keyword
MENU ▼
Read by QxMD icon Read
search

Cowpox

keyword
https://www.readbyqxmd.com/read/29320650/cowpox-virus-infection
#1
Ewa Talarek, Magdalena Marczynska
An 11-year-old girl presented to the hospital with a skin lesion on her left cheek that had been present for 3 weeks. She lived in a suburban area in Poland and had direct contact with cats that lived in her home and roamed freely; no bites or scratches were reported. Her parents reported that..
January 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29224735/a-novel-three-dimensional-cell-culture-method-enhances-antiviral-drug-screening-in-primary-human-cells
#2
Robert Koban, Markus Neumann, Aila Daugs, Oliver Bloch, Andreas Nitsche, Stefan Langhammer, Heinz Ellerbrok
Gefitinib is a specific inhibitor of the epidermal growth factor receptor (EGFR) and FDA approved for treatment of non-small cell lung cancer. In a previous study we could show the in vitro efficacy of gefitinib for treatment of poxvirus infections in monolayer (2D) cultivated cell lines. Permanent cell lines and 2D cultures, however, are known to be rather unphysiological; therefore it is difficult to predict whether determined effective concentrations or the drug efficacy per se are transferable to the in vivo situation...
December 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29215552/two-distinct-clinical-courses-of-human-cowpox-germany-2015
#3
Ines Eder, Patrick Vollmar, Martin Pfeffer, Philipp Naether, Arne Christian Rodloff, Hermann Meyer
Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case-an unvaccinated young veterinary assistant-a pustule was treated locally with cortisone. The lesion turned into a large ulcer accompanied by severe lymphadenitis. Based on her close contact to a sick stray cat, infection with cowpox virus was assumed and confirmed by virus isolation, PCR, and serology. The clinical course took up to eleven months until healing of the wound was complete...
December 7, 2017: Viruses
https://www.readbyqxmd.com/read/29156539/epidemiological-investigations-of-four-cowpox-virus-outbreaks-in-alpaca-herds-germany
#4
Almut Prkno, Donata Hoffmann, Daniela Goerigk, Matthias Kaiser, Anne Catherine Franscisca van Maanen, Kathrin Jeske, Maria Jenckel, Florian Pfaff, Thomas W Vahlenkamp, Martin Beer, Rainer G Ulrich, Alexander Starke, Martin Pfeffer
Four cowpox virus (CPXV) outbreaks occurred in unrelated alpaca herds in Eastern Germany during 2012-2017. All incidents were initially noticed due to severe, generalized, and finally lethal CPXV infections, which were confirmed by testing of tissue and serum samples. As CPXV-infection has been described in South American camelids (SACs) only three times, all four herds were investigated to gain a deeper understanding of CPXV epidemiology in alpacas. The different herds were investigated twice, and various samples (serum, swab samples, and crusts of suspicious pox lesions, feces) were taken to identify additionally infected animals...
November 18, 2017: Viruses
https://www.readbyqxmd.com/read/29137821/equination-inoculation-of-horsepox-an-early-alternative-to-vaccination-inoculation-of-cowpox-and-the-potential-role-of-horsepox-virus-in-the-origin-of-the-smallpox-vaccine
#5
REVIEW
José Esparza, Livia Schrick, Clarissa R Damaso, Andreas Nitsche
For almost 150 years after Edward Jenner had published the "Inquiry" in 1798, it was generally assumed that the cowpox virus was the vaccine against smallpox. It was not until 1939 when it was shown that vaccinia, the smallpox vaccine virus, was serologically related but different from the cowpox virus. In the absence of a known natural host, vaccinia has been considered to be a laboratory virus that may have originated from mutational or recombinational events involving cowpox virus, variola viruses or some unknown ancestral Orthopoxvirus...
November 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29125539/combined-proteomics-genomics-approach-reveals-proteomic-changes-of-mature-virions-as-a-novel-poxvirus-adaptation-mechanism
#6
Marica Grossegesse, Joerg Doellinger, Alona Tyshaieva, Lars Schaade, Andreas Nitsche
DNA viruses, like poxviruses, possess a highly stable genome, suggesting that adaptation of virus particles to specific cell types is not restricted to genomic changes. Cowpox viruses are zoonotic poxviruses with an extraordinarily broad host range, demonstrating their adaptive potential in vivo. To elucidate adaptation mechanisms of poxviruses, we isolated cowpox virus particles from a rat and passaged them five times in a human and a rat cell line. Subsequently, we analyzed the proteome and genome of the non-passaged virions and each passage...
November 10, 2017: Viruses
https://www.readbyqxmd.com/read/29121668/seasonal-recurrence-of-cowpox-virus-outbreaks-in-captive-cheetahs-acinonyx-jubatus
#7
Julia Stagegaard, Andreas Kurth, Daniel Stern, Piotr Wojciech Dabrowski, Ann Pocknell, Andreas Nitsche, Livia Schrick
Cowpox virus infections in captive cheetahs (Acinonyx jubatus) with high morbidity and mortality have already been reported in the UK and Russia in the 1970s. However, most of the reported cases have been singular events. Here, we report a total of five cowpox virus outbreaks in cheetahs in the same safari park in Denmark between 2010 and 2014. Nine cheetahs showed varying severity of clinical disease; two of them died (22%). All episodes occurred between August and October of the respective year. No other carnivores kept at the same institution nor the keepers taking care of the animals were clinically affected...
