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early neoplasia

David H Smith, Maureen O'Keeffe Rosetti, David M Mosen, A Gabriela Rosales, Erin Keast, Nancy Perrin, Adrianne C Feldstein, Theodore R Levin, Elizabeth G Liles
Colorectal cancer (CRC) causes more than 50,000 deaths each year in the United States but early detection through screening yields survival gains; those diagnosed with early stage disease have a 5-year survival greater than 90%, compared to 12% for those diagnosed with late stage disease. Using data from a large integrated health system, this study evaluates the cost-effectiveness of fecal immunochemical testing (FIT), a common CRC screening tool. A probabilistic decision-analytic model was used to examine the costs and outcomes of positive test results from a 1-FIT regimen compared with a 2-FIT regimen...
June 21, 2018: Population Health Management
Alan Rogol, Bradley D Anawalt
Many neoplastic diseases that are common in childhood, adolescence and early adulthood were previously uniformly and swiftly fatal. These neoplastic diseases and their therapies are associated with an increased incidence of multiple endocrinopathies. For example, intracranial neoplasias invade the hypothalamus and/or pituitary and cause deficiencies of growth hormone, gonadotropins, thyrotropin or adrenocorticotropin. Cranial radiation used to treat intra-cranial neoplasia is often associated with progressive hypopituitarism that may take years to develop into a clinically significant endocrinopathy [1]...
June 19, 2018: Clinical Endocrinology
J Ortiz-Fernandez-Sordo, S S Sami, R Mansilla-Vivar, V Subramanian, J Mannath, E Telakis, K Ragunath
No abstract text is available yet for this article.
April 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Liming Zhang, Yulan Liu, Peng You, Guijian Feng
BACKGROUND: Additional data on the incidence of gastric neoplasia in the Chinese atrophic gastritis (AG) population during long-term follow-up are needed and the influence of the endoscopic surveillance interval on gastric neoplasia occurrence remains unknown. AIMS: Retrospectively investigated the occurrence of gastric cancer (GC) and precancerous lesions in AG patients during long-term follow-up and assessed risk factors, such as the endoscopic surveillance interval for the development of gastric neoplasia...
June 16, 2018: Scandinavian Journal of Gastroenterology
Jae Myung Cha, Danielle La Selva, Richard A Kozarek, Michael Gluck, Andrew Ross, Otto S Lin
BACKGROUND AND AIMS: For young individuals (<40) without strong family histories that would put them at risk for genetic colorectal cancer syndromes, it is unclear if national Multi-Society Task Force surveillance recommendations apply or if endoscopists follow these guideline recommendations when such patients are incidentally found to have adenoma(s) on colonoscopy. METHODS: We reviewed records on young (<40-year-old) patients, with either no family history or only a "moderate" family history (one first-degree family member with colorectal cancer at age ≥50), who were found to have neoplastic polyp(s) on their index colonoscopy...
June 13, 2018: Gastrointestinal Endoscopy
Anthony Adimonye, Elzbieta Stankiewicz, Susannah La-Touche, Sakunthala Kudahetti, Giorgia Trevisan, Brendan Tinwell, Cathy Corbishley, Yong-Jie Lu, Nick Watkin, Daniel Berney
BACKGROUND: Therapeutic targeting of the PI3K-AKT-mTOR pathway may benefit patients with advanced penile squamous cell carcinoma (PSCC). OBJECTIVES: To determine the prevalence of PIK3CA copy number gain and correlate this with the activity status of PI3K-AKT-mTOR pathway in pre-malignant penile intraepithelial neoplasia (PeIN) and invasive PSCC. MATERIALS AND METHODS: Archival tissue blocks were obtained from 58 PeIN and 244 primary PSCC patients treated at St George's Hospital...
2018: PloS One
Kyoko Hayakawa, Anthony M Formica, Yuka Nakao, Daiju Ichikawa, Susan A Shinton, Joni Brill-Dashoff, Mitchell R Smith, Herbert C Morse, Richard R Hardy
In mice, fetal/neonatal B-1 cell development generates murine CD5+ B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a VH 11/D/JH knock-in mouse line (VH 11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcholine B1a cells develop in liver, mature in spleen, and distribute in intestine/colon, mesenteric lymph node (mLN), and body cavity as the outcome of B-1 cell development before B-2 cell development. Throughout life, self-renewing B-1 B1a cells circulate through intestine, mesenteric vessel, and blood...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Youichi Kumagai, Tetsuhiko Tachikawa, Morihiro Higashi, Jun Sobajima, Akemi Takahashi, Kunihiko Amano, Minoru Fukuchi, Kei-Ichiro Ishibashi, Erito Mochiki, Koji Yakabi, Jun-Ichi Tamaru, Hideyuki Ishida
BACKGROUND: The relationship between thymidine phosphorylase (TP) and angiogenesis at the early stage of esophageal squamous cell carcinoma has been unclear. METHODS: Using 14 samples of normal squamous epithelium, 11 samples of low-grade intraepithelial neoplasia, and 64 samples of superficial esophageal cancer, microvessel density (MVD) was estimated using immunostaining for CD34 and CD105. TP expression was also evaluated in both cancer cells and stromal monocytic cells (SMCs)...
