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https://www.readbyqxmd.com/read/28346865/repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-executive-function-deficits-in-autism-spectrum-disorder-clinical-trial-approach
#1
Stephanie H Ameis, Zafiris J Daskalakis, Daniel M Blumberger, Pushpal Desarkar, Irene Drmic, Donald J Mabbott, Meng-Chuan Lai, Paul E Croarkin, Peter Szatmari
OBJECTIVE: Executive function (EF) deficits in patients with autism spectrum disorder (ASD) are ubiquitous and understudied. Further, there are no effective, neuroscience-based treatments to address this impairing feature of ASD. Repetitive transcranial magnetic stimulation (rTMS) has demonstrated promise in addressing EF deficits in adult neuropsychiatric disorders. This article will outline the design of a novel randomized-controlled trial of bilateral, 20 Hz, rTMS applied to the dorsolateral prefrontal cortex (DLPFC) for treatment of EF deficits in ASD that is currently ongoing...
March 27, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28343872/orbital-decompression-for-thyroid-eye-disease
#2
Daniel B Rootman
The literature regarding orbital decompression for thyroid eye disease is vast, spanning multiple specialty areas including neurosurgery, head and neck, maxillofacial and ophthalmic plastic surgery. Although techniques have advanced considerably over the more than 100 years during which this procedure has been performed, the four major approaches remain: transorbital, transcranial, transantral and transnasal. The explosion in literature related to orbital decompression has mostly involved minor technical variations on broader surgical themes...
March 23, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28341754/proportional-recovery-from-lower-limb-motor-impairment-after-stroke
#3
Marie-Claire Smith, Winston D Byblow, P Alan Barber, Cathy M Stinear
BACKGROUND AND PURPOSE: In people with preserved corticospinal tract (CST) function after stroke, upper limb impairment resolves by ≈70% within 3 months. This is known as the proportional recovery rule. Patients without CST function do not fit this rule and have worse upper limb outcomes. This study investigated resolution of motor impairment in the lower limb (LL). METHODS: Patients with stroke and LL weakness were assessed 3 days and 3 months after stroke with the LL Fugl-Meyer...
March 24, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28341235/physiological-markers-of-motor-inhibition-during-human-behavior
#4
REVIEW
Julie Duque, Ian Greenhouse, Ludovica Labruna, Richard B Ivry
Transcranial magnetic stimulation (TMS) studies in humans have shown that many behaviors engage processes that suppress excitability within the corticospinal tract. Inhibition of the motor output pathway has been extensively studied in the context of action stopping, where a planned movement needs to be abruptly aborted. Recent TMS work has also revealed markers of motor inhibition during the preparation of movement. Here, we review the evidence for motor inhibition during action stopping and action preparation, focusing on studies that have used TMS to monitor changes in the excitability of the corticospinal pathway...
March 21, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28341161/predictive-position-computations-mediated-by-parietal-areas-tms-evidence
#5
Grace Edwards, Céline Paeye, Philippe Marque, Rufin VanRullen, Patrick Cavanagh
When objects move or the eyes move, the visual system can predict the consequence and generate a percept of the target at its new position. This predictive localization may depend on eye movement control in the frontal eye fields (FEF) and the intraparietal sulcus (IPS) and on motion analysis in the medial temporal area (MT). Across two experiments we examined whether repetitive transcranial magnetic stimulation (rTMS) over right FEF, right IPS, right MT, and a control site, peripheral V1/V2, diminished participants' perception of two cases of predictive position perception: trans-saccadic fusion, and the flash grab illusion, both presented in the contralateral visual field...
