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https://www.readbyqxmd.com/read/28540068/serendipity-and-innovation-history-and-evolution-of-transthoracic-echocardiography
#1
REVIEW
Antonino Di Franco, Lucas B Ohmes, Mario Gaudino, Lisa Q Rong, Leonard N Girardi, Filippo M Sarullo, Ylenia Salerno, Silvia Sarullo, Jonathan W Weinsaft, Jiwon Kim
The history of echocardiography is sprinkled with many interesting episodes and anecdotes showing that devoting your life to the pursuit of one goal is praiseworthy, and that at the same time, a little luck goes a long way. Transthoracic echocardiography (TTE) has led to dramatic improvements in cardiovascular medicine, and is now the most widely used diagnostic cardiac test after electrocardiography (ECG). The present review pays tribute to the pioneering efforts of those who believed in this innovative technology despite mounted skepticism and briefly describes the evolution of TTE from its early days to the most recent developments...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28528674/sodium-channels-and-venom-peptide-pharmacology
#2
Mathilde R Israel, Bryan Tay, Jennifer R Deuis, Irina Vetter
Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have evolved a myriad of components in their venoms that target the opening and/or closing of voltage-gated sodium channels to cause devastating effects on the neuromuscular systems of predators and prey. These venom peptides, through design and serendipity, have not only contributed significantly to our understanding of sodium channel pharmacology and structure, but they also represent some of the most phyla- and isoform-selective molecules that are useful as valuable tool compounds and drug leads...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28496113/the-beneficial-role-of-mobility-for-the-emergence-of-innovation
#3
Giuliano Armano, Marco Alberto Javarone
Innovation is a key ingredient for the evolution of several systems, including social and biological ones. Focused investigations and lateral thinking may lead to innovation, as well as serendipity and other random discovery processes. Some individuals are talented at proposing innovation (say innovators), while others at deeply exploring proposed novelties, at getting further insights on a theory, or at developing products, services, and so on (say developers). This separation in terms of innovators and developers raises an issue of paramount importance: under which conditions a system is able to maintain innovators? According to a simple model, this work investigates the evolutionary dynamics that characterize the emergence of innovation...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494256/designing-multi-targeted-agents-an-emerging-anticancer-drug-discovery-paradigm
#4
REVIEW
Rong-Geng Fu, Yuan Sun, Wen-Bing Sheng, Duan-Fang Liao
The dominant paradigm in drug discovery is to design ligands with maximum selectivity to act on individual drug targets. With the target-based approach, many new chemical entities have been discovered, developed, and further approved as drugs. However, there are a large number of complex diseases such as cancer that cannot be effectively treated or cured only with one medicine to modulate the biological function of a single target. As simultaneous intervention of two (or multiple) cancer progression relevant targets has shown improved therapeutic efficacy, the innovation of multi-targeted drugs has become a promising and prevailing research topic and numerous multi-targeted anticancer agents are currently at various developmental stages...
May 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28486209/bioactivity-guided-mixed-synthesis-accelerate-the-serendipity-in-lead-optimization-discovery-of-fungicidal-homodrimanyl-amides
#5
Dangdang Li, Shasha Zhang, Zehua Song, Guotong Wang, Shengkun Li
The bioactivity-guided mixed synthesis was conceived, in which the designed mix-reactions were run in parallel for simultaneous construction of different kinds of analogs. The valuable ones were protruded by biological screening. This tactic will facilitate more rapid incorporation of bioactive candidates into pesticide chemists' repertoire, exemplified by the optimization of less explored homodrimanes as antifungal ingredients. The discovery of D9 as a potent fungicidal agent can be completed in <2 weeks by one student, with EC50 of 3...
May 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28442085/sim-serendipity
#6
EDITORIAL
Mina Attaalla
No abstract text is available yet for this article.
