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https://www.readbyqxmd.com/read/29913436/nefa-sensitive-orai1-expression-in-regulation-of-de-novo-lipogenesis
#1
Bingbing Zhang, Wei Yang, Ying Zou, Ming Li, Han Guo, Hongyou Zhang, Cheng Xia, Chuang Xu
BACKGROUND/AIMS: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with metabolic syndrome and type-2 diabetes. NFκB is known to upregulate Orai1, the Ca2+ channel responsible for store-operated Ca2+ entry. The present study explored the role of NEFA-sensitive NFκB-dependent Orai1 expression in the regulation of lipid synthesis...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913276/is-granulocyte-colony-stimulating-factor-a-new-treatment-for-alcoholic-hepatitis
#2
EDITORIAL
Timothy R Morgan
No abstract text is available yet for this article.
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29912944/increasing-success-and-evolving-barriers-in-the-hepatitis-c-cascade-of-care-during-the-direct-acting-antiviral-era
#3
Autumn Zuckerman, Andrew Douglas, Sam Nwosu, Leena Choi, Cody Chastain
Barriers remain in the hepatitis C virus (HCV) cascade of care (CoC), limiting the overall impact of direct acting antivirals. This study examines movement between the stages of the HCV CoC and identifies reasons why patients and specific patient populations fail to advance through care in a real world population. We performed a single-center, ambispective cohort study of patients receiving care in an outpatient infectious diseases clinic between October 2015 and September 2016. Patients were followed from treatment referral through sustained virologic response...
2018: PloS One
https://www.readbyqxmd.com/read/29912922/impact-of-pre-sarcopenia-in-sorafenib-treatment-for-advanced-hepatocellular-carcinoma
#4
Hitomi Takada, Masayuki Kurosaki, Hiroyuki Nakanishi, Yuka Takahashi, Jun Itakura, Kaoru Tsuchiya, Yutaka Yasui, Nobuharu Tamaki, Kenta Takaura, Yasuyuki Komiyama, Mayu Higuchi, Youhei Kubota, Wann Wang, Mao Okada, Nobuyuki Enomoto, Namiki Izumi
BACKGROUND: The present study aimed to investigate the impact of pre-sarcopenia on the prognosis of patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. METHODS: We enrolled 214 patients (71 ± 10 years old; 166 men and 48 women; 90% Child-Pugh grade A and 10% Child-Pugh grade B) treated with sorafenib in our hospital from July 2009 to August 2016. The muscle volume was measured from CT images just before sorafenib administration using software (SliceOmatic)...
2018: PloS One
https://www.readbyqxmd.com/read/29912897/hepatitis-c-virus-notification-rates-in-australia-are-highest-in-socioeconomically-disadvantaged-areas
#5
Samuel W Hainsworth, Paul M Dietze, David P Wilson, Brett Sutton, Margaret E Hellard, Nick Scott
BACKGROUND: Poor access to health services is a significant barrier to achieving the World Health Organization's hepatitis C virus (HCV) elimination targets. We demonstrate how geospatial analysis can be performed with commonly available data to identify areas with the greatest unmet demand for HCV services. METHODS: We performed an Australia-wide cross-sectional analysis of 2015 HCV notification rates using local government areas (LGAs) as our unit of analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29912589/lactobacillus-plantarum-prevents-and-mitigates-alcohol-induced-disruption-of-colonic-epithelial-tight-junctions-endotoxemia-and-liver-damage-by-an-egf-receptor-dependent-mechanism
#6
Pradeep K Shukla, Avtar S Meena, Bhargavi Manda, Maria Gomes-Solecki, Paula Dietrich, Ioannis Dragatsis, RadhaKrishna Rao
Pathogenesis of alcohol-related diseases such as alcoholic hepatitis involves gut barrier dysfunction, endotoxemia, and toxin-mediated cellular injury. Here we show that Lactobacillus plantarum not only blocks but also mitigates ethanol (EtOH)-induced gut and liver damage in mice. L. plantarum blocks EtOH-induced protein thiol oxidation, and down-regulation of antioxidant gene expression in colon L. plantarum also blocks EtOH-induced expression of TNF-α, IL-1β, IL-6, monocyte chemotactic protein 1 ( MCP1), C-X-C motif chemokine ligand ( CXCL)1, and CXCL2 genes in colon...
