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https://www.readbyqxmd.com/read/27615597/circulating-angiotensin-converting-enzyme-2-activity-as-a-biomarker-of-silent-atherosclerosis-in-patients-with-chronic-kidney-disease
#1
Lidia Anguiano, Marta Riera, Julio Pascual, José Manuel Valdivielso, Clara Barrios, Angels Betriu, Sergi Clotet, Sergi Mojal, Elvira Fernández, María José Soler
BACKGROUND AND AIMS: Circulating Angiotensin Converting Enzyme 2 (ACE2) activity in chronic kidney disease (CKD) patients without previous history of cardiovascular disease (CVD) has been associated with classical risk factors (older age, diabetes and male gender). Furthermore, silent atherosclerosis has been described as a pathological link between CKD and CVD. We analyzed baseline ACE2 activity in non-dialysis CKD stages 3-5 (CKD3-5) patients as a biomarker of renal progression, silent atherosclerosis and CV events after 2 years of follow-up...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27566835/mineral-metabolism-factors-predict-accelerated-progression-of-common-carotid-intima-media-thickness-in-chronic-kidney-disease-the-nefrona-study
#2
Maria Abajo, Àngels Betriu, David Arroyo, Marta Gracia, M Dolores Del Pino, Isabel Martínez, Jose M Valdivielso, Elvira Fernández
BACK GROUND: The leading cause of premature death in chronic kidney disease (CKD) is cardiovascular disease (CVD), but risk assessment in renal patients is challenging. The aim of the study was to analyse the factors that predict accelerated progression of common carotid intima-media thickness (CCIMT) in a CKD cohort after 2 years of follow-up (2010-12). METHODS: The study included 1152 patients from the NEFRONA cohort with CKD stages 3-5D and without a clinical history of CVD...
August 27, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27190385/factors-influencing-pathological-ankle-brachial-index-values-along-the-chronic-kidney-disease-spectrum-the-nefrona-study
#3
David Arroyo, Angels Betriu, Joan Valls, Jose L Gorriz, Vicente Pallares, Maria Abajo, Marta Gracia, Jose Manuel Valdivielso, Elvira Fernandez
BACKGROUND: The ankle-brachial index (ABI) is widely used to diagnose subclinical peripheral artery disease (PAD) in the general population, but data assessing its prevalence and related factors in different chronic kidney disease (CKD) stages are scarce. The aim of this study is to evaluate the prevalence and associated factors of pathological ABI values in CKD patients. METHODS: NEFRONA is a multicentre prospective project that included 2445 CKD patients from 81 centres and 559 non-CKD subjects from 9 primary care centres across Spain...
May 4, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26177272/diabetic-nephropathy-is-an-independent-factor-associated-to-severe-subclinical-atheromatous-disease
#4
MULTICENTER STUDY
Clara Barrios, Julio Pascual, Sol Otero, Maria J Soler, Eva Rodríguez, Silvia Collado, Anna Faura, Sergi Mojal, Juan F Navarro-González, Angels Betriu, Elvira Fernandez, Jose M Valdivielso
BACKGROUND: Atheromatous disease (AD) is a risk factor for death in renal patients. Traditional CV risk factors do not predict the presence of AD in this population. The aim of this study is to analyze whether the etiology of the primary renal disease influences in the risk of having silent AD. STUDY DESIGN: Observational cross-sectional study in chronic kidney disease patients without previous cardiovascular events. SETTINGS AND PARTICIPANTS: 2436 CKD subjects without any previous CV event included in the prospective Spanish multicenter NEFRONA study...
September 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25813276/circulating-angiotensin-converting-enzyme-2-activity-in-patients-with-chronic-kidney-disease-without-previous-history-of-cardiovascular-disease
#5
COMPARATIVE STUDY
Lidia Anguiano, Marta Riera, Julio Pascual, José Manuel Valdivielso, Clara Barrios, Angels Betriu, Sergi Mojal, Elvira Fernández, María José Soler
BACKGROUND: Patients with cardiovascular (CV) disease have an increased circulating angiotensin-converting enzyme 2 (ACE2) activity, but there is little information about changes in ACE2 in chronic kidney disease (CKD) patients without history of CV disease. We examined circulating ACE2 activity in CKD patients at stages 3-5 (CKD3-5) and in dialysis (CKD5D) without any history of CV disease. METHODS: Circulating ACE2 activity was measured in human ethylenediamine-tetraacetic acid (EDTA)-plasma samples from the NEFRONA study (n = 2572): control group (CONT) (n = 568), CKD3-5 (n = 1458) and CKD5D (n = 546)...
