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Serendipity

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https://www.readbyqxmd.com/read/29388962/the-serendipity-test
#1
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2018: Nature
https://www.readbyqxmd.com/read/29383765/rational-syntheses-and-serendipity-the-compounds-lsnptcl2-sme2-2-lsnptcl-sme2-2sncl2-lsn-3-ptcl2-ptclsncl-lsn-cl-oh-and-o-sncl-2-snl-2-with-l-men-ch2cme2o-2
#2
Thomas Zöller, Christina Dietz, Florian Winter, Rainer Pöttgen, Serge I Gorelsky, Alexander Hoffmann, Sonja Herres-Pawlis, Klaus Jurkschat
The syntheses and molecular structures of the novel dimeric tin-platinum complex [LSnPtCl2(SMe2)]2 (2), of the novel tin platinum clusters [{LSnPtCl(SMe2)}2SnCl2)] (3), and [(LSn)3(PtCl2)(PtClSnCl)(LSnOHCl)] (6) [L = MeN(CH2CMe2O-)2] and of the unprecedented tin(II) aminoalkoxide-tin oxide chloride complex [O(SnCl)2∙(SnL)2] (5) are reported. The compounds were characterized by multinuclear NMR spectroscopy (1H, 13C, 119Sn, 195Pt), 119Sn Mössbauer spectroscopy (1-3, 6), electrospray ionization mass spectrometry, elemental analyses and single crystal X-ray diffraction analyses (2∙CH2Cl2, 3∙2C4H8O, 5, 6∙3CH2Cl2)...
January 31, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29358359/the-serendipity-of-electroweak-baryogenesis
#3
Géraldine Servant
The origin of the matter-antimatter asymmetry of the universe remains unexplained in the Standard Model (SM) of particle physics. The origin of the flavour structure is another major puzzle of the theory. In this article, we report on recent work attempting to link the two themes through the appealing framework of electroweak (EW) baryogenesis. We show that Yukawa couplings of SM fermions can be the source of CP violation for EW baryogenesis if they vary at the same time as the Higgs is acquiring its vacuum expectation value, offering new avenues for EW baryogenesis...
March 6, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29344345/when-the-drugs-don-t-work-treatment-resistant-schizophrenia-serotonin-and-serendipity
#4
Penelope Lowe, Amir Krivoy, Lilla Porffy, Erna Henriksdottir, Whiskey Eromona, Sukhwinder S Shergill
Treatment-resistant schizophrenia is a serious clinical problem. We adopt a systems-level approach positing a greater role for cognitive control mechanisms in the development of psychotic symptoms and illustrate the clinical application of this via a case report of treatment-resistant patients treated successfully with adjunct pro-cognitive serotonergic medication.
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29333374/asymptomatic-bilateral-maxillary-and-mandibular-impacted-permanent-canines-serendipity-in-dental-outpatient-department
#5
Thorakkal Shamim, Prabha Surendran Renjini
No abstract text is available yet for this article.
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29328649/phenylthiomethyl-ketone-based-fragments-show-selective-and-irreversible-inhibition-of-enteroviral-3c-proteases
#6
Robert Schulz, Amira Atef, Daniel Becker, Franziska Gottschalk, Carolin Tauber, Stefan Wagner, Christoph Arkona, Atef A Abdel-Hafez, Hassan H Farag, Jörg Rademann, Gerhard Wolber
Lead structure discovery mainly focuses on the identification of noncovalently binding ligands. Covalent linkage, however, is an essential binding mechanism for a multitude of successfully marketed drugs although discovered by serendipity in most cases. We present a concept for the design of fragments covalently binding to proteases. Covalent linkage enables fragment binding unrelated to affinity to shallow protein binding sites and at the same time allows differentiated targeted hit verification and binding location verification through mass spectrometry...
