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IV acetaminophen

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https://www.readbyqxmd.com/read/27916694/regenerated-cellulose-capsules-for-controlled-drug-delivery-part-iv-in-vitro-evaluation-of-novel-self-pore-forming-regenerated-cellulose-capsules
#1
Bhavik Bhatt, Vijay Kumar
In the present work, the release mechanisms of active pharmaceutical ingredients (APIs) enclosed in self-pore forming regenerated cellulose (RC) two-piece hard shell capsules are described. The RC capsules were fabricated using a modified dip-coating approach, which yielded an assembled dosage form that was equivalent in size and shape to a conventional gelatin two-piece hard shell capsule. Drug release characteristics from RC capsules were evaluated using potassium chloride, diphenhydramine hydrochloride, tramadol hydrochloride, niacinamide, acetaminophen and ketoprofen as model APIs...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27899166/pain-management-of-acute-appendicitis-in-canadian-pediatric-emergency-departments
#2
Andrea L Robb, Samina Ali, Naveen Poonai, Graham C Thompson
OBJECTIVES: Children with suspected appendicitis are at risk for suboptimal pain management. We sought to describe pain management patterns for suspected appendicitis across Canadian pediatric emergency departments (PEDs). METHODS: A retrospective medical record review was undertaken at 12 Canadian PEDs. Children ages 3 to 17 years who were admitted to the hospital in February or October 2010 with suspected appendicitis were included. Patients were excluded if partially assessed or treated at another hospital...
November 30, 2016: CJEM
https://www.readbyqxmd.com/read/27830448/estimating-the-effect-of-intravenous-acetaminophen-for-postoperative-pain-management-on-length-of-stay-and-inpatient-hospital-costs
#3
E Eve Shaffer, An Pham, Robert L Woldman, Andrew Spiegelman, Scott A Strassels, George J Wan, Thomas Zimmerman
INTRODUCTION: The provision of safe, effective, cost-efficient perioperative inpatient acute pain management is an important concern among clinicians and administrators within healthcare institutions. Overreliance on opioid monotherapy in this setting continues to present health risks for patients and increase healthcare costs resulting from preventable adverse events. The goal of this study was to model length of stay (LOS), potential opioid-related complications, and costs for patients reducing opioid use and adding intravenous acetaminophen (IV APAP) for management of postoperative pain...
November 9, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27828892/exploring-opioid-sparing-multimodal-analgesia-options-in-trauma-a-nursing-perspective
#4
Denise Sullivan, Mary Lyons, Robert Montgomery, Ann Quinlan-Colwell
Challenges with opioids (e.g., adverse events, misuse and abuse with long-term administration) have led to a renewed emphasis on opioid-sparing multimodal management of trauma pain. To assess the extent to which currently available evidence supports the efficacy and safety of various nonopioid analgesics and techniques to manage trauma pain, a literature search of recently published references was performed. Additional citations were included on the basis of authors' knowledge of the literature. Effective options for opioid-sparing analgesics include oral and intravenous (IV) acetaminophen; nonsteroidal anti-inflammatory drugs available via multiple routes; and anticonvulsants, which are especially effective for neuropathic pain associated with trauma...
November 2016: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/27813031/-the-effectiveness-of-preemptive-analgesic-techniques-on-postoperative-analgesia-in-patients-undergoing-open-septorhinoplasty
#5
İlknur Keskioğlu, Meltem Aktay İnal, Onur Özlü
OBJECTIVES: A comparison was made of effects of preincisional intravenous (IV) dexketoprofen trometamol and acetaminophen on postoperative pain, analgesic requirement, hemodynamic parameters, postoperative tramadol consumption, and patient satisfaction in patients undergoing elective septorhinoplasty. METHODS: Sixty patients scheduled for elective septorhinoplasty under general anesthesia were divided into 3 groups. Groups were similar with respect to gender, mean age, body weight, mean duration of surgery and anesthesia (p>0...
