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https://www.readbyqxmd.com/read/29344413/therapeutic-potential-and-cellular-mechanisms-of-panax-notoginseng-on-prevention-of-aging-and-cell-senescence-associated-diseases
#1
REVIEW
Haiping Zhao, Ziping Han, Guangwen Li, Sijia Zhang, Yumin Luo
Owing to a dramatic increase in average life expectancy, most countries in the world are rapidly entering an aging society. Therefore, extending health span with pharmacological agents targeting aging-related pathological changes, are now in the spotlight of gerosciences. Panax notoginseng (Burk.) F. H. Chen, a species of the genus Panax, has been called the "Miracle Root for the Preservation of Life," and has long been used as a Chinese herb with magical medicinal value. Panax notoginseng has been extensively employed in China to treat microcirculatory disturbances, inflammation, trauma, internal and external bleeding due to injury, and as a tonic...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29338263/promiscuous-glycosyltransferase-from-bacillus-subtilis-168-for-the-enzymatic-synthesis-of-novel-protopanaxatriol-type-ginsenosides
#2
Longhai Dai, Jiao Li, Jiangang Yang, Yueming Zhu, Yan Men, Yan Zeng, Yi Cai, Caixia Dong, Zhubo Dai, Xueli Zhang, Yuanxia Sun
Ginsenosides are the principally bioactive ingredients of Panax ginseng and possess diverse notable pharmacological activities. UDP-glycosyltransferase (UGT)-mediated glycosylation of C6-OH and/or C20-OH of protopanaxatriol (PPT) is the prominent biological modification that contributes to the immense structural and functional diversity of PPT-type ginsenosides. In this study, glycosylation of PPT and PPT-type ginsenosides was achieved using a promiscuous glycosyltransferase (Bs-YjiC) from Bacillus subtilis 168...
January 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29329646/effects-of-gardenia-jasminoides-extracts-on-cognition-and-innate-immune-response-in-an-adult-drosophila-model-of-alzheimer-s-disease
#3
Wei-Wei Ma, Ye Tao, Yan-Ying Wang, I-Feng Peng
Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329092/effect-of-aspirin-on-the-pharmacokinetics-and-absorption-of-panax-notoginseng-saponins
#4
Zhihao Tian, Huanhuan Pang, Qiang Zhang, Shouying Du, Yang Lu, Lin Zhang, Jie Bai, Pengyue Li, Danqi Li, Mengdi Zhao, Xiaonan Chen
BACKGROUND: Panax notoginseng saponins, a traditional Chinese medicine extraction, and aspirin are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved, when Panax notoginseng saponins was taken together with aspirin. METHODS: To investigate the interaction of the two drugs in vivo, the concentration of notoginsenoside R1, ginsenoside Rg1, Rb1, Re and Rd. in blood were simultaneously measured by UPLC/MS/MS...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29321807/different-modulation-of-panax-notoginseng-on-the-absorption-profiling-of-triptolide-and-tripterine-from-tripterygium-wilfordii-in-rat-intestine
#5
Yiqun Li, Huiting Cao, Mengzhu Liu, Benyong Zhang, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu, Qichun Zhang
Background: Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney. Methods: The absorption of triptolide, triptonide, wilforlide and tripterine from monomer, TW, TW-PN, TW-Caulis Sinomenii (TW-CS) and Qing-Luo Tong-Bi were analyzed in duodenum, jejunum, ileum and colon of rat via single-pass intestinal perfusion model...
