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JOURNAL ARTICLE
Tahmida Sultana Bhuiyan, Mohamed A Said, Md Z H Bulbul, Sumeer Ahmed, Ajmal R Bhat, Mohammed Chalkha, Sarkar M A Kawsar
Nucleoside derivatives are important therapeutic drugs that have drawn significant attention recently. In this study, cytidine ( 1 ) was first exposed to react with cinnamoyl chloride in N , N -dimethylformamide, and trimethylamine to obtain 5'- O -(cinnamoyl)cytidine, which was further treated with several acylating agents to obtain a series of 2',3'-di- O -acyl derivatives. The chemical structures of the synthesized compounds were established through spectral, analytical, and physicochemical techniques. In vitro antimicrobial efficacy was evaluated, and the antimicrobial effect was greater than that of the precursor compound; in particular, compound 3 exhibited the most promising activity...
March 28, 2024: Nucleosides, Nucleotides & Nucleic Acids
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JOURNAL ARTICLE
Matthew Marquardt, Sheila Pontis
PURPOSE: To pilot a novel approach investigating the interplay of social and institutional determinants influencing university undergraduate student sleep patterns. DESIGN: A two-part, three-phase mixed-methods approach. SETTING: A mid-size US university conducted in spring and fall 2020. PARTICIPANTS: 191 undergraduate students (69 first-years, 43 second-years, 48 third-years, 31 fourth-years). METHOD: For Part A, participants texted their activities and emotions in real time, producing a data-rich, weeklong diary of comprehensive activity logs, emoticons, multimedia submissions, and juxtapositions of ideal vs real schedules...
March 21, 2024: American Journal of Health Promotion: AJHP
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JOURNAL ARTICLE
Lillian W Dattilo, Trinity I Russell, Chloe B Warinner, Heather Starmer, Donald J Annino, Laura A Goguen, Rosh K V Sethi, Ravindra Uppaluri, Melina J Windon, Regan W Bergmark, Eleni M Rettig
IMPORTANCE: Major head and neck surgery with microvascular free tissue transfer reconstruction is complex, with considerable risk of morbidity. Little is known about patients' experiences, including decision-making prior to, and regret following, free flap surgery. OBJECTIVE: To characterize patient experiences and decision regret of patients undergoing head and neck reconstructive free flap surgery. DESIGN, SETTING, AND PARTICIPANTS: This mixed-methods cohort study comprising semistructured interviews was conducted June to August 2021 at a single tertiary academic cancer center...
February 22, 2024: JAMA Otolaryngology—Head & Neck Surgery
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JOURNAL ARTICLE
Pietro Sarasso, Irene Ronga, Francesca Piovesan, Paolo Barbieri, Elena Del Fante, Daniela De Luca, Ludovico Bechis, Anna Osello, Katiuscia Sacco
Shared attention effects on learning and memory demonstrate that experiences are amplified when we are not alone. Virtual reality poses new challenges to the study of co-presence. Above all, is coattending together with someone else's avatar in an immersive VR setting comparable with shared experiences at a neural processing level? In the present study we investigate shared attention effects in VR for the first time. We recorded mismatch negativities (MMN) during an auditory roving paradigm, a well-known index of implicit perceptual learning...
February 14, 2024: Scientific Reports
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JOURNAL ARTICLE
Christoph Lüthy
We are all used to drawing straight lines to represent time, and above them, we plot historical events or physical or economic data. What to us is a self-evident convention, is however of an astonishingly recent date: it emerged only in the second half of the eighteenth century. To us, this late date seems paradoxical and cries out for an explanation. How else did earlier periods measure change, if not as a function of time? it will be argued that since Antiquity, time was taken to measure change, and change to occur in space...
February 3, 2024: Annals of Science
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JOURNAL ARTICLE
Anna K Porter, Sarah E Kleinschmidt, Kara L Andres, Courtney N Reusch, Ryan M Krisko, Oyebode A Taiwo, Geary W Olsen, Matthew P Longnecker
Per - and polyfluoroalkyl substances (PFAS) are a broad class of synthetic chemicals; some are present in most humans in developed countries. Some studies suggest that certain PFAS may have immunotoxic effects in humans, which could put individuals with high levels of exposure at increased risk for infectious diseases such as COVID-19. We conducted a case-control study to examine the association between COVID-19 diagnosis and PFAS serum concentrations among employees and retirees from two 3 M facilities, one of which historically generated perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS)...