July 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/27803502/effect-of-intravenous-acetaminophen-on-postoperative-opioid-consumption-in-adult-orthopedic-surgery-patients
#6
Nwamaka Nwagbologu, Preeyaporn Sarangarm, Richard D'Angio
Background: Postoperative pain is managed with opioids, which are associated with adverse effects. The efficacy of intravenous (IV) acetaminophen in reducing opioid consumption has been studied with inconsistent results. The primary outcome of this study was to assess the effect of IV acetaminophen on opioid consumption 24 hours postoperatively. Secondary outcomes included the opiate consumption at 48 hours after the operation, opioid-related side effects 72 hours after the operation, discharge disposition, and length of stay...
October 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27779484/intravenous-acetaminophen-for-renal-colic-in-the-emergency-department-where-do-we-stand
#7
Billy Sin, Kimberly Koop, Michelle Liu, Jun-Yen Yeh, Pardeep Thandi
BACKGROUND: The efficacy, safety, opioid-sparing effects, and cost-benefit analyses of intravenous (IV) acetaminophen (APAP) in treating renal colic remain controversial. STUDY QUESTION: To evaluate the safety, efficacy, opioid-sparing effects, and cost-benefits of IV APAP in patients who present with renal colic in the emergency department (ED). DATA SOURCES: We systematically searched PubMed (January 1970 to April 2016). STUDY DESIGN: Randomized controlled trials which evaluated IV APAP for renal colic in the ED were eligible...
October 24, 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/27689348/neither-nefopam-nor-acetaminophen-can-be-used-as-post-operative-analgesics-in-a-rat-model-of-ischemic-stroke
#8
Maud Pétrault, Sophie Gautier, Vincent Bérézowski, Thavarak Ouk, Michèle Bastide, Olivier Pétrault, Régis Bordet
Analgesics such as opioid agonists are usually not given during the post-operative phase of experimental stroke because they are susceptible to interfere with the evaluation of neuroprotective therapies. Here we investigate the potential of acetaminophen and nefopam, two non-opioid analgesic drugs, to exert an analgesic effect without inducing neuroprotection in a murine model of ischemic stroke. We demonstrate that acetaminophen (200 mg/kg, PO) induces a significant decrease in the infarct volume, particularly in the cortex (VEHICLE: 200...
September 30, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27642582/diclofenac-suppository-vs-iv-acetaminophen-combined-with-iv-pca-for-postoperative-pain-management-in-patients-undergoing-laminectomy-a-randomized-double-blinded-clinical-trial
#9
Mahshid Nikooseresht, Mohammad Ali Seifrabiei, Maryam Davoodi, Mashhood Aghajanlou, Mohammad Taghi Sardari
BACKGROUND: Tissue damage caused by surgical procedures nearly always results in pain. The effective management of postoperative pain remains a challenge because of its influence on the surgical outcome and its critical role in early mobilization and functionality. Recent research on postoperative pain management supports a treatment approach known as "multimodal analgesia," which comprises the use of more than one method or modality of pain control and management. OBJECTIVES: In the present study, we compared the effects of diclofenac suppository and intravenous (IV) acetaminophen combined with IV patient-controlled analgesia (PCA) for pain management after laminectomy surgery...
June 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27630458/can-intravenous-acetaminophen-reduce-the-needs-to-more-opioids-to-control-pain-in-intubated-patients
#10
Babak Mahshidfar, Azadeh Sameti, Saeed Abbasi, Davood Farsi, Mani Mofidi, Peyman Hafezimoghadam, Popak Rahimzadeh, Mahdi Rezai
AIMS: To evaluate the effect of intravenous (IV) acetaminophen on reducing the need for morphine sulfate in intubated patients admitted to the Intensive Care Unit (ICU). SETTINGS AND DESIGN: Current study was done as a clinical trial on the patients supported by mechanical ventilator. SUBJECTS AND METHODS: Behavioral pain scale (BPS) scoring system was used to measure pain in the patients. All of the patients received 1 g, IV acetaminophen, every 6 h during the 1(st) and 3(rd) days of admission and placebo during the 2(nd) and 4(th) days...
