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Serendipity

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https://www.readbyqxmd.com/read/29033605/onabotulinum-toxin-a-in-the-treatment-of-chronic-migraine-patient-selection-and-special-considerations
#1
REVIEW
Piero Barbanti, Patrizia Ferroni
Discovered by serendipity, onabotulinum toxin A (BoNT-A) is the only US Food and Drug Administration-approved treatment for the prevention of chronic migraine (CM), one of the most disabling and burdensome human conditions. Its efficacy, safety and tolerability, proved by the largest and longest migraine therapeutic trial (the Phase III Research Evaluating Migraine Prophylaxis Therapy program [PREEMPT]), have been replicated by various real-life studies also in the presence of medication overuse. The benefit of BoNT-A prophylaxis is likely due to its ability to counteract peripheral and central nociceptive sensitization through reversible chemical denervation of pericranial sensitive afferents...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28977688/digenic-inheritance-and-genetic-modifiers
#2
REVIEW
Constantinos Deltas
Digenic inheritance (DI) concerns pathologies with the simplest form of multigenic aetiology, implicating more than one gene (and perhaps the environment). True DI is when biallelic or even triallelic mutations in two distinct genes, in cis or in trans, are necessary and sufficient to cause pathology with a defined diagnosis. In true DI, a heterozygous mutation in each of two genes alone is not associated with a recognizable phenotype. Well-documented diseases with true DI are so far rare and follow non-Mendelian inheritance...
October 4, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28960281/serendipity-in-a-salt-marsh-detecting-frequent-sea-otter-haul-outs-in-a-marsh-ecosystem
#3
Ron Eby, Robert Scoles, Brent Bancroft Hughes, Kerstin Wasson
No abstract text is available yet for this article.
September 28, 2017: Ecology
https://www.readbyqxmd.com/read/28922867/discoveries-of-the-structures-of-sialic-acid-and-cmp-sialic-acid-1957-1960-a-letter-from-saul-roseman
#4
Ronald L Schnaar, Yuan C Lee
Sialic acids have a special place in vertebrate glycobiology, where they constitute the dominant terminal saccharides on many cell surface glycans. From early studies that identified sialoglycans as receptors for important pathogens and toxins to more recent discoveries of sialic acid-binding proteins essential for immune system (and other) functions in humans, sialic acids and sialoglycans have become cornerstones in understanding vertebrate glycobiology and pathology. During a remarkable 3-year period in the late 1950s, a newly minted postdoctoral fellow (Donald G...
June 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28900272/from-malaria-to-cancer-computational-drug-repositioning-of-amodiaquine-using-plip-interaction-patterns
#5
Sebastian Salentin, Melissa F Adasme, Jörg C Heinrich, V Joachim Haupt, Simone Daminelli, Yixin Zhang, Michael Schroeder
Drug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent. While most repositioning efforts emerge through serendipity, we have devised a computational approach, which exploits interaction patterns shared between compounds. As a test case, we took the anti-viral drug brivudine (BVDU), which also has anti-cancer activity, and defined ten interaction patterns using our tool PLIP. These patterns characterise BVDU's interaction with its target s...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28889281/discovery-of-the-second-messenger-cyclic-di-gmp
#6
Ute Römling, Michael Y Galperin
The nearly ubiquitous bacterial second messenger cyclic di-GMP is involved in a multitude of fundamental physiological processes such as sessility/motility transition and the switch between the acute and chronic infection status, combined with cell cycle control. The discovery of cyclic di-GMP, though, has been an example par excellence of scientific serendipity. We recapitulate here its years-long discovery process as an activator of the cellulose synthase of the environmental bacterium Komagataeibacter xylinus and its consequences for follow-up research...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28856807/finding-serendipity
#7
Nipon Chattipakorn
No abstract text is available yet for this article.
September 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28854560/the-princes-of-serendip
#8
I K Moppett, S R Moonesinghe, M P Grocott
No abstract text is available yet for this article.
August 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28773088/4-2-6-4-and-3-2-6-3-terpyridines-the-conflict-between-well-defined-vectorial-properties-and-serendipity-in-the-assembly-of-1d-2d-and-3d-architectures
#9
Y Maximilian Klein, Alessandro Prescimone, Edwin C Constable, Catherine E Housecroft
A comparative investigation of the coordination assemblies formed between Co(NCS)₂ and two monotopic 4,2':6',4''-terpyridine (4,2':6',4"-tpy) ligands or two related ditopic ligands is reported. Crystals were grown by layering MeOH solutions of Co(NCS)₂ over a CHCl₃ or 1,2-C₆H₄Cl₂ solution of the respective ligand at room temperature. With 4'-(2-methylpyrimidin-5-yl)-4,2':6',4"-terpyridine (6), the 1D-coordination polymer {[Co₂(NCS)₄(MeOH)₄(6)₂]∙2MeOH∙8H₂O}n assembles with 6 coordinating only through the outer N-donors of the 4,2':6',4"-tpy unit; coordination by the MeOH solvent blocks two cobalt coordination sites preventing propagation in a higher-dimensional network...
June 30, 2017: Materials
https://www.readbyqxmd.com/read/28670453/novel-aspects-in-diagnostic-approach-to-respiratory-patients-is-it-the-time-for-a-new-semiotics
#10
Gino Soldati, Andrea Smargiassi, Alberto A Mariani, Riccardo Inchingolo
Medical approach to patients is a fundamental step to get the correct diagnosis. The aim of this paper is to analyze some aspects of the reasoning process inherent in medical diagnosis in our era. Pathologic signs (anamnestic data, symptoms, semiotics, laboratory and strumental findings) represent informative phenomena to be integrated for inferring a diagnosis. Thus, diagnosis begins with "signs" and finishes in a probability of disease. The abductive reasoning process is the generation of a hypothesis to explain one or more observations (signs) in order to decide between alternative explanations searching the best one...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28653277/moving-beyond-serendipity-to-mechanism-driven-psychiatric-therapeutics
#11
EDITORIAL
Andrew A Pieper, Jay M Baraban
No abstract text is available yet for this article.
