keyword
https://read.qxmd.com/read/38527344/industry-sponsorship-bias-in-collagenase-clinical-trials-for-dupuytren-disease-a-meta-analysis
#1
JOURNAL ARTICLE
Kelsey M Gray, Priyenka Khatiwada, Anthony E Capito
BACKGROUND: Collagenase clostridium histolyticum (collagenase) was introduced in 2010 creating a nonoperative treatment option for Dupuytren disease with promising results in sponsored clinical trials. A meta-analysis was performed to investigate industry sponsorship bias. METHODS: A systematic review of collagenase treatment of Dupuytren contracture was conducted. Articles containing mesh terms including "microbial collagenase" and "Dupuytren's contracture" were searched and limited to only clinical trials with similar protocols for inclusion...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38488516/mortality-in-patients-with-dupuytren-s-disease-in-the-first-5-years-after-diagnosis-a-population-based-survival-analysis
#2
JOURNAL ARTICLE
Bente A van den Berge, Feikje Groenhof, Paul M N Werker, Dominic Furniss, Rachel Kuo, Edwin R van den Heuvel, Dieuwke C Broekstra
Previous studies suggest that Dupuytren's disease is associated with increased mortality, but most studies failed to account for important confounders. In this population-based cohort study, general practitioners' (GP) data were linked to Statistics Netherlands to register all-cause and disease-specific mortality. Patients with Dupuytren's disease were identified using the corresponding diagnosis code and assessing free-text fields from GP consultations. Multiple imputations were performed to estimate missing values of covariates, followed by 1:7 propensity score matching to balance cases with controls on confounding factors...
March 15, 2024: Journal of Hand Surgery, European Volume
https://read.qxmd.com/read/38420076/comparing-complications-and-patient-satisfaction-following-injectable-collagenase-versus-limited-fasciectomy-for-dupuytren-s-disease-a-systematic-review-and-meta-analysis
#3
REVIEW
Zainah A Alhebshi, Aya O Bamuqabel, Zainab Alqurain, Dana Dahlan, Hanan I Wasaya, Ziyad S Al Saedi, Gutaybah S Alqarni, Danah Alqarni, Bayan Ghalimah
Dupuytren's disease (DD) is a fibroproliferative disorder that manifests as an abnormal growth of myofibroblasts, causing nodule formation and contractures and affecting digit function. If left untreated, these contractures can lead to a loss of mobility and potentially impact hand function. This systematic review critically compares and evaluates the existing literature on the complications and patient satisfaction following injectable collagenase Clostridium histolyticum (CCH) versus limited fasciectomy (LF) for DD...
January 2024: Curēus
https://read.qxmd.com/read/38398678/pain-relieving-effects-of-shockwave-therapy-for-ledderhose-disease-an-ultrasound-based-study-of-an-unusual-bilateral-case
#4
Federica Fulceri, Larisa Ryskalin, Gabriele Morucci, Francesco Busoni, Paola Soldani, Marco Gesi
Ledderhose disease (LD, or plantar fibromatosis) is a rare, nodular, hyperproliferative condition affecting the plantar aponeurosis of the foot. At present, several conservative, non-surgical treatments have been documented, although with various degrees of success, with little evidence in the literature supporting their efficacy. In this scenario, extracorporeal shock wave therapy (ESWT) has emerged as a safe, effective, and less invasive approach for the successful treatment of several refractory musculoskeletal conditions and soft tissue injuries...
