Emily Harrop, Christina Liossi, Liz Jamieson, Silke Gastine, Kate Oulton, Simon S Skene, Richard F Howard, Margaret Johnson, Katherine Boyce, Lorraine Mitchell, Satbir Jassal, Anna-Karenia Anderson, Richard D W Hain, Michelle Hills, Julie Bayliss, Archana Soman, Joanna Laddie, David Vickers, Charlotte Mellor, Tim Warlow, Ian Ck Wong
OBJECTIVES: No randomised controlled trials have been conducted for breakthrough pain in paediatric palliative care and there are currently no standardised outcome measures. The DIPPER study aims to establish the feasibility of conducting a prospective randomised controlled trial comparing oral and transmucosal administration of opioids for breakthrough pain. The aim of the current study was to achieve consensus on design aspects for a small-scale prospective study to inform a future randomised controlled trial of oral morphine, the current first-line treatment, versus transmucosal diamorphine...
December 13, 2021: BMJ Supportive & Palliative Care