2018: Chinese Medicine
https://www.readbyqxmd.com/read/29318835/-study-on-extraction-method-of-panax-notoginseng-plots-in-wenshan-of-yunnan-province-based-on-decision-tree-model
#6
Ting-Ting Shi, Xiao-Bo Zhang, Lan-Ping Guo, Lu-Qi Huang
The herbs used as the material for traditional Chinese medicine are always planted in the mountainous area where the natural environment is suitable. As the mountain terrain is complex and the distribution of planting plots is scattered, the traditional survey method is difficult to obtain accurate planting area. It is of great significance to provide decision support for the conservation and utilization of traditional Chinese medicine resources by studying the method of extraction of Chinese herbal medicine planting area based on remote sensing and realizing the dynamic monitoring and reserve estimation of Chinese herbal medicines...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29317237/antitumor-immunostimulatory-activity-of-polysaccharides-from-panax-japonicus-c-a-mey-roles-of-their-effects-on-cd4-t-cells-and-tumor-associated-macrophages
#7
Guangwen Shu, Shanqing Jiang, Jun Mu, Huifan Yu, Huan Duan, Xukun Deng
In this study, chemical properties of polysaccharides from rhizomes of Panax japonicus C. A. Mey (PSPJ) were investigated and the antitumor immunostimulatory activity of PSPJ was assessed in mice bearing H22 hepatoma cells. Chemical properties of PSPJ were determined by GC, FT-IR, 1H NMR and 13C NMR analysis. Furthermore, we showed that PSPJ repressed H22 tumor growth in vivo with undetectable toxic effects on tumor-bearing mice. PSPJ upregulated host thymus/spleen indexes and ConA/LPS-induced splenocyte proliferation...
January 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29317167/sirt1-activator-isolated-from-artificial-gastric-juice-incubate-of-total-saponins-in-stems-and-leaves-of-panax-ginseng
#8
Xiu-Wei Yang, Li-Yuan Ma, Qi-Le Zhou, Wei Xu, You-Bo Zhang
Panax ginseng as a traditional Chinese medicine has been extensively used for the treatment of many diseases, especially in prolonging life and anti-tumor. Dammarane-type triterpenoids from P. ginseng have diverse beneficial effects and their chemical structures can be modified in the gastrointestinal tract after oral administration. In this paper, the dammarane-type triterpenoids were isolated from artificial gastric juice incubate of total saponins in the stems and leaves of P. ginseng through column chromatographic methods and their chemical structures were determined based on spectral data...
December 30, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29312623/notoginsenoside-r7-suppresses-cervical-cancer-via-pi3k-pten-akt-mtor-signaling
#9
Li Li, Jin-Xia Sun, Xiao-Qi Wang, Xiao-Kai Liu, Xian-Xiong Chen, Bo Zhang, Zhen-Dan He, Dong-Zhou Liu, Li-Xin Chen, Li-Wei Wang, Zhong Huang
Notoginsenoside R7 was isolated from Panax notoginseng, a plant used commonly in traditional Chinese medicine. We investigated the anti-cancer effects of R7 in HeLa cells in vitro and in vivo, and explored the underlying mechanisms of action. R7 dose-dependently inhibited HeLa cell proliferation and induced apoptosis in vitro, In silico docking-based screening assays showed that R7 can directly bind Akt. Pretreatment with the Akt inhibitor LY294002 synergistically enhanced the R7 anti-proliferation and anti-apoptosis effects in HeLa cells, confirming that R7 acts through the PI3K/Akt pathway...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302971/metabonomics-approach-to-comparing-the-anti-stress-effects-of-four-panax-ginseng-components-in-rats
#10
Jingcheng Wang, Yuanlong Hou, Zhiying Jia, Xie Xie, Jiajian Liu, Yani Kang, Xin Wang, Xiaoyan Wang, Wei Jia
Different components of P. ginseng have different properties and medicinal effects. Metabonomics was a perspective approach to analyze global endogenous metabolites response to physiological and pathological processe. In this study, untargeted -metabonomics method using GC/TOFMS combined with multivariate statistical techniques was applied to compare entire metabolite differences and the anti-stress variations among four components of P. ginseng, total ginsenosides (TG), panaxadiol (PD), panaxatriol (PT) and ginseng polysaccharide (PS), in Sprague Dawley rats...
January 5, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29298645/the-inhibitory-effect-of-panax-ginseng-extract-on-amyloid-like-fibril-formation-of-trypsin-in-aqueous-ethanol
#11
Phanindra Babu Kasi, Marta Kotorman, Attila Borics, Beata Gabriella Hervay, Kinga Molnar, Lajos Laszlo
People have used ginseng as a traditional herbal medicine for over 2000 years, mainly for its protective effect against neurological disorders. In vitro studies were performed to study the formation of amyloid-like fibrils by the well-known protease trypsin as a model protein in 60% ethanol at pH 7.0. Possible inhibitory effects of ginseng extracts on the formation of amyloid-like fibrils was examined. The aggregation of trypsin was followed via turbidity measurements, aggregation kinetics, the Congo red (CR) binding assay, electronic circular dichroism (ECD) spectroscopy, size exclusion chromatography, and transmission electron microscopy (TEM) in the presence or absence of Panax ginseng extracts, as well as other, previously studied inhibitors of natural origin...