January 2018: Esophagus: Official Journal of the Japan Esophageal Society
Preithy Uthamalingam, Ashim Das, Arunanshu Behra, Naveen Kalra, Yogesh Chawla
Background and objectives: Histopathological distinction of various nodular lesions in liver with sufficient sensitivity and specificity is a challenge even in an expert set up. The panel of immunohistochemical markers composed of glutamine synthetase (GS), Glypican3 (GPC3) and heat shock protein 70 (HSP70) was recommended by the International Consensus Group for Hepatocellular Neoplasia group for the differentiation of high grade dysplastic nodule and early hepatocellular carcinoma (HCC)...
June 2018: Journal of Clinical and Experimental Hepatology
Julie Richer, Anne-Marie Laberge
PURPOSE: We aimed to assess the definition of actionability of secondary findings in childhood, using a screening framework. METHODS: For 31 disorders on the American College of Medical Genetics and Genomics SF v.2.0 list, World Health Organization screening criteria were applied to assess actionability in childhood. RESULTS: The age of onset was variable. We categorized disorders based on the proportion of cases that presented in childhood: rare (n = 6), fewer than half the cases (n = 9), the majority of cases (n = 12), or unclear (n = 4)...
June 6, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Wouter J den Hollander, I Lisanne Holster, Caroline M den Hoed, Lisette G Capelle, Tjon J Tang, Marie-Paule Anten, Ingrid Prytz-Berset, Ellen M Witteman, Frank Ter Borg, Gijsbert den Hartog, Marco J Bruno, Maikel Petrus Peppelenbosch, Wilco Lesterhuis, Michael Doukas, Ernst J Kuipers, Manon C W Spaander
OBJECTIVE: International guidelines recommend endoscopic surveillance of premalignant gastric lesions. However, the diagnostic yield and preventive effect require further study. We therefore aimed to assess the incidence of neoplastic progression and to assess the ability of various tests to identify patients most at risk for progression. DESIGN: Patients from the Netherlands and Norway with a previous diagnosis of atrophic gastritis (AG), intestinal metaplasia (IM) or dysplasia were offered endoscopic surveillance...
June 6, 2018: Gut
L C Duits, E Klaver, A Bureo Gonzalez, D F Boerwinkel, F J W Ten Kate, G J A Offerhaus, S L Meijer, M Visser, C A Seldenrijk, K K Krishnadath, E J Schoon, Bas L A M Weusten, Rosalie C Mallant-Hent, Roos E Pouw, Jacques J G H M Bergman
Patient selection is suboptimal in most studies focused on identifying biological markers for neoplastic progression in Barrett's esophagus (BE). This study aims to describe a stringently selected community-based case-control cohort of non-dysplastic BE (NDBE) patients who progressed to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) and BE patients who never progressed to be used for future biomarker studies. We identified all patients referred for endoscopic work-up of BE neoplasia at three tertiary referral centers for treatment of BE neoplasia between 2000 and 2013...
June 4, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Margaret A Hill, William B Alexander, Bing Guo, Yasutaka Kato, Krushna Chandra Patra, Michael R O'Dell, Matthew N McCall, Christa L Whitney-Miller, Nabeel Bardeesy, Aram F Hezel
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver cancer epidemiologically linked with liver injury which has poorly understood incipient stages and lacks early diagnostics and effective therapies. While iCCA is conventionally thought to arise from the biliary tract, studies have suggested that both hepatocytes and biliary cells (cholangiocytes) may give rise to iCCA. Consistent with the plasticity of these cell lineages, primary liver carcinomas exhibit a phenotypic range from hepatocellular carcinoma (HCC) to iCCA with intermediates along this spectrum...
