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https://www.readbyqxmd.com/read/29454182/the-positive-effect-of-venlafaxine-on-central-motor-conduction
#1
Chunyong Li, Fuda Liu, Haiyan Peng, Yongjun Huang, Xuezhu Song, Qi Xie, Yingkai Li, Yan Liu
OBJECTIVES: Using the triple stimulation technique (TST) and conventional transcranial magnetic stimulation (TMS), this study was designed to investigate the effect of venlafaxine on central motor conduction in healthy adults. PATIENTS AND METHODS: In this crossover, self-controlled trial, eight healthy adult volunteers were randomly divided into groups A and B. In group A, the volunteers were administered 1 venlafaxine capsule once daily for 7 consecutive days, followed by a 3-day break...
February 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29454034/add-on-high-frequency-deep-transcranial-magnetic-stimulation-dtms-to-bilateral-prefrontal-cortex-in-depressive-episodes-of-patients-with-major-depressive-disorder-bipolar-disorder-i-and-major-depressive-with-alcohol-use-disorders
#2
Chiara Rapinesi, Georgios D Kotzalidis, Stefano Ferracuti, Nicoletta Girardi, Abraham Zangen, Gabriele Sani, Ruggero N Raccah, Paolo Girardi, Maurizio Pompili, Antonio Del Casale
BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is critically involved in mood and alcohol use disorders. OBJECTIVE: We aimed to investigate the safety of intervention with add-on bilateral prefrontal high-frequency deep transcranial magnetic stimulation (dTMS) and between-group differences in treatment response in patients with different types of depressive episodes, including major depressive episodes in the course of major depressive disorder (MDD), bipolar disorder, type I (BD-I), and MDD with alcohol use disorder (MDAUD)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29452906/extracranial-arterial-wall-volume-is-increased-and-shows-relationships-with-vascular-mri-measures-in-idiopathic-parkinson-s-disease
#3
Stephen Ball, Sarah Al-Bachari, Laura M Parkes, Hedley C A Emsley, Charles N McCollum
OBJECTIVE: Idiopathic Parkinson's disease (IPD) is the second most common neurodegenerative disorder, often complicated by dementia. Cardiovascular risk factors and spontaneous cerebral emboli (SCE) are strongly associated with Alzheimer's (AD) and vascular dementia (VaD). We measured SCE in the middle cerebral artery and arterial wall volume in the extracranial arteries in patients with IPD and controls, and explored the relationships with structural and physiological MRI brain neurovascular measures...
February 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29452150/cerebral-blood-flow-velocity-and-autoregulation-in-paediatric-patients-following-a-global-hypoxic-ischaemic-insult
#4
Marlina E Lovett, Tensing Maa, Melissa G Chung, Nicole F O'Brien
AIM: To describe the cerebral blood flow velocity pattern and investigate cerebral autoregulation using transcranial Doppler ultrasonography (TCD) following a global hypoxic-ischaemic (HI) event in children. METHODS: This was a prospective, observational study in a quaternary-level paediatric intensive care unit. Intubated children, newborn to 17 years admitted to the PICU following HI injury (asphyxia, drowning, cardiac arrest) were eligible for inclusion. TCD was performed daily until post-injury day 8, discharge, or death, whichever occurred earliest...
February 13, 2018: Resuscitation
https://www.readbyqxmd.com/read/29450801/enhancement-of-pain-inhibition-by-working-memory-with-anodal-transcranial-direct-current-stimulation-of-the-left-dorsolateral-prefrontal-cortex
#5
Zoha Deldar, Nabi Rustamov, Suzie Bois, Isabelle Blanchette, Mathieu Piché
The aim of this study was to examine whether transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) enhances pain inhibition by improving working memory (WM). Forty healthy volunteers participated in two tDCS sessions. Pain was evoked by electrical stimulation at the ankle. Participants performed an n-back task (0-back and 2-back). The experimental protocol comprised five counterbalanced conditions (0-back, 2-back, pain, 0-back with pain and 2-back with pain) that were performed twice (pre-tDCS baseline and during tDCS)...
February 15, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29449805/screen-position-preference-offers-a-new-direction-for-action-observation-research-preliminary-findings-using-tms
#6
Martin Riach, David J Wright, Zoë C Franklin, Paul S Holmes
Action observation has been suggested to be an effective adjunct to physical practice in motor (re)learning settings. However, optimal viewing conditions for interventions are yet to be established. Single-pulse transcranial magnetic stimulation (TMS) was used to investigate the effect of two different screen positions and participants' screen position viewing preference on the amplitude of motor evoked potentials (MEPs) during observation of a ball pinch action. Twenty-four participants observed four blocked conditions that contained either a dynamic index finger-thumb ball pinch or a static hand holding a ball in a similar position on a horizontally or vertically positioned screen...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29447137/emerging-therapies-for-neuropathic-pain-new-molecules-or-new-indications-for-old-treatments
#7
Didier Bouhassira, Nadine Attal
Neuropathic pain represents a highly unmet medical need because most of the available treatments have a modest efficacy or dose-limiting side effects. Hence, novel therapeutic perspectives are warranted. Many compounds acting on new pain targets are in preclinical or early clinical development. Only few clinical trials have suggested their clinical relevance in neuropathic pain. This concerns in particular NaV1.7 antagonists and angiotensin type II inhibitors. Another type of emerging drug therapy in neuropathic pain is represented by drugs largely used for other indications, such as botulinum toxin A and the antiepileptic oxcarbazepine, which have recently found to be effective in peripheral neuropathic pain...
