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https://www.readbyqxmd.com/read/29624892/antibiotic-mediated-bacteriome-depletion-in-apc-min-mice-is-associated-with-reduction-in-mucus-producing-goblet-cells-and-increased-colorectal-cancer-progression
#1
Kamaljeet Kaur, Arpit Saxena, Irina Debnath, Jacqueline L O'Brien, Nadim J Ajami, Thomas A Auchtung, Joseph F Petrosino, Alexander-Jacques Sougiannis, Sarah Depaep, Alexander Chumanevich, Phani M Gummadidala, Mayomi H Omebeyinje, Sourav Banerjee, Ioulia Chatzistamou, Paramita Chakraborty, Raja Fayad, Franklin G Berger, James A Carson, Anindya Chanda
Recent epidemiological evidence suggests that exposure to antibiotics in early-to-middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis...
April 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29615825/epigenetic-alterations-to-polycomb-targets-precede-malignant-transition-in-a-mouse-model-of-breast-cancer
#2
Ying Cai, Jhih-Rong Lin, Quanwei Zhang, Kelly O'Brien, Cristina Montagna, Zhengdong D Zhang
Malignant breast cancer remains a major health threat to women of all ages worldwide and epigenetic variations on DNA methylation have been widely reported in cancers of different types. We profiled DNA methylation with ERRBS (Enhanced Reduced Representation Bisulfite Sequencing) across four main stages of tumor progression in the MMTV-PyMT mouse model (hyperplasia, adenoma/mammary intraepithelial neoplasia, early carcinoma and late carcinoma), during which malignant transition occurs. We identified a large number of differentially methylated cytosines (DMCs) in tumors relative to age-matched normal mammary glands from FVB mice...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29607395/efficacy-of-endocuff-assisted-colonoscopy-in-the-detection-of-colorectal-polyps
#3
Yoshiki Wada, Masayoshi Fukuda, Kazuo Ohtsuka, Mamoru Watanabe, Yumiko Fukuma, Yoko Wada, Masahiro Wada
Background and study aims : Colonoscopy is the gold standard for detecting colorectal adenomas and cancers. Endoscopic surveillance has been shown to be effective for preventing colorectal cancer. Although detection of colorectal polyps at an early stage is important, endoscopic visualization of early neoplasia can be difficult. The Endocuff is a new device that can be attached to the tip of the colonoscope to hold the colonic folds away from the field of view during withdrawal. The aim of this study was to compare the adenoma detection rate (ADR) and the mean number of adenomas detected per patient (MAP) achieved using Endocuff-assisted colonoscopy (EAC) and standard colonoscopy (SC)...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29603824/expression-of-protein-arginine-methyltransferase-5-in-oral-squamous-cell-carcinoma-and-its-significance-in-epithelial-to-mesenchymal-transition
#4
Yusuke Amano, Daisuke Matsubara, Taichiro Yoshimoto, Tomoko Tamura, Hiroshi Nishino, Yoshiyuki Mori, Toshiro Niki
Protein arginine methyltransferases (PRMT) 5, a member of type II arginine methyltransferases, catalyzes the symmetrical dimethylation of arginine residues on histone and non-histone substrates. Although the overexpression of PRMT5 has been reported in various cancers, its role in oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, we immunohistochemically examined the expression of PRMT5 in surgically resected oral epithelial dysplasia (OED, n = 8), oral intraepithelial neoplasia (OIN)/carcinoma in situ (CIS) (n = 11) and OSCC (n = 52) with or without contiguous OED lesions...
March 30, 2018: Pathology International
https://www.readbyqxmd.com/read/29600361/macroscopic-assessment-and-cut-up-of-endoscopic-resection-specimens-for-early-esophageal-glandular-malignancies
#5
Benjamin M Allanson, M Priyanthi Kumarasinghe
Pathological assessment of tissue is the gold standard for diagnosis and staging of neoplasia and provides key prognostic information for clinical management. Proper macroscopic assessment and cut-up technique is essential to ensure that the overall assessment is correct and reproducible. Endoscopic mucosal resection is a technique used for removing early neoplastic glandular lesions of the esophagus at the level of submucosa. Here, we describe the macroscopic assessment and dissection techniques used for the routine handling of endoscopic mucosal resection specimens in the clinical laboratory...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29596773/-fulminant-emphysematous-pyelonephritis-secondary-to-urothelial-neoplasia-with-reno-colic-fistula
#6
Ana Rita Elvas, Bruno Jorge Pereira, Filipa Carrega, Leopoldina Vicente
The emphysematous pyelonephritis is a uncommon and potentially fatal entity. The recognition of this condition enables the early correct management of patients. Diabetes and ureteral obstruction are the main risk factors identified. We present the case of a patient with no relevant risk factors or prior medical history, in which the reason of admission to the emergency department was back pain, eventually evolving into septic shock in the early hours. The imaging tests identified the presence of peri-renal and subcutaneous gas which guided the medical team to the right diagnosis (emphysematous pyelonephritis secondary to fistulized urothelial neoplasia) and the optimal surgical treatment...
