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https://www.readbyqxmd.com/read/29676609/generation-of-life-in-a-test-tube-albert-szent-gyorgyi-bruno-straub-and-the-discovery-of-actin
#1
Jack A Rall
This is a story about a great scientist, luck, great discovery that changed the future direction of muscle research, war, a clandestine war mission, postwar politics, and an attempt to rewrite scientific history. Albert Szent-Gyorgyi, at 44 yr of age, won the Nobel Prize in 1937 for his work on vitamin C and the establishment of the groundwork of the citric acid cycle. He now wanted to investigate one of the fundamental aspects of life and settled on the study of muscle contraction. The Szent-Gyorgyi laboratory in Hungary during World War II demonstrated that contraction could be reproduced in vitro by threads consisting of just two proteins, myosin and the newly discovered protein by Bruno Straub that they called actin...
June 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29620097/structure-based-design-of-targeted-covalent-inhibitors
#2
Richard Lonsdale, Richard A Ward
Covalent inhibition is a rapidly growing discipline within drug discovery. Many historical covalent inhibitors were discovered by serendipity, with such a mechanism of action often regarded as undesirable due to potential toxicity issues. Recent progress has seen a major shift in this outlook, as covalent inhibition shows promise for targets where previous efforts to identify non-covalent small molecule inhibitors have failed. Targeted covalent inhibitors (TCIs) can offer drug discovery scientists the ability to increase the potency and/or selectivity of small molecule inhibitors, by attachment of reactive functional groups designed to covalently bind to specific sites in a target...
April 5, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29616173/beyond-serendipity-to-an-algorithmic-approach
#3
Shaghayegh Harbi, Ali Soltani, Hannah Lui Park
No abstract text is available yet for this article.
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29614947/serendipity-and-the-joy-of-surgery
#4
Cate Swannell
No abstract text is available yet for this article.
April 2, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29593744/studies-of-mast-cells-adventures-in-serendipity
#5
REVIEW
Melissa A Brown
Like many of us who had the great fortune to work with Bill Paul, my science life was immeasurably altered by my interactions with him. Although intimidating at first because of his stature in the immunology world, it was soon clear that he not only truly cared about the specific research we were doing together, but he wished to convey to his trainees an approach to science that was open, always questioning, and infinitely fun. His enthusiasm was infectious and after my training with him, despite stresses due to funding and publishing hurdles, I never regretted the path I took...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29571234/cervicocranial-artery-dissection-and-scuba-diving-is-there-a-link-or-is-it-serendipity
#6
Gerald K Walters
Introduction: Numerous reports have documented cervicocranial artery dissection (CCAD) associated with scuba diving. The question remains as to whether there are risk factors unique to scuba diving related to the occurrence of CCAD. Objectives: This article aims to perform an examination of the reported cases to demonstrate any commonality among the injured divers and association with known risk factors for CCAD. Methods: A PubMed search was performed utilizing the key words: carotid artery dissection, dissection, arterial dissection, cranial artery dissection, scuba, diving, scuba diving...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29556492/vaccines-meet-big-data-state-of-the-art-and-future-prospects-from-the-classical-3is-isolate-inactivate-inject-vaccinology-1-0-to-vaccinology-3-0-vaccinomics-and-beyond-a-historical-overview
#7
REVIEW
Nicola Luigi Bragazzi, Vincenza Gianfredi, Milena Villarini, Roberto Rosselli, Ahmed Nasr, Amr Hussein, Mariano Martini, Masoud Behzadifar
Vaccines are public health interventions aimed at preventing infections-related mortality, morbidity, and disability. While vaccines have been successfully designed for those infectious diseases preventable by preexisting neutralizing specific antibodies, for other communicable diseases, additional immunological mechanisms should be elicited to achieve a full protection. "New vaccines" are particularly urgent in the nowadays society, in which economic growth, globalization, and immigration are leading to the emergence/reemergence of old and new infectious agents at the animal-human interface...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29532695/a-rare-mammary-serendipity-mucinous-metaplasia-of-the-breast
#8
Mieke Van Bockstal
No abstract text is available yet for this article.
March 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29523692/membrane-protein-serendipity
#9
Gunnar von Heijne
My scientific career has taken me from chemistry, via theoretical physics and bioinformatics, to molecular biology and even structural biology. Along the way, serendipity led me to work on problems such as the identification of signal peptides that direct protein trafficking, membrane protein biogenesis, and cotranslational protein folding. I've had some great collaborations that came about because of a stray conversation or from following up on an interesting paper. And I've had the good fortune to be asked to sit on the Nobel Committee for Chemistry, where I am constantly reminded of the amazing pace and often intricate history of scientific discovery...
March 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29512440/serendipity-and-margin-of-safety
#10
Prakash P Punjabi
No abstract text is available yet for this article.