July 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25748053/association-of-serum-phosphorus-with-subclinical-atherosclerosis-in-chronic-kidney-disease-sex-makes-a-difference
#6
MULTICENTER STUDY
Marisa Martín, Joan Valls, Angels Betriu, Elvira Fernández, Jose M Valdivielso
BACKGROUND: Cardiovascular disease is the leading cause of mortality in chronic kidney disease (CKD). Serum phosphate has been associated to cardiovascular disease in the general population and this effect seems to be different according to sex. In the present study we analyze the effect of phosphate on subclinical atherosclerosis in the NEFRONA population and its effect depending on sex. DESIGN: Carotid ultrasound assessing the presence of plaques was performed by an itinerant team in 1687 CKD patients not in dialysis without previous cardiovascular events...
July 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25326683/observational-multicenter-study-to-evaluate-the-prevalence-and-prognosis-of-subclinical-atheromatosis-in-a-spanish-chronic-kidney-disease-cohort-baseline-data-from-the-nefrona-study
#7
MULTICENTER STUDY
David Arroyo, Angels Betriu, Montserrat Martinez-Alonso, Teresa Vidal, Jose Manuel Valdivielso, Elvira Fernández
BACKGROUND: Cardiovascular events (CVE) are more prevalent in chronic kidney disease (CKD) than in general population, being the main cause of morbimortality. Specific risk factors related to CKD have been suggested, because traditional factors do not fully explain this increase in cardiovascular disease rates. However, the role of atheromatosis, its pathogenesis and evolution are still unclear. The potential use of diagnostic tests to detect subclinical atheromatosis has to be determined...
2014: BMC Nephrology
https://www.readbyqxmd.com/read/24586070/prevalence-of-subclinical-atheromatosis-and-associated-risk-factors-in-chronic-kidney-disease-the-nefrona-study
#8
MULTICENTER STUDY
Angels Betriu, Montserrat Martinez-Alonso, Maria Vittoria Arcidiacono, Jorge Cannata-Andia, Julio Pascual, José Manuel Valdivielso, Elvira Fernández
BACKGROUND: The causes of the high cardiovascular mortality observed in chronic kidney disease (CKD) are unknown. Here, we report data on prevalence of subclinical atherosclerosis in the NEFRONA population and a stratified multivariate logistic analysis of factors associated with the presence of plaque. METHODS: We analysed 2445 patients with an estimated glomerular filtration rate (eGFR) <60 mL/min (CKD 3: 937; CKD 4-5: 820; CKD 5D: 688) and 559 non-CKD subjects (eGFR >60 mL/min), 18-75 years old, without previous cardiovascular events...
July 2014: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/21270907/nefrona-project-open-access-database
#9
EDITORIAL
E Fernández, A Martínez Castelao
No abstract text is available yet for this article.
2011: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/20609210/predicting-cardiovascular-disease-morbidity-and-mortality-in-chronic-kidney-disease-in-spain-the-rationale-and-design-of-nefrona-a-prospective-multicenter-observational-cohort-study
#10
Mireia Junyent, Montserrat Martínez, Mercè Borràs, Blai Coll, Jose Manuel Valdivielso, Teresa Vidal, Felipe Sarró, Jordi Roig, Lourdes Craver, Elvira Fernández
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of traditional risk factors to fully account for the elevated CVD risk (reverse epidemiology effect) and the presence of emerging risk factors specifically related to kidney failure. Therefore, diagnostic tools capable of improving cardiovascular risk assessment beyond traditional risk factors are currently warranted...
2010: BMC Nephrology
https://www.readbyqxmd.com/read/20098474/-usefulness-of-imaging-techniques-and-novel-biomarkers-in-the-prediction-of-cardiovascular-risk-in-patients-with-chronic-kidney-disease-in-spain-the-nefrona-project
#11
M Junyent, M Martínez, M Borrás, A Bertriu, B Coll, L Craver, M P Marco, F Sarró, J M Valdivielso, E Fernández
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of traditional risk factors to fully account for the elevated CVD risk, mainly due to the reverse epidemiology effect, and the presence of risk factors specifically related to uremia. Hereby, we present the protocol of a prospective study aimed to assess the predictive value of imaging techniques and biomarkers for CVD in patients with CKD...
2010: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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