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https://www.readbyqxmd.com/read/29334160/fine-tuning-of-molecular-packing-and-energy-level-through-methyl-substitution-enabling-excellent-small-molecule-acceptors-for-nonfullerene-polymer-solar-cells-with-efficiency-up-to-12-54
#1
Zhenghui Luo, Haijun Bin, Tao Liu, Zhi-Guo Zhang, Yankang Yang, Cheng Zhong, Beibei Qiu, Guanghao Li, Wei Gao, Dongjun Xie, Kailong Wu, Yanming Sun, Feng Liu, Yongfang Li, Chuluo Yang
A novel small molecule acceptor MeIC with a methylated end-capping group is developed. Compared to unmethylated counterparts (ITCPTC), MeIC exhibits a higher lowest unoccupied molecular orbital (LUMO) level value, tighter molecular packing, better crystallites quality, and stronger absorption in the range of 520-740 nm. The MeIC-based polymer solar cells (PSCs) with J71 as donor, achieve high power conversion efficiency (PCE), up to 12.54% with a short-circuit current (JSC ) of 18.41 mA cm-2 , significantly higher than that of the device based on J71:ITCPTC (11...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333790/crohn-s-disease-behavior-and-location-is-altered-when-associated-with-primary-sclerosing-cholangitis
#2
Oren Iny, Henit Yanai, Shay Matalon, Erwin Santo, Oren Shibolet, Iris Dotan, Nitsan Maharshak
BACKGROUND: Up to 3.4% of Crohn's disease (CD) patients will be diagnosed with concomitant primary sclerosing cholangitis (PSC). Despite the worldwide increase incidence of CD, data on the clinical characteristics of PSC-CD patients are scarce. OBJECTIVES: To clinically characterize CD in patients who have concomitant PSC. METHODS: A retrospective case-control analysis was conducted with 18 CD patients with concomitant PSC who attended the Inflammatory Bowel Disease Center at the Tel Aviv Sourasky Medical Center between 2011-2014 (PSC-CD patients)...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29331684/reprogramming-neurodegeneration-in-the-big-data-era
#3
REVIEW
Lujia Zhou, Patrik Verstreken
Recent genome-wide association studies (GWAS) have identified numerous genetic risk variants for late-onset Alzheimer's disease (AD) and Parkinson's disease (PD). However, deciphering the functional consequences of GWAS data is challenging due to a lack of reliable model systems to study the genetic variants that are often of low penetrance and non-coding identities. Pluripotent stem cell (PSC) technologies offer unprecedented opportunities for molecular phenotyping of GWAS variants in human neurons and microglia...
January 10, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29329535/measurement-of-the-potential-geographic-accessibility-from-call-to-definitive-care-for-patient-with-acute-stroke
#4
J Freyssenge, F Renard, A M Schott, L Derex, N Nighoghossian, K Tazarourte, C El Khoury
BACKGROUND: The World Health Organization refers to stroke, the second most frequent cause of death in the world, in terms of pandemic. Present treatments are only effective within precise time windows. Only 10% of thrombolysis patients are eligible. Late assessment of the patient resulting from admission and lack of knowledge of the symptoms is the main explanation of lack of eligibility. METHODS: The aim is the measurement of the time of access to treatment facilities for stroke victims, using ambulances (firemen ambulances or EMS ambulances) and private car...
January 12, 2018: International Journal of Health Geographics
https://www.readbyqxmd.com/read/29328490/galectin-1-expression-in-activated-pancreatic-satellite-cells-promotes-fibrosis-in-chronic-pancreatitis-pancreatic-cancer-via-the-tgf-%C3%AE-1-smad-pathway
#5
Dong Tang, Qi Wu, Jingqiu Zhang, Hongpeng Zhang, Zhongxu Yuan, Jiaming Xu, Yang Chong, Yuqin Huang, Qingquan Xiong, Sen Wang, Ying Tian, Yongdie Lu, Xiao Ge, Wenjing Shen, Daorong Wang
Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated in activated PSCs and is important for the continuing activation of PSCs. The aim of this study was to evaluate the effect of galectin-1 derived from activated PSCs on the progression of fibrosis in CP/PC. To this end, the expression of desmin, α-SMA, galectin-1, fibronectin and collagen type I in normal pancreatic, CP and PC tissues, as well as quiescent/activated PSCs, was investigated...