March 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28340445/an-updated-meta-analysis-short-term-therapeutic-effects-of-repeated-transcranial-magnetic-stimulation-in-treating-obsessive-compulsive-disorder
#6
REVIEW
Dong-Dong Zhou, Wo Wang, Gao-Mao Wang, Da-Qi Li, Li Kuang
BACKGROUND: This study was conducted to evaluate the short-term therapeutic effects of using repeated transcranial magnetic stimulation (rTMS) to treat obsessive-compulsive disorder (OCD) and to examine potential influencing factors. METHOD: We searched the PubMed, EMBASE, CENTRAL, Wanfang, CNKI, and Sinomed databases on September 18, 2016 and reviewed the references of previous meta-analyses. Sham-controlled, randomized clinical trials using rTMS to treat OCD were included...
March 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340375/repetitive-tms-in-right-sensorimotor-areas-affects-the-selection-and-completion-of-contralateral-movements
#7
Maria Gutierrez-Herrera, Styrmir Saevarsson, Thomas Huber, Joachim Hermsdörfer, Waltraud Stadler
Although the existence of directional motor deficits (DMD) associated with movement planning and/or execution seems to be widely recognized, neglect and single cell studies examining their neuroanatomical foundation have produced contradictory and inconclusive findings. The present study assessed the occurrence of DMD following the application of repetitive transcranial magnetic stimulation (rTMS) over two regions, as commonly reported in the neglect literature, namely the right middle frontal gyrus (rMFG) and the right angular gyrus (rAG)...
February 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28340134/primary-motor-cortex-organization-is-altered-in-persistent-patellofemoral-pain
#8
Maxine Te, Abrahão F Baptista, Lucy S Chipchase, Siobhan M Schabrun
Objective.:  Reorganization of the primary motor cortex (M1) may be a feature of persistent patellofemoral pain (PFP), but no studies have investigated M1 organization in this condition. Here we aimed to examine the organization of the M1 representation of the quadriceps muscles in people with PFP and healthy controls. Design.:  Using a cross-sectional design, the M1 representation of the rectus femoris, vastus lateralis, and vastus medialis was mapped using transcranial magnetic stimulation in 11 individuals with PFP and 11 controls...
March 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339828/single-session-of-functional-electrical-stimulation-assisted-walking-produces-corticomotor-symmetry-changes-related-to-changes-in-poststroke-walking-mechanics
#9
Jacqueline A Palmer, HaoYuan Hsiao, Tamara Wright, Stuart A Binder-Macleod
Background: Recent research demonstrated that symmetry of corticomotor drive to paretic and nonparetic plantarflexor muscles are related to the biomechanical ankle moment strategy that individuals with chronic stroke used to achieve their greatest walking speeds. Rehabilitation strategies that promote corticomotor balance could potentially improve post-stroke walking mechanics and enhance functional ambulation. Objective: To 1) test the effectiveness of a single session of gait training using functional electrical stimulation (FES) to improve plantarflexor corticomotor symmetry and plantarflexion ankle moment symmetry and 2) determine if changes in corticomotor symmetry relate to changes in ankle moment symmetry within the session...
February 23, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28338436/letter-to-the-editor-threshold-criterion-in-transcranial-motor-evoked-potentials
#10
Jose L Sanmillan, Gerard Plans, Andreu Gabarrós, Isabel Fernández-Conejero
No abstract text is available yet for this article.
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28338389/somatosensory-electrical-stimulation-does-not-augment-motor-skill-acquisition-and-intermanual-transfer-in-healthy-young-adults-a-pilot-study
#11
János Négyesi, Menno P Veldman, Kelly M M Berghuis, Marie Javet, József Tihanyi, Tibor Hortobágyi
Sensory input can modify motor function and magnify interlimb transfer. We examined the effects of low-intensity somatosensory electrical stimulation (SES) on motor practice-induced (MP) skill acquisition and intermanual transfer. Participants practiced a visuomotor skill for 25 minutes and received SES to the practice or the transfer arm. Responses to single- and double pulse transcranial magnetic stimulation (TMS) were measured in both extensor carpi radialis. SES did not further increase skill acquisition (RMP: 30...