June 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29912588/zinc-reduces-hepatic-lipid-deposition-and-activates-lipophagy-via-zn-2-mtf-1-ppar%C3%AE-and-ca-2-camkk%C3%AE-ampk-pathways
#7
Chuan-Chuan Wei, Zhi Luo, Christer Hogstrand, Yi-Huan Xu, Li-Xiang Wu, Guang-Hui Chen, Ya-Xiong Pan, Yu-Feng Song
Zinc (Zn) deficiency is the most consistently discovered nutritional manifestations of fatty liver disease. Although Zn is known to stimulate hepatic lipid oxidation, little is known about its underlying mechanism of action in lipolysis. Given the potential role of lipophagy in lipid metabolism, the purpose of this study was to test the hypothesis that Zn attenuates hepatic lipid accumulation by modulating lipophagy. The present study indicated that Zn is a potent promoter of lipophagy. Zn administration significantly alleviated hepatocellular lipid accumulation and increased the release of free fatty acids in association with enhanced fatty acid oxidation and inhibited lipogenesis, which was accompanied by activation of autophagy...
June 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29910570/the-role-of-biochemical-variations-and-genotype-testing-in-determining-the-virological-response-of-patients-infected-with-hepatitis-c-virus
#8
Abid Shoukat, Mosin S Khan, Syed Mudassar, Zaffar Kawoosa, Altaf H Shah, Showkat Ali Zargar
Background: In hepatitis C virus (HCV), infection viral and IL28B genotype along with many clinical and biochemical factors can influence response rates to pegylated interferon plus ribavirin (Peg-IFN-a/R) therapy and progression to chronic hepatitis C (CHC). Aims: The present study was conducted to determine the effect of biochemical and risk factors on treatment outcome in CHC patients in relation to their viral and host genotype. Settings and Design: The present study was a prospective Pe- IFN efficacy study consisting of Peg-IFN-a/R therapy for 24-48 weeks including 250 HCV infected patients...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29910226/a-compound-heterozygous-mutation-of-lipase-maturation-factor-1-is-responsible-for-hypertriglyceridemia-of-a-patient
#9
Yihui Liu, Jiang Xu, Wanyun Tao, Rong Yu, Xinjiang Zhang
AIM: Dyslipidemia is the most common lipid metabolism disorder in humans, and its etiology remains elusive. Hypertriglyceridemia (HTG) is a type of dyslipidemia that contributes to atherosclerosis and coronary heart disease. Previous studies have demonstrated that mutations in lipoprotein lipase (LPL), apolipoprotein CII (APOC2), apolipoprotein AV (APOA5), glycosylphosphatidylinositol anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1), and glycerol-3 phosphate dehydrogenase 1 (GPD1) are responsible for HTG by using genomic microarrays and next-generation sequencing...
June 15, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29909969/short-term-fasting-reveals-amino-acid-metabolism-as-a-major-sex-discriminating-factor-in-the-liver
#10
Sara Della Torre, Nico Mitro, Clara Meda, Federica Lolli, Silvia Pedretti, Matteo Barcella, Luisa Ottobrini, Daniel Metzger, Donatella Caruso, Adriana Maggi
Sex impacts on liver physiology with severe consequences for energy metabolism and response to xenobiotic, hepatic, and extra-hepatic diseases. The comprehension of the biology subtending sex-related hepatic differences is therefore very relevant in the medical, pharmacological, and dietary perspective. The extensive application of metabolomics paired to transcriptomics here shows that, in the case of short-term fasting, the decision to maintain lipid synthesis using amino acids (aa) as a source of fuel is the key discriminant for the hepatic metabolism of male and female mice...