2017: PloS One
https://www.readbyqxmd.com/read/29058218/ontology-based-vaccine-adverse-event-representation-and-analysis
#8
Jiangan Xie, Yongqun He
Vaccine is the one of the greatest inventions of modern medicine that has contributed most to the relief of human misery and the exciting increase in life expectancy. In 1796, an English country physician, Edward Jenner, discovered that inoculating mankind with cowpox can protect them from smallpox (Riedel S, Edward Jenner and the history of smallpox and vaccination. Proceedings (Baylor University. Medical Center) 18(1):21, 2005). Based on the vaccination worldwide, we finally succeeded in the eradication of smallpox in 1977 (Henderson, Vaccine 29:D7-D9, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29027916/a-next-generation-sequencing-approach-uncovers-viral-transcripts-incorporated-in-poxvirus-virions
#9
Marica Grossegesse, Joerg Doellinger, Berit Haldemann, Lars Schaade, Andreas Nitsche
Transcripts are known to be incorporated in particles of DNA viruses belonging to the families of Herpesviridae and Mimiviridae, but the presence of transcripts in other DNA viruses, such as poxviruses, has not been analyzed yet. Therefore, we first established a next-generation-sequencing (NGS)-based protocol, enabling the unbiased identification of transcripts in virus particles. Subsequently, we applied our protocol to analyze RNA in an emerging zoonotic member of the Poxviridae family, namely Cowpox virus...
October 13, 2017: Viruses
https://www.readbyqxmd.com/read/28975882/fatal-outbreak-in-tonkean-macaques-caused-by-possibly-novel-orthopoxvirus-italy-january-2015-1
#10
Giusy Cardeti, Cesare Ernesto Maria Gruber, Claudia Eleni, Fabrizio Carletti, Concetta Castilletti, Giuseppe Manna, Francesca Rosone, Emanuela Giombini, Marina Selleri, Daniele Lapa, Vincenzo Puro, Antonino Di Caro, Raniero Lorenzetti, Maria Teresa Scicluna, Goffredo Grifoni, Annapaola Rizzoli, Valentina Tagliapietra, Lorenzo De Marco, Maria Rosaria Capobianchi, Gian Luca Autorino
In January 2015, during a 3-week period, 12 captive Tonkean macacques at a sanctuary in Italy died. An orthopoxvirus infection was suspected because of negative-staining electron microscopy results. The diagnosis was confirmed by histology, virus isolation, and molecular analysis performed on different organs from all animals. An epidemiologic investigation was unable to define the infection source in the surrounding area. Trapped rodents were negative by virologic testing, but specific IgG was detected in 27...
December 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28951885/cowpox-virus-a-new-and-armed-oncolytic-poxvirus
#11
Marine Ricordel, Johann Foloppe, Christelle Pichon, Nathalie Sfrontato, Delphine Antoine, Caroline Tosch, Sandrine Cochin, Pascale Cordier, Eric Quemeneur, Christelle Camus-Bouclainville, Stéphane Bertagnoli, Philippe Erbs
Oncolytic virus therapy has recently been recognized as a promising new therapeutic approach for cancer treatment. In this study, we are proposing for the first time to evaluate the in vitro and in vivo oncolytic capacities of the Cowpox virus (CPXV). To improve the tumor selectivity and oncolytic activity, we developed a thymidine kinase (TK)-deleted CPXV expressing the suicide gene FCU1, which converts the non-toxic prodrug 5-fluorocytosine (5-FC) into cytotoxic 5-fluorouracil (5-FU) and 5-fluorouridine-5'-monophosphate (5-FUMP)...
December 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28885569/re-assembly-and-analysis-of-an-ancient-variola-virus-genome
#12
Chad Smithson, Jacob Imbery, Chris Upton
We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with camelpox and taterapox genomes, permitted new dates to be calculated for the last common ancestor of all VARV genomes. The analysis of recently sequenced VARV-like cowpox virus genomes showed that single nucleotide polymorphisms (SNPs) and amino acid changes in the vaccinia virus (VACV)-Cop-O1L ortholog, predicted to be associated with VARV host specificity and virulence, were introduced into the lineage before the divergence of these viruses...
September 8, 2017: Viruses
https://www.readbyqxmd.com/read/28839944/novel-characteristics-identified-in-two-cases-of-feline-cowpox-virus-infection
#13
Craig R Breheny, Victoria Fox, Alice Tamborini, Conor O'Halloran, Elise Robertson, Paola Cazzini, Daniela Birn-Jeffery, Julia Henkin, Tobias Schwartz, Tim Scase, Roger Powell, Danièlle Gunn-Moore
CASE SERIES SUMMARY: This case series discusses novel characteristics identified in two cases of cowpox. One presented with upper airway signs, and was identified to have a focal laryngeal lesion. The other had central neurological signs at the terminal stages, with intracytoplasmic inclusion bodies identified within the cerebral hemispheres on histopathology. RELEVANCE AND NOVEL INFORMATION: Currently, cowpox would be an unlikely consideration in patients with neurological signs or upper respiratory noise...
