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https://www.readbyqxmd.com/read/28302733/continuing-professional-development-putting-the-learner-back-at-the-centre
#1
Colin Macdougall, Melanie Epstein, Lorna Highet
Continuing professional development (CPD) is changing. Once seen as flexible on the basis of personal choice and mainly consisting of conferences and lecture style meetings, it is now much more likely to be specified, mandatory and linked to specific regulatory or quality improvement activities. This may not be well aligned with how adult professionals learn best and the evidence of resulting change in practice is limited. Also there is a danger of losing out on serendipity in learning by pushing experienced professionals into focusing excessively on mandatory activities that seem to be increasingly 'ticking the box'...
March 16, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28282812/the-identification-of-alpha-synuclein-as%C3%A2-the%C3%A2-first-parkinson-disease-gene
#2
Robert L Nussbaum
In this Commentary, I describe the events that led from an NINDS-sponsored Workshop on Parkinson Disease Research in 1995, where I was asked to speak about the genetics of Parkinson disease, to the identification a mere two years later of a mutation in alpha-synuclein as the cause of autosomal dominant Parkinson disease in the Contursi kindred. I review the steps we took to first map and then find the mutation in the alpha-synuclein locus and describe the obstacles and the role of serendipity in facilitating the work...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28196903/ankyrin-b-defects-serendipity-and-inquisitiveness-are-the-mothers-of-invention
#3
EDITORIAL
Henry Duff, Robert S Sheldon
No abstract text is available yet for this article.
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28161409/gain-of-function-stat1-mutations-are-associated-with-intracranial-aneurysms
#4
Mete Dadak, Roland Jacobs, Jelena Skuljec, Adan Chari Jirmo, Özlem Yildiz, Frank Donnerstag, Niklas Thomas Baerlecken, Reinhold Ernst Schmidt, Heinrich Lanfermann, Thomas Skripuletz, Philipp Schwenkenbecher, Christoph Kleinschnitz, Hayrettin Tumani, Martin Stangel, Refik Pul
Chronic mucocutaneous candidiasis, characterized by persistent or recurrent fungal infections, represents the clinical hallmark in gain-of-function (GOF) signal transducer and activator of transcription 1 (STAT1) mutation carriers. Several cases of intracranial aneurysms have been reported in patients with GOF STAT1 mutation but the paucity of reported cases likely suggested this association still as serendipity. In order to endorse this association, we link the development of intracranial aneurysms with STAT1 GOF mutation by presenting the two different cases of a patient and her mother, and demonstrate upregulated phosphorylated STAT4 and IL-12 receptor β1 upon stimulation in patient's blood cells...
February 1, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28160522/isoprene-research-60%C3%A2-years-later-the-biology-is-still-enigmatic
#5
REVIEW
Thomas D Sharkey, Russell K Monson
Isoprene emission is a major component of biosphere-atmosphere interactions. It is the single largest source of non-methane hydrocarbon in the atmosphere. The first report of isoprene emission from plants was published in 1957 by Professor Guivi Sanadze. While humans have smelled the monoterpene hydrocarbons made by coniferous trees since their earliest migrations, only in 1957 did the world became aware that other trees make a type of hydrocarbon in even greater amounts, but one to which the human nose is much less sensitive...
February 4, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28089621/exaptation-serendipity-and-aging
#6
Pierpaolo Andriani
The paper shows the importance of serendipity and exaptation in selected key moments of ageing research and argue that rationalistic dominant models in scientific research have masked the importance of reverse models of discovery based on serendipity and exaptation. I ask why this is the case and analyze three contributing factors: unprestatability of the functions of technologies, multidimensionality and astronomical complexity of the space over which biological reactions occurs and role of scientific paradigms in channeling research toward incrementalism...
January 12, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28010759/looking-back-while-stepping-forward-a-path-made-possible-by-serendipity-a-few-good-decisions-and-helpful-colleagues
#7
EDITORIAL
Mark C Udey
No abstract text is available yet for this article.