August 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27609941/intravenous-acetaminophen-for-postoperative-pain-management-in-patients-undergoing-living-laparoscopic-living-donor-nephrectomy
#11
Van Vu, William L Baker, Elizabeth M Tencza, Caroline Rochon, Patricia A Sheiner, Spencer T Martin
BACKGROUND: Postoperative pain is a common complication of laparoscopic living-donor nephrectomies (LLDNs). OBJECTIVE: To determine whether intravenous (IV) acetaminophen administration post-LLDN influenced length of stay (LOS) when used for pain management. METHODS: This single-center, retrospective study compared patients undergoing LLDN who had received IV acetaminophen for pain control versus those who did not between June 1, 2011, and November 30, 2015...
September 8, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27562836/erratum-to-comparative-analysis-of-length-of-stay-and-inpatient-costs-for-orthopedic-surgery-patients-treated-with-iv-acetaminophen-and-iv-opioids-vs-iv-opioids-alone-for-post-operative-pain
#12
Ryan N Hansen, An Pham, Scott A Strassels, Stela Balaban, George J Wan
No abstract text is available yet for this article.
August 25, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27487640/comparison-of-the-effects-of-preemptive-intravenous-and-rectal-acetaminophen-on-pain-management-after-inguinal-herniorrhaphy-in-children-a-placebo-controlled-study
#13
RANDOMIZED CONTROLLED TRIAL
Gholam Reza Khalili, Amir Shafa, Ramin Yousefi
BACKGROUND: Postoperative pain management is a critical concern in pediatric surgery. Acetaminophen is the safest and most widely used analgesic in children. The present study compared the analgesic efficacy of intravenous (IV) and rectal acetaminophen versus placebo in children undergoing inguinal herniorrhaphy. METHODS: A total of 120 children, who were candidate for elective surgical repair of unilateral inguinal hernia, were enrolled and randomly allocated to four groups of 30 patients each to receive IV acetaminophen, acetaminophen suppository, IV placebo, and placebo suppository during surgery...
June 2016: Middle East Journal of Anesthesiology
https://www.readbyqxmd.com/read/27454264/a-randomized-trial-comparing-the-safety-and-efficacy-of-intravenous-ibuprofen-versus-ibuprofen-and-acetaminophen-in-knee-or-hip-arthroplasty
#14
Anita Gupta, Hawa Abubaker, Eleni Demas, Leigh Ahrendtsen
BACKGROUND: All surgical procedures are associated with a degree of pain. The experience of uncontrolled post-operative pain can have significant implications on health care costs. Recent studies have demonstrated that intravenous (IV) ibuprofen is an effective, safe, well-tolerated analgesic when administered for both abdominal hysterectomy and orthopedic surgery. The use of ibuprofen leads to a reduction in pain severity at rest and with movement and also decreases narcotic consumption...
July 2016: Pain Physician
https://www.readbyqxmd.com/read/27423648/comparative-analysis-of-length-of-stay-and-inpatient-costs-for-orthopedic-surgery-patients-treated-with-iv-acetaminophen-and-iv-opioids-vs-iv-opioids-alone-for-post-operative-pain
#15
Ryan N Hansen, An Pham, Scott A Strassels, Stela Balaban, George J Wan
INTRODUCTION: Recovery from orthopedic surgery is oriented towards restoring functional health outcomes while reducing hospital length of stay (LOS) and medical expenditures. Optimal pain management is a key to reaching these objectives. We sought to compare orthopedic surgery patients who received combination intravenous (IV) acetaminophen and IV opioid analgesia to those who received IV opioids alone and compared the two groups on LOS and hospitalization costs. METHODS: We performed a retrospective analysis of the Premier Database (Premier, Inc...
