases, such as obesity, dyslipidemia, diabetes, and cardiovascular disease. Elderly men with testosterone deficiency are strongly associated with many of the aforementioned metabolic diseases. The aim of this study was to determine the effects of ginseng on obesity and lipid metabolism in a mouse model of testosterone deficiency (castrated C57BL/6J mice)...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28842680/small-rna-profiles-from-panax-notoginseng-roots-differing-in-sizes-reveal-correlation-between-mir156-abundances-and-root-biomass-levels
#20
Yun Zheng, Kun Chen, Zhenning Xu, Peiran Liao, Xiaotuo Zhang, Li Liu, Kangning Wei, Diqiu Liu, Yong-Fang Li, Ramanjulu Sunkar, Xiuming Cui
Plant genomes encode several classes of small regulatory RNAs (sRNAs) that play critical roles in both development and stress responses. Panax notoginseng (Burk.) F.H. Chen (P. notoginseng) is an important traditional Chinese herbal medicinal plant species for its haemostatic effects. Therefore, the root yield of P. notoginseng is a major economically important trait since the roots of P. notoginseng are the parts used to produce medicine. To identify sRNAs that are critical for the root biomass of P. notoginseng, we performed a comprehensive study of miRNA transcriptomes from P...
August 25, 2017: Scientific Reports
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