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https://www.readbyqxmd.com/read/28732844/efficacy-and-safety-of-collagenase-treatment-for-dupuytren-s-disease-2-year-follow-up-results
#1
A Van Beeck, M Van den Broek, M Michielsen, K Didden, K Vuylsteke, F Verstreken
Dupuytren's contracture is a common hand problem that affects the palmar fascia. Several treatment options exist, but none are curative and recurrence is common. Bacterial collagenase has recently been proven beneficial for treating Dupuytren's disease, cleaving the collagen fibers at different sites, with weakening and eventually rupture of the fibrous cords after manipulation. An independent prospective follow-up study was organized on 87 patients, treated with one or more collagenase injections. Inclusion criteria were a contracture of at least 20° at the metacarpophalangeal (MCP) or the proximal interphalangeal (PIP) joint...
July 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28732843/preliminary-results-with-non-centrifuged-autologous-fat-graft-and-percutaneous-aponeurotomy-for-treating-dupuytren-s-disease
#2
U Tuncel, A Kurt, M Gumus, O Aydogdu, N Güzel, O Demir
The aim of this study was to describe our experience with treating Dupuytren's disease using needle aponeurotomy and non-centrifuged autologous fat grafting. The study included 17 patients (18 hands). Patients were treated with needle aponeurotomy and non-centrifuged autologous fat graft under general anesthesia. The fat grafts were injected into the surgical area so as to stay in contact with the operated site. An extension splint was used for 1 week postoperatively and the patients received hand therapy for 3 weeks...
July 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28705609/hand-shoulder-and-back-stiffness-in-long-term-type-1-diabetes-cross-sectional-association-with-skin-collagen-advanced-glycation-end-products-the-dialong-study
#3
Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kristian Folkvord Hanssen, Dag Sigurd Fosmark, David R Sell, Vincent M Monnier, Tore Julsrud Berg
AIMS: We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). METHODS: Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study...
June 22, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28692190/dupuytren-s-contracture-and-handwork-a-case-control-study
#4
Alfred Haines, Carolyn Levis, Charles H Goldsmith, Manraj Kaur, Eric Duku, Richard Wells, Stephen D Walter, Cheryl Rook, Susan Stock, Gary Liss, Jessica Murphy, Achilleas Thoma
OBJECTIVE: The objective of this study was to examine the association between Dupuytren's contracture (DC), repetitive handwork (RHW), heavy handwork (HHW), and/or vibration exposure. METHODS: Frequency and intensity of the three types of handwork were collected and compared between DC patients and controls. Hours of work were weighted by average "frequency," for RHW, and average "intensity," for HHW and use of vibrating tool. Logistic regression was used to evaluate risk of developing DC associated with the above-mentioned factors...
August 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28691512/the-incidence-of-complex-regional-pain-syndrome-in-simultaneous-surgical-treatment-of-carpal-tunnel-syndrome-and-dupuytren-contracture
#5
Mitchell Buller, Steven Schulz, Morton Kasdan, Bradon J Wilhelmi
BACKGROUND: To determine the incidence of complex regional pain syndrome (CRPS) in the concurrent surgical treatment of Dupuytren contracture (DC) and carpal tunnel syndrome (CTS) through a thorough review of evidence available in the literature. METHODS: The indices of 260 hand surgery books and PubMed were searched for concomitant references to DC and CTS. Studies were eligible for inclusion if they evaluated the outcome of patients treated with simultaneous fasciectomy or fasciotomy for DC and carpal tunnel release using CRPS as a complication of treatment...
July 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28676223/prevalence-of-peyronie-s-disease-like-symptoms-in-men-presenting-with-dupuytren-contractures
#6
Alan W Shindel, Genevieve Sweet, William Thieu, Blythe Durbin-Johnson, Jennifer Rothschild, Robert Szabo
INTRODUCTION: Peyronie's disease (PD) and Dupuytren contractures (DC) are often comorbid and are believed to have a similar underlying pathophysiologic mechanism. AIM: To investigate the prevalence of PD-like symptoms (PDLS) in men with DC. METHODS: From October 2013 to December 2016, men who were seen and evaluated for DC were offered the opportunity to participate in an anonymous survey. The survey assessed several basic demographic and sexual health factors and included items from the International Index of Erectile Function and the Erection Hardness Scale...