February 28, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29587290/chemoprevention-and-treatment-of-pancreatic-cancer-update-and-review-of-the-literature
#7
Julia Benzel, Volker Fendrich
BACKGROUND: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29581795/the-association-of-digit-ratio-2d-4d-with-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Adomas Bunevicius
Objective: Intrauterine sex hormone environment as indicated by the second to the fourth digit ratio (2D : 4D) can be associated with cancer risk. This systematic review and meta-analysis aimed to evaluate the association of 2D : 4D with cancer diagnosis, malignancy, and age at presentation. Methods: Studies that evaluated the association of 2D : 4D with cancer risk were collected from Pubmed/MEDLINE and Clarivate Analytics databases. Nineteen studies were included in the qualitative analysis...
2018: Disease Markers
https://www.readbyqxmd.com/read/29577937/hepatitis-c-virus-hcv-mimics-effects-of-glypican-3-gpc3-on-cd81-and-promotes-development-of-hepatocellular-carcinomas-via-activation-of-hippo-pathway-in-hepatocytes
#9
Yuhua Xue, Wendy M Mars, William Bowen, Aatur D Singhi, John Stoops, George K Michalopoulos
Glypican 3 (GPC3) is over-expressed in hepatocellular carcinomas (HCC). GPC3 binds to CD81. Forced expression of CD81 in a GPC3 expressing HCC cell line caused activation of Hippo, decrease in Ezrin phosphorylation, and decrease in Yap. CD81 is also associated with HCV entry into hepatocytes. Activation of CD81 by agonistic antibody causes activation of spleen kinase (Syk) and phosphorylation of Ezrin, a regulator of Hippo pathway. In cultures of normal hepatocytes, CD81 agonistic antibody led to enhanced phosphorylation of Ezrin and increase in nuclear Yap...
March 22, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29573963/high-rate-of-over-staging-of-barrett-s-neoplasia-with-endoscopic-ultrasound-systemic-review-and-meta-analysis
#10
REVIEW
Bashar J Qumseya, Michael J Bartel, Sherif Gendy, Paul Bain, Amira Qumseya, Herbert Wolfsen
BACKGROUND: The use of endoscopic ultrasound (EUS) to stage patients with Barrett's esophagus (BE) with suspected neoplasia is controversial due to high rates of over-staging. However, this rate of over-staging has not been adequately investigated or quantified. AIM: To determine the rate of over-staging related EUS in this population. METHODS: Search included Medline, Embase, Web of Science, and Cochrane Central ending on 9/30/2016. The primary effect-estimate of interest was the false positive rate of advanced disease on EUS at the tumor level (T1a vs...
March 1, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29568659/primary-nocardia-infection-causing-a-fluorodeoxyglucose-avid-right-renal-mass-in-a-redo-lung-transplant-recipient
#11
Sreeja Biswas Roy, Mitchell D Ross, Pradnya D Patil, Richard Trepeta, Ross M Bremner, Tanmay S Panchabhai
Immunosuppression after lung transplantation may increase susceptibility to opportunistic infection and is associated with early and delayed deaths in lung transplant recipients. Factors that may predispose lung transplant recipients to opportunistic bacterial and fungal infections include prolonged corticosteroid use, renal impairment, treatment of acute rejection, and post-transplant diabetes mellitus. We present a unique case of a 63-year-old woman with diabetes mellitus who underwent redo lung transplantation...
2018: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29562930/telomerase-promoter-mutations-in-human-immunodeficiency-virus-related-conjunctiva-neoplasia
#12
Noemy Starita, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HIV on the occurrence of telomerase reverse transcriptase (TERT) promoter mutations among a cohort of conjunctiva neoplasia Ugandan patients. METHODS: Telomerase reverse transcriptase promoter mutations were searched in 72 conjunctiva neoplasia cases, comprising SCC and intraepithelial neoplasia grade 1-3 (CIN1-3), as well as in 53 conjunctiva normal tissues and in 24 HIV-related Kaposi sarcoma...
March 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29559813/ocular-surface-squamous-neoplasia-in-hiv-infected-patients-current-perspectives
#13
REVIEW
Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki
Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure...
2018: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/29551245/early-esophageal-squamous-cell-carcinoma-management-through-endoscopic-submucosal-dissection
#14
V Arantes, J Espinoza-Ríos
The incidence of esophageal cancer is steadily increasing worldwide. Outcome is poor, given that the majority of cases are diagnosed at advanced disease stages. However, when detected at early stages, esophageal tumors can be curatively treated through less invasive methods, resulting in a 5-year survival rate above 90%. Therefore, it is essential to identify the high-risk population and recommend those patients undergo screening using high-resolution endoscopy, adding the resources of chromoendoscopy with Lugol solution (or digital chromoendoscopy) and magnification...