September 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27414476/acetaminophen-induced-changes-in-systemic-blood-pressure-in-critically-ill-patients-results-of-a-multicenter-cohort-study
#16
Aymeric Cantais, David Schnell, François Vincent, Zeineb Hammouda, Sophie Perinel, Sarah Balichard, Fekri Abroug, Fabrice Zeni, Ferhat Meziani, Caroline Bornstain, Michael Darmon
OBJECTIVES: We sought to assess the incidence of acetaminophen-induced hypotension. Our secondary objectives were to describe systemic hemodynamic changes and factors associated with this complication. DESIGN: Prospective observational study. SETTING: Three ICUs. PATIENTS: Adult patients requiring IV acetaminophen infusion. Arterial pressure was monitored via an arterial catheter for 3 hours. Hypotension was defined as a decrease in the mean arterial pressure of greater than or equal to 15% compared with the baseline...
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27353198/acetaminophen-use-in-pregnancy-and-neurodevelopment-attention-function-and-autism-spectrum-symptoms
#17
Claudia B Avella-Garcia, Jordi Julvez, Joan Fortuny, Cristina Rebordosa, Raquel García-Esteban, Isolina Riaño Galán, Adonina Tardón, Clara L Rodríguez-Bernal, Carmen Iñiguez, Ainara Andiarena, Loreto Santa-Marina, Jordi Sunyer
BACKGROUND: Acetaminophen is extensively used during pregnancy. But there is a lack of population-representative cohort studies evaluating its effects on a range of neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure to acetaminophen is adversely associated with neurodevelopmental outcomes at 1 and 5 years of age. METHODS: This Spanish birth cohort study included 2644 mother-child pairs recruited during pregnancy. The proportion of liveborn participants evaluated at 1 and 5 years was 88...
June 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27351176/intravenous-versus-oral-acetaminophen-for-pain-control-in-neurocritical-care-patients
#18
Dan C Nichols, Pramit A Nadpara, Perry D Taylor, Gretchen M Brophy
BACKGROUND: Acetaminophen (APAP) is used in neurocritical care (NCC) patients for analgesia without sedation or antiplatelet activity. Research suggests that intravenous (IV) APAP produces earlier and higher serum levels compared to oral (PO) APAP. This retrospective study evaluates the associated analgesic effects of IV and PO APAP and use of adjunctive opioids in NCC patients with moderate-severe pain. METHODS: Patients admitted to the neuroscience intensive care unit (NSICU) between May 2012 and April 2013 who received ≥1 dose of IV APAP were included in the study...
December 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27324218/delayed-gastric-emptying-in-diabetic-rats-caused-by-decreased-expression-of-cystathionine-gamma-lyase-and-h2-s-synthesis-in-vitro-and-in-vivo-studies
#19
S A Mard, I Ahmadi, A Ahangarpour, M K Gharib-Naseri, M Badavi
BACKGROUND: This study aimed to evaluate the role of H2 S on gastric emptying rate (GER) and also to determine the effect of gastric distention on mRNA and protein expression of cystathionine β-lyase (CBS) and cystathionine γ-synthase (CSE) in diabetic-gastroparetic and normal rats. METHODS: Adult normal rats intraperitoneally received either propargylglycine (PAG), L-cysteine or NaHS 30 min prior to GER marker (acetaminophen) to investigate H2 S involvement in GER and the same protocols were performed in diabetes-induced gastroparesis rats...
June 20, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27213715/single-dose-intravenous-paracetamol-or-intravenous-propacetamol-for-postoperative-pain
#20
REVIEW
Ewan D McNicol, McKenzie C Ferguson, Simon Haroutounian, Daniel B Carr, Roman Schumann
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 10, 2011. Paracetamol (acetaminophen) is the most commonly prescribed analgesic for the treatment of acute pain. It may be administered orally, rectally, or intravenously. The efficacy and safety of intravenous (IV) formulations of paracetamol, IV paracetamol, and IV propacetamol (a prodrug that is metabolized to paracetamol), compared with placebo and other analgesics, is unclear. OBJECTIVES: To assess the efficacy and safety of IV formulations of paracetamol for the treatment of postoperative pain in both adults and children...
2016: Cochrane Database of Systematic Reviews
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