June 2024: Global epidemiology
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JOURNAL ARTICLE
Maëlle de Ville de Goyet, Michal Kicinski, Stefan Suciu, Els Vandecruys, Anne Uyttebroeck, Alina Ferster, Claire Freycon, Geneviève Plat, Caroline Thomas, Mélissa Barbati, Marie-Françoise Dresse, Catherine Paillard, Claire Pluchart, Pauline Simon, Christophe Chantrain, Odile Minckes, Jutte van der Werff Ten Bosch, Yves Bertrand, Pierre Rohrlich, Frederic Millot, Robert Paulus, Yves Benoit, Caroline Piette
Survival after childhood acute lymphoblastic leukemia (ALL) has increased over the last 40 years with an overall survival above 90%. Survivors may experience neurological late effects secondary to chemotherapy and radiotherapy. This observational retrospective study evaluated the cumulative incidence of neurological late effects among 890 childhood ALL survivors treated in EORTC CLG trials (58741, 58831/2 and 58881) between 1971 and 1998. Median follow-up was 19 years and interquartile range of the follow-up was 15-22 years...
January 29, 2024: Discover. Oncology
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JOURNAL ARTICLE
Else Holmfred, Abdulla Alrijjal, C Page Chamberlain, Katharine Maher, Stefan Stürup
Trace elements are found in most drugs as a result of the drug formulation and drug production methods. An inductively coupled plasma-mass spectrometry method for the determination of 24 trace elements (Mg, Ti, V, Cr, Mn, Cu, Fe, Co, Ni, Zn, As, Se, Mo, Ru, Rh, Pd, Ag, Cd, Sb, Ba, Ir, Pt, Au, and Pb) in solid ibuprofen tablets was established in relation to the ICH Q3D(R1) guideline, to evaluate the possibility of linking trace elemental profiles to drug formulation strategies, and to differentiate between drug products based on the trace elemental profiles...
January 15, 2024: Heliyon
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JOURNAL ARTICLE
Paul Welaga, Martin Kavao Mutua, Syed Manzoor Ahmed Hanifi, Patrick Ansah, Peter Aaby, Sebastian Nielsen
BACKGROUND: Studies from Guinea-Bissau and Bangladesh have shown that campaigns with oral polio vaccine (C-OPV) may be associated with 25-31% lower child mortality. Between 1996 and 2015, Ghana had 50 national C-OPVs and numerous campaigns with vitamin A supplementation (VAS), and measles vaccine (MV). We investigated whether C-OPVs had beneficial non-specific effects (NSEs) on child survival in northern Ghana. METHODS: We used data from a health and demographic surveillance system in the Navrongo Health Research Centre in rural northern Ghana to examine mortality from day 1-5 years of age...
December 2023: EClinicalMedicine
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JOURNAL ARTICLE
Stephen K Liu, Fabienne Bourgeois, Joe Dong, Kendall Harcourt, Elizabeth Lowe, Liz Salmi, Eric J Thomas, Natalie Riblet, Sigall K Bell
OBJECTIVES: Accurate and timely diagnosis relies on close collaboration between patients/families and clinicians. Just as patients have unique insights into diagnostic breakdowns, positive patient feedback may also generate broader perspectives on what constitutes a "good" diagnostic process (DxP). METHODS: We evaluated patient/family feedback on "what's going well" as part of an online pre-visit survey designed to engage patients/families in the DxP. Patients/families living with chronic conditions with visits in three urban pediatric subspecialty clinics (site 1) and one rural adult primary care clinic (site 2) were invited to complete the survey between December 2020 and March 2022...