January 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27986826/the-contribution-of-genome-mining-strategies-to-the-understanding-of-active-principles-of-pgpr-strains
#8
Julia Paterson, Ghazaleh Jahanshah, Yan Li, Qi Wang, Samina Mehnaz, Harald Gross
Pathogenic microorganisms and insects affecting plant health are a major and chronic threat to food production and the ecosystem worldwide. As agricultural production has intensified over the years, the use of agrochemicals has in turn increased. However, this extensive usage has had several detrimental effects, with a pervasive environmental impact and the emergence of pathogen resistance. In addition, there is an increasing tendency among consumers to give preference to pesticide-free food products. Biological control, through the employment of plant growth-promoting rhizobacteria (PGPR), is therefore considered a possible route to the reduction, even the elimination, of the use of agrochemicals...
March 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27977195/improved-potency-of-indole-based-nora-efflux-pump-inhibitors-from-serendipity-toward-rational-design-and-development
#9
Federica Buonerba, Susan Lepri, Laura Goracci, Bryan D Schindler, Susan M Seo, Glenn W Kaatz, Gabriele Cruciani
The NorA efflux pump is a potential drug target for reversal of resistance to selected antibacterial agents, and recently we described indole-based inhibitor candidates. Herein we report a second class of inhibitors derived from them but with significant differences in shape and size. In particular, compounds 13 and 14 are very potent inhibitors in that they demonstrated the lowest IC50 values (2 μM) ever observed among all indole-based compounds we have evaluated.
December 15, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27974174/women-in-metabolism-part-iv
#10
(no author information available yet)
The "Rosies" of Cell Metabolism are wrapping up 2016 with a fourth installment of the "Women in Metabolism" series. We are delighted to present ten women scientists who are leaders in the metabolism field, with their words on the value of perseverance, passion, ingenuity, and a bit of serendipity.
December 13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27958193/lily-and-yuh-nung-jan
#11
(no author information available yet)
Lily and Yuh Nung Jan's collaboration started with the identification of Shaker as the first known potassium channel gene and has flourished to produce over 100 former students and postdocs who are now leading their own research groups. In an interview with Neuron, they reflect on their scientific discoveries, serendipity in science, and the value of curiosity-driven basic research.
November 23, 2016: Neuron
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#12
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27864630/the-interlaminar-glia-from-serendipity-to-hypothesis
#13
REVIEW
Jorge A Colombo
An account of work performed at the UNA laboratories since 1992 on the detection and description of interlaminar glial processes, is presented. The incidental observation (serendipity) of longer than expected glial processes in the superficial layers of the cerebral cortex in hemiparkinsonian Cebus apella monkeys, was expanded afterwards to cover the largest possible sampling of representatives of mammalian orders and species, as well as in experimental and pathological conditions, in human and non-human primates...
November 18, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27832101/animal-study-registries-results-from-a-stakeholder-analysis-on-potential-strengths-weaknesses-facilitators-and-barriers
#14
Susanne Wieschowski, Diego S Silva, Daniel Strech
Publication bias in animal research, its extent, its predictors, and its potential countermeasures are increasingly discussed. Recent reports and conferences highlight the potential strengths of animal study registries (ASRs) in this regard. Others have warned that prospective registration of animal studies could diminish creativity, add administrative burdens, and complicate intellectual property issues in translational research. A literature review and 21 international key-informant interviews were conducted and thematically analyzed to develop a comprehensive matrix of main- and subcategories for potential ASR-related strengths, weaknesses, facilitators, and barriers (SWFBs)...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27826501/straightforward-and-robust-synthesis-of-monodisperse-surface-functionalized-gold-nanoclusters
#15
Silvia Varela-Aramburu, Richard Wirth, Chian-Hui Lai, Guillermo Orts-Gil, Peter H Seeberger
Gold nanoclusters are small (1-3 nm) nanoparticles with a high surface area that are useful for biomedical studies and drug delivery. The synthesis of small, surface-functionalized gold nanoclusters is greatly dependent on the reaction conditions. Here, we describe a straightforward, efficient and robust room temperature one-pot synthesis of 2 nm gold nanoclusters using thioglucose as a reducing and stabilizing agent, which was discovered by serendipity. The resultant monodisperse gold nanoclusters are more stable than those generated using some other common methods...