May 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28368582/pomzites-a-family-of-zeolitic-polyoxometalate-frameworks-from-a-minimal-building-block-library
#7
Thomas Boyd, Scott G Mitchell, David Gabb, De-Liang Long, Yu-Fei Song, Leroy Cronin
We describe why the cyclic heteropolyanion [P8W48O184](40-) (abbreviated as {P8W48}) is an ideal building block for the construction of intrinsically porous framework materials by classifying and analyzing >30 coordination polymers incorporating this polyoxometalate (POM) ligand. This analysis shows that the exocyclic coordination of first-row transition metals (TMs) to {P8W48} typically yields frameworks which extend through {W-O-TM-O-W} bridges in one, two, or three dimensions. However, despite the rich structural diversity of such compounds, the coordination of TMs to the {P8W48} ring is poorly understood, and therefore largely unpredictable, and had not until now been present with any structural classification that could allow rational design...
April 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28326916/pay-attention-to-serendipity
#8
Layla Haidrani
When and why did you develop an interest in research? My first nursing job was as a staff nurse in an oncology intensive care unit and a bone marrow transplant unit taking care of patients who were participating in high intensity clinical trials. During my master's degree, I worked as a research assistant for two faculty members whose research was making an impact at state and national levels, and I was able to lead a small research project of my own. During my doctoral and post-doctoral studies, my research interests continued to grow...
March 22, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/28302733/continuing-professional-development-putting-the-learner-back-at-the-centre
#9
Colin Macdougall, Melanie Epstein, Lorna Highet
Continuing professional development (CPD) is changing. Once seen as flexible on the basis of personal choice and mainly consisting of conferences and lecture style meetings, it is now much more likely to be specified, mandatory and linked to specific regulatory or quality improvement activities. This may not be well aligned with how adult professionals learn best and the evidence of resulting change in practice is limited. Also there is a danger of losing out on serendipity in learning by pushing experienced professionals into focusing excessively on mandatory activities that seem to be increasingly 'ticking the box'...
March 16, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28282812/the-identification-of-alpha-synuclein-as%C3%A2-the%C3%A2-first-parkinson-disease-gene
#10
Robert L Nussbaum
In this Commentary, I describe the events that led from an NINDS-sponsored Workshop on Parkinson Disease Research in 1995, where I was asked to speak about the genetics of Parkinson disease, to the identification a mere two years later of a mutation in alpha-synuclein as the cause of autosomal dominant Parkinson disease in the Contursi kindred. I review the steps we took to first map and then find the mutation in the alpha-synuclein locus and describe the obstacles and the role of serendipity in facilitating the work...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28196903/ankyrin-b-defects-serendipity-and-inquisitiveness-are-the-mothers-of-invention
#11
EDITORIAL
Henry Duff, Robert S Sheldon
No abstract text is available yet for this article.
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28161409/gain-of-function-stat1-mutations-are-associated-with-intracranial-aneurysms
#12
Mete Dadak, Roland Jacobs, Jelena Skuljec, Adan Chari Jirmo, Özlem Yildiz, Frank Donnerstag, Niklas Thomas Baerlecken, Reinhold Ernst Schmidt, Heinrich Lanfermann, Thomas Skripuletz, Philipp Schwenkenbecher, Christoph Kleinschnitz, Hayrettin Tumani, Martin Stangel, Refik Pul
Chronic mucocutaneous candidiasis, characterized by persistent or recurrent fungal infections, represents the clinical hallmark in gain-of-function (GOF) signal transducer and activator of transcription 1 (STAT1) mutation carriers. Several cases of intracranial aneurysms have been reported in patients with GOF STAT1 mutation but the paucity of reported cases likely suggested this association still as serendipity. In order to endorse this association, we link the development of intracranial aneurysms with STAT1 GOF mutation by presenting the two different cases of a patient and her mother, and demonstrate upregulated phosphorylated STAT4 and IL-12 receptor β1 upon stimulation in patient's blood cells...
