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https://www.readbyqxmd.com/read/28559209/short-post-weaning-social-isolation-induces-long-term-changes-in-the-dopaminergic-system-and-increases-susceptibility-to-psychostimulants-in-female-rats
#1
Carine Lampert, Danusa Mar Arcego, Natividade de Sá Couto-Pereira, Aline Dos Santos Vieira, Ana Paula Toniazzo, Rachel Krolow, Emily Garcia, Deusa Aparecida Vendite, Maria Elisa Calcagnotto, Carla Dalmaz
Childhood and adolescence are sensitive periods of development, marked by high brain maturation and plasticity. Exposure to early life stress, such as social isolation, is able to prompt changes in sensitive brain circuitries, essentially in the mesolimbic dopaminergic system and increase the risk for addictive behaviors later in life. Post-weaning social isolation can stimulate the consumption of rewarding substances, like drugs of abuse and palatable foods. However, most studies analyze long periods of social isolation and very little is known about the effects of a brief social isolation in a sensitive period of development and its association with palatable food on the reward system sensitization...
May 27, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28536692/wistar-kyoto-female-rats-are-more-susceptible-to-develop-sugar-binging-a-comparison-with-wistar-rats
#2
Helena Papacostas-Quintanilla, Víctor Manuel Ortiz-Ortega, Carolina López-Rubalcava
The hedonic component of the feeding behavior involves the mesolimbic reward system and resembles addictions. Nowadays, the excessive consumption of sucrose is considered addictive. The Wistar-Kyoto (WKY) rat strain is prone to develop anxiety and addiction-like behavior; nevertheless, a lack of information regarding their vulnerability to develop sugar binging-like behavior (SBLB) and how it affects the reward system persist. Therefore, the first aim of the present study was to compare the different predisposition of two rat strains, Wistar (W) and WKY to develop the SBLB in female and male rats...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28533660/genes-emotions-and-gut-microbiota-the-next-frontier-for-the-gastroenterologist
#3
REVIEW
Arturo Panduro, Ingrid Rivera-Iñiguez, Maricruz Sepulveda-Villegas, Sonia Roman
Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal (GI) system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. Based on the current knowledge, this mini-review aims to provide an integrated synopsis of this interaction to achieve a better understanding of the GI disorders related to bad eating habits and stress-related disease...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28435669/reframing-the-science-and-policy-of-nicotine-illegal-drugs-and-alcohol-conclusions-of-the-alice-rap-project
#4
Peter Anderson, Virginia Berridge, Patricia Conrod, Robert Dudley, Matilda Hellman, Dirk Lachenmeier, Anne Lingford-Hughes, David Miller, Jürgen Rehm, Robin Room, Laura Schmidt, Roger Sullivan, Tamyko Ysa, Antoni Gual
In 2013, illegal drug use was responsible for 1.8% of years of life lost in the European Union, alcohol was responsible for 8.2% and tobacco for 18.2%, imposing economic burdens in excess of 2.5% of GDP. No single European country has optimal governance structures for reducing the harm done by nicotine, illegal drugs and alcohol, and existing ones are poorly designed, fragmented, and sometimes cause harm. Reporting the main science and policy conclusions of a transdisciplinary five-year analysis of the place of addictions in Europe, researchers from 67 scientific institutions addressed these problems by reframing an understanding of addictions...
2017: F1000Research
https://www.readbyqxmd.com/read/28330706/eating-dependence-and-weight-gain-no-human-evidence-for-a-sugar-addiction-model-of-overweight
#5
C Rob Markus, Peter J Rogers, Fred Brouns, Robbie Schepers
BACKGROUND AND AIMS: There is an increasing societal concern that consumption of specific foods such as sugar might become 'addictive' and, hence, promote weight gain. Claims about the addictiveness of sugar however are based largely on findings from few animal studies, whereas there is a lack of direct human evidence for symptoms of sugar-related substance dependence. The current study examined in a large sample of human participants whether foods mainly containing sugar in particular might cause 'addiction-like' problems that meet clinical DSM criteria for substance dependence, and, also whether in turn this relates to body weight and negative affectivity (depressed mood)...