January 9, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327744/spinel-co3o4-nanomaterials-for-efficient-and-stable-large-area-carbon-based-printed-perovskite-solar-cells
#6
Amna Bashir, Sudhanshu Shukla, Jia Haur Lew, Shashwat Shukla, Annalisa Bruno, Disha Gupta, Tom Baikie, Rahul Patidar, Zareen Akhter, Anish Priyadarshi, Nripan Mathews, Subodh G Mhaisalkar
Carbon based perovskite solar cells (PSCs) are fabricated through easily scalable screen printing techniques, using abundant and cheap carbon to replace the hole transport material (HTM) and the gold electrode further reduces costs, and carbon acts as a moisture repellent that helps in maintaining the stability of the underlying perovskite active layer. An inorganic interlayer of spinel cobaltite oxides (Co3O4) can greatly enhance the carbon based PSC performance by suppressing charge recombination and extracting holes efficiently...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29323896/different-proteomic-processes-related-to-the-cultivar-dependent-cadmium-accumulation-of-amaranthus-gangeticus
#7
Chun-Tao He, Yihui Zhou, Ying-Ying Huang, Hui-Ling Fu, Xue-Song Wang, Fei-Yue Gong, Xiao Tan, Zhongyi Yang
To deal with the Cd-contaminant of agricultural soil, pollution-safe cultivar (PSC) is developed to minimize Cd accumulation risk in crops. The present study aimed to investigate the different proteomic responses related to Cd accumulation in different tissue between two Amaranthus gangeticus cultivars, Pen and Nan. Significant higher Cd accumulation in Pen than in Nan was unraveled, especially in shoot. The proportions of soluble Cd in root and stem of Nan were significantly lower than those of Pen, implying lower Cd transportation from root to shoot in Nan...
January 11, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29321484/loss-of-tolerance-to-gut-immunity-protein-glycoprotein-2-gp2-is-associated-with-progressive-disease-course-in-primary-sclerosing-cholangitis
#8
Tamas Tornai, David Tornai, Nora Sipeki, Istvan Tornai, Rayan Alsulaimani, Kai Fechner, Dirk Roggenbuck, Gary L Norman, Gabor Veres, Gabriella Par, Alajos Par, Ferenc Szalay, Peter Laszlo Lakatos, Peter Antal-Szalmas, Maria Papp
Glycoprotein 2[GP2] is a specific target of pancreatic autoantibodies[PAbs] in Crohn's disease(CD) and is involved in gut innate immunity processes. Our aim was to evaluate the prevalence and prognostic potential of PAbs in primary sclerosing cholangitis(PSC). Sixty-five PSC patients were tested for PAbs by indirect immunofluorescence and compared with healthy (n = 100) and chronic liver disease controls(CLD, n = 488). Additionally, a panel of anti-microbial antibodies and secretory (s)IgA levels were measured, as markers of bacterial translocation and immune dysregulation...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320760/a-standard-nomenclature-for-referencing-and-authentication-of-pluripotent-stem-cells
#9
REVIEW
Andreas Kurtz, Stefanie Seltmann, Amos Bairoch, Marie-Sophie Bittner, Kevin Bruce, Amanda Capes-Davis, Laura Clarke, Jeremy M Crook, Laurence Daheron, Johannes Dewender, Adam Faulconbridge, Wataru Fujibuchi, Alexander Gutteridge, Derek J Hei, Yong-Ou Kim, Jung-Hyun Kim, Anja Kolb- Kokocinski, Fritz Lekschas, Geoffrey P Lomax, Jeanne F Loring, Tenneille Ludwig, Nancy Mah, Tohru Matsui, Robert Müller, Helen Parkinson, Michael Sheldon, Kelly Smith, Harald Stachelscheid, Glyn Stacey, Ian Streeter, Anna Veiga, Ren-He Xu
Unambiguous cell line authentication is essential to avoid loss of association between data and cells. The risk for loss of references increases with the rapidity that new human pluripotent stem cell (hPSC) lines are generated, exchanged, and implemented. Ideally, a single name should be used as a generally applied reference for each cell line to access and unify cell-related information across publications, cell banks, cell registries, and databases and to ensure scientific reproducibility. We discuss the needs and requirements for such a unique identifier and implement a standard nomenclature for hPSCs, which can be automatically generated and registered by the human pluripotent stem cell registry (hPSCreg)...
