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https://www.readbyqxmd.com/read/28315720/the-protective-effect-of-the-active-components-of-erpc-on-diabetic-peripheral-neuropathy-in-rats
#1
Gai-Mei Hao, Yong-Gang Liu, Yan Wu, Wei Xing, Shu-Zhen Guo, Yong Wang, Zheng-Lin Wang, Chun Li, Tian-Tian Lv, Hong-Liang Wang, Tian-Jiao Shi, Wei Wang, Jing Han
ETHNOPHARMACOLOGICAL RELEVANCE: Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY: The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis (cERPC) on diabetic peripheral neuropathy in the rats and explore the underlying mechanism involved...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28314177/gintonin-attenuates-depressive-like-behaviors-associated-with-alcohol-withdrawal-in-mice
#2
Hyeon-Joong Kim, Sang-Deuk Park, Ra Mi Lee, Byung-Hwan Lee, Sun-Hye Choi, Sung-Hee Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Seung-Yeol Nah
BACKGROUND: Panax ginseng Meyer extracts have been used to improve mood and alleviate symptoms of depression. However, little is known about the extracts' active ingredients and the molecular mechanisms underlying their reported anti-depressive effects. METHODS: Gintonin is an exogenous lysophosphatidic acid (LPA) receptor ligand isolated from P. ginseng. BON cells, an enterochromaffin cell line, and C57BL/6 mice were used to investigate whether gintonin stimulates serotonin release...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28301605/ocf-can-repress-tumor-metastasis-by-inhibiting-epithelial-mesenchymal-transition-involved-in-pten-pi3k-akt-pathway-in-lung-cancer-cells
#3
Ye Yang, Shuang Qiu, Lei Qian, Yuan Tian, Yingna Chen, Lei Bi, Weiping Chen
A component formula with definite compositions provides a new approach to treat various diseases. Salvia miltiorrhiza and Panax ginseng are widely used in China because of their antitumor properties. In the previous study, the optimizing component formula (OCF), prepared with salvianolic acids, ginsenosides, and ginseng polysaccharides (5, 10, and 5 mg·L-1, respectively) extracted from S. miltiorrhiza and P. ginseng on the basis of IC50 in lung cancer A549 cells and damage minimization on human bronchial epithelial cells in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28299913/endophytic-fungi-harbored-in-the-root-of-sophora-tonkinensis-gapnep-diversity-and-biocontrol-potential-against-phytopathogens
#4
Yu Qun Yao, Fang Lan, Yun Ming Qiao, Ji Guang Wei, Rong Shao Huang, Liang Bo Li
This work, for the first time, investigated the diversity of endophytic fungi harbored in the xylem and phloem of the root of Sophora tonkinensis Gapnep from three geographic localities with emphasis on the influence of the tissue type and geographic locality on endophytic fungal communities and their potential as biocontrol agents against phytopathogens of Panax notoginseng. A total of 655 fungal strains representing 47 taxa were isolated. Forty-two taxa (89.4%) were identified but not five taxa (10.6%) according to morphology and molecular phylogenetics...
March 15, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28296594/vasodilatory-effects-of-combined-traditional-chinese-medicinal-herbs-in-optimized-ratio
#5
Yean Chun Loh, Chu Shan Tan, Yung Sing Ch'ng, Mariam Ahmad, Mohd Zaini Asmawi, Mun Fei Yam
Recently, a new syndromic disease combination theory of traditional Chinese medicine (TCM) for hypertensive treatment has been introduced. In the wake of this new concept, a new science-based TCM formula that counteracts various syndromes is needed. The objective of this study was to develop such a formula. Five of the most clinically prescribed TCM herbs that work on different syndromes, namely Gastrodia elata, Uncaria rhynchophylla, Pueraria thomsonii, Panax notoginseng, and Alisma orientale, were selected for this study...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28287442/a-strategy-for-simultaneous-isolation-of-less-polar-ginsenosides-including-a-pair-of-new-20-methoxyl-isomers-from-flower-buds-of-panax-ginseng
#6
Sha-Sha Li, Ke-Ke Li, Fei Xu, Li Tao, Li Yang, Shu-Xiao Chen, Xiao-Jie Gong
The present study was designed to simultaneously isolate the less polar ginsenosides from the flower buds of Panax ginseng (FBPG). Five ginsenosides, including a pair of new 20-methoxyl isomers, were extracted from FBPG and purified through a five-step integrated strategy, by combining ultrasonic extraction, Diaion Hp-20 macroporous resin column enrichment, solid phase extraction (SPE), reversed-phase high-performance liquid chromatography (RP-HPLC) analysis and preparation, and nuclear magnetic resonance (NMR) analysis...