July 1, 2017: Appetite
https://www.readbyqxmd.com/read/28192219/a-qualitative-study-of-overweight-and-obese-australians-views-of-food-addiction
#6
A J Cullen, A Barnett, P A Komesaroff, W Brown, K S O'Brien, W Hall, A Carter
The concept of food addiction is increasingly used in the academic literature and popular media to explain some forms of overweight and obesity. However, there is limited evidence on how this term is understood by and impacts overweight and obese individuals. This qualitative study investigated the views of overweight and obese individuals on food addiction, and its likely impact upon stigma, treatment-seeking, and support for public policies to reduce overeating. Semi-structured interviews were conducted with 23 overweight and obese individuals (Mage = 38, MBMI = 33, 74% female) and analysed thematically...
August 1, 2017: Appetite
https://www.readbyqxmd.com/read/27989563/preclinical-evidence-for-the-addiction-potential-of-highly-palatable-foods-current-developments-related-to-maternal-influence
#7
David A Wiss, Kristen Criscitelli, Mark Gold, Nicole Avena
It is well established that obesity has reached pandemic proportions. Over the last four decades the prevalence of obesity and morbid obesity have risen substantially in both men and women worldwide. Although there are many causative factors leading to excessive weight gain including genetics and sedentary lifestyle, the transformation of the food environment has undoubtedly contributed to the dangerously high rates of obesity. The current food landscape is inundated with food engineered to contain artificially high levels of sugar and fat...
August 1, 2017: Appetite
https://www.readbyqxmd.com/read/27984189/a-commentary-on-the-eating-addiction-versus-food-addiction-perspectives-on-addictive-like-food-consumption
#8
Erica M Schulte, Marc N Potenza, Ashley N Gearhardt
The food addiction construct posits that vulnerable individuals may experience an addictive-like response to certain foods, such as those high in fat and refined carbohydrates. Recently, an alternative model to food addiction was proposed, suggesting that the act of eating may be a behavioral addiction that can trigger an addictive-like response in susceptible individuals. One major rationale for the eating addiction framework is that the assessment of food addiction is based on behavioral indicators, such as consuming greater quantities of food than intended and eating certain foods despite negative consequences...
August 1, 2017: Appetite
https://www.readbyqxmd.com/read/27975356/-is-nutritional-obesity-a-substance-use-disorder
#9
Özgür Albayrak, Martina de Zwaan
Today, food addiction has become an increasing area of research. Multiple studies aim to characterize individuals in terms of food addiction based on the assumption, that hyperpalatable foods rich of salt, sugar and fat may induce a cluster of behavioral changes that may resemble a substance use disorder, despite the fact that to date there is no evidence, that nutritional factors lead to an addictive eating-like behavior in humans. In this review article, we aim to introduce the basic experiments, that build the framework upon which food addiction is being investigated and to critically discuss the concept of food addiction...
December 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27817910/sugars-exercise-and-health
#10
REVIEW
Roberto Codella, Ileana Terruzzi, Livio Luzi
BACKGROUND: There is a direct link between a variety of addictions and mood states to which exercise could be relieving. Sugar addiction has been recently counted as another binge/compulsive/addictive eating behavior, differently induced, leading to a high-significant health problem. Regularly exercising at moderate intensity has been shown to efficiently and positively impact upon physiological imbalances caused by several morbid conditions, including affective disorders. Even in a wider set of physchiatric diseases, physical exercise has been prescribed as a complementary therapeutic strategy...