January 12, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29244479/discovery-of-intermetallic-compounds-from-traditional-to-machine-learning-approaches
#7
Anton O Oliynyk, Arthur Mar
Intermetallic compounds are bestowed by diverse compositions, complex structures, and useful properties for many materials applications. How metallic elements react to form these compounds and what structures they adopt remain challenging questions that defy predictability. Traditional approaches offer some rational strategies to prepare specific classes of intermetallics, such as targeting members within a modular homologous series, manipulating building blocks to assemble new structures, and filling interstitial sites to create stuffed variants...
December 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29243514/serendipity-how-the-search-for-meaning-of-serum-uric-acid-might-lead-to-the-repurposing-of-an-old-drug-in-patients-with-cardiovascular-disease
#8
Mark Nidorf, Michael Jelinek
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29222458/serendipity-and-strategy-in-rapid-innovation
#9
T M A Fink, M Reeves, R Palma, R S Farr
Innovation is to organizations what evolution is to organisms: it is how organizations adapt to environmental change and improve. Yet despite advances in our understanding of evolution, what drives innovation remains elusive. On the one hand, organizations invest heavily in systematic strategies to accelerate innovation. On the other, historical analysis and individual experience suggest that serendipity plays a significant role. To unify these perspectives, we analysed the mathematics of innovation as a search for designs across a universe of component building blocks...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29174954/cell-milieu-significantly-affects-the-fate-of-aapoai-amyloidogenic-variants-predestination-or-serendipity
#10
Rosa Gaglione, Giovanni Smaldone, Rocco Di Girolamo, Renata Piccoli, Emilia Pedone, Angela Arciello
BACKGROUND: Specific apolipoprotein A-I variants are associated to severe hereditary amyloidoses. The organ distribution of AApoAI amyloidosis seems to depend on the position of the mutation, since mutations in residues from 1 to 75 are mainly associated to hepatic and renal amyloidosis, while mutations in residues from 173 to 178 are mostly responsible for cardiac, laryngeal, and cutaneous amyloidosis. Molecular bases of this tissue specificity are still poorly understood, but it is increasingly emerging that protein destabilization induced by amyloidogenic mutations is neither necessary nor sufficient for amyloidosis development...
November 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29163515/nanobody-based-delivery-systems-for-diagnosis-and-targeted-tumor-therapy
#11
REVIEW
Yaozhong Hu, Changxiao Liu, Serge Muyldermans
The development of innovative targeted therapeutic approaches are expected to surpass the efficacy of current forms of treatments and cause less damage to healthy cells surrounding the tumor site. Since the first development of targeting agents from hybridoma's, monoclonal antibodies (mAbs) have been employed to inhibit tumor growth and proliferation directly or to deliver effector molecules to tumor cells. However, the full potential of such a delivery strategy is hampered by the size of mAbs, which will obstruct the targeted delivery system to access the tumor tissue...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29154280/sisyphus-in-neverland
#12
Isidro Ferrer
The study of life and living organisms and the way in which these interact and organize to form social communities have been central to my career. I have been fascinated by biology, neurology, and neuropathology, but also by history, sociology, and art. Certain current historical, political, and social events, some occurring proximally but others affecting people in apparently distant places, have had an impact on me. Epicurus, Seneca, and Camus shared their philosophical positions which I learned from. Many scientists from various disciplines have been exciting sources of knowledge as well...
November 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29095986/autobiography-series-from-there-to-here-a-crooked-trail-of-families-crossroads-serendipity-and-impatience
#13
James M Powers
No abstract text is available yet for this article.
October 31, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29094573/chance-serendipity-and-antiepileptic-drugs
#14
Karl Otto Nakken, Eylert Brodtkorb
No abstract text is available yet for this article.