December 29, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29280337/analysis-of-bioactive-components-and-multi-component-pharmacokinetics-of-saponins-from-leaves-of-panax-notoginseng-in-rat-plasma-after-oral-administration-by-lc-ms-ms
#12
Zhengcai Ju, Jia Li, Han Han, Li Yang, Zhengtao Wang
In this study, simple ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass tandem mass spectrometry was used to characterize the absorbed components in rat plasma after the oral administration of saponins from leaves of Panax notoginseng. Seventeen prototype compounds were structurally characterized. Furthermore, a simple and sensitive liquid chromatography with tandem mass spectrometry method was also used for the simultaneous determination of notoginsenoside Fc, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rb3, ginsenoside Rd and notoginsenoside Fe in rat plasma within 5 min...
December 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29277608/triptolide-induced-hepatotoxicity-can-be-alleviated-when-combined-with-panax-notoginseng-saponins-and-catapol
#13
Lingling Zhou, Cong Zhou, Zhe Feng, Zhangpu Liu, Huaxu Zhu, Xueping Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: The hepatotoxicity of Tripterygium wilfordii Hook. f. (TW), due to the presence of triptolide (TP), limits its therapeutic potential. Based on the traditional Chinese medicine theory, the theory of "Yi lei xiang zhi" was proposed that Chinese herbs with different efficacy can restrict each other to achieve the least adverse reactions. AIM OF THE STUDY: To observe the effects of Catapol (CAT) and Panax notoginseng saponins (PNS), active ingredients in Rehmannia glutinosa (RG) and Panax notoginseng (PN) respectively, on reducing TP-induced hepatotoxicity, and further to explore the mechanisms...
December 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29276207/effects-of-antrodia-camphorata-and-panax-ginseng-supplementation-on-anti-fatigue-properties-in-mice
#14
Chien-Yu Hsiao, Yi-Ju Hsu, Yu-Tang Tung, Mon-Chien Lee, Chi-Chang Huang, City C Hsieh
Antrodia camphorata and Panax ginseng are well-known medicinal plants in Taiwan folk and traditional Chinese medicine, which have been reported for multifunctional bioactivities. However, there is limited evidence that a fixed combination formula of these two plant extracts is effective for the exercise improvement or anti-fatigue. We aimed to evaluate the potential beneficial effects of the mix formulation of these two herbal medicines (AG formulation) on fatigue and ergogenic functions following physiological challenge...
December 25, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29245089/metabolic-analysis-of-panax-notoginseng-saponins-with-gut-microbiota-mediated-biotransformation-by-hplc-dad-q-tof-ms-ms
#15
Man-Yun Chen, Li Shao, Wei Zhang, Chong-Zhi Wang, Hong-Hao Zhou, Wei-Hua Huang, Chun-Su Yuan
Saponins such as notoginsenosides and ginsenosides from Panax notoginseng are responsible for the herb's clinical applications. Unfortunately, there is poor oral bioavailability of saponins. However, gut microbiota can transform saponins to yield the metabolites that are potential bioactive substances. In this study, we aimed to characterize the metabolic profiles of P. notoginseng saponins (PNS) by incubating them with human gut microbiota. The notoginsenosides, ginsenosides and related metabolites were separated and identified using a highly sensitive and selective high-performance liquid chromatography coupled with diode array detection/quadrupole tandem time-of-flight mass spectrometry (HPLC-DAD-Q-TOF-MS/MS)...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29243439/-identification-of-saponins-from-panax-notoginseng-in-metabolites-of-rats
#16
Wen-Wen Shen, Yin Zhang, Shou-Bei Qiu, Fen-Xia Zhu, Xiao-Bin Jia, Dao-Quan Tang, Bin Chen