October 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27766464/calorie-intake-and-gambling-is-fat-and-sugar-consumption-impulsive
#11
Samuel R Chamberlain, Sarah A Redden, Jon E Grant
Excessive calorie intake constitutes a global public health concern, due to its associated range of untoward outcomes. Gambling is commonplace and gambling disorder is now considered a behavioral addiction in DSM-5. The relationships between calorie intake, gambling, and other types of putatively addictive and impulsive behaviors have received virtually no research attention. Two-hundred twenty-five young adults who gamble were recruited from two Mid-Western university communities in the United States using media advertisements...
October 20, 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/27699212/reduced-vglut2-slc17a6-gene-expression-levels-throughout-the-mouse-subthalamic-nucleus-cause-cell-loss-and-structural-disorganization-followed-by-increased-motor-activity-and-decreased-sugar-consumption
#12
Nadine Schweizer, Thomas Viereckel, Casey J A Smith-Anttila, Karin Nordenankar, Emma Arvidsson, Souha Mahmoudi, André Zampera, Hanna Wärner Jonsson, Jonas Bergquist, Daniel Lévesque, Åsa Konradsson-Geuken, Malin Andersson, Sylvie Dumas, Åsa Wallén-Mackenzie
The subthalamic nucleus (STN) plays a central role in motor, cognitive, and affective behavior. Deep brain stimulation (DBS) of the STN is the most common surgical intervention for advanced Parkinson's disease (PD), and STN has lately gained attention as target for DBS in neuropsychiatric disorders, including obsessive compulsive disorder, eating disorders, and addiction. Animal studies using STN-DBS, lesioning, or inactivation of STN neurons have been used extensively alongside clinical studies to unravel the structural organization, circuitry, and function of the STN...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27622657/oxidative-and-inert-pyrolysis-on-line-coupled-to-gas-chromatography-with-mass-spectrometric-detection-on-the-pyrolysis-products-of-tobacco-additives
#13
Meike Paschke, Christoph Hutzler, Frank Henkler, Andreas Luch
According to European legislation, tobacco additives may not increase the toxicity or the addictive potency of the product, but there is an ongoing debate on how to reliably characterize and measure such properties. Further, too little is known on pyrolysis patterns of tobacco additives to assume that no additional toxicological risks need to be suspected. An on-line pyrolysis technique was used and coupled to gas chromatography-mass spectrometry (GC/MS) to identify the pattern of chemical species formed upon thermal decomposition of 19 different tobacco additives like raw cane sugar, licorice or cocoa...
September 4, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27588558/extended-exposure-to-sugar-and-or-caffeine-produces-distinct-behavioral-and-neurochemical-profiles-in-the-orbitofrontal-cortex-of-rats-implications-for-neural-function
#14
Jane L Franklin, Mehdi Mirzaei, Travis A Wearne, Judi Homewood, Ann K Goodchild, Paul A Haynes, Jennifer L Cornish
Caffeine is a psychostimulant commonly consumed with high levels of sugar. The increased availability of highly caffeinated, high sugar energy drinks could put some consumers at risk of being exposed to high doses of caffeine and sugar. Notably, research that has examined the consequences of this combination is limited. Here, we explored the effect of chronic exposure to caffeine and/or sugar on behavior and protein levels in the orbitofrontal cortex (OFC) of rats. The OFC brain region has been implicated in neuropsychiatric conditions, including obesity and addiction behaviors...
September 2, 2016: Proteomics
https://www.readbyqxmd.com/read/27583555/effects-of-chronic-consumption-of-sugar-enriched-diets-on-brain-metabolism-and-insulin-sensitivity-in-adult-yucatan-minipigs
#15
Melissa Ochoa, Charles-Henri Malbert, Paul Meurice, David Val-Laillet
Excessive sugar intake might increase the risk to develop eating disorders via an altered reward circuitry, but it remains unknown whether different sugar sources induce different neural effects and whether these effects are dependent from body weight. Therefore, we compared the effects of three high-fat and isocaloric diets varying only in their carbohydrate sources on brain activity of reward-related regions, and assessed whether brain activity is dependent on insulin sensitivity. Twenty-four minipigs underwent 18FDG PET brain imaging following 7-month intake of high-fat diets of which 20% in dry matter weight (36...