January 24, 2024: Life
https://read.qxmd.com/read/38346307/surgery-needle-fasciotomy-or-collagenase-injection-for-dupuytren-contracture-a-randomized-controlled-trial
#5
JOURNAL ARTICLE
Mikko Petteri Räisänen, Olli V Leppänen, Janne Soikkeli, Aleksi Reito, Antti Malmivaara, Rachelle Buchbinder, Hannu Kautiainen, Antti Kaivorinne, Susanna Stjernberg-Salmela, Minna Lappalainen, Toni Luokkala, Annele Pönkkö, Hanna-Stiina Taskinen, Markus Pääkkönen, Kati Jaatinen, Joona Juurakko, Venla-Linnea Karjalainen, Teemu Karjalainen
BACKGROUND: Surgery, needle fasciotomy, and collagenase injection are used to treat Dupuytren contracture. The treatment decision requires balancing initial morbidity and costs of surgery against its potential long-term benefits over needle fasciotomy and collagenase. OBJECTIVE: To compare the effectiveness of surgery, needle fasciotomy, and collagenase injection at 3 months and 2 years (secondary time points of the trial). DESIGN: A multicenter, randomized, outcome assessor-blinded, superiority trial...
February 13, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38333027/modified-scoring-of-the-quickdash-can-achieve-previously-unattained-interval-level-measurement-in-dupuytren-disease-and-carpal-tunnel-syndrome
#6
JOURNAL ARTICLE
Paul H C Stirling, Jane E McEachan, Jeremy N Rodrigues, Luke Geoghegan, Conrad J Harrison
BACKGROUND: Rasch measurement theory can be used to identify scales within questionnaires and to map responses to more precise continuous scales. The aim of this article was to use RMT to refine the scoring of the QuickDASH in patients with Dupuytren disease and carpal tunnel syndrome (CTS). METHODS: Data were collected between 2013 and 2019 from a single center in the UK. Preoperative QuickDASH responses from patients diagnosed with Dupuytren disease and CTS were used...
February 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38332241/gwas-data-help-unravel-dupuytren-disease
#7
JOURNAL ARTICLE
Sarah Onuora
No abstract text is available yet for this article.
February 8, 2024: Nature Reviews. Rheumatology
https://read.qxmd.com/read/38313593/tips-tricks-and-pearls-for-a-superior-patient-and-surgeon-experience-for-wide-awake-dupuytren-surgery
#8
JOURNAL ARTICLE
Natasha Barone, Donald H Lalonde, Jean Paul Brutus
Fasciectomy for Dupuytren disease is a common procedure traditionally performed with a tourniquet under general or regional anesthesia. Since the year 2001, the wide-awake local anesthesia no tourniquet (WALANT) approach has been applied successfully to Dupuytren surgery, with current excellent surgeon and patient satisfaction. However, using WALANT for Dupuytren surgery may be intimidating for hand surgeons who want to begin using this method. The purpose of this article is to offer a series of tips and tricks the authors have learned after having performed hundreds of WALANT fasciectomies, to make this technique easier for surgeons and a more pleasurable experience for patients...
February 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38289897/treatment-durability-of-limited-fasciectomy-vs-percutaneous-needle-fasciotomy-for-dupuytren-s-disease
#9
JOURNAL ARTICLE
Bente A van den Berge, Fatuma M A Omar, Paul M N Werker, Zhuozhao Zhan, Edwin R van den Heuvel, Dieuwke C Broekstra
BACKGROUND: Patients with Dupuytren's disease (DD) are mostly surgically treated by percutaneous needle fasciotomy (PNF) or limited fasciectomy (LF), but data on time intervals to retreatment is lacking. We aimed to estimate the risk of retreatment within certain time periods after treatment with PNF and LF. METHODS: We used data of participants of a cohort study on the course of DD who were treated only with PNF or LF. Our primary outcome measure was time to retreatment of DD...
January 30, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38288717/incidence-prevalence-and-outcomes-of-hand-manifestations-in-patients-with-diabetes-mellitus-a-comprehensive-literature-review
#10
REVIEW
Thomas G Knoedler, Aidan P Gaertner, Paul J Wilkinson, A Neil Salvapongse
Diabetes mellitus is a metabolic disease that results in long-term hyperglycemia. Among the many long-term complications associated with diabetes, manifestations in the hand include Dupuytren's contracture, trigger finger, compressive neuropathies, and infections. These conditions can have a profound impact on a patient's quality of life, highlighting the importance of timely recognition and treatment of these manifestations. This review aims to provide updated information regarding the incidence and outcomes of these clinical manifestations in the diabetic versus nondiabetic population...
