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IV acetaminophen

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https://www.readbyqxmd.com/read/29734456/intravenous-acetaminophen-may-be-associated-with-reduced-odds-of-30-day-readmission-after-total-knee-arthroplasty
#1
Michael A Mont, Belinda Lovelace, An T Pham, Ryan N Hansen, Morad Chughtai, Chukwuweike U Gwam, Anton Khlopas, John W Barrington
The purpose of this study was (1) to evaluate 30-day readmission rates in total knee arthroplasty (TKA) patients who either received intravenous (IV) or oral (PO) acetaminophen (APAP) perioperatively and (2) to extrapolate the potential annual cost savings on the national level. This was a review of 190,691 TKA recipients between the years 2012 and 2015 who received either IV ( n  = 56,475) or PO APAP ( n  = 134,216). All-cause readmissions that occurred between patient discharge and 30 days postdischarge were recorded...
May 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29707092/improved-outcomes-associated-with-the-use-of-intravenous-acetaminophen-for-management-of-acute-post-surgical-pain-in-cesarean-sections-and-hysterectomies
#2
Richard D Urman, Elaine A Boing, An T Pham, Victor Khangulov, Randi Fain, Brian H Nathanson, Xuan Zhang, George J Wan, Belinda Lovelace, Jessica Cirillo
Background: Post-surgical pain impacts many patient outcomes. Effective pain management increasingly relies on multimodal analgesia regimens in which acetaminophen (APAP) is a key component. The aim of our study was to examine the impact of oral APAP versus intravenous (IV) APAP as a component of post-surgical pain management after Cesarean sections and hysterectomies. Methods: A retrospective analysis of the Cerner HealthFacts® database (from January, 2011 to December, 2015) was conducted to compare outcomes of Cesarean section and hysterectomy surgery patients who received oral APAP to those who received IV APAP post-surgically...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29676689/intravenous-acetaminophen-for-postoperative-supratentorial-craniotomy-pain-a-prospective-randomized-double-blinded-placebo-controlled-trial
#3
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29659631/the-hemodynamic-effects-of-intravenous-paracetamol-acetaminophen-vs-normal-saline-in-cardiac-surgery-patients-a-single-center-placebo-controlled-randomized-study
#4
Elizabeth Chiam, Rinaldo Bellomo, Leonid Churilov, Laurence Weinberg
The hemodynamic effects of intravenous (IV) paracetamol in patients undergoing cardiac surgery are unknown. We performed a prospective single center placebo controlled randomized study with parallel group design in adult patients undergoing elective cardiac surgery. Participants received paracetamol (1 gram) IV or placebo (an equal volume of 0.9% saline) preoperatively followed by two postoperative doses 6 hours apart. The primary endpoint was the absolute change in systolic (SBP) 30 minutes after the preoperative infusion, analysed using an ANCOVA model...
2018: PloS One
https://www.readbyqxmd.com/read/29628196/effectiveness-of-novel-adjuncts-in-pain-management-following-total-knee-arthroplasty-a-randomized-clinical-trial
#5
Juan C Suarez, Ahmed A Al-Mansoori, Sumit Kanwar, Jesus M Villa, Colin A McNamara, Preetesh D Patel
BACKGROUND: Total knee arthroplasty (TKA) can be associated with significant pain which can negatively impact outcomes. Multiple strategies have been employed to reduce pain. The aim of this study is to compare the effectiveness of 3 different pain management modalities after TKA that included (1) our standardized knee injection cocktail and oral acetaminophen, (2) liposomal bupivacaine periarticular injection and oral acetaminophen, and (3) our standardized knee injection cocktail and intravenous (IV) acetaminophen...