July 1, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28669261/dupuytren-s-disease-my-personal-view
#7
D Warwick
Dupuytren's disease is a heterogenous condition for which a palette of treatment options is required. Randomized control trial evidence is sparse; design challenges, such as validated outcome measures, blinding, equipoise, funding and assessment of recurrence, may limit further data accrual. Recurrence has different significance with different treatments and so rates are not directly comparable. The risk of any treatment is a function of both the chance of a complication and the clinical sequelae of that complication...
June 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28654597/involvement-of-the-interosseous-and-lumbrical-muscle-tendon-units-in-the-lateral-and-spiral-cords-in-dupuytren-s-disease-of-the-middle-fingers
#8
Achilleas Thoma, Marta Karpinski
BACKGROUND: The nature of intrinsic muscle involvement in Dupuytren's disease of the middle fingers (long and ring) remains poorly characterized. Over the years, the authors have observed that both the spiral and lateral digital cords in the middle fingers receive contribution from intrinsic muscle-tendon units. This report describes the anatomical characteristics and frequency of intrinsic muscle-tendon unit involvement in Dupuytren's disease of the middle fingers. METHODS: Intrinsic muscle involvement in the middle digits was recorded in the operative reports of patients undergoing Dupuytren's surgery between October of 2013 and February of 2016...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28645702/use-of-adipose-tissue-and-stromal-vascular-fraction-in-hand-surgery
#9
REVIEW
Iad Nseir, Flore Delaunay, Charles Latrobe, Albane Bonmarchand, Dorothée Coquerel-Beghin, Isabelle Auquit-Auckbur
Adipose tissue is an abundant source of various cell types including not only adipocytes, but also progenitor and endothelial cells from thestroma. Interest in adipose tissue has surged since the identification in 2001 of adipose-derived stem cells (ADSCs) and of the stromal vascular fraction (SVF) obtained from adipose tissue by enzymatic digestion and centrifugation. SVF has been proven effective in ensuring tissue regeneration, thus improving tissue trophicityand vascularisation. These effects have generated strong interest among both physicians and surgeons, particularly in the field of hand surgery...
June 20, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28642664/surgical-treatment-results-for-dupuytren-s-disease
#10
Serkan Aykut, Mehmet Baydar, Abdul Fettah Büyük, İbrahim Avşin Öztürk, Erdem Özden, Kahraman Öztürk
OBJECTIVE: To present the results of our cases of Dupuytren's disease treated with regional selective fasciectomy in light of the literature. METHODS: Patients diagnosed with Dupuytren's contracture and surgically treated with regional selective fasciectomy at our institution with adequate follow-up data were included in the study. All patients were routinely followed after surgery to assess results and complications. QuickDASH scoring was used to evaluate the patients and recurrences and complications were recorded...
May 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642214/dupuytren-disease-is-there-enough-comprehensive-patient-information-on-the-internet
#11
Grzegorz Zuk, Katharina B Reinisch, Dimitri A Raptis, Sonia Fertsch, Merlin Guggenheim, Adrian F Palma
BACKGROUND: Dupuytren disease is a chronic nonmalign fibroproliferative disorder that causes finger contractures via proliferation of new tissue under the glabrous skin of the hand, resulting in multiple functional limitations for the patient. As many surgical therapy options exist, patients suffering from this condition actively search for information in their environment before consulting a health professional. OBJECTIVE: As little is known about the quality of Web-based patient information, the aim of this study was to conduct its systematic evaluation using a validated tool...
June 22, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28635316/complications-following-collagenase-treatment-for-dupuytren-contracture
#12
Jennifer Wozniczka, Clifford Canepa, Adam Mirarchi, Joel S Solomon
BACKGROUND: Collagenase Clostridium histolyticum (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome. METHODS: This study describes a case report of 2 patients seen at our institution...
June 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28630994/dupuytren-s
#13
Veneta Masson
No abstract text is available yet for this article.