July 2017: JFMS Open Reports
https://www.readbyqxmd.com/read/28827144/revisiting-jenner-s-mysteries-the-role-of-the-beaugency-lymph-in-the-evolutionary-path-of-ancient-smallpox-vaccines
#14
REVIEW
Clarissa R Damaso
In 1796, Edward Jenner developed the smallpox vaccine consisting of pustular material obtained from lesions on cows affected by so-called cow-pox. The disease, caused by cowpox virus, confers crossprotection against smallpox. However, historical evidence suggests that Jenner might have used vaccinia virus or even horsepox virus instead of cowpox virus. Mysteries surrounding the origin and nature of the smallpox vaccine persisted during the 19th century, a period of intense exchange of vaccine strains, including the Beaugency lymph...
August 18, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28747505/insufficient-innate-immunity-contributes-to-the-susceptibility-of-the-castaneous-mouse-to-orthopoxvirus-infection
#15
Patricia L Earl, Jeffrey L Americo, Bernard Moss
The castaneous (CAST) mouse, a wild-derived inbred strain, is highly susceptible to orthopoxvirus infection by intranasal and systemic routes. The 50% lethal intraperitoneal dose of vaccinia virus (VACV) was 3 PFU for CAST mice, whereas BALB/c mice survived 10(6) PFU. At all times and in all organs analyzed, virus titers were higher in CAST than in BALB/c mice. In individual CAST mice, luciferase-expressing VACV was seen to replicate rapidly leading to death, whereas virus levels increased for a few days and then declined in BALB/c mice...
October 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28727764/vaccinia-virus-and-cowpox-virus-are-not-susceptible-to-the-interferon-induced-antiviral-protein-mxa
#16
María M Lorenzo, Juana M Sanchez-Puig, Rafael Blasco
MxA protein is expressed in response to type I and type III Interferon and constitute an important antiviral factor with broad antiviral activity to diverse RNA viruses. In addition, some studies expand the range of MxA antiviral activity to include particular DNA viruses like Monkeypox virus (MPXV) and African Swine Fever virus (ASFV). However, a broad profile of activity of MxA to large DNA viruses has not been established to date. Here, we investigated if some well characterized DNA viruses belonging to the Poxviridae family are sensitive to human MxA...
2017: PloS One
https://www.readbyqxmd.com/read/28669644/generalised-cowpox-virus-infection
#17
Lisa-Lena Grönemeyer, Anne Baltzer, Sigrid Broekaert, Livia Schrick, Lars Möller, Andreas Nitsche, Rotraut Mössner, Michael P Schön, Timo Buhl
No abstract text is available yet for this article.
October 14, 2017: Lancet
https://www.readbyqxmd.com/read/28615415/cutting-edge-the-aging-immune-system-reveals-the-biological-impact-of-direct-antigen-presentation-on-cd8-t-cell-responses
#18
Jennifer L Uhrlaub, Megan J Smithey, Janko Nikolich-Žugich
The vertebrate immune system uses multiple, sometimes redundant, mechanisms to contain pathogenic microorganisms that are always evolving to evade host defenses. Thus, the cowpox virus (CPXV) uses genes encoding CPXV12 and CPXV203 to prevent direct MHC class I presentation of viral peptides by infected cells. However, CD8 T cells are effectively primed against CPXV by cross-presentation of viral Ags in young mice. Old mice accumulate defects in both CD8 T cell activation and cross-presentation. Using a double-deletion mutant (∆12∆203) of CPXV, we show that direct priming of CD8 T cells in old mice yields superior recall responses, establishing a key contribution of this mechanism to host antipoxvirus responses and enhancing our fundamental understanding of how viral manipulation of direct presentation impacts pathogenesis...
July 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28604604/classification-of-cowpox-viruses-into-several-distinct-clades-and-identification-of-a-novel-lineage
#19
Annika Franke, Florian Pfaff, Maria Jenckel, Bernd Hoffmann, Dirk Höper, Markus Antwerpen, Hermann Meyer, Martin Beer, Donata Hoffmann
Cowpox virus (CPXV) was considered as uniform species within the genus Orthopoxvirus (OPV). Previous phylogenetic analysis indicated that CPXV is polyphyletic and isolates may cluster into different clades with two of these clades showing genetic similarities to either variola (VARV) or vaccinia viruses (VACV). Further analyses were initiated to assess both the genetic diversity and the evolutionary background of circulating CPXVs. Here we report the full-length sequences of 20 CPXV strains isolated from different animal species and humans in Germany...
June 10, 2017: Viruses
https://www.readbyqxmd.com/read/28594571/zmpste24-is-downstream-effector-of-interferon-induced-transmembrane-antiviral-activity
#20
Shitao Li, Bishi Fu, Lingyan Wang, Martin E Dorf
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common antiviral pathway that is associated with interferon-induced transmembrane proteins...
July 2017: DNA and Cell Biology
keyword
keyword
6621
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"