March 24, 2017: Motor Control
https://www.readbyqxmd.com/read/28337537/is-prepulse-modification-altered-by-continuous-theta-burst-stimulation-dat1-genotype-and-motor-threshold-interact-on-prepulse-modification-following-brain-stimulation
#12
S Notzon, N Vennewald, A Gajewska, A L Klahn, J Diemer, B Winter, I Fohrbeck, V Arolt, P Pauli, K Domschke, P Zwanzger
Previous studies suggest an inhibitory top-down control of the amygdala by the prefrontal cortex (PFC). Both brain regions play a role in the modulation of prepulse modification (PPM) of the acoustic startle response by a pre-stimulus. Repetitive transcranial magnetic stimulation (rTMS) can modulate the activity of the PFC and might thus affect PPM. This study tested the effect of inhibitory rTMS on PPM accounting for a genetic variant of the dopamine transporter gene (DAT1). Healthy participants (N = 102) were stimulated with continuous theta burst stimulation (cTBS, an intense form of inhibitory rTMS) or sham treatment over the right PFC...
March 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28337129/novel-neuromodulation-techniques-to-assess-interhemispheric-communication-in-neural-injury-and-neurodegenerative-diseases
#13
REVIEW
Samuel S Shin, Galit Pelled
Interhemispheric interaction has a major role in various neurobehavioral functions. Its disruption is a major contributor to the pathological changes in the setting of brain injury such as traumatic brain injury, peripheral nerve injury, and stroke, as well as neurodegenerative diseases. Because interhemispheric interaction has a crucial role in functional consequence in these neuropathological states, a review of noninvasive and state-of-the-art molecular based neuromodulation methods that focus on or have the potential to elucidate interhemispheric interaction have been performed...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28337114/precondition-of-right-frontal-region-with-anodal-tdcs-can-restore-the-fear-memory-impairment-induced-by-acpa-in-male-mice
#14
Fariborz Manteghi, Mohammad Nasehi, Mohammad-Reza Zarrindast
Fear memory and learning cause behavioural patterns such as fight or flight responses, which increase survival probability, but unfit processing of fear memory and learning can lead to maladaptive behaviours and maladies such as phobias, Post-Traumatic Stress Disorder (PTSD) and anxiety disorders. The growing prevalence of these maladies shows the need to quest novel methods for their treatment. We used anodal transcranial direct current stimulation (tDCS) on the right frontal region as a precondition neuromodulator and arachidonylcyclopropylamide (ACPA), a selective CB1 cannabinoid receptor agonist, as a fear memory impairing agent to assess their effects on contextual and auditory fear conditioning (reliable model for fear studies)...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28336358/assessing-hemispheric-specialization-for-processing-arithmetic-skills-in-adults-a-functional-transcranial-doppler-ultrasonography-ftcd-study
#15
Veronica M Connaughton, Azhani Amiruddin, Karen L Clunies-Ross, Noel French, Allison M Fox
BACKGROUND: A major model of the cerebral circuits that underpin arithmetic calculation is the triple-code model of numerical processing. This model proposes that the lateralization of mathematical operations is organized across three circuits: a left-hemispheric dominant verbal code; a bilateral magnitude representation of numbers and a bilateral Arabic number code. NEW METHOD: This study simultaneously measured the blood flow of both middle cerebral arteries using functional transcranial Doppler ultrasonography to assess hemispheric specialization during the performance of both language and arithmetic tasks...
March 20, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28334708/repetitive-transcranial-magnetic-stimulation-improved-symptoms-of-obsessive-compulsive-disorders-but-not-executive-functions-results-from-a-randomized-clinical-trial-with-crossover-design-and-sham-condition
#16
Mehran Shayganfard, Leila Jahangard, Marzieh Nazaribadie, Mohammad Haghighi, Mohammad Ahmadpanah, Dena Sadeghi Bahmani, Hafez Bajoghli, Edith Holsboer-Trachsler, Serge Brand
OBJECTIVE: Whereas there is growing evidence that repetitive transcranial magnetic stimulation (rTMS) favorably impacts on symptoms of obsessive-compulsive disorders (OCD), less is known regarding the influence of rTMS on cognitive performance of patients with OCD. Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and executive functions in such patients. METHODS: We assessed 10 patients diagnosed with OCD (mean age: 33.5 years) and treated with a standard medication; they were randomly assigned either to a treatment-first or to a sham-first condition...