2016: PloS One
https://www.readbyqxmd.com/read/27581476/heritability-of-high-sugar-consumption-through-drinks-and-the-genetic-correlation-with-substance-use
#16
Jorien L Treur, Dorret I Boomsma, Lannie Ligthart, Gonneke Willemsen, Jacqueline M Vink
BACKGROUND: High sugar consumption contributes to the rising prevalence of obesity. Sugar can have rewarding effects that are similar to, but less strong than, the effects of addictive substances. People who consume large amounts of sugar also tend to use more addictive substances, but it is unclear whether this is due to shared genetic or environmental risk factors. OBJECTIVE: We examined whether there are genetic influences on the consumption of sugar-containing drinks and whether genetic factors can explain the association with substance use...
October 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27503449/psychological-and-neurobiological-correlates-of-food-addiction
#17
E Kalon, J Y Hong, C Tobin, T Schulte
Food addiction (FA) is loosely defined as hedonic eating behavior involving the consumption of highly palatable foods (ie, foods high in salt, fat, and sugar) in quantities beyond homeostatic energy requirements. FA shares some common symptomology with other pathological eating disorders, such as binge eating. Current theories suggest that FA shares both behavioral similarities and overlapping neural correlates to other substance addictions. Although preliminary, neuroimaging studies in response to food cues and the consumption of highly palatable food in individuals with FA compared to healthy controls have shown differing activation patterns and connectivity in brain reward circuits including regions such as the striatum, amygdala, orbitofrontal cortex, insula, and nucleus accumbens...
2016: International Review of Neurobiology
https://www.readbyqxmd.com/read/27478624/the-impact-of-demographic-factors-and-blood-sugar-control-on-the-incidence-of-urinary-tract-infections-in-khorramabad-in-2013
#18
Azam Raoofi, Maryam Ghavami, Maryam Shahhamzeh, Mahmood Ghasemi, Rostam Hedartabar, Leili Salehi
BACKGROUND: Diabetes is one of the most serious metabolic disorders to affect different organs in the body. Patients with diabetes are hence at risk of developing other problems. Urinary tract infections (UTI) are one of the problems that occur more commonly in diabetic patients than in others. There are several risk factors that lead to the incidence of UTI in diabetic patients. OBJECTIVES: We conducted this study to determine the effect of different factors on the incidence of UTI in diabetic patients in order to decrease the incidence of this problem...
May 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27372453/sugar-addiction-the-state-of-the-science
#19
REVIEW
Margaret L Westwater, Paul C Fletcher, Hisham Ziauddeen
PURPOSE: As obesity rates continue to climb, the notion that overconsumption reflects an underlying 'food addiction' (FA) has become increasingly influential. An increasingly popular theory is that sugar acts as an addictive agent, eliciting neurobiological changes similar to those seen in drug addiction. In this paper, we review the evidence in support of sugar addiction. METHODS: We reviewed the literature on food and sugar addiction and considered the evidence suggesting the addictiveness of highly processed foods, particularly those with high sugar content...
November 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27350195/-sucrose-reward-promotes-rats-motivation-for-cocaine
#20
Yan-Qing Li, Qiu-Min LE, Xiang-Chen Yu, Lan Ma, Fei-Fei Wang
Caloric diet, such as fat and sugar intake, has rewarding effects, and has been indicated to affect the responses to addictive substances in animal experiments. However, the possible association between sucrose reward and the motivation for addictive drugs remains to be elucidated. Thus, we carried out behavioral tests after sucrose self-administration training to determine the effects of sucrose experience on rats' motivation for cocaine, locomotor sensitivity to cocaine, basal locomotor activity, anxiety level, and associative learning ability...
June 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
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