October 31, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29093987/targeting-the-epitope-spreader-pep19-by-na%C3%A3-ve-human-cd45ra-regulatory-t-cells-dictates-a-distinct-suppressive-t-cell-fate-in-a-novel-form-of-immunotherapy
#15
Hyun-Joo Kim, Gil Sun Cha, Ji-Young Joo, Juyoun Lee, Sung-Jo Kim, Jeongae Lee, So Youn Park, Jeomil Choi
Purpose: Beyond the limited scope of non-specific polyclonal regulatory T cell (Treg)-based immunotherapy, which depends largely on serendipity, the present study explored a target Treg subset appropriate for the delivery of a novel epitope spreader Pep19 antigen as part of a sophisticated form of immunotherapy with defined antigen specificity that induces immune tolerance. Methods: Human polyclonal CD4(+)CD25(+)CD127(lo-) Tregs (127-Tregs) and naïve CD4(+)CD25(+)CD45RA(+) Tregs (45RA-Tregs) were isolated and were stimulated with target peptide 19 (Pep19)-pulsed dendritic cells in a tolerogenic milieu followed by ex vivo expansion...
October 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29052220/efficacy-from-strange-sources
#16
Lawrence J Lesko
Reverse translation (RT) refers to perceptions and observations of clinical outcomes, both beneficial and harmful, that can lead to a hypothesis intended to identify a new use of a drug that is different from the original use. I provide a panoramic view of successes in RT from the historic discovery of penicillin to the contemporary development of CAR (chimeric antigen receptor) T therapies. I delineate the core principles of RT that shift discovery from serendipity to a systematic strategy based on target identification and causal biology, pharmacodynamic biomarkers that recapitulate disease pathophysiology, confirmation of target engagement by clinical proof of concept studies, and optimal selection of dose and interval...
February 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29033605/onabotulinum-toxin-a-in-the-treatment-of-chronic-migraine-patient-selection-and-special-considerations
#17
REVIEW
Piero Barbanti, Patrizia Ferroni
Discovered by serendipity, onabotulinum toxin A (BoNT-A) is the only US Food and Drug Administration-approved treatment for the prevention of chronic migraine (CM), one of the most disabling and burdensome human conditions. Its efficacy, safety and tolerability, proved by the largest and longest migraine therapeutic trial (the Phase III Research Evaluating Migraine Prophylaxis Therapy program [PREEMPT]), have been replicated by various real-life studies also in the presence of medication overuse. The benefit of BoNT-A prophylaxis is likely due to its ability to counteract peripheral and central nociceptive sensitization through reversible chemical denervation of pericranial sensitive afferents...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28977688/digenic-inheritance-and-genetic-modifiers
#18
REVIEW
Constantinos Deltas
Digenic inheritance (DI) concerns pathologies with the simplest form of multigenic aetiology, implicating more than one gene (and perhaps the environment). True DI is when biallelic or even triallelic mutations in two distinct genes, in cis or in trans, are necessary and sufficient to cause pathology with a defined diagnosis. In true DI, a heterozygous mutation in each of two genes alone is not associated with a recognizable phenotype. Well-documented diseases with true DI are so far rare and follow non-Mendelian inheritance...
October 4, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28960281/serendipity-in-a-salt-marsh-detecting-frequent-sea-otter-haul-outs-in-a-marsh-ecosystem
#19
Ron Eby, Robert Scoles, Brent Bancroft Hughes, Kerstin Wasson
No abstract text is available yet for this article.
November 2017: Ecology
https://www.readbyqxmd.com/read/28922867/discoveries-of-the-structures-of-sialic-acid-and-cmp-sialic-acid-1957-1960-a-letter-from-saul-roseman
#20
Ronald L Schnaar, Yuan C Lee
Sialic acids have a special place in vertebrate glycobiology, where they constitute the dominant terminal saccharides on many cell surface glycans. From early studies that identified sialoglycans as receptors for important pathogens and toxins to more recent discoveries of sialic acid-binding proteins essential for immune system (and other) functions in humans, sialic acids and sialoglycans have become cornerstones in understanding vertebrate glycobiology and pathology. During a remarkable 3-year period in the late 1950s, a newly minted postdoctoral fellow (Donald G...
June 1, 2017: Glycobiology
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