March 12, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29626421/characterisation-of-peroxidasin-activity-in-isolated-extracellular-matrix-and-direct-detection-of-hypobromous-acid-formation
#6
Boushra Bathish, Rufus Turner, Martina Paumann-Page, Anthony J Kettle, Christine C Winterbourn
Peroxidasin is a heme peroxidase that catalyses the oxidation of bromide by hydrogen peroxide to form an essential sulfilimine crosslink between methionine and hydroxylysine residues in collagen IV. We investigated cross-linking by peroxidasin embedded in extracellular matrix isolated from cultured epithelial cells and its sensitivity to alternative substrates and peroxidase inhibitors. Peroxidasin showed peroxidase activity as measured with hydrogen peroxide and Amplex red. Using a specific mass spectrometry assay that measures NADH bromohydrin, we showed definitively that the enzyme releases hypobromous acid (HOBr)...
April 4, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29619627/new-advances-in-acute-postoperative-pain-management
#7
REVIEW
Sukanya Mitra, Daniel Carlyle, Gopal Kodumudi, Vijay Kodumudi, Nalini Vadivelu
PURPOSE OF REVIEW: Postoperative pain remains one of the most common challenges following inpatient and outpatient surgeries. With our advances in modern medicine, pain following surgical procedures still remains a challenge, though significant accomplishments have been made over the past few decades. This article highlights some of the promising new advances and approaches in postoperative pain management. RECENT FINDINGS: Over the last decade, Enhanced Recovery after Surgery (ERAS) pathways and protocols are becoming the benchmark standards for enhancing postoperative recovery...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29578803/opioid-sparing-in-cleft-palate-surgery
#8
Logan Carr, Megan Gray, Brad Morrow, Morgan Brgoch, Donald Mackay, Thomas Samson
OBJECTIVE: This study aimed to determine whether intraoperative acetaminophen was able to decrease opioid consumption, pain scores, and length of stay while increasing oral intake in cleft palate surgery. DESIGN/SETTING/PATIENTS: One hundred consecutive patients with cleft palate who underwent a von Langenbeck or 2-flap palatoplasty and intravelar veloplasty at a tertiary medical center by the 2 senior authors from 2010 to 2015 were reviewed. INTERVENTIONS: Three intraoperative treatment groups were analyzed: intravenous (IV) acetaminophen, per rectal (PR) acetaminophen, and no acetaminophen...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29569172/a-retrospective-evaluation-of-the-perioperative-drug-use-and-comparison-of-its-cost-in-robotic-vs-open-surgery-for-endometrial-cancer
#9
Reshu Agarwal, Anupama Rajanbabu, U G Unnikrishnan
To compare the usage and cost of analgesics (opioid and non-opioids), antiemetics, and IV fluids and its associated costs in robotic vs open staging surgery for endometrial cancer (EC). This retrospective study was performed at a single academic institution from January 2014 to June 2017 in the department of Gynecology Oncology at Amrita Institute of Medical Science, Kerala, India. The study included women with biopsy confirmed clinically early stage endometrial cancer or atypical hyperplasia, who underwent robotic-assisted or open staging surgery...
March 22, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29559326/canadian-trends-in-carpal-tunnel-surgery
#10
Blair Peters, Jennifer L Giuffre
PURPOSE: Treatment patterns of carpal tunnel surgery by members of the American Society of Surgery of the Hand (ASSH) have recently been published. The majority of cases in this study were performed in the general operating room with intravenous (IV) sedation or a Bier block. Patients were most commonly prescribed hydrocodone for postoperative pain. The majority of carpal tunnel releases at our center are performed under local anesthesia alone, with plain acetaminophen (Tylenol) or codeine prescribed for postoperative pain...
March 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29544564/the-analgesic-effect-of-rescue-administration-of-intravenous-acetaminophen-in-cancer-patients-may-be-associated-with-sex-and-opioid-dose-and-the-effect-would-appear-to-patients-administered-under-45-mg-day-opioid-oral-morphine-equivalents
#11
K Niki, Y Okamoto, S Nakajima, E Uejima
There have been no investigations examining the analgesic effect of rescue administration of intravenous acetaminophen (IV APAP) for pain in cancer patients. Fifty cancer patients who received IV APAP for pain at Ashiya Municipal Hospital (Hyogo, Japan) between January 2014 and July 2016 were retrospectively evaluated. The degree of pain was evaluated using a 4-point verbal rating scale. Pain intensity differences ≥ 1 defined the IV APAP effective group, and the patient' characteristics were compared by a medical chart review...