June 20, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28604542/outcome-of-dupuytren-contractures-after-collagenase-clostridium-histolyticum-injection-a-single-institution-experience
#14
Yin Kan Hwee, Daniel Park, Marisa Vinas, Christopher Litts, David Friedman
BACKGROUND: Collagenase clostridium histolyticum (CCH) injection is an alternative to surgery for patients with Dupuytren disease (DD) of the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. The success of surgical and nonsurgical treatment modalities for DD is reported to vary widely between 25% and 80% (J Bone Joint Surg Am. 1985;67:1439-1443; Plast Reconstr Surg. 2007;120:44e-54e; J Bone Joint Surg Am. 2007;89:189-198; J Hand Surg Am. 2011:36:936-942; J Hand Surg Am...
August 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28587568/ultrasonographic-examination-of-the-ruptured-cord-after-collagenase-treatment-or-needle-fasciotomy-for-dupuytren-s-contracture
#15
J Strömberg, P Vanek, J Fridén, Y Aurell
Local treatment of Dupuytren's contracture, either by collagenase or needle fasciotomy, allows disruption of the pathological cord during forced extension. The purpose of this study was to investigate the cord before and after both treatments by ultrasound. A total of 39 patients with a minimum of 20° contracture in the metacarpophalangeal joint were included and randomized to treatment with either collagenase (20 patients) or needle fasciotomy (19 patients). The distance between the distal and the proximal parts of the ruptured cord was measured by ultrasound and the difference in passive joint movement before and after treatment was measured with a goniomenter...
June 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28538569/early-postoperative-results-of-percutaneous-needle-fasciotomy-in-451-patients-with-dupuytren-disease
#16
Sanne Molenkamp, Tanneke A M Schouten, Dieuwke C Broekstra, Paul M N Werker, J Daniel Moolenburgh
BACKGROUND: Percutaneous needle fasciotomy is a minimally invasive treatment modality for Dupuytren disease. In this study, the authors analyzed the efficacy and complication rate of percutaneous needle fasciotomy using a statistical method that takes the multilevel structure of data, regarding multiple measurements from the same patient, into account. METHODS: The data of 470 treated rays from 451 patients with Dupuytren disease that underwent percutaneous needle fasciotomy were analyzed retrospectively...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28515727/basics-of-radiation-biology-when-treating-hyperproliferative-benign-diseases
#17
REVIEW
Franz Rödel, Claudia Fournier, Julia Wiedemann, Felicitas Merz, Udo S Gaipl, Benjamin Frey, Ludwig Keilholz, M Heinrich Seegenschmiedt, Claus Rödel, Stephanie Hehlgans
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28507849/difference-in-success-treating-proximal-interphalangeal-and-metacarpophalangeal-joints-with-collagenase-results-of-208-treatments
#18
Karina Liv Hansen, Jens Christian Werlinrud, Søren Larsen, Tune Ipsen, Jens Lauritsen
BACKGROUND: Dupuytren disease (DD) is a fibroproliferative disorder of the palmar fasciae causing extension deficit and impaired hand function. Treatment with injection of collagenase clostridium histolyticum (CCH) is a nonsurgical treatment method. The aim of this study was to evaluate the difference in efficiency and recurrence at 12-month follow-up when treating metacarpophalangeal (MP) and proximal interphalangeal (PIP) joints with CCH. None of the patients had received previous treatments of their condition...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28505213/dupuytren-s-disease-how-to-recognize-its-early-signs
#19
REVIEW
Thomas Auld, Joanne R Werntz
Palmar skin dimpling and nodule or cord formation signal advancing disease. Treatments vary in effectiveness--in part, depending on condition severity.
March 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28505187/recurrence-of-dupuytren-s-contracture-a-consensus-based-definition
#20
Hester J Kan, Frank W Verrijp, Steven E R Hovius, Christianne A van Nieuwenhoven, Ruud W Selles
PURPOSE: One of the major determinants of Dupyutren disease (DD) treatment efficacy is recurrence of the contracture. Unfortunately, lack of agreement in the literature on what constitutes recurrence makes it nearly impossible to compare the multiple treatments alternatives available today. The aim of this study is to bring an unbiased pool of experts to agree upon what would be considered a recurrence of DD after treatment; and from that consensus establish a much-needed definition for DD recurrence...
2017: PloS One
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