January 9, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29318870/improving-the-optoelectronic-properties-of-mesoporous-tio2-by-cobalt-doping-for-high-performance-hysteresis-free-perovskite-solar-cells
#10
Siraj Sidhik, Andrea Cerdan-Pasaran, Diego Esparza, Tzarara Lopez-Luke, Ramon Carriles, Elder De La Rosa
We for the first time report the incorporation of cobalt into a mesoporous TiO2 electrode for application in perovskite solar cells (PSCs).The Co-doped PSC exhibits excellent optoelectronic properties; we explain the improvements by passivation of electronic trap or sub-band gap states arising due to the oxygen vacancies in pristine-TiO2, enabling faster electron transport and collection. A simple post-annealing treatment is used to prepare the cobalt-doped mesoporous electrode; UV-vis, XPS, SCLC, photoluminescence and electrochemical impedance measurements confirm the incorporation of cobalt, enhanced conductivity and the passivation effect induced in the TiO2...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29315700/binding-affinity-and-decontamination-of-dermal-decontamination-gel-to-model-chemical-warfare-agent-simulants
#11
Yachao Cao, Akram Elmahdy, Hanjiang Zhu, Xiaoying Hui, Howard Maibach
Six chemical warfare agent simulants (trimethyl phosphate, dimethyl adipate, 2-chloroethyl methyl sulfide, diethyl adipate, chloroethyl phenyl sulfide and diethyl sebacate) were studied in in vitro human skin to explore relationship between dermal penetration/absorption and the mechanisms of simulant partitioning between stratum corneum (SC) and water as well as between dermal decontamination gel (DDGel) and water. Both binding affinity to and decontamination of simulants using DDGel were studied. Partition coefficients of six simulants between SC and water (Log PSC/w ) and between DDGel and water (Log PDDGel/w ) were determined...
January 7, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29310470/new-therapies-target-the-toxic-consequences-of-cholestatic-liver-disease
#12
Peter L M Jansen
Introduction In most cholestatic liver diseases the primary cholestasis-causing lesions are located in the biliary tree and may be of (auto)immune origin. Bile salts are responsible for the secondary toxic consequences. Bile salt and nuclear hormone directed therapies primarily aim at improving this secondary toxic injury. In primary biliary cholangitis, trials show statistically significant responses on biochemical endpoints. Preclinical studies suggest that FXR- and PPAR-agonists, inhibitors of the apical sodium-dependent bile salt transporter (ASBT-inhibitors) and the C23 UDCA derivative nor-UDCA are promising agents for the treatment of primary sclerosing cholangitis (PSC)...
January 9, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29309268/assessment-of-pharmacy-department-patient-safety-culture-with-the-use-of-validated-work-environment-survey-indices
#13
Julia E Rawlings, Sheryl J Herner, Thomas Delate, Kelsey E Palmer, Kelly A Swartzendruber
CONTEXT: Patient safety culture (PSC) improvement is a strategy that can foster patient well-being. Measuring PSC without using a validated instrument has been proposed. OBJECTIVE: To assess the strengths of correlations between the Agency for Healthcare Research and Quality's validated Community Pharmacy Survey on Patient Safety Culture (CPSPSC) composites and nonvalidated People Pulse (PP) work environment indices. DESIGN: This was a cross-sectional, anonymous, voluntary survey...
2018: Permanente Journal
https://www.readbyqxmd.com/read/29307583/transcriptionally-and-functionally-distinct-mesenchymal-subpopulations-are-generated-from-human-pluripotent-stem-cells
#14
Chee Jia Chin, Suwen Li, Mirko Corselli, David Casero, Yuhua Zhu, Chong Bin He, Reef Hardy, Bruno Péault, Gay M Crooks
Various mesenchymal cell types have been identified as critical components of the hematopoietic stem/progenitor cell (HSPC) niche. Although several groups have described the generation of mesenchyme from human pluripotent stem cells (hPSCs), the capacity of such cells to support hematopoiesis has not been reported. Here, we demonstrate that distinct mesenchymal subpopulations co-emerge from mesoderm during hPSC differentiation. Despite co-expression of common mesenchymal markers (CD73, CD105, CD90, and PDGFRβ), a subset of cells defined as CD146hiCD73hi expressed genes associated with the HSPC niche and supported the maintenance of functional HSPCs ex vivo, while CD146loCD73lo cells supported differentiation...