March 5, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29530747/use-of-intravenous-acetaminophen-in-postoperative-pain-management-after-partial-and-full-bony-impacted-third-molar-extractions-a-randomized-double-blind-controlled-trial
#12
Isabel Atencio, Max Beushausen, John J Kowalczyk, Andres Flores-Hidalgo, Nora F Fino, Dale A Baur
PURPOSE: Currently, there is a concern at the national level of the overuse of both prescription and nonprescription opioid use. The purpose of this study was to identify whether the use of the intravenous (IV) formulation of acetaminophen (Ofirmev; Mallinckrodt Pharmaceuticals, Staines-upon-Thames, United Kingdom) is an effective tool in the reduction of postoperative pain, with a secondary goal of reduction of postoperative narcotic use. MATERIALS AND METHODS: A total of 72 patients with previously diagnosed either partial bony or complete bony impacted third molars were selected with care to avoid long-acting local anesthetics or dissociative anesthetic agents...
February 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29514362/impact-of-intravenous-acetaminophen-on-lengths-of-stay-and-discharge-status-after-total-knee-arthroplasty
#13
John W Barrington, Ryan N Hansen, Belinda Lovelace, Elaine A Böing, Morad Chughtai, Jared M Newman, An T Pham, Anton Khlopas, Nipun Sodhi, Assem A Sultan, Michael A Mont
Postoperative pain remains difficult to control after total knee arthroplasty (TKA). While various modalities have been used, they have been associated with several side effects. For example, opioids have many side effects including: sedation, dizziness, nausea, vomiting, constipation, respiratory depression, and can lead to dependency. Recently, intravenous (IV) acetaminophen has been introduced as a method to manage postoperative pain. Therefore, the purpose of this study was to compare the postoperative outcomes of TKA patients who received oral acetaminophen versus IV acetaminophen...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29423816/anaphylactoid-reactions-to-intravenous-n-acetylcysteine-during-treatment-for-acetaminophen-poisoning
#14
Mark Yarema, Puja Chopra, Marco L A Sivilotti, David Johnson, Alberto Nettel-Aguirre, Benoit Bailey, Charlemaigne Victorino, Sophie Gosselin, Roy Purssell, Margaret Thompson, Daniel Spyker, Barry Rumack
BACKGROUND: Anaphylactoid reactions to intravenous (IV) N-acetylcysteine (NAC) are well-recognized adverse events during treatment for acetaminophen (APAP) poisoning. Uncertainty exists regarding their incidence, severity, risk factors, and management. We sought to determine the incidence, risk factors, and treatment of anaphylactoid reactions to IV NAC in a large, national cohort of patients admitted to hospital for acetaminophen overdose. METHODS: This retrospective medical record review included all patients initiated on the 21-h IV NAC protocol for acetaminophen poisoning in 34 Canadian hospitals between February 1980 and November 2005...
February 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29412051/prehospital-analgesia-for-pediatric-trauma-patients-in-iraq-and-afghanistan
#15
Steven G Schauer, Allyson A Arana, Jason F Naylor, Guyon J Hill, Michael D April
BACKGROUND: Previous studies have evaluated prehospital analgesia during combat operations in Iraq and Afghanistan, but were limited to the adult population. However, a significant portion of the casualties of those conflicts were children. We describe the prehospital analgesia administered to wartime pediatric trauma patients. METHODS: We queried the Department of Defense Trauma Registry (DODTR) for all pediatric patients (<18 years of age) admitted to United States and Coalition fixed-facility hospitals in Iraq and Afghanistan from January 2007 to January 2016...