March 15, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29542870/left-ventricular-myxoma-with-carney-complex
#15
Naoto Kuyama, Yasuhiro Hamatani, Satsuki Fukushima, Yoshihiko Ikeda, Eri Nakai, Atsushi Okada, Hiroyuki Takahama, Makoto Amaki, Takuya Hasegawa, Yasuo Sugano, Hideaki Kanzaki, Tomoyuki Fujita, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Toshihisa Anzai, Junjiro Kobayashi
The left ventricle is a less frequent location of cardiac myxomas overall. Meanwhile, cardiac myxomas related to Carney complex (CNC), which is a multiple neoplasia syndrome involving cardiac, endocrine, neural, and cutaneous tumours, more frequently occur in the left ventricle compared with sporadic cardiac myxomas. Herein, we report a case of a 20-year-old woman with CNC who underwent complete surgical excision of a large and mobile left ventricular myxoma. In our case, echocardiography performed 4 years earlier was normal...
March 15, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29536060/laparoscopic-splenectomy-for-splenic-rupture-secondary-to-metastatic-choriocarcinoma
#16
Tan Ming Ngan Aloysius, Vishalkumar G Shelat
Gestational choriocarcinoma is a rare and aggressive type of gestational trophoblastic neoplasia, which is characterized by early vascular invasion and widespread metastases. Choriocarcinoma metastasizes hematogenously, and bleeding from metastases is common. Splenic rupture from a metastatic tumour is exceedingly rare, with only a few reports. We report a case of a 41-year-old female presenting with acute abdomen and haemorrhagic shock secondary to splenic rupture from metastatic choriocarcinoma, which was managed with emergency laparoscopic splenectomy...
February 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29534888/prognostication-of-superficial-barrett-s-carcinoma-a-japanese-multicenter-study
#17
Junko Aida, Tatsuro Ishizaki, Tomio Arai, Kaiyo Takubo
Endoscopic resection (ER) has become the standard therapy for superficial Barrett's carcinoma (BC) in Japan and other countries. Patients undergoing ER sometimes require additional treatment because of recurrence of lymph node metastasis (LNM). We attempted to clarify the histopathologic risk factors for LNM, and the difference between these risk factors for Japanese patients and the conventional risk factors documented for Western patients. This multi-center study included 12 leading institutions belonging to the Japan Research Society for Early Esophageal Cancer and Chromoendoscopy, and was based on a questionnaire designed to gather data on the features of superficial BC cases, except for high-grade intraepithelial neoplasia, treated at those institutions...
March 10, 2018: Human Pathology
https://www.readbyqxmd.com/read/29529089/rage-specific-single-chain-fv-for-pet-imaging-of-pancreatic-cancer
#18
Hye-Yeong Kim, Xiaolei Wang, Rui Kang, Daolin Tang, Brian A Boone, Herbert J Zeh, Michael T Lotze, W Barry Edwards
Noninvasive detection of both early pancreatic neoplasia and metastases could enhance strategies to improve patient survival in this disease that is notorious for an extremely poor prognosis. There are almost no identifiable targets for non-invasive diagnosis by positron emission tomography (PET) for patients with pancreatic ductal adenocarcinoma (PDAC). Over-expression of the receptor for advanced glycation end products (RAGE) is found on the cell surface of both pre-neoplastic lesions and invasive PDAC. Here, a RAGE-specific single chain (scFv) was developed, specific for PET imaging in syngeneic mouse models of PDAC...
2018: PloS One
https://www.readbyqxmd.com/read/29517459/a-retrospective-study-of-morbidity-and-mortality-in-the-north-american-amur-leopard-panthera-pardus-orientalis-population-in-zoologic-institutions-from-1992-to-2014
#19
Julia E Napier, Michael S Lund, Douglas L Armstrong, Denise McAloose
The Amur leopard ( Panthera pardus orientalis) is one of the most critically endangered leopards on the International Union for the Conservation of Nature red list. The primary objective of this retrospective study was to identify common and significant causes of morbidity and mortality in the North American Amur leopard zoo population. This information provides insights that contribute to their improved care, health, and medical management and, ultimately, affects the sustainability of this leopard subspecies in the wild...
March 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29511550/endoscopic-submucosal-dissection-of-gastric-superficial-neoplastic-lesions-a-single-western-center-experience
#20
Lucio Petruzziello, Mariachiara Campanale, Cristiano Spada, Riccardo Ricci, Cesare Hassan, Gaia Gullo, Guido Costamagna
Background: Endoscopic submucosal dissection (ESD) allows "en bloc" resection of superficial gastric lesions. Objective: The aim of this study is to report "en bloc" resection rate, procedure results, post resection features, analysis of complications, and relapses at mid-long term follow-up on an Italian center case series of patients with superficial gastric neoplastic lesions treated with ESD. Methods: This is a retrospective evaluation of a prospectively collected series of patients diagnosed with gastric superficial lesions who underwent ESD between November 2007 and May 2015...
March 2018: United European Gastroenterology Journal
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