March 2018: Pain
https://www.readbyqxmd.com/read/29446753/correction-measurements-and-models-of-electric-fields-in-the-in-vivo-human-brain-during-transcranial-electric-stimulation
#8
Yu Huang, Anli A Liu, Belen Lafon, Daniel Friedman, Michael Dayan, Xiuyuan Wang, Marom Bikson, Werner K Doyle, Orrin Devinsky, Lucas C Parra
No abstract text is available yet for this article.
February 15, 2018: ELife
https://www.readbyqxmd.com/read/29445329/the-effects-of-transcranial-direct-current-stimulation-tdcs-on-psychomotor-and-visual-perception-functions-related-to-driving-skills
#9
Alexander Brunnauer, Felix M Segmiller, Sabine Löschner, Valérie Grun, Frank Padberg, Ulrich Palm
Objective: It could be demonstrated that anodal transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) enhances accuracy in working memory tasks and reaction time in healthy adults and thus may also have an influence on complex everyday tasks like driving a car. However, no studies have applied tDCS to psychomotor skills related to a standard driving test so far. Methods: 10 female and 5 male healthy adults without any medication and history of psychiatric or neurological illness were randomly assigned to two groups receiving active and sham stimulation in a double blind, cross-over study design...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29444972/usefulness-of-adamts13-to-predict-response-to-recanalization-therapies-in-acute-ischemic-stroke
#10
Alejandro Bustamante, MingMing Ning, Teresa García-Berrocoso, Anna Penalba, Cristina Boada, Alba Simats, Jorge Pagola, Marc Ribó, Carlos Molina, Eng Lo, Joan Montaner
OBJECTIVE: We aimed to analyze ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in relation to arterial recanalization in patients treated with IV tissue plasminogen activator (tPA) and in relation to futile recanalization in patients treated with mechanical thrombectomy. METHODS: Acute ischemic stroke patients (n = 108) with documented arterial occlusions treated with IV-tPA were selected. ADAMTS13 activity was measured by ELISA in samples collected before treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444659/right-to-left-shunt-and-subclinical-ischemic-brain-lesions-in-chinese-migraineurs-a-multicentre-mri-study
#11
Xiao-Han Jiang, Si-Bo Wang, Qian Tian, Chi Zhong, Guan-Ling Zhang, Ya-Jie Li, Pan Lin, Yong You, Rong Guo, Ying-Hua Cui, Ying-Qi Xing
BACKGROUND: Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs. METHODS: We enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Participants were all evaluated using contrast-enhanced transcranial Doppler, magnetic resonance imaging (MRI), and completed a questionnaire covering demographics, the main risk factors of vascular disease, and migraine status...
February 14, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29444558/limitations-of-the-endoscopic-endonasal-transcribriform-approach
#12
Neil Majmundar, Naveed Kamal, Renuka Reddy, Jean A Eloy, James K Liu
The endoscopic endonasal transcribriform approach (EETA) has become a useful strategy in the treatment of various anterior skull base pathology, including meningoencephaloceles, olfactory groove meningiomas, schwannomas, esthesioneuroblastomas, and other sinonasal malignancies. However, not all pathologies are optimally treated through this approach due to tumor size, extent of the lesion, vascular involvement, and the presence of intact olfaction. One must be prepared to use a transcranial approach if the EETA is not favorable...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29444557/limits-of-the-endoscopic-transnasal-trans-tubercular-approach
#13
Verena Gellner, Peter V Tomazic
INTRODUCTION: The endoscopic transnasal transsphenoidal transtubercular approach has become a standard alternative approach to neurosurgical transcranial routes for lesions of the anterior skull base in particular pathologies of the anterior tubercle, sphenoid plane, and midline lesions up to the interpeduncular cistern. For both the endoscopic and the transcranial approach indications must strictly be evaluated and tailored to the patients' morphology and condition. The purpose of this review is to evaluate the evidence in literature of the limitations of the endoscopic transtubercular approach...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29444239/therapeutic-efficacy-of-microtube-embedded-chondroitinase-abc-in-a-canine-clinical-model-of-spinal-cord-injury
#14
Hilary Z Hu, Nicolas Granger, S Balakrishna Pai, Ravi V Bellamkonda, Nick D Jeffery
Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies. Laboratory research in experimental animals has identified a large number of potentially translatable interventions but transition to the clinic is not straightforward. Further evidence of efficacy in more clinically-relevant lesions is required to gain sufficient confidence to commence human clinical trials. Of the many therapeutic candidates currently available, intraspinally applied chondroitinase ABC has particularly well documented efficacy in experimental animals...