July 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28647023/how-i-became-a-clinician-scientist-in-dermatology-a-tale-of-serendipity-wise-mentors-and-a-good-pinch-of-tenacity
#12
EDITORIAL
Thomas Krieg
No abstract text is available yet for this article.
July 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28540068/serendipity-and-innovation-history-and-evolution-of-transthoracic-echocardiography
#13
REVIEW
Antonino Di Franco, Lucas B Ohmes, Mario Gaudino, Lisa Q Rong, Leonard N Girardi, Filippo M Sarullo, Ylenia Salerno, Silvia Sarullo, Jonathan W Weinsaft, Jiwon Kim
The history of echocardiography is sprinkled with many interesting episodes and anecdotes showing that devoting your life to the pursuit of one goal is praiseworthy, and that at the same time, a little luck goes a long way. Transthoracic echocardiography (TTE) has led to dramatic improvements in cardiovascular medicine, and is now the most widely used diagnostic cardiac test after electrocardiography (ECG). The present review pays tribute to the pioneering efforts of those who believed in this innovative technology despite mounted skepticism and briefly describes the evolution of TTE from its early days to the most recent developments...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28528674/sodium-channels-and-venom-peptide-pharmacology
#14
Mathilde R Israel, Bryan Tay, Jennifer R Deuis, Irina Vetter
Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have evolved a myriad of components in their venoms that target the opening and/or closing of voltage-gated sodium channels to cause devastating effects on the neuromuscular systems of predators and prey. These venom peptides, through design and serendipity, have not only contributed significantly to our understanding of sodium channel pharmacology and structure, but they also represent some of the most phyla- and isoform-selective molecules that are useful as valuable tool compounds and drug leads...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28496113/the-beneficial-role-of-mobility-for-the-emergence-of-innovation
#15
Giuliano Armano, Marco Alberto Javarone
Innovation is a key ingredient for the evolution of several systems, including social and biological ones. Focused investigations and lateral thinking may lead to innovation, as well as serendipity and other random discovery processes. Some individuals are talented at proposing innovation (say innovators), while others at deeply exploring proposed novelties, at getting further insights on a theory, or at developing products, services, and so on (say developers). This separation in terms of innovators and developers raises an issue of paramount importance: under which conditions a system is able to maintain innovators? According to a simple model, this work investigates the evolutionary dynamics that characterize the emergence of innovation...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494256/designing-multi-targeted-agents-an-emerging-anticancer-drug-discovery-paradigm
#16
REVIEW
Rong-Geng Fu, Yuan Sun, Wen-Bing Sheng, Duan-Fang Liao
The dominant paradigm in drug discovery is to design ligands with maximum selectivity to act on individual drug targets. With the target-based approach, many new chemical entities have been discovered, developed, and further approved as drugs. However, there are a large number of complex diseases such as cancer that cannot be effectively treated or cured only with one medicine to modulate the biological function of a single target. As simultaneous intervention of two (or multiple) cancer progression relevant targets has shown improved therapeutic efficacy, the innovation of multi-targeted drugs has become a promising and prevailing research topic and numerous multi-targeted anticancer agents are currently at various developmental stages...
August 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28486209/bioactivity-guided-mixed-synthesis-accelerate-the-serendipity-in-lead-optimization-discovery-of-fungicidal-homodrimanyl-amides
#17
Dangdang Li, Shasha Zhang, Zehua Song, Guotong Wang, Shengkun Li
The bioactivity-guided mixed synthesis was conceived, in which the designed mix-reactions were run in parallel for simultaneous construction of different kinds of analogs. The valuable ones were protruded by biological screening. This tactic will facilitate more rapid incorporation of bioactive candidates into pesticide chemists' repertoire, exemplified by the optimization of less explored homodrimanes as antifungal ingredients. The discovery of D9 as a potent fungicidal agent can be completed in <2 weeks by one student, with EC50 of 3...
August 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28442085/sim-serendipity
#18
EDITORIAL
Mina Attaalla
No abstract text is available yet for this article.
May 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28368582/pomzites-a-family-of-zeolitic-polyoxometalate-frameworks-from-a-minimal-building-block-library
#19
Thomas Boyd, Scott G Mitchell, David Gabb, De-Liang Long, Yu-Fei Song, Leroy Cronin
We describe why the cyclic heteropolyanion [P8W48O184](40-) (abbreviated as {P8W48}) is an ideal building block for the construction of intrinsically porous framework materials by classifying and analyzing >30 coordination polymers incorporating this polyoxometalate (POM) ligand. This analysis shows that the exocyclic coordination of first-row transition metals (TMs) to {P8W48} typically yields frameworks which extend through {W-O-TM-O-W} bridges in one, two, or three dimensions. However, despite the rich structural diversity of such compounds, the coordination of TMs to the {P8W48} ring is poorly understood, and therefore largely unpredictable, and had not until now been present with any structural classification that could allow rational design...
April 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28326916/pay-attention-to-serendipity
#20
Layla Haidrani
When and why did you develop an interest in research? My first nursing job was as a staff nurse in an oncology intensive care unit and a bone marrow transplant unit taking care of patients who were participating in high intensity clinical trials. During my master's degree, I worked as a research assistant for two faculty members whose research was making an impact at state and national levels, and I was able to lead a small research project of my own. During my doctoral and post-doctoral studies, my research interests continued to grow...
March 22, 2017: Nurse Researcher
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