December 20, 2023: Diagnosis
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JOURNAL ARTICLE
Angela Mc Rose, Nathalie Nicolay, Virginia Sandonis Martín, Clara Mazagatos, Goranka Petrović, Joaquin Baruch, Sarah Denayer, Lucie Seyler, Lisa Domegan, Odile Launay, Ausenda Machado, Cristina Burgui, Roberta Vaikutyte, F Annabel Niessen, Isabela I Loghin, Petr Husa, Nassera Aouali, George Panagiotakopoulos, Kristin Tolksdorf, Judit Krisztina Horváth, Jennifer Howard, Francisco Pozo, Virtudes Gallardo, Diana Nonković, Aušra Džiugytė, Nathalie Bossuyt, Thomas Demuyser, Róisín Duffy, Liem Binh Luong Nguyen, Irina Kislaya, Iván Martínez-Baz, Giedre Gefenaite, Mirjam J Knol, Corneliu Popescu, Lenka Součková, Marc Simon, Stella Michelaki, Janine Reiche, Annamária Ferenczi, Concepción Delgado-Sanz, Zvjezdana Lovrić Makarić, John Paul Cauchi, Cyril Barbezange, Els Van Nedervelde, Joan O'Donnell, Christine Durier, Raquel Guiomar, Jesús Castilla, Indrė Jonikaite, Patricia Cjl Bruijning-Verhagen, Mihaela Lazar, Regina Demlová, Gil Wirtz, Marina Amerali, Ralf Dürrwald, Mihály Pál Kunstár, Esther Kissling, Sabrina Bacci, Marta Valenciano
IntroductionThe I-MOVE-COVID-19 and VEBIS hospital networks have been measuring COVID-19 vaccine effectiveness (VE) in participating European countries since early 2021.AimWe aimed to measure VE against PCR-confirmed SARS-CoV-2 in patients ≥ 20 years hospitalised with severe acute respiratory infection (SARI) from December 2021 to July 2022 (Omicron-dominant period).MethodsIn both networks, 46 hospitals (13 countries) follow a similar test-negative case-control protocol. We defined complete primary series vaccination (PSV) and first booster dose vaccination as last dose of either vaccine received ≥ 14 days before symptom onset (stratifying first booster into received < 150 and ≥ 150 days after last PSV dose)...
November 2023: Euro Surveillance
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JOURNAL ARTICLE
Jones Arkoh Paintsil, Kenneth Setorwu Adde, Edward Kwabena Ameyaw, Kwamena Sekyi Dickson, Sanni Yaya
BACKGROUND: The World Health Organization (WHO) has cited domestic violence as an urgent global maternal and child health priority. Gender differences in the acceptance of wife-beating have not been explored at the multi-country level in sub-Saharan Africa (SSA) where the occurrence of wife-beating (36%) is greater than the global average (30%). It is against this backdrop that we examine the gender differences in the acceptance of wife beating in SSA. METHODS: We used Demographic and Health Survey data from 30 SSA countries...
August 27, 2023: BMC Women's Health
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JOURNAL ARTICLE
Kathryn D Winters, Jennifer Byrne, Natasha Eckholm, Rabia S Atayee, Timothy Furnish
Introduction: Patients with advanced cancer nearing end of life often present with complex multifactorial pain. Although epidural analgesia is routinely used in inpatient hospital settings for targeted pain control, there is scant description in the literature of the use of low-dose epidural analgesia for relief of cancer-related pain at end of life. In this study, we present a case of difficult to control cancer-related rectal and pelvic pain in a patient who responded well in her last days of life to a low-dose bupivacaine epidural...
August 22, 2023: Journal of Palliative Medicine
#14
JOURNAL ARTICLE
Christian J Resick, Lorenzo Lucianetti, Mary B Mawritz, Jae Young Choi, Stacy L Boyer, Lauren D'Innocenzo
Drawing on goal shielding theory (Shah et al., 2002), our study highlights the roles of bottom-line mentality climates and shared vision in encouraging collective unethical conduct in pursuit of financial results. Consistent with the theory, we hypothesize that high bottom-line mentality leaders shape their unit's bottom-line mentality climate by explicitly clarifying the importance of prioritizing financial results above all else and using motivational resources to encourage a sole focus on bottom-line attainment...