June 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29909805/the-effect-of-maternal-intake-of-sucrose-or-high-fructose-corn-syrup-hfcs-55-during-gestation-and-lactation-on-lipogenic-gene-expression-in-rat-offspring-at-3-and-12-weeks-of-age
#11
H Kaur, C R Toop, B S Muhlhausler, S Gentili
Perinatal exposure to sucrose or high-fructose corn syrup-55 (HFCS-55) in rats has previously been associated with altered hepatic fat content and composition post-weaning, although the effects on hepatic metabolism are unknown. The current study aimed to determine the sex-specific effects of maternal consumption of sucrose or HFCS-55 on the expression of hepatic lipogenic genes in the offspring. Liver samples were collected from offspring of albino Wistar rats provided with ad libitum access to either water (control), 10% sucrose or 10% HFCS-55 solution during pregnancy and lactation at 3 weeks (control n=16, sucrose n=22, HFCS-55 n=16) and 12 weeks (control n=16, sucrose n=10, HFCS-55 n=16) of age...
June 18, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29909773/chronic-hepatitis-b-virus-infection-and-risk-of-chronic-kidney-disease-a-population-based-prospective-cohort-study-of-0-5-million-chinese-adults
#12
Jiahui Si, Canqing Yu, Yu Guo, Zheng Bian, Chenxi Qin, Ling Yang, Yiping Chen, Li Yin, Hui Li, Jian Lan, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
BACKGROUND: Existing evidence remains inconclusive as to the association between chronic hepatitis B virus (HBV) infection and the risk of chronic kidney disease (CKD). We prospectively examined the association between chronic HBV infection and CKD risk, and the joint associations of HBV infection with established risk factors of several lifestyle factors and prevalent diseases on CKD risk. METHODS: Participants from the China Kadoorie Biobank were enrolled during 2004-2008 and followed up until 31 December 2015...
June 18, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29908940/a-nomogram-integrating-hepatic-reserve-and-tumor-characteristics-for-hepatocellular-carcinoma-following-curative-liver-resection
#13
Bin-Bin Cai, Ke-Qing Shi, Peng Li, Bi-Cheng Chen, Liang Shi, Philip J Johnson, Paul Lai, Hidenori Toyoda, Meng-Tao Zhou
BACKGROUND: Because of the mutual influence of liver dysfunction and malignancy, overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC). We developed a nomogram integrating albumin-bilirubin (ALBI) grade, a new index of hepatic reserve, and tumor characteristics of HCC for predicting OS following curative liver resection. METHODS: The nomogram was built to estimate the probabilities of 1, 3, and 5-y OS based on training cohort of 709 HCC, which was validated in an international independent dataset...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29908921/il-15-and-ifn-%C3%AE-signal-through-the-erk-pathway-to-inhibit-hcv-replication-independent-of-type-i-ifn-signaling
#14
Fatemeh Vahedi, Amanda J Lee, Susan E Collins, Marianne V Chew, Evan Lusty, Branson Chen, Anisha Dubey, Carl D Richards, Jordan J Feld, Rodney S Russell, Karen L Mossman, Ali A Ashkar
Despite effective new treatments for Hepatitis C virus (HCV) infection, development of drug resistance, safety concerns and cost are remaining challenges. More importantly, there is no vaccine available against hepatitis C infection. Recent data suggest that there is a strong correlation between spontaneous HCV clearance and human NK cell function, particularly IFN-γ production. Further, IL-15 has innate antiviral activity and is also one of the main factors that activates NK cells to produce IFN-γ. To examine whether IL-15 and IFN-γ have direct antiviral activity against HCV, Huh7...