2016: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/27809819/helping-palliative-care-healthcare-professionals-get-the-most-out-of-mentoring-in-a-low-income-country-a-qualitative-study
#16
J L Whitehurst, J Rowlands
BACKGROUND: Being a mentor in any setting brings challenges in addition to recognised benefits. Working in a low-income country confers specific challenges including logistical and communication issues. The need to adequately support UK-based international health volunteers prior to, during and after their trip is recognised at government level. Whilst the need to support mentors is recognised little is known about their support needs. This study aims to explore the lived experience of mentorship in a low-income country and gain insight into mentors' support and information needs and the barriers and facilitators to mentoring...
November 4, 2016: BMC Palliative Care
https://www.readbyqxmd.com/read/27809321/rational-serendipity-undirected-synthesis-of-a-large-mncu-complex-from-pre-formed-mn-ii-building-blocks
#17
Jamie M Frost, Fraser J Kettles, Claire Wilson, Mark Murrie
Use of an aminopolyalcohol-based Mn(II) complex in solvothermal Cu(II) chemistry leads to a rare example of a high nuclearity heterometallic {MnCu} system, in which four Cu(II)(H1Edte) units trap an inner {MnCu(II)} oxide core.
November 3, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27689204/serendipity-in-refractory-celiac-disease-full-recovery-of-duodenal-villi-and-clinical-symptoms-after-fecal-microbiota-transfer
#18
Yvette H van Beurden, Tom van Gils, Nienke A van Gils, Zain Kassam, Chris J J Mulder, Nieves Aparicio-Pagés
Treatment of refractory celiac disease type II (RCD II) and preventing the development of an enteropathy associated T-cell lymphoma in these patients is still difficult. In this case report, we describe a patient with RCD II who received fecal microbiota transfer as treatment for a recurrent Clostridium difficile infection, and remarkably showed a full recovery of duodenal villi and disappearance of celiac symptoms. This case suggests that altering the gut microbiota may hold promise in improving the clinical and histological consequences of celiac disease and/or RCD II...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27686018/highly-effective-new-treatments-for-psoriasis-target-the-il-23-type-17-t-cell-autoimmune-axis
#19
Jaehwan Kim, James G Krueger
Psoriasis vulgaris, affecting the skin, is one of the most common organ-specific autoimmune diseases in humans. Until recently, psoriasis was treated by agents or approaches discovered largely through serendipity. Many of the available drugs were inherently quite toxic when used as continuous treatment for many years in this chronic disease. However, an increasing understanding of disease-specific immune pathways has spurred development of pathway-targeted therapeutics during the past decade. Psoriasis is now the most effectively treated human autoimmune disease, with high-level clinical improvements possible in ∼90% of patients using a new generation of drugs that selectively target the IL-23/Type 17 T cell axis...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/27673346/the-alternative-strategy-for-designing-covalent-drugs-through-kinetic-effects-of-pi-stacking-on-the-self-assembled-nanoparticles-a-model-study-with-antibiotics
#20
Libo Du, Siqingaowa Suo, Han Zhang, Hongying Jia, Ke Jian Liu, Xue Ji Zhang, Yang Liu
It is still a huge challenge to find a new strategy for rationally designing covalent drugs because most of them are discovered by serendipity. Considering that the effect of covalent drugs is closely associated with the kinetics of the reaction between drug molecule and its target protein, here we first demonstrate an example of the kinetic effect of pi-stacking of drug molecules on covalent antimicrobial drug design. When PEGylated 7-aminocephalosporanic acid (PEG-ACA) is used as a substrate drug, pi-stacking of  the ACA group via the self-assembly of PEG-ACA on the surface of gold nanoparticles (i...
November 4, 2016: Nanotechnology
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