June 5, 2018: Cancer Research
Jing Chen, Juan Zhou, Zhenghong Gao, Xue Li, Fa Wang, Xiyu Duan, Gaoming Li, Bishnu Joshi, Rork D Kuick, Henry D Appelman, Thomas Wang
Esophageal adenocarcinoma (EAC) is a molecularly heterogeneous disease that is rising rapidly in incidence and has poor prognosis. We developed a heterobivalent peptide to target detection of early Barrett's neoplasia by combining monomer heptapeptides specific for either EGFR or ErbB2 in a heterodimer configuration. The structure of a triethyleneglycol linker was optimized to maximize binding interactions to the surface receptors on cells. The Cy5.5-labeled heterodimer QRH*-KSP*-E3-Cy5.5 demonstrated specific binding to each target and showed 3-fold greater fluorescence intensity and 2-fold higher affinity compared with either monomer alone...
June 5, 2018: Journal of Medicinal Chemistry
Joakim Dillner, Pär Sparén, Bengt Andrae, Björn Strander
Cervical cancer has increased in Sweden in recent years. The increase is 17% in 2014-15 compared to the reference period 2002-13. The increase is largest for adenocarcinoma (+ 31%) and shows remarkable differences between counties, from continued incidence decreases to increases of >80%. The increase is seen in most ages that are offered screening, but is confined to early stage cancers and there is no increase in mortality. Population test coverage of screening has increased since 2002. The Swedish National Cervical Screening Registry has analysed the increase in relation to screening history...
June 5, 2018: Läkartidningen
Yinjun Lou, Ying Lu, Zhijuan Zhu, Yafang Ma, Shanshan Suo, Yungui Wang, Dong Chen, Hongyan Tong, Wenbin Qian, Haitao Meng, Wenyuan Mai, Wenjun Yu, Weilai Xu, Lei Wang, Liping Mao, Renzhi Pei, Jie Jin
Limited data was available for long-term follow-up in newly diagnosed acute promyelocytic leukemia (APL) patients treated with all-trans-retinoic acid (ATRA) plus intravenously arsenic trioxide (ATO)-based front-line therapy. The aim of this work was to retrospectively analyze the long-term survival rate and frequency of therapy-related myeloid neoplasia (t-MN) occurring in a large cohort of APL patients. A total of 760 newly diagnosed patients with APL between January 1999 and May 2016 were evaluated. The early death rate was 9...
June 3, 2018: Hematological Oncology
Allen Mo, Rong Wu, James P Grady, Matthew P Hanley, Margaret Toro, Helen Swede, Thomas J Devers, Terryl J Hartman, Daniel W Rosenberg
PURPOSE: Excess dietary fat consumption is strongly associated with the risk of colorectal cancer, but less is known about its role in the earliest stages of carcinogenesis, particularly within the proximal colon. In the following case-control study, we evaluated the relationship between the intake of dietary fats and the frequency of early proximal neoplasia [aberrant crypt foci (ACF) or polyps], detectable by high-definition colonoscopy with contrast dye-spray. METHODS: Average-risk screening individuals underwent a high-definition colonoscopy procedure as part of larger ongoing clinical study of precancerous lesions in the proximal colon...
May 30, 2018: Cancer Causes & Control: CCC
Carola Fleischmann, Helmut Messmann
Esophageal squamous cell carcinoma (ESCC) remains the most common esophageal cancer in the world, though a rising incidence of esophageal adenocarcinoma could be seen during the last decade in the western world. There are several known risk factors for ESCC, such as smoking, alcohol consumption, radiation or others. As there is a risk of lymph node metastasis already in early stages, early endoscopic detection is crucial for curative endoscopic treatment options. Therefore, newest techniqual improvements such as enhancement techniques or virtual chromoendoscopy are helpful for the diagnosis of mucosal carcinoma...
May 29, 2018: Minerva Chirurgica
Jacopo Manso, Raffaele Pezzani
Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. It has been undergone to in-depth clinical and laboratory investigations, with the help of the most important research groups of all over the world. Nonetheless the cure for this kind of neoplasia is not right around the corner, given its complexity and multi-faceted feature, that lead researchers to think at "one person one ACC". Currently total resection is the most concrete option for ACC patients, whenever possible. Although years are still necessary for an effective treatment, indubitably the use of mitotane, among the available pharmacological treatments, in the early 60's revolutionized the approach to this rare disease...
May 28, 2018: Minerva Endocrinologica
Marek Kollar, Julius Spicak, Eva Honsova, Jana Krajciova, Zuzana Vackova, Jan Martinek
Probe-based confocal laser endomicroscopy (pCLE) enables realtime histopathological assessment during endoscopic procedures to evaluate epithelial and subepithelial structures with a 1000x magnification. It may be used in various localizations not only in the digestive tract, but its role in clinical practice is still a matter of discussion. The main advantages of pCLE compared to standard biopsies may be: (1) realtime diagnosis, (2) which may be done by the endoscopist and (3) a larger evaluated area compared to standard biopsies...
May 25, 2018: Minerva Chirurgica
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