UPLC-QTOF-MS/MS was used to identify metabolites in rat blood, urine and feces after the administration of n-butanol extract derived from steamed notoginseng. The metabolic process of saponins came from steamed notoginseng was analyzed. The metabolites were processed by PeakView software, and identified according to the structural characteristics of prototype compounds and the accurate qualitative and quantitative changes of common metabolic pathways. Four saponins metabolites were identified based on MS/MS information of metabolites, namely ginsenoside Rh₄, Rk₃, Rk₁, Rg₅,and their 15 metabolites were verified...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29239335/saponins-from-panax-japonicus-attenuate-age-related-neuroinflammation-via-regulation-of-the-mitogen-activated-protein-kinase-and-nuclear-factor-kappa-b-signaling-pathways
#17
Li-Li Deng, Ding Yuan, Zhi-Yong Zhou, Jing-Zhi Wan, Chang-Cheng Zhang, Chao-Qi Liu, Yao-Yan Dun, Hai-Xia Zhao, Bo Zhao, Yuan-Jian Yang, Ting Wang
Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29237268/sesquiterpenoids-from-the-root-of-panax-ginseng-attenuates-lipopolysaccharide-induced-depressive-like-behavior-through-the-bdnf-trkb-and-sirt-1-nf-%C3%AE%C2%BAb-signaling-pathways
#18
Weidong Wang, Xiaofeng Liu, Jinping Liu, Enbo Cai, Yan Zhao, Haijun Li, Lianxue Zhang, Pingya Li, Yugang Gao
The previous study indicated sesquiterpenoids from the root of Panax ginseng (SPG) exhibited significant antidepressant-like effect, which might be mediated by the modification of the dopaminergic, GABAergic and glutamatergic systems. This study was to investigate SPG's antidepressant effects and mechanisms on lipopolysaccharide (LPS)-induced depression-like behavior. In the tail suspension test (TST) and forced swimming test (FST), SPG (0.25 and 1 mg/kg, i.g.) and fluoxetine (20 mg/kg, i.p.) effectively reduced the immobility time...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29235296/-effect-of-astragaloside-%C3%A2-combined-with-panax-notoginseng-saponins-on-cerebral-ischemia-reperfusion-injury-and-study-of-pharmacokinetics-in-rats
#19
Jing-Xian Li, Xiao-Qian Yang, Biao Tang, Xiao-Dan Liu, Ying-Hong Tang, Chang-Qing Deng, Xiao-Ping Huang
The aim is to study the effect of astragaloside Ⅳ (AST Ⅳ) combined with Panax notoginseng saponins (PNS) on cerebral ischemia-reperfusion injury, and to probe the synergistic mechanism through the pharmacokinetics of the four major components such as AST Ⅳ, ginsenoside Rg₁ (Rg₁), ginsenoside Rb₁ (Rb₁), notoginsenoside R₁ (R₁) in cerebral ischemia-reperfusion rats. Following the establishment of cerebral ischemia/reperfusion model in rats by modified suture method, neurological function score, cerebral infarction area and pathomorphology were used to evaluate the pharmacological effect that the combination of AST Ⅳ and PNS antagonized cerebral ischemia-reperfusion injury; the contents of AST Ⅳ, Rg₁, Rb₁, R₁ in rat plasma of different time points were determined with ultra performance liquid chromatography tandem massspectrometry (UPLC-MS/MS), pharmacokinetic parameters were calculated and pharmacokinetics changes of the main effective components were analyzed...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29232922/study-on-the-correlation-between-gene-expression-and-enzyme-activity-of-seven-key-enzymes-and-ginsenoside-content-in-ginseng-in-over-time-in-ji-an-china
#20
Juxin Yin, Daihui Zhang, Jianjian Zhuang, Yi Huang, Ying Mu, Shaowu Lv
Panax ginseng is a traditional medicine. Fresh ginseng is one of the most important industries related to ginseng development, and fresh ginseng of varying ages has different medicinal properties. Previous research has not systematically reported the correlation between changes in key enzyme activity with changes in ginsenoside content in fresh ginseng over time. In this study, for the first time, we use ginseng samples of varying ages in Ji'an and systematically reported the changes in the activity of seven key enzymes (HMGR, FPS, SS, SE, DS, CYP450, and GT)...
December 11, 2017: International Journal of Molecular Sciences
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