March 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28285072/purity-assessment-of-ginsenoside-rg1-using-quantitative-1-h-nuclear-magnetic-resonance
#7
Bao-Ming Huang, Sheng-Yuan Xiao, Ting-Bo Chen, Ying Xie, Pei Luo, Liang Liu, Hua Zhou
Ginseng herbs comprise a group of the most popular herbs, including Panax ginseng, P. notoginseng and P. quinquefolius (Family Araliaceae), which are used as traditional Chinese medicine (TCM) and are some of the best-selling natural products in the world. The accurate quantification of ginsenoside Rg1 is one of the major aspects of its quality control. However, the purity of the commercial Rg1 chemical reference substance (CRS) is often measured with high-performance chromatography coupled with an ultraviolet detector (HPLC-UV), which is a selective detector with unequal responses to different compounds; thus, this detector introduces probable error to purity assessments...
March 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28284427/pharmacokinetics-and-correlation-between-in-vitro-release-and-in-vivo-absorption-of-bio-adhesive-pellets-of-panax-notoginseng-saponins
#8
Ying Li, Yun Zhang, Chun-Yan Zhu
The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins (PNS) with hydroxy propyl methyl cellulose (HPMC), chitosan, and chitosan : carbomer, explore the influence of different bio-adhesive materials on pharmacokinetics behaviors of PNSbio-adhesive pellets, and evaluate the correlation between in vivo absorption and in vitro release (IVIVC). In order to predict the in vivo concentration-time profile by the in vitro release data of bio-adhesive pellets, the release experiment was performed using the rotating basket method in pH 6...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28282601/isolation-and-characterization-of-bioactive-polyacetylenes-panax-ginseng-meyer-roots
#9
Chia-Rou Yeo, Jin-Jie Yong, David G Popovich
Panax ginseng has been studied for its chemo-preventive properties and pharmaceutical potential. Polyacetylenic compounds isolated from Panax ginseng root typically comprised of non-polar C17 compound have been reported to exhibit bioactive properties. The objective of this project is to extract, isolate, and characterize bioactive polyacetylenes from Panax ginseng root using various extraction and separation methods Ginseng was extracted by reflux using methanol, ethanol, hexane, ethyl acetate, methanolic ultrasonication...