January 30, 2024: Hand: Official Journal of the American Association for Hand Surgery
https://read.qxmd.com/read/38278697/orthotic-interventions-for-restoring-proximal-interphalangeal-joint-motion-for-patients-with-hand-injuries-or-conditions-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Sally E Yates, Joanne V Glinsky, Melissa J Hirth, Joel T Fuller
BACKGROUND: Limitations to proximal interphalangeal joint (PIPJ) motion can result in significant functional impairment for people with hand injuries and conditions. The role of orthotic intervention to improve PIPJ motion has been studied; however, high-quality systematic reviews and meta-analyses are lacking. PURPOSE: This study aimed to determine the effectiveness of orthotic intervention for restoring PIPJ extension/flexion following hand injuries or conditions...
January 26, 2024: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://read.qxmd.com/read/38265010/a-systematic-review-of-qualitative-research-in-hand-surgery
#12
REVIEW
Caroline Hircock, Xue-Wei Lin, Rafael P Lansang, Cameron F Leveille, Lucas Gallo, Achilles Thoma
No formal review of qualitative research in hand surgery has been previously performed. The primary objective of this study was to evaluate the reporting quality of hand surgery qualitative research with the Standards for Reporting Qualitative Research (SRQR), a 21-item checklist. The secondary objectives were to describe qualitative research in hand surgery by domain, determine differences in reporting quality based on use of a reporting guideline, publication of SRQR and journal of publication, and to identify important outcomes in hand surgery conditions...
January 24, 2024: Hand: Official Journal of the American Association for Hand Surgery
https://read.qxmd.com/read/38205890/hyperglycaemia-is-a-causal-risk-factor-for-upper-limb-pathologies
#13
JOURNAL ARTICLE
Harry D Green, Ella Burden, Ji Chen, Jonathan Evans, Kashyap Patel, Andrew R Wood, Robin N Beaumont, Jessica Tyrrell, Timothy M Frayling, Andrew T Hattersley, Richard A Oram, Jack Bowden, Inês Barroso, Christopher Smith, Michael N Weedon
BACKGROUND: Diabetes (regardless of type) and obesity are associated with a range of musculoskeletal disorders. The causal mechanisms driving these associations are unknown for many upper limb pathologies. We used genetic techniques to test the causal link between glycemia, obesity and musculoskeletal conditions. METHODS: In the UK Biobank's unrelated European cohort (N = 379 708) we performed mendelian randomisation (MR) analyses to test for a causal effect of long-term high glycaemia and adiposity on four musculoskeletal pathologies: frozen shoulder, Dupuytren's disease, carpal tunnel syndrome and trigger finger...
January 10, 2024: International Journal of Epidemiology
https://read.qxmd.com/read/38187218/rna-seq-unravels-distinct-expression-profiles-of-keloids-and-dupuytren-s-disease
#14
JOURNAL ARTICLE
Marcus Stocks, Annika S Walter, Elif Akova, Gerd Gauglitz, Attila Aszodi, Wolfgang Boecker, Maximilian M Saller, Elias Volkmer
Keloid scars and Dupuytren's disease are two common, chronic, and incurable fibroproliferative disorders that, among other shared clinical features, may induce joint contractures. We employed bulk RNA sequencing to discern potential shared gene expression patterns and underlying pathological pathways between these two conditions. Our aim was to uncover potential molecular targets that could pave the way for novel therapeutic strategies. Differentially expressed genes (DEGs) were functionally annotated using Gene Ontology (GO) terms and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways with the Database for Annotation, Visualization, and Integrated Discovery (DAVID)...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38172110/a-genome-wide-association-meta-analysis-implicates-hedgehog-and-notch-signaling-in-dupuytren-s-disease
#15
JOURNAL ARTICLE
Sophie A Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M N Werker, Dominic Furniss, Ilja M Nolte
Dupuytren's disease (DD) is a highly heritable fibrotic disorder of the hand with incompletely understood etiology. A number of genetic loci, including Wnt signaling members, have been previously identified. Our overall aim was to identify novel genetic loci, to prioritize genes within the loci for functional studies, and to assess genetic correlation with associated disorders. We performed a meta-analysis of six DD genome-wide association studies from three European countries and extensive bioinformatic follow-up analyses...