February 2, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28160522/isoprene-research-60%C3%A2-years-later-the-biology-is-still-enigmatic
#13
REVIEW
Thomas D Sharkey, Russell K Monson
Isoprene emission is a major component of biosphere-atmosphere interactions. It is the single largest source of non-methane hydrocarbon in the atmosphere. The first report of isoprene emission from plants was published in 1957 by Professor Guivi Sanadze. While humans have smelled the monoterpene hydrocarbons made by coniferous trees since their earliest migrations, only in 1957 did the world became aware that other trees make a type of hydrocarbon in even greater amounts but one to which the human nose is much less sensitive...
February 4, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28089621/exaptation-serendipity-and-aging
#14
Pierpaolo Andriani
The paper shows the importance of serendipity and exaptation in selected key moments of ageing research and argue that rationalistic dominant models in scientific research have masked the importance of reverse models of discovery based on serendipity and exaptation. I ask why this is the case and analyze three contributing factors: unprestatability of the functions of technologies, multidimensionality and astronomical complexity of the space over which biological reactions occurs and role of scientific paradigms in channeling research toward incrementalism...
January 12, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28010759/looking-back-while-stepping-forward-a-path-made-possible-by-serendipity-a-few-good-decisions-and-helpful-colleagues
#15
EDITORIAL
Mark C Udey
No abstract text is available yet for this article.
January 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27986826/the-contribution-of-genome-mining-strategies-to-the-understanding-of-active-principles-of-pgpr-strains
#16
Julia Paterson, Ghazaleh Jahanshah, Yan Li, Qi Wang, Samina Mehnaz, Harald Gross
Pathogenic microorganisms and insects affecting plant health are a major and chronic threat to food production and the ecosystem worldwide. As agricultural production has intensified over the years, the use of agrochemicals has in turn increased. However, this extensive usage has had several detrimental effects, with a pervasive environmental impact and the emergence of pathogen resistance. In addition, there is an increasing tendency among consumers to give preference to pesticide-free food products. Biological control, through the employment of plant growth-promoting rhizobacteria (PGPR), is therefore considered a possible route to the reduction, even the elimination, of the use of agrochemicals...
March 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27977195/improved-potency-of-indole-based-nora-efflux-pump-inhibitors-from-serendipity-toward-rational-design-and-development
#17
Federica Buonerba, Susan Lepri, Laura Goracci, Bryan D Schindler, Susan M Seo, Glenn W Kaatz, Gabriele Cruciani
The NorA efflux pump is a potential drug target for reversal of resistance to selected antibacterial agents, and recently we described indole-based inhibitor candidates. Herein we report a second class of inhibitors derived from them but with significant differences in shape and size. In particular, compounds 13 and 14 are very potent inhibitors in that they demonstrated the lowest IC50 values (2 μM) ever observed among all indole-based compounds we have evaluated.
December 15, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27974174/women-in-metabolism-part-iv
#18
(no author information available yet)
The "Rosies" of Cell Metabolism are wrapping up 2016 with a fourth installment of the "Women in Metabolism" series. We are delighted to present ten women scientists who are leaders in the metabolism field, with their words on the value of perseverance, passion, ingenuity, and a bit of serendipity.
December 13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27958193/lily-and-yuh-nung-jan
#19
(no author information available yet)
Lily and Yuh Nung Jan's collaboration started with the identification of Shaker as the first known potassium channel gene and has flourished to produce over 100 former students and postdocs who are now leading their own research groups. In an interview with Neuron, they reflect on their scientific discoveries, serendipity in science, and the value of curiosity-driven basic research.
November 23, 2016: Neuron
https://www.readbyqxmd.com/read/27932945/monoaminergic-and-histaminergic-strategies-and-treatments-in-brain-diseases
#20
REVIEW
Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith F Tipton, Dorotea Mück-Šeler, Irene Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse J Smolders, Anna Stasiak, Wieslawa A Fogel, Philippe De Deurwaerdère
The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson's disease where the pathophysiology led almost immediately to the introduction of dopamine restoring agents. Extensive neuropharmacological studies first showed that the primary target of antipsychotics, antidepressants, and anxiolytic drugs were specific components of the monoaminergic systems...
2016: Frontiers in Neuroscience
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