March 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28334353/suppression-of-v1-feedback-produces-a-shift-in-the-topographic-representation-of-receptive-fields-of-lgn-cells-by-unmasking-latent-retinal-drives
#17
Jordi Aguila, F Javier Cudeiro, Casto Rivadulla
In awake monkeys, we used repetitive transcranial magnetic stimulation (rTMS) to focally inactivate visual cortex while measuring the responsiveness of parvocellular lateral geniculate nucleus (LGN) neurons. Effects were noted in 64/75 neurons, and could be divided into 2 main groups: (1) for 39 neurons, visual responsiveness decreased and visual latency increased without apparent shift in receptive field (RF) position and (2) a second group (n = 25, 33% of the recorded cells) whose excitability was not compromised, but whose RF position shifted an average of 4...
March 18, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334214/tdcs-modulates-visual-gamma-oscillations-and-basal-alpha-activity-in-occipital-cortices-evidence-from-meg
#18
Tony W Wilson, Timothy J McDermott, Mackenzie S Mills, Nathan M Coolidge, Elizabeth Heinrichs-Graham
Transcranial direct-current stimulation (tDCS) is now a widely used method for modulating the human brain, but the resulting physiological effects are not understood. Recent studies have combined magnetoencephalography (MEG) with simultaneous tDCS to evaluate online changes in occipital alpha and gamma oscillations, but no study to date has quantified the offline (i.e., after tDCS) alterations in these responses. Thirty-five healthy adults received active or sham anodal tDCS to the occipital cortices, and then completed a visual stimulation paradigm during MEG that is known to elicit robust gamma and alpha oscillations...
March 10, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334143/boosting-and-decreasing-action-prediction-abilities-through-excitatory-and-inhibitory-tdcs-of-inferior-frontal-cortex
#19
Alessio Avenanti, Riccardo Paracampo, Laura Annella, Emmanuele Tidoni, Salvatore Maria Aglioti
Influential theories suggest that humans predict others' upcoming actions by using their own motor system as an internal forward model. However, evidence that the motor system is causally essential for predicting others' actions is meager. Using transcranial direct current stimulation (tDCS), we tested the role of the inferior frontal cortex (IFC), in action prediction (AP). We devised a novel AP task where participants observed the initial phases of right-hand reaching-to-grasp actions and had to predict their outcome (i...
March 14, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28333037/cerebral-hemodynamic-with-intra-aortic-balloon-pump-business-as-usual
#20
Juliana Caldas, Ronney B Panerai, Edson Bor-Seng-Shu, Juliano Almeida, Graziela Ferreira, Ligia Cunha, Ricardo Nogueira, Marcelo Oliveira, Fabio Jatene, Thompson Robinson, Ludhmila Hajjar
Intra-aortic balloon pump (IABP) is commonly used as mechanical support after cardiac surgery or cardiac shock. Although its benefits for cardiac function have been well documented, its effects on cerebral circulation are still controversial. We hypothesized that transfer function analysis (TFA) and continuous estimates of dynamic cerebral autoregulation (CA) provide consistent results in the assessment of cerebral autoregulation in patients with IABP. Continuous recordings of blood pressure (BP, intra-arterial line), end-tidal CO2, heart rate and cerebral blood flow velocity (CBFV, transcranial Doppler) were obtained i) 5 minutes with IABP ratio 1:3, ii) 5 minutes, starting 1 minute with the IABP-ON, and continuing for another 4 minutes without pump assistance (IABP-OFF)...
March 23, 2017: Physiological Measurement
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