Diego Martínez-López, Raquel Roldan-Montero, Fernando García-Marqués, Estefania Nuñez, Inmaculada Jorge, Emilio Camafeita, Pablo Minguez, Santiago Rodriguez de Cordoba, Beatriz López-Melgar, Enrique Lara-Pezzi, Antonio Fernández-Ortiz, Borja Ibáñez, Jose Manuel Valdivielso, Valentín Fuster, Jean-Baptiste Michel, Luis Miguel Blanco-Colio, Jesús Vázquez, Jose Luis Martin-Ventura
BACKGROUND: The mechanisms underlying early atherosclerotic plaque formation are not completely understood. Moreover, plasma biomarkers of subclinical atherosclerosis are lacking. OBJECTIVES: The purpose of this study was to analyze the temporal and topologically resolved protein changes taking place in human aortas with early atherosclerosis to find new potential diagnostic and/or therapeutic targets. METHODS: The protein composition of healthy aortas (media layer) or with early atheroma (fatty streak and fibrolipidic, media and intima layers) was analyzed by deep quantitative multiplexed proteomics...
April 28, 2020: Journal of the American College of Cardiology