March 2018: Perfusion
https://www.readbyqxmd.com/read/29388962/the-serendipity-test
#11
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2018: Nature
https://www.readbyqxmd.com/read/29383765/rational-syntheses-and-serendipity-the-compounds-lsnptcl2-sme2-2-lsnptcl-sme2-2sncl2-lsn-3-ptcl2-ptclsncl-lsn-cl-oh-and-o-sncl-2-snl-2-with-l-men-ch2cme2o-2
#12
Thomas Zöller, Christina Dietz, Florian Winter, Rainer Pöttgen, Serge I Gorelsky, Alexander Hoffmann, Sonja Herres-Pawlis, Klaus Jurkschat
The syntheses and molecular structures of the novel dimeric tin-platinum complex [LSnPtCl2(SMe2)]2 (2), of the novel tin platinum clusters [{LSnPtCl(SMe2)}2SnCl2)] (3), and [(LSn)3(PtCl2)(PtClSnCl)(LSnOHCl)] (6) [L = MeN(CH2CMe2O-)2] and of the unprecedented tin(II) aminoalkoxide-tin oxide chloride complex [O(SnCl)2∙(SnL)2] (5) are reported. The compounds were characterized by multinuclear NMR spectroscopy (1H, 13C, 119Sn, 195Pt), 119Sn Mössbauer spectroscopy (1-3, 6), electrospray ionization mass spectrometry, elemental analyses and single crystal X-ray diffraction analyses (2∙CH2Cl2, 3∙2C4H8O, 5, 6∙3CH2Cl2)...
January 31, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29358359/the-serendipity-of-electroweak-baryogenesis
#13
Géraldine Servant
The origin of the matter-antimatter asymmetry of the universe remains unexplained in the Standard Model (SM) of particle physics. The origin of the flavour structure is another major puzzle of the theory. In this article, we report on recent work attempting to link the two themes through the appealing framework of electroweak (EW) baryogenesis. We show that Yukawa couplings of SM fermions can be the source of CP violation for EW baryogenesis if they vary at the same time as the Higgs is acquiring its vacuum expectation value, offering new avenues for EW baryogenesis...
March 6, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29344345/when-the-drugs-don-t-work-treatment-resistant-schizophrenia-serotonin-and-serendipity
#14
Penelope Lowe, Amir Krivoy, Lilla Porffy, Erna Henriksdottir, Whiskey Eromona, Sukhwinder S Shergill
Treatment-resistant schizophrenia is a serious clinical problem. We adopt a systems-level approach positing a greater role for cognitive control mechanisms in the development of psychotic symptoms and illustrate the clinical application of this via a case report of treatment-resistant patients treated successfully with adjunct pro-cognitive serotonergic medication.
January 2018: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29333374/asymptomatic-bilateral-maxillary-and-mandibular-impacted-permanent-canines-serendipity-in-dental-outpatient-department
#15
Thorakkal Shamim, Prabha Surendran Renjini
No abstract text is available yet for this article.
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29328649/phenylthiomethyl-ketone-based-fragments-show-selective-and-irreversible-inhibition-of-enteroviral-3c-proteases
#16
Robert Schulz, Amira Atef, Daniel Becker, Franziska Gottschalk, Carolin Tauber, Stefan Wagner, Christoph Arkona, Atef A Abdel-Hafez, Hassan H Farag, Jörg Rademann, Gerhard Wolber
Lead structure discovery mainly focuses on the identification of noncovalently binding ligands. Covalent linkage, however, is an essential binding mechanism for a multitude of successfully marketed drugs, although discovered by serendipity in most cases. We present a concept for the design of fragments covalently binding to proteases. Covalent linkage enables fragment binding unrelated to affinity to shallow protein binding sites and at the same time allows differentiated targeted hit verification and binding location verification through mass spectrometry...
February 8, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29244479/discovery-of-intermetallic-compounds-from-traditional-to-machine-learning-approaches
#17
Anton O Oliynyk, Arthur Mar
Intermetallic compounds are bestowed by diverse compositions, complex structures, and useful properties for many materials applications. How metallic elements react to form these compounds and what structures they adopt remain challenging questions that defy predictability. Traditional approaches offer some rational strategies to prepare specific classes of intermetallics, such as targeting members within a modular homologous series, manipulating building blocks to assemble new structures, and filling interstitial sites to create stuffed variants...
January 16, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29243514/serendipity-how-the-search-for-meaning-of-serum-uric-acid-might-lead-to-the-repurposing-of-an-old-drug-in-patients-with-cardiovascular-disease
#18
Mark Nidorf, Michael Jelinek
No abstract text is available yet for this article.
February 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29222458/serendipity-and-strategy-in-rapid-innovation
#19
T M A Fink, M Reeves, R Palma, R S Farr
Innovation is to organizations what evolution is to organisms: it is how organizations adapt to environmental change and improve. Yet despite advances in our understanding of evolution, what drives innovation remains elusive. On the one hand, organizations invest heavily in systematic strategies to accelerate innovation. On the other, historical analysis and individual experience suggest that serendipity plays a significant role. To unify these perspectives, we analysed the mathematics of innovation as a search for designs across a universe of component building blocks...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29174954/cell-milieu-significantly-affects-the-fate-of-aapoai-amyloidogenic-variants-predestination-or-serendipity
#20
Rosa Gaglione, Giovanni Smaldone, Rocco Di Girolamo, Renata Piccoli, Emilia Pedone, Angela Arciello
BACKGROUND: Specific apolipoprotein A-I variants are associated to severe hereditary amyloidoses. The organ distribution of AApoAI amyloidosis seems to depend on the position of the mutation, since mutations in residues from 1 to 75 are mainly associated to hepatic and renal amyloidosis, while mutations in residues from 173 to 178 are mostly responsible for cardiac, laryngeal, and cutaneous amyloidosis. Molecular bases of this tissue specificity are still poorly understood, but it is increasingly emerging that protein destabilization induced by amyloidogenic mutations is neither necessary nor sufficient for amyloidosis development...
March 2018: Biochimica et Biophysica Acta
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