P A Robinson, C J Rennie, D L Rowe, S C O'Connor, J J Wright, E Gordon, R W Whitehouse
A recent neurophysical model of brain electrical activity is outlined and applied to EEG phenomena. It incorporates single-neuron physiology and the large-scale anatomy of corticocortical and corticothalamic pathways, including synaptic strengths, dendritic propagation, nonlinear firing responses, and axonal conduction. Small perturbations from steady states account for observed EEGs as functions of arousal. Evoked response potentials (ERPs), correlation, and coherence functions are also reproduced. Feedback via thalamic nuclei is critical in determining the forms of these quantities, the transition between sleep and waking, and stability against seizures...
July 2003: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology