keyword
https://read.qxmd.com/read/38498159/role-of-the-complement-system-in-kidney-cell-death-induced-by-loxosceles-venom-sphingomyelinases-d
#1
JOURNAL ARTICLE
Cinthya Kimori Okamoto, Carmen W van den Berg, Paula C Pohl, Denise V Tambourgi
Envenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by intravascular hemolysis, platelet aggregation, and acute kidney injury. Sphingomyelinase D (SMase D) in Loxosceles spider venom is responsible for both local and systemic pathologies, and has been shown to induce metalloprotease activity. As the complement system is involved in many renal pathologies and is involved in hemolysis in systemic loxoscelism, the aim of this study was to investigate its role and the role of complement regulators and metalloproteases in an in vitro model of Loxosceles venom induced renal pathology...
March 18, 2024: Archives of Toxicology
https://read.qxmd.com/read/38476933/in-silico-prospection-of-receptors-associated-with-the-biological-activity-of-u1-sctrx-lg1a-an-antimicrobial-peptide-isolated-from-the-venom-of-loxosceles-gaucho
#2
JOURNAL ARTICLE
André Souza de Oliveira, Elias Jorge Muniz Seif, Pedro Ismael da Silva Junior
UNLABELLED: The emergence of antibiotic-resistant pathogens generates impairment to human health. U1-SCTRX-lg1a is a peptide isolated from a phospholipase D extracted from the spider venom of Loxosceles gaucho with antimicrobial activity against Gram-negative bacteria (between 1.15 and 4.6 μM). The aim of this study was to suggest potential receptors associated with the antimicrobial activity of U1-SCTRX-lg1a using in silico bioinformatics tools. The search for potential targets of U1-SCRTX-lg1a was performed using the PharmMapper server...
2024: In Silico Pharmacology
https://read.qxmd.com/read/38422241/utilization-of-dapsone-and-hemoglobin-in-the-epithelial-skin-regeneration-therapy-of-cutaneous-loxoscelism-a-case-report-and-integrative-literature-review
#3
JOURNAL ARTICLE
Omar Azuara-Antonio, Mario Isidoro Ortiz, Karla Daniela Jiménez-Oliver, Marco Castillo-Cabrera, Ana Karen Méndez-Salinas, Luz Hernández-Ramírez
BACKGROUND: Loxosceles spp are arthropods found worldwide. Its bite may produce cutaneous loxoscelism (necrotic or edematous) or cutaneous-visceral loxoscelism. Depending on their severity and location, cutaneous forms are managed with local cold application and systemic administration of antihistamines, corticosteroids, antibiotics, polymorphonuclear inhibitors, and analgesics. OBJECTIVE: This study aimed to report a case of cutaneous loxoscelism and to identify the main dermatological manifestations associated with the Loxosceles spp bite...
2024: São Paulo Medical Journal
https://read.qxmd.com/read/38414843/integrative-taxonomy-reveals-first-record-of-loxoscelesrufescens-dufour-1820-araneae-sicariidae-in-the-philippines
#4
JOURNAL ARTICLE
Aimee Lynn A Barrion-Dupo, Ireneo L Lit, Camille Faith D Duran, Ma Francia Kyla M Cammayo, Marnelli S Alviola, Sheila Mae Q Mercado, Cecille Ann L Osio, Orlando L Eusebio, Cristian C Lucañas, Alberto T Barrion
BACKGROUND: The spider family Sicariidae Keyserling, 1880 represented by the synanthropic Mediterranean recluse spider, Loxoscelesrufescens (Dufour, 1820), is reported in the Philippines for the first time, based on morphological and molecular data. The introduced spider was observed in a small cave (Kamantigue Cave) in Lobo, Batangas Province. Considering the medical importance of this spider, the proximity of its habitat to human habitation and tourist sites poses a potential public health concern...
2024: Biodiversity Data Journal
https://read.qxmd.com/read/38358130/discovery-of-broadly-neutralizing-antibodies-against-brown-recluse-spider-and-gadim-scorpion-sphingomyelinases-using-consensus-toxins-as-antigens
#5
JOURNAL ARTICLE
Esperanza Rivera-de-Torre, Stefanos Lampadariou, Mark Møiniche, Markus F Bohn, Seyed Mahdi Kazemi, Andreas H Laustsen
Broadly-neutralizing monoclonal antibodies are becoming increasingly important tools for treating infectious diseases and animal envenomings. However, designing and developing broadly-neutralizing antibodies can be cumbersome using traditional low-throughput iterative protein engineering methods. Here, we present a new high-throughput approach for the standardized discovery of broadly-neutralizing monoclonal antibodies relying on phage display technology and consensus antigens representing average sequences of related proteins...
March 2024: Protein Science
https://read.qxmd.com/read/38333678/histopathology-aiding-diagnosis-of-viscerocutaneous-loxoscelism-in-a-nonendemic-region
#6
Smrithi Mani, Charles Katzman, Vincent Liu
No abstract text is available yet for this article.
March 2024: JAAD Case Reports
https://read.qxmd.com/read/38232241/brown-spiders-loxosceles-are-taking-hold-in-pernambuco-brazil-a-case-series-2018-2022
#7
JOURNAL ARTICLE
Maria Lucineide Porto Amorim, Diógenes Gayo de Oliveira Simão, João Paulo Vieira E Silva de Albuquerque, Beatriz Maria Tenório Ramos, Gustavo José Lopes do Nascimento, Maria Júlia Gonçalves de Mello
OBJECTIVE: To describe accidents involving brown spider (genus Loxosceles) bites notified by the Pernambuco Poison Information and Care Center (CIATox-PE), Brazil, from January 2018 to December 2022. METHODS: This was a case series study of brown spider bites notified by the CIATox-PE. RESULTS: The study included 22 cases with median age of 35 years, the majority being female (13); the cases occurred in rural and urban areas (12 versus 10), at night (10); Petrolina was the municipality with the highest number of notifications (6); spider bites occurred mainly in the lower (11) and upper (9) limbs, almost exclusively inside households (21); specific serum therapy was not indicated for 8 cases because the time for its effectiveness had already elapsed...
2024: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://read.qxmd.com/read/38155427/the-combined-treatment-of-gold-nanoparticles-associated-with-photobiomodulation-accelerate-the-healing-of-dermonecrotic-lesion
#8
JOURNAL ARTICLE
Daysiane de Oliveira, Gabriel Paulino Luiz, Rahisa Scussel, Mirian Ivens Fagundes, Nathália Coral Galvani, Jessica da Silva Abel, Rubya Pereira Zaccaron, Gustavo de Bem Silveira, Thiago Antônio Moretti de Andrade, Paulo Cesar Lock Silveira, Ricardo Andrez Machado-de-Ávila
Introduction: The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the Loxosceles simillis , is a demand in health. Prednisolone is one of the most used drugs, however it has side effects. In this context, addictionally gold nanoparticles (GNPs) have anti-inflammatory, antioxidant, and antibacterial properties. The use of photobiomodulation has show to be efficient in the process of tissue repair. Therefore, the purpose of this study was to investigate the anti-inflammatory effect of photobiomodulation and GNPs associated or not with a low concentration of prednisolone in animal models of dermonecrotic lesion...
December 28, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38049721/genome-wide-identification-structural-homology-analysis-and-evolutionary-diversification-of-the-phospholipase-d-gene-family-in-the-venom-gland-of-three-scorpion-species
#9
JOURNAL ARTICLE
Masoumeh Baradaran, Fatemeh Salabi
BACKGROUND: Venom phospholipase D (PLDs), dermonecrotic toxins like, are the major molecules in the crude venom of scorpions, which are mainly responsible for lethality and dermonecrotic lesions during scorpion envenoming. The purpose of this study was fivefold: First, to identify transcripts coding for venom PLDs by transcriptomic analysis of the venom glands from Androctonus crassicauda, Hottentotta saulcyi, and Hemiscorpius lepturus; second, to classify them by sequence similarity to known PLDs and motif extraction method; third, to characterize scorpion PLDs; fourth to structural homology analysis with known dermonecrotic toxins; and fifth to investigate phylogenetic relationships of the PLD proteins...
December 4, 2023: BMC Genomics
https://read.qxmd.com/read/38029054/clinical-evolution-after-administering-antivenom-in-patients-with-loxoscelism
#10
Omar Azuara-Antonio, Mario I Ortiz, Karla D Jimenez-Oliver, Luis E Hernandez-Cruz, Gamaliel Rivero-Veras, Luz Hernandez-Ramirez
Spiders are the most numerous arthropods of the arachnid class. More than 45 thousand species of spiders have been identified, and only a few are dangerous to humans. Among them, the "violin spider" or "brown spider" of the genus Loxosceles (family Sicariidae) has a worldwide distribution, and its bite can cause loxoscelism. Initial treatment of a Loxosceles spider bite includes application of local cold, rest, elevation of the extremity if possible, and systemic pharmacotherapy with antihistamines, corticosteroids, antibiotics, polymorphonuclear inhibitors, and analgesics or nonsteroidal anti-inflammatory drugs...
November 2023: Journal of Medical Cases
https://read.qxmd.com/read/38021570/rare-loxoscelism-associated-igg-coombs-positive-hemolytic-anemia-treated-successfully-with-systemic-corticosteroids
#11
Anas Alqam, Joud Zakhour, Wissam Karam, Gerson Maldonado, Pavan S Reddy
Loxoscelism-associated hemolytic anemia is a rare but critical complication of brown recluse spider bites. It may lead to various systemic manifestations, including jaundice, dark urine, and anemia-related symptoms, in addition to general loxoscelism symptoms such as skin lesions, fever, myalgia, nausea, and vomiting. Prompt diagnosis is crucial and requires recognizing typical laboratory findings such as low hemoglobin, elevated lactate dehydrogenase, reduced haptoglobin levels, and possibly a positive direct antiglobulin test...
October 2023: Curēus
https://read.qxmd.com/read/37950477/cutaneous-visceral-loxoscelism-with-delayed-hemolysis-in-an-adolescent
#12
JOURNAL ARTICLE
Pradeep Kumar Gunasekaran, Bharat Choudhary, Megha Patel, Saurabh Singh
No abstract text is available yet for this article.
November 15, 2023: Indian Pediatrics
https://read.qxmd.com/read/37927720/acute-on-chronic-liver-failure-triggered-by-cutaneous-loxoscelism
#13
Francisco Javier Alvarez-Rubio, Arturo Robles-Tenorio, Víctor Manuel Tarango-Martínez
Acute-on-chronic liver failure is a syndrome associated with a high short-term mortality rate. Severe systemic inflammation and single- and multiple-organ failure are a hallmark of this syndrome, with pro-inflammatory precipitating events occurring in the liver or extrahepatic regions. We report a case of a 69-year-old man with a previous diagnosis of alcohol-induced liver cirrhosis who presented with a poorly defined, erythematous-purplish, and edematous plaque with multiple hemorrhagic blisters over the left leg, one day after receiving a spider bite...
October 2023: Curēus
https://read.qxmd.com/read/37888620/the-health-status-of-horses-used-for-at-least-six-complete-cycles-of-loxoscelic-antivenom-production
#14
JOURNAL ARTICLE
Ana Luísa Soares de Miranda, Bruno Cesar Antunes, João Carlos Minozzo, Sabrina de Almeida Lima, Ana Flávia Machado Botelho, Marco Túlio Gomes Campos, Carlos Chávez-Olórtegui, Benito Soto-Blanco
Antivenom production against Loxosceles venom relies on horses being immunized and bled for plasma harvest. One horse can partake in several cycles of antivenom production, which will require years of constant venom and adjuvant inoculation and bleeding. The actual impact on the health of horses that participate in several antivenom-producing cycles is unknown. Therefore, this study aimed to evaluate the general health status of horses that underwent at least six cycles of loxoscelic antivenom production. Seven crossbred horses that had partaken in six to eight complete antivenom-producing cycles were used and established as the immunized group (IG)...
September 26, 2023: Toxins
https://read.qxmd.com/read/37739813/a-brief-overview-of-the-toxic-sphingomyelinase-ds-of-brown-recluse-spider-venom-and-other-organisms-and-simple-methods-to-detect-production-of-its-signature-cyclic-ceramide-phosphate
#15
JOURNAL ARTICLE
Hannah Lachmayr, Alfred H Merrill
A special category of phospholipase Ds (PLD) in the venom of the brown recluse spider ( Loxosceles reclusa ) and several other Sicariid spiders accounts for the dermonecrosis and many of the other clinical symptoms of envenomation. Related proteins are produced by other organisms including fungi and bacteria. These PLDs are often referred to as sphingomyelinase Ds (SMase D) because they cleave sphingomyelin (SM) to choline and "ceramide phosphate." The lipid product has actually been found to be a novel sphingolipid: ceramide 1,3-cyclic phosphate (Cer1,3P)...
September 22, 2023: Molecular Pharmacology
https://read.qxmd.com/read/37707622/role-of-erbb-and-il-1-signaling-pathways-in-the-dermonecrotic-lesion-induced-by-loxosceles-sphingomyelinases-d
#16
JOURNAL ARTICLE
Bruna Fernandes Pinto, Priscila Hess Lopes, Carlos Eduardo Madureira Trufen, Ana Tung Ching Ching, Inácio de Loiola Meirelles Junqueira De Azevedo, Milton Yutaka Nishiyama, Paula Cristiane Pohl, Denise V Tambourgi
Sphingomyelinase D (SMase D), the main toxic component of Loxosceles venom, has a well-documented role on dermonecrotic lesion triggered by envenomation with these species; however, the intracellular mechanisms involved in this event are still poorly known. Through differential transcriptomics of human keratinocytes treated with L. laeta or L. intermedia SMases D, we identified 323 DEGs, common to both treatments, as well as upregulation of molecules involved in the IL-1 and ErbB signaling. Since these pathways are related to inflammation and wound healing, respectively, we investigated the relative expression of some molecules related to these pathways by RT-qPCR and observed different expression profiles over time...
December 2023: Archives of Toxicology
https://read.qxmd.com/read/37569382/comparative-biochemical-structural-and-functional-analysis-of-recombinant-phospholipases-d-from-three-loxosceles-spider-venoms
#17
JOURNAL ARTICLE
Hanna Câmara da Justa, Jorge Enrique Hernández González, Larissa Vuitika, Ricardo Barros Mariutti, Pedro Augusto Martinho Magnago, Fábio Rogério de Moraes, Andrea Senff-Ribeiro, Luiza Helena Gremski, Raghuvir Krishnaswamy Arni, Silvio Sanches Veiga
Spiders of Loxosceles genus are widely distributed and their venoms contain phospholipases D (PLDs), which degrade phospholipids and trigger inflammatory responses, dermonecrosis, hematological changes, and renal injuries. Biochemical, functional, and structural properties of three recombinant PLDs from L. intermedia , L. laeta, and L. gaucho , the principal species clinically relevant in South America, were analyzed. Sera against L. gaucho and L. laeta PLDs strongly cross-reacted with other PLDs, but sera against L...
July 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37521219/kounis-syndrome-a-rare-case-of-allergic-angina-secondary-to-loxoscelism
#18
Alpana Mohta, Alok Mohta, Apoorv Mohta
Kounis syndrome or allergic angina is characterized by a sudden transient or permanent myocardial dysfunction caused by inflammatory mediators such as histamine, leukotrienes, platelet-activating factor, neutral proteases, and a number of cytokines and chemokines. Herein, we discuss a case of Kounis syndrome, which was brought on by loxoscelism.
2023: Indian Dermatology Online Journal
https://read.qxmd.com/read/37399872/identification-of-a-common-epitope-in-knottins-and-phospholipases-d-present-in-loxosceles-sp-venom-by-a-monoclonal-antibody
#19
JOURNAL ARTICLE
Camila Alves-Mondini, Martina Beltramino, Isabella Gizzi Jiacomini, Sabrina Karim-Silva, Nicolle Dos Santos Antunes, Juliana de Moura, Nicolas Aubrey, Philippe Billiald, Ricardo Andrez Machado-de-Ávila, Larissa M Alvarenga, Alessandra Becker-Finco
In the Americas and specially in Brazil, the Loxosceles intermedia, Loxosceles gaucho and Loxosceles laeta are the three most medically relevant brown spider species, and whose bites can lead to the condition known as loxoscelism. Here, we report the development of a tool capable of identifying a common epitope amongst Loxosceles sp. venom's toxins. A murine monoclonal antibody (LmAb12) and its recombinant fragments (scFv12P and diabody12P) have been produced and characterized. This antibody and its recombinant constructs were able to recognize proteins of Loxosceles spider venoms with specificity...
July 1, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37011787/partial-characterization-of-loxosceles-anomala-mello-leit%C3%A3-o-1917-venom-a-brown-spider-of-potential-medical-concern
#20
JOURNAL ARTICLE
Pamella Peres-Damásio, Rafaela Silva-Magalhães, Ana Luiza Silva-Araújo, Elaine Henriques Teixeira Pereira, Adriano Lima Silveira, Luana Silveira da Rocha Nowicki Varella, Márcia Helena Borges, Carlos Chavez-Olórtegui, Ana Luiza Bittencourt Paiva, Clara Guerra-Duarte
The spider's genus Loxosceles (also known as "brown spiders") is one of the few ones of medical importance in Brazil, being Loxosceles anomala a species of common occurrence in the Southeast region. This species is usually smaller in size than the other members of the Loxosceles group. A single human accident involving L. anomala was reported to date and the clinical picture shared similar characteristics with accidents caused by other Loxosceles species. Despite the potential relevance of L. anomalafor loxocelism in Minas Gerais state, its venom activity has never been characterized...
June 1, 2023: Toxicon: Official Journal of the International Society on Toxinology
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