January 3, 2024: Nature Communications
https://read.qxmd.com/read/38161884/internet-search-trends-for-common-hand-surgery-diagnoses
#16
JOURNAL ARTICLE
William Kilgallen, Brandon Earp, Dafang Zhang
PURPOSE: The internet is a common resource for patients seeking health information. Trends in internet search interests for common hand surgery diagnoses and their seasonal variations have not been previously studied. The objectives of this study were (1) to describe the temporal trends in internet search interest for common hand surgery diagnoses in the recent five-year time period and (2) to assess seasonal variations in search term interest. METHODS: An internet-based study of internet search term interest of 10 common hand surgery diagnoses was performed using Google Trends (Google, Inc...
November 2023: Curēus
https://read.qxmd.com/read/38106945/collagenase-treatment-for-dupuytren-contracture-of-the-metacarpophalangeal-joint-after-arthrodesis-of-the-proximal-interphalangeal-joint
#17
Calista S Stevens, Colin Pavano, Craig M Rodner
Successful collagenase (Xiaflex) treatment of Dupuytren's contracture in the metacarpophalangeal joint is possible in the presence of previous arthrodesis of the proximal interphalangeal joint.
November 2023: Journal of hand surgery global online
https://read.qxmd.com/read/38106934/patient-reported-outcome-in-dupuytren-s-disease-treated-with-fasciectomy-collagenase-or-needle-fasciotomy-a-swedish-registry-study
#18
JOURNAL ARTICLE
Madeleine Harryson, Martin Eklund, Marianne Arner, Stephan Wilbrand
PURPOSE: This registry study compares the patient-reported outcomes of 3 treatments for Dupuytren´s disease: open fasciectomy (OF), collagenase injection (CCH) and percutaneous needle fasciotomy (PNF). METHODS: From the Swedish national quality registry for hand surgery (HAKIR) we included 2,585 procedures (in 2,414 patients): 1,200 treatments were OF, 918 CCH, and 467 PNF. The choice between CCH and PNF varied mainly because of regional differences in reimbursement of CCH...
November 2023: Journal of hand surgery global online
https://read.qxmd.com/read/38074359/retracted-risk-factors-for-dupuytren-s-contracture-a-case-control-study
#19
Computational Intelligence And Neuroscience
[This retracts the article DOI: 10.1155/2022/3574037.].
2023: Computational Intelligence and Neuroscience
https://read.qxmd.com/read/38073413/isolated-distal-interphalangeal-joint-flexion-contracture-of-the-ring-finger-due-to-dupuytren-disease-a-case-report
#20
JOURNAL ARTICLE
Hiroki Yamada, Akira Ikumi, Yuichi Yoshii, Masashi Yamazaki
Dupuytren disease is a common benign fibromatosis of the palmar and finger fascia caused by pathological cord formation. As both the retrovascular and lateral cords are jointly responsible for the flexion contracture of the distal interphalangeal (DIP) joint, isolated DIP joint contracture caused by Dupuytren disease is rare. We present a 34-year-old right-hand-dominant male patient with a 6-month history of an isolated DIP joint flexion contracture in the right ring finger due to Dupuytren disease. Surgical fasciotomy of the retrovascular cord improved the contracture without adverse events...
December 5, 2023: Journal of Hand Surgery Asian-Pacific Volume
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