January 3, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29301479/risk-factors-and-prognosis-for-recurrent-primary-sclerosing-cholangitis-after-liver-transplantation-a-nordic-multicentre-study
#15
Lina Lindström, Kristin K Jørgensen, Kirsten M Boberg, Maria Castedal, Allan Rasmussen, Andreas Arendtsen Rostved, Helena Isoniemi, Matteo Bottai, Annika Bergquist
OBJECTIVES: The risk for recurrent primary sclerosing cholangitis (rPSC) after liver transplantation is associated with inflammatory bowel disease (IBD). We assessed the frequency of rPSC and studied risk factors for recurrent disease with special focus on IBD. We also evaluated the importance of rPSC for prognosis. MATERIALS AND METHODS: All liver transplanted PSC patients in the Nordic countries between 1984 and 2007 (n = 440), identified by the Nordic Liver Transplant Registry, were studied...
January 4, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29300450/alkali-salt-doped-highly-transparent-and-thickness-insensitive-electron-transport-layer-for-high-performance-polymer-solar-cell
#16
Rongguo Xu, Kai Zhang, Xi Liu, Yaocheng Jin, Xiao-Fang Jiang, Qing-Hua Xu, Fei Huang, Yong Cao
Solution-processable highly transparent and thickness-insensitive hybrid electron-transport layer (ETL) with enhanced electron-extraction and electron-transport properties for high-performance polymer solar cell was reported. With the incorporation of Cs2CO3 into the poly[(9,9-bis(6'-((N,N-diethyl)-N-ethylammonium)-hexyl)-2,7-fluorene)-alt-1,4-diphenylsulfide]dibromide (PF6NPSBr) ETL, the power conversion efficiency (PCE) of resulted polymer solar cells (PSCs) was significantly enhanced due to the favorable interfacial contact, energy-level alignment, and thus facile electron transport in the PSC device...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29300287/a-randomized-controlled-trial-determining-variances-in-ostomy-skin-conditions-and-the-economic-impact-advocate-trial
#17
Janice C Colwell, Joyce Pittman, Rose Raizman, Ginger Salvadalena
PURPOSE: To compare ostomy-related costs and incidence of peristomal skin complications (PSCs) for ceramide-infused ostomy skin barriers and control skin barriers. DESIGN: The ADVOCATE trial is a multi-centered randomized controlled trial, and double-blinded international study with an adaptive design. SUBJECTS AND SETTING: The sample comprised 153 adults from 25 sites from the United States, Canada, and Europe. Participants were seen in hospital and outpatient care settings...
January 2018: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29285679/human-neural-stem-cell-extracellular-vesicles-improve-tissue-and-functional-recovery-in-the-murine-thromboembolic-stroke-model
#18
Robin L Webb, Erin E Kaiser, Shelley L Scoville, Tyler A Thompson, Sumbul Fatima, Chirayukumar Pandya, Karishma Sriram, Raymond L Swetenburg, Kumar Vaibhav, Ali S Arbab, Babak Baban, Krishnan M Dhandapani, David C Hess, M N Hoda, Steven L Stice
Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be attributed in part to limited and isolated testing often solely in "young" rodent models and focusing on a single secondary injury mechanism. Here, extracellular vesicles (EVs), nanometer-sized cell signaling particles, were tested in a mouse thromboembolic (TE) stroke model. Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function...
December 28, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29283600/job-design-for-mindful-work-the-boosting-effect-of-psychosocial-safety-climate
#19
Emily J Lawrie, Michelle R Tuckey, Maureen F Dollard
Despite a surge in workplace mindfulness research, virtually nothing is known about how organizations can cultivate everyday mindfulness at work. Using the extended job demands-resources model, we explored daily psychological demands and job control as potential antecedents of daily mindfulness, and the moderating effect of psychosocial safety climate (PSC, which relates to the value organizations place on psychological health at work). We also examined the relationship between mindfulness and learning to augment understanding of the benefits of everyday mindfulness at work...
December 28, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/29278002/cholestasis-after-tips-placement-in-a-patient-with-primary-sclerosing-cholangitis-an-uncommon-complication
#20
Alejandro Salagre García, Carolina Muñoz Codoceo, Elena Gómez Domínguez, Inmaculada Fernández Vázquez, Gregorio Castellano Tortajada
We present the case of a patient with primary sclerosing cholangitis who presented a rapidly evolving cholestatic syndrome, with severe hyperbilirubinemia after placing a TIPS. It was resolved with a biliary prosthesis inserted by ERCP. To date, no similar cases have been described in the literature, as it is a rare complication and, on the other hand, the experience with TIPS in patients with PSC is limited. The causes of hyperbilirubinemia after TIPS placement are very varied and it is crucial to perform a differential diagnosis to establish an early treatment...
December 26, 2017: Revista Española de Enfermedades Digestivas
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