June 13, 2018: Cytokine
https://www.readbyqxmd.com/read/29908807/hepatic-phosphorylation-status-of-serine-threonine-kinase-1-mammalian-target-of-rapamycin-signaling-proteins-and-growth-rate-in-holstein-heifer-calves-in-response-to-maternal-supply-of-methionine
#15
T Xu, A S M Alharthi, F Batistel, A Helmbrecht, C Parys, E Trevisi, X Shen, J J Loor
The study investigated whether methionine supply during late pregnancy is associated with liver mammalian target of rapamycin (MTOR) pathway phosphorylation, plasma biomarkers, and growth in heifer calves born to cows fed a control diet (CON) or the control diet plus ethylcellulose rumen-protected methionine (MET; 0.09% of dry matter intake) for the last 28 d prepartum. Calves were fed and managed similarly during the first 56 d of age. Plasma was harvested at birth and 2, 7, 21, 42, and 50 d of age and was used for biomarker profiling...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908303/hemoglobin-adducts-of-furfuryl-alcohol-in-genetically-modified-mouse-models-role-of-endogenous-sulfotransferases-1a1-and-1d1-and-transgenic-human-sulfotransferases-1a1-1a2
#16
Bernhard H Monien, Benjamin Sachse, Walter Meinl, Klaus Abraham, Alfonso Lampen, Hansruedi Glatt
Furfuryl alcohol (FFA) is a heat-induced food contaminant. Conversion by sulfotransferases (SULT) yields 2-sulfoxymethylfuran, which is prone to react with DNA and proteins. In order to monitor the internal FFA exposure we developed a technique for the mass spectrometric quantification of the adduct N-((furan-2-yl)methyl)-valine (FFA-Val) after cleavage from the N-termini of hemoglobin. In the current study the method was applied to investigate the influence of different SULT forms on the adduct formation in wild-type mice and three genetically modified mouse models treated with FFA...
June 13, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29908040/dual-energy-ct-for-noninvasive-staging-of-liver-fibrosis-accuracy-of-iodine-density-measurements-from-contrast-enhanced-data
#17
Keitaro Sofue, Masakatsu Tsurusaki, Achille Mileto, Tomoko Hyodo, Kosuke Sasaki, Tatsuya Nishii, Takaaki Chikugo, Norihisa Yada, Masatoshi Kudo, Kazuro Sugimura, Takamichi Murakami
AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy CT data can noninvasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (noncontrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29907965/the-genetic-architecture-of-diet-induced-hepatic-fibrosis-in-mice
#18
Simon T Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C Davis, Calvin Pan, Darwin L Dirks, Clara E Magyar, Samuel W French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos-Pérez, Nahum Méndez-Sánchez, Luis Macías-Kauffer, Paola León-Mimila, Samuel Canizales-Quinteros, Xia Yang, Simon W Beaven, Adriana Huertas-Vazquez, Aldons J Lusis
We report the genetic analysis of a "humanized" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human APOE*3-Leiden and CETP and fed a "Western" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly dependent on genetic background, with vast differences in the degree of fibrosis. Histological analysis showed features characteristic of human NASH, including macrovesicular steatosis, hepatocellular ballooning, inflammatory foci and pericellular collagen deposition...
June 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29906746/linc-pou3f3-is-overexpressed-in-hepatocellular-carcinoma-and-regulates-cell-proliferation-migration-and-invasion
#19
Yichun Li, Yannan Li, Dan Wang, Qingdong Meng
Linc-POU3F3 showed an up-regulated tendency and functioned as tumor promoter in glioma, esophageal cancer and colorectal cancer. There was no report about the expression pattern and clinical value of linc-POU3F3 in hepatocellular carcinoma. Thus, the purpose of our study is to explore the clinical significance and biological role of linc-POU3F3 in hepatocellular carcinoma. Our results suggested that levels of linc-POU3F3 were dramatically increased in hepatocellular carcinoma tissues and cell lines compared with paired normal hepatic tissues and normal hepatic cell line, respectively...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906476/adar1-affects-hcv-infection-by-modulating-innate-immune-response
#20
Maria Pujantell, Sandra Franco, Iván Galván-Femenía, Roger Badia, Marc Castellví, Edurne Garcia-Vidal, Bonaventura Clotet, Rafael de Cid, Cristina Tural, Miguel A Martínez, Eva Riveira-Muñoz, José A Esté, Ester Ballana
The hepatitis C virus (HCV) is a globally prevalent infectious pathogen. As many as 80% of people infected with HCV do not control the virus and develop a chronic infection. Response to interferon (IFN) therapy is widely variable in chronic HCV infected patients, suggesting that HCV has evolved mechanisms to suppress and evade innate immunity responsible for its control and elimination. Adenosine deaminase acting on RNA 1 (ADAR1) is a relevant factor in the regulation of the innate immune response. The loss of ADAR1 RNA-editing activity and the resulting loss of inosine bases in RNA are critical in producing aberrant RLR-mediated innate immune response, mediated by RNA sensors MDA5 and RIG-I...
June 12, 2018: Antiviral Research
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