February 7, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29352454/decreased-opioid-consumption-and-enhance-recovery-with-the-addition-of-iv-acetaminophen-in-colorectal-patients-a-prospective-multi-institutional-randomized-double-blinded-placebo-controlled-study-dociva-study
#16
Amir H Aryaie, Sepehr Lalezari, Wallace K Sergent, Yana Puckett, Christopher Juergens, Craig Ratermann, Cari Ogg
BACKGROUND: We hypothesized that administration of IV acetaminophen alone would reduce the opioid consumption in post-operative colorectal surgery and reduce the side effects of narcotics. METHODS: Patients were randomized to receive either IV acetaminophen or placebo in addition to opioid PCA. Primary endpoints evaluated were opioid consumption and pain visual analogue scale score (PVASS) during first 48 h post-operatively. Secondary endpoints evaluated were time of return of GI function (ROGIF), time to diet ordered (TTDO), length of hospital stay (LOHS), and occurrence of ileus...
January 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29277312/-subcostal-transversus-abdominis-plane-block-can-improve-analgesia-after-laparoscopic-cholecystectomy
#17
Vladimir Vrsajkov, Nedjica Mančić, Dunja Mihajlović, Suzana Tonković Milićević, Arsen Uvelin, Jelena Pantić Vrsajkov
BACKGROUND AND GOAL OF STUDY: After laparoscopic cholecystectomy, patients have moderate pain in the early postoperative period. Some studies shown beneficial effects of subcostal transversus abdominis plane block on reducing this pain. Our goal was to investigate influence of subcostal transversus abdominis plane block on postoperative pain scores and opioid consumption. MATERIALS AND METHODS: We have randomized 76 patients undergoing laparoscopic cholecystectomy to receive either subcostal transversus abdominis plane block (n=38) or standard postoperative analgesia (n=38)...
March 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29274831/preoperative-cesarean-delivery-intravenous-acetaminophen-treatment-for-postoperative-pain-control-a-randomized-double-blinded-placebo-control-trial
#18
Craig V Towers, Sarah Shelton, Jaclyn van Nes, Emily Gregory, Emily Liske, Arion Smalley, Edward Mobley, Barbara Faircloth, Kim B Fortner
BACKGROUND: The United States currently has an opioid use disorder epidemic and research evaluating ways to minimize the use of opioids postsurgery are needed. One of these options is intravenous acetaminophen. If the use of preoperative intravenous acetaminophen was found to be effective for cesarean delivery, this would be beneficial for both the mother and breast-feeding neonate. OBJECTIVE: The primary study objective was to see if maternal opioid use was significantly less in the postoperative period for the study group that received 1 g of intravenous acetaminophen preoperatively compared with a control group that received placebo...
March 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29200016/intravenous-acetaminophen-reduces-length-of-stay-via-mediation-of-postoperative-opioid-consumption-following-posterior-spinal-fusion-in-a-pediatric-cohort
#19
Vanessa A Olbrecht, Lili Ding, Kristie Spruance, Monir Hossain, Senthilkumar Sadhasivam, Vidya Chidambaran
OBJECTIVES: Since approval of IV acetaminophen (IV APAP), its use has become quite common without strong positive evidence. Our goal was to determine the effect of IV APAP on hospital length of stay (LOS) via mediation of opioid-related side effects in pediatric patients. METHODS: Following IRB approval, 114 adolescents undergoing posterior spinal fusion were prospectively recruited and managed postoperatively with patient controlled analgesia and adjuvant therapy...
December 1, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29192528/hospitalization-costs-and-resource-allocation-in-cholecystectomy-with-use-of-intravenous-versus-oral-acetaminophen
#20
Ryan N Hansen, An T Pham, Elaine A Böing, Belinda Lovelace, George J Wan, Donna A Thomas, Manuel L Fontes
OBJECTIVE: To evaluate intravenous (IV) acetaminophen (APAP) vs oral APAP use as adjunctive analgesics in cholecystectomy patients by comparing associated hospital length of stay (LOS), hospital costs, opioid use, and rates of nausea/vomiting, respiratory depression, and bowel obstruction. METHODS: We conducted a retrospective analysis of the Premier Database (January 2012 to September 2015) including cholecystectomy patients who received either IV APAP or oral APAP...
January 4, 2018: Current Medical Research and Opinion
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