March 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28278662/antimicrobial-activity-of-saponins-produced-by-two-novel-endophytic-fungi-from-panax-notoginseng
#10
Zhaoxia Jin, Lin Gao, Lin Zhang, Tianyi Liu, Fang Yu, Zongshen Zhang, Qiong Guo, Biying Wang
Endophytes in plants may be co-producer of the bioactive compounds of their hosts. We conducted a study to bioprospect for saponin-producing endophytic fungi from Panax notoginseng and evaluate the antimicrobial activity of saponins. Two novel fungal endophytes, Fusarium sp. PN8 and Aspergillus sp. PN17, were isolated from traditional Chinese medicinal herb P. notoginseng. After eight days of fermentation, the total saponins produced in the culture broth of PN8 and PN17 were 1.061 and 0.583 mg mL(-1), respectively...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#11
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28260881/ginseng-berry-mediated-gold-and-silver-nanoparticle-synthesis-and-evaluation-of-their-in-vitro-antioxidant-antimicrobial-and-cytotoxicity-effects-on-human-dermal-fibroblast-and-murine-melanoma-skin-cell-lines
#12
Zuly Elizabeth Jiménez Pérez, Ramya Mathiyalagan, Josua Markus, Yeon-Ju Kim, Hyun Mi Kang, Ragavendran Abbai, Kwang Hoon Seo, Dandan Wang, Veronika Soshnikova, Deok Chun Yang
There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. Panax ginseng Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically active compounds in ginseng berry extract (GBE) and the ability of ginseng berry (GB) as novel material for the biosynthesis of gold nanoparticles (GBAuNPs) and silver nanoparticles (GBAgNPs) was conducted...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28260016/effects-of-r-type-and-s-type-ginsenoside-rg3-on-dna-methylation-in-human-hepatocarcinoma-cells
#13
Siying Teng, Yi Wang, Pingya Li, Jinhua Liu, Anhui Wei, Haotian Wang, Xiangkun Meng, Di Pan, Xinmin Zhang
Ginsenoside Rg3, a bioactive constituent isolated from Panax ginseng, exhibits antitumorigenic, antioxidative, antiangiogenic, neuroprotective and other biological activities are associated with the regulation of multiple genes. DNA methylation patterns, particularly those in the promoter region, affect gene expression, and DNA methylation is catalyzed by DNA methylases. However, whether ginsenoside Rg3 affects DNA methylation is unknown. High performance liquid chromatography assay, MspI/HpaII polymerase chain reaction (PCR) and reverse transcription‑quantitative PCR were performed to assess DNA methylation...
February 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28257788/antidepressant-like-effects-of-ginsenoside-rg5-in-mice-involving-of-hippocampus-bdnf-signaling-pathway
#14
Dawei Xu, Chengniu Wang, Wei Zhao, Shengfeng Gao, Zhiming Cui
Ginsenoside Rg5 is one of the major bioactive ingredients of Panax ginseng with little toxicity and has been shown to have pharmacological effects on the central nervous system. In this study, we investigated the antidepressant effects of Rg5 in mice models of depression. The effects of Rg5 were first assessed in the forced swimming test (FST) and tail suspension test (TST), and then investigated in the chronic social defeat stress (CSDS) model of depression. The changes in hippocampal brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and Rg5 treatment were also examined...
March 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28256039/biotransformation-of-ginsenoside-rb1-to-ginsenoside-rg3-by-endophytic-bacterium-burkholderia-sp-ge-17-7-isolated-from-panax-ginseng
#15
Yu Fu, Zhenhao Yin, Chengri Yin
AIMS: To isolate a novel endophytic bacteriums from Panax ginseng that could have excellent properties on converting ginsenoside Rb1 to ginsenoside Rg3. METHODS AND RESULTS: Based on 16S rDNA gene sequence, the strain named GE 17-7 was identified as Burkholderia sp. This strain have showed the highest activity in convertion ginsenosides Rb1 into 20(S)-ginsenoside Rg3. During the biotransformation of ginsenoside Rb1, the final metabolite was identified by Nuclear Magnetic Resonance (NMR) analysis and the transformation pathway of ginsenoside Rb1 was also identified by Thin-layer chromatography (TLC) and high performance liquid chromatography (HPLC) analysis in this study...