February 9, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29443433/effects-of-anodal-transcranial-direct-current-stimulation-over-lower-limb-primary-motor-cortex-on-motor-learning-in-healthy-individuals
#15
Águida Foerster, Anirban Dutta, Min-Fang Kuo, Walter Paulus, Michael A Nitsche
Transcranial direct current stimulation (tDCS) is a neuromodulatory technique which alters motor functions in healthy humans and in neurological patients. Most studies so far investigated the effects of tDCS on mechanisms underlying improvements of upper limb performance. To investigate the effect of anodal tDCS over the lower limb motor cortex (M1) on lower limb motor learning in healthy volunteers, we conducted a randomized, single blind and sham-controlled study. Thirty three (25.81 ± 3.85, 14 female) volunteers were included, and received anodal or sham tDCS over the left M1 (M1-tDCS)...
February 14, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29442072/cortical-excitability-correlates-with-the-event-related-desynchronization-during-brain-computer-interface-control
#16
Ian Daly, Caroline Blanchard, Nicholas P Holmes
OBJECTIVE: Brain-computer interfaces (BCIs) based on motor control have been suggested as tools for stroke rehabilitation. Some initial successes have been achieved with this approach, however the mechanism by which they work is not yet fully understood. One possible part of this mechanism is a, previously suggested, relationship between the strength of the event-related desynchronization (ERD), a neural correlate of motor imagination and execution, and corticospinal excitability. Additionally, a key component of BCIs used in neurorehabilitation is the provision of visual feedback to positively reinforce attempts at motor control...
February 14, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29441471/transcranial-direct-current-stimulation-generates-a-transient-increase-of-small-world-in-brain-connectivity-an-eeg-graph-theoretical-analysis
#17
Fabrizio Vecchio, Riccardo Di Iorio, Francesca Miraglia, Giuseppe Granata, Roberto Romanello, Placido Bramanti, Paolo Maria Rossini
Transcranial direct current stimulation (tDCS) is a non-invasive technique able to modulate cortical excitability in a polarity-dependent way. At present, only few studies investigated the effects of tDCS on the modulation of functional connectivity between remote cortical areas. The aim of this study was to investigate-through graph theory analysis-how bipolar tDCS modulate cortical networks high-density EEG recordings were acquired before and after bipolar cathodal, anodal and sham tDCS involving the primary motor and pre-motor cortices of the dominant hemispherein 14 healthy subjects...
February 13, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29441401/exercise-induced-fatigue-in-young-people-advances-and-future-perspectives
#18
REVIEW
Dimitrios A Patikas, Craig A Williams, Sébastien Ratel
PURPOSE: In recent decades, the interest for exercise-induced fatigue in youth has substantially increased, and the effects of growth on the peripheral (muscular) and central (neural) mechanisms underpinning differences in neuromuscular fatigue between healthy children and adults have been described more extensively. The purpose of this review is to retrieve, report, and analyse the findings of studies comparing neuromuscular fatigue between children and adults. Objective measures of the evaluation of the physiological mechanisms are discussed...
February 13, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29441004/reverse-engineering-tone-deafness-disrupting-pitch-matching-by-creating-temporary-dysfunctions-in-the-auditory-motor-network
#19
Anja Hohmann, Psyche Loui, Charles H Li, Gottfried Schlaug
Perceiving and producing vocal sounds are important functions of the auditory-motor system and are fundamental to communication. Prior studies have identified a network of brain regions involved in pitch production, specifically pitch matching. Here we reverse engineer the function of the auditory perception-production network by targeting specific cortical regions (e.g., right and left posterior superior temporal (pSTG) and posterior inferior frontal gyri (pIFG)) with cathodal transcranial direct current stimulation (tDCS)-commonly found to decrease excitability in the underlying cortical region-allowing us to causally test the role of particular nodes in this network...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29440566/comprehensive-systematic-review-summary-treatment-of-cerebellar-motor-dysfunction-and-ataxia-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#20
Theresa A Zesiewicz, George Wilmot, Sheng-Han Kuo, Susan Perlman, Patricia E Greenstein, Sarah H Ying, Tetsuo Ashizawa, S H Subramony, Jeremy D Schmahmann, K P Figueroa, Hidehiro Mizusawa, Ludger Schöls, Jessica D Shaw, Richard M Dubinsky, Melissa J Armstrong, Gary S Gronseth, Kelly L Sullivan
OBJECTIVE: To systematically review evidence regarding ataxia treatment. METHODS: A comprehensive systematic review was performed according to American Academy of Neurology methodology. CONCLUSIONS: For patients with episodic ataxia type 2, 4-aminopyridine 15 mg/d probably reduces ataxia attack frequency over 3 months (1 Class I study). For patients with ataxia of mixed etiology, riluzole probably improves ataxia signs at 8 weeks (1 Class I study)...
February 9, 2018: Neurology
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