July 27, 2023: Journal of Applied Psychology
#15
JOURNAL ARTICLE
Christy A Comeaux, Stephan Bart, Arangassery Rosemary Bastian, Vladislav Klyashtornyy, Els De Paepe, Edmund Omoruyi, Leslie van der Fits, Roy van Heesbeen, Esther Heijnen, Benoit Callendret, Jerald Sadoff
BACKGROUND: Ad26.RSV.preF is an adenovirus serotype 26 vector-based RSV vaccine encoding a pre-fusion conformation-stabilized RSV fusion protein (preF) that demonstrated robust humoral and cellular immunogenicity and showed promising efficacy in a human challenge study in younger adults. Addition of recombinant RSV preF protein might further enhance RSV-specific humoral immune responses, especially in older populations. METHODS: This randomized, double-blind, placebo-controlled phase 1/2a study (NCT03502707; https://www...
July 11, 2023: Journal of Infectious Diseases
#16
JOURNAL ARTICLE
Nicole Valentine, Carmel Williams, Jeanette Vega, Orielle Solar, Michaela Told
Health in All Policies approaches support the integration of health considerations into the policies of traditionally siloed governance systems. These siloed systems are often ignorant of the fact that health is created outside of the health system and starts long before you see a health professional. Thus, the purpose of Health in All Policies approaches is to raise the importance of the broad-based impacts on health from these public policies and to implement healthy public policy that delivers human rights for all...
June 28, 2023: Health Promotion Journal of Australia
#17
JOURNAL ARTICLE
Jacob D Moses, Agnes Arnold-Forster, Samuel V Schotland
From the stress of burnout to the gratification of camaraderie, medicine is suffused with emotions that educators, administrators, and reformers have sought to shape. Yet historians of medicine have only begun to analyze how emotions have structured health care work. This introductory essay frames a special issue on health care practitioners' emotions in the twentieth-century United Kingdom and United States. We argue that the massive bureaucratic and scientific changes in medicine after the Second World War helped to reshape affective aspects of care...
September 23, 2023: Journal of the History of Medicine and Allied Sciences
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JOURNAL ARTICLE
Julie Domen, Jan Yvan Jos Verbakel, Niels Adriaenssens, Beatrice Scholtes, Bart Peeters, Robin Bruyndonckx, An De Sutter, Stefan Heytens, Ann Van den Bruel, Isabelle Desombere, Pierre Van Damme, Herman Goossens, Laetitia Buret, Els Duysburgh, Samuel Coenen
OBJECTIVES: To validate a rapid serological test (RST) for SARS-CoV-2 antibodies used in seroprevalence studies in healthcare providers, including primary healthcare providers (PHCPs) in Belgium. DESIGN: A phase III validation study of the RST (OrientGene) within a prospective cohort study. SETTING: Primary care in Belgium. PARTICIPANTS: Any general practitioner (GP) working in primary care in Belgium and any other PHCP from the same GP practice who physically manages patients were eligible in the seroprevalence study...
May 2, 2023: BMJ Open
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REVIEW
Elspeth Jane Rose Hill, Jayme Augusto Bertelli
People with spinal cord injury (SCI) prioritize hand function above all else as a reconstructive goal, yet remain a markedly undertreated population by hand surgeons. This review article provides an overview of the epidemiology of SCI and the unmet clinical need of these patients. Further, this article outlines the natural history of SCI, including the expected spontaneous recovery over time and the expectations of hand function when treated with hand therapy alone. This review aims to equip reconstructive hand surgeons with a sound understanding of the basic principles of SCI and recovery and provide a rationale for when to intervene with surgery...
March 22, 2023: Journal of Hand Surgery
#20
JOURNAL ARTICLE
Xiuyan Zhang, Xing Ma, Xiaowei Fan, Tongling Ge, Robert E Leiby, Bryan Swingle, Steven B Johnson, Robert Larkin, Bee Khim Chim, Jianjun Hao
Potato (Solanum tuberosum) plants showing blackleg and soft rot symptoms were collected at a commercial vegetable farm near Newmanstown, PA in August 2021 (Fig. S1). The incidence of potato blackleg in the unirrigated field was about 5 to 8%, but approximately 30% in the irrigated field. The diseased stems were cut into 5 cm and surface disinfected. The stem segments were placed into a 50-mL tube containing 15 mL of sterile water for 15 min for bacterial release. The bacterial suspension was streaked on crystal violet polypectate (CVP) (Hélias et al...
February 12, 2023: Plant Disease
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