March 3, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28250796/neuroprotective-properties-of-panax-notoginseng-saponins-via-preventing-oxidative-stress-injury-in-samp8-mice
#16
Jin-Lan Huang, Xin Jing, Xin Tian, Mei-Chun Qin, Zhe-Hao Xu, Deng-Pan Wu, Zhen-Guo Zhong
Inhibiting oxidative damage in early stage of Alzheimer's disease (AD) is considered as a strategy for AD treatment. Our previous study has shown that Panax notoginseng saponins (PNS) have an antiaging action by increasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of aged rats. In this study, we aimed to investigate the effects of PNS on antioxidant enzymes and uncoupling proteins (UCPs) involved in oxidative stress in AD mice. The results showed that PNS prevented neuronal loss in hippocampal CA1 region and alleviated pathomorphological change of neurons in CA1 region...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28244162/exploring-the-effect-of-ginsenoside-rh1-in-a-sleep-deprivation-induced-mouse-memory-impairment-model
#17
Cong Lu, Zhe Shi, Liming Dong, Jingwei Lv, Pan Xu, Yinghui Li, Lina Qu, Xinmin Liu
Panax ginseng C.A. Meyer (Araliaceae) has been used in traditional Chinese medicine for enhancing cognition for thousands of years. Ginsenoside Rh1, a constituent of ginseng root, as with other constituents, has memory-improving effects in normal mice and scopolamine-induced amnesic mice. Sleep deprivation (SD) is associated with memory impairment through induction of oxidative stress. The present study investigated the effect of Rh1 against SD-induced cognitive impairment and attempted to define the possible mechanisms involved...
February 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28243734/heterologous-production-of-a-ginsenoside-saponin-compound-k-and-its-precursors-in-transgenic-tobacco-impairs-the-vegetative-and-reproductive-growth
#18
Yu Shin Gwak, Jung Yeon Han, Prakash Babu Adhikari, Chang Ho Ahn, Yong Eui Choi
Production of compound K (a ginsenoside saponin) and its precursors in transgenic tobacco resulted in stunted growth and seed set failure, which may be caused by strong autotoxicity of heterologously produced phytochemicals against the tobacco itself. Panax ginseng roots contain various saponins (ginsenosides), which are major bioactive compounds. A monoglucosylated saponin, compound K (20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol), has high medicinal and cosmetic values but is present in undetectable amounts in naturally grown ginseng roots...
February 27, 2017: Planta
https://www.readbyqxmd.com/read/28238184/biodegradation-of-pentachloronitrobenzene-by-cupriavidus-sp-yns-85-and-its-potential-for-remediation-of-contaminated-soils
#19
Ying Teng, Xiaomi Wang, Ye Zhu, Wei Chen, Peter Christie, Zhengao Li, Yongming Luo
Pentachloronitrobenzene (PCNB) is a toxic chlorinated nitroaromatic compound. However, only a few bacteria have been reported to be able to utilize PCNB. In the present study, one pentachloronitrobenzene (PCNB)-degrading bacterium, Cupriavidus sp. YNS-85, was isolated from a contaminated Panax notoginseng plantation. The strain co-metabolized 200 mg L(-1) PCNB in aqueous solution with a removal rate of 73.8% after 5 days. The bacterium also degraded PCNB effectively under acid conditions (pH 4-6) and showed resistance to toxic trace elements (arsenic, copper, and cadmium)...
February 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28231544/ginsenoside-rg3-promotes-cytotoxicity-of-paclitaxel-through-inhibiting-nf-%C3%AE%C2%BAb-signaling-and-regulating-bax-bcl-2-expression-on-triple-negative-breast-cancer
#20
Zuguo Yuan, Hao Jiang, Xinhai Zhu, Xinge Liu, Jinhui Li
Taxane-based chemotherapy regimen is the most effective therapeutic strategy for triple-negative breast cancer (TNBC) which is an aggressive subtype of breast cancer with high rate of recurrence and distant metastasis. Ginsenoside Rg3 is isolated from Panax ginseng with anti-cancer activity against carcinomas. We aim to evaluate the chemosensitizing effects of Ginsenoside Rg3 on TNBC cells and xenograft and explore the underlying mechanism. Human triple-negative breast cancer lines MDA-MB-231, MDA-MB-453 and BT-549 were used...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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