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Juliana Marioni, María Angel da Silva, José Luis Cabrera, Susana C Núñez Montoya, María Gabriela Paraje
BACKGROUND: Candida tropicalis is increasingly becoming among the most commonly isolated pathogens causing fungal infections with an important biofilm-forming capacity. PURPOSE: This study addresses the antifungal effect of rubiadin (AQ1) and rubiadin 1-methyl ether (AQ2), two photosensitizing anthraquinones (AQs) isolated from Heterophyllaea pustulata, against C. tropicalis biofilms, by studying the cellular stress and antioxidant response in two experimental conditions: darkness and irradiation...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Ruobin Dai, Xiaoguang Chen, Ying Luo, Puyue Ma, Shengsheng Ni, Xinyi Xiang, Gang Li
Inhibitory effect of azo dyes on anaerobic methanogenic wastewater treatment (AMWT) has been studied mainly focusing on biological toxicity in the batch test with simulated sole co-substrate. Detailed information on inhibitory effect and mechanism of azo dyes during the long-term operation with real complex co-substrate is limited. Moreover, whether redox mediator (RM) could remediate the inhibition is still unclear in previous studies, especially under the complex scenario. In this study, the real textile wastewater with alternative concentrations of azo dyes (0-600 mg/L) were used to operate a lab-scale high-rate anaerobic methanogenic bioreactor for 127 days, and 50 μM anthraquinone-2-sulfonate (AQS) as RM was added at the last period of operation...
November 1, 2016: Water Research
Lipeng Gu, Bin Huang, Zhixiang Xu, Xiaodong Ma, Xuejun Pan
Steroid estrogen in natural waters may be biodegraded by quinone-reducing bacteria, dissolved organic matter (DOM) may serve as a terminal electron acceptor in this process. The influence of temperature, pH, dissolved oxygen and light illumination on the reduction efficiency of anthraquinone-2-disulfonate (AQS) was investigated using 17β-estradiol (E2) as the target species. The optimum reduction conditions were found to be in the dark under anaerobic conditions at pH 8.0 and 30 °C. Quinone-reducing bacteria can use the quinone structure of DOM components as a terminal electron acceptor coupling with microbial growth to promote biodegradation...
November 2016: Environmental Pollution
Angela T Nguyen, Jace W Jones, Miguel Cámara, Paul Williams, Maureen A Kane, Amanda G Oglesby-Sherrouse
Cystic fibrosis (CF) is a hereditary disease that predisposes individuals to pulmonary dysfunction and chronic infections. Early infection of the CF lung with Staphylococcus aureus is common, while Pseudomonas aeruginosa becomes dominant as disease progresses. Emergence of P. aeruginosa likely depends on the action of multiple 2-alkyl-4-(1H)-quinolones (AQ) secreted by this organism. We recently showed that antimicrobial activity against S. aureus is enhanced by iron depletion and is dependent upon multiple AQ metabolites...
2016: Frontiers in Microbiology
Kazuya Kobayashi, Yasushi Miyaguni
Parthenogenesis is a relatively rare reproductive mode in nature compared to sex. In social insects, the evolution of parthenogenesis has a notable impact on their life histories. Some termites with parthenogenetic ability produce numerous non-dispersing supplementary queens asexually, whereas other castes are produced via sexual reproduction. This asexual queen succession (AQS) system is adaptive because hundreds of the asexual queens improve the reproductive potential of the colony and maintain the genetic diversity within the colony...
2016: Scientific Reports
Bin Huang, Lipeng Gu, Huan He, Zhixiang Xu, Xuejun Pan
This study investigated the simultaneous transformation of Cr(vi) via a closely coupled biotic and abiotic pathway in an anaerobic system of quinone-reducing bacteria/dissolved organic matters (DOM)/Fe(iii). Batch studies were conducted with quinone-reducing bacteria to assess the influences of sodium formate (NaFc), electron shuttling compounds (DOM) and the Fe(iii) on Cr(vi) reduction rates as these chemical species are likely to be present in the environment during in situ bioremediation. Results indicated that the concentration of sodium formate and anthraquinone-2-sodium sulfonate (AQS) had apparently an effect on Cr(vi) reduction...
September 14, 2016: Environmental Science. Processes & Impacts
Qian Di, Sebastian Rowland, Petros Koutrakis, Joel Schwartz
Ground-level ozone is an important atmospheric oxidant, which exhibits considerable spatial and temporal variability in its concentration level. Existing modeling approaches for ground-level ozone include chemical transport models, land-use regression, Kriging, and data fusion of chemical transport models with monitoring data. Each of these methods has both strengths and weaknesses. Combining those complementary approaches could improve model performance. Meanwhile, satellite-based total column ozone, combined with ozone vertical profile, is another potential input...
June 22, 2016: Journal of the Air & Waste Management Association
I B Wissink, C Colonnesi, G J J M Stams, M Hoeve, J J Asscher, M J Noom, N Polderman, M G Kellaert-Knol
The Attachment Insecurity Screening Inventory (AISI) 2-5 years is a parent-report questionnaire for assessing attachment insecurity in preschoolers. Validity and reliability of the AISI 2-5 years were examined in a general sample (n = 429) and in a clinical sample (n = 71). Confirmatory factor analysis (CFA) confirmed a three-factor model of avoidant, ambivalent/resistant and disorganized attachment, and one higher-order factor of total attachment insecurity. Multi-group CFA indicated measurement invariance across mothers and fathers, and across the general and clinical population sample...
2016: Child Indicators Research
Denis Fournier, Simon Hellemans, Robert Hanus, Yves Roisin
Termite colonies are typically founded by a pair of sexually reproducing dispersers, which can sometimes be replaced by some of their offspring. Some Reticulitermes and Embiratermes species routinely practice asexual queen succession (AQS): the queen is replaced by neotenic daughters produced by parthenogenesis, which mate with the primary king. Here, to cast light on the evolution of AQS, we investigated another candidate species, Cavitermes tuberosus (Termitinae). Of 95 nests, 39 contained a primary queen and 28 contained neotenic females (2-667 individuals), usually with the primary king...
June 15, 2016: Proceedings. Biological Sciences
Yuanqing Ding, Haining Liu, Babu L Tekwani, N P Dhammika Nanayakkara, Ikhlas A Khan, Larry A Walker, Robert J Doerksen
The administration of primaquine (PQ), an essential drug for the treatment and radical cure of malaria, can lead to methemoglobin formation and life-threatening hemolysis for glucose-6-phosphate dehydrogenase deficient patients. The ionization potential (IP, a quantitative measure of the ability to lose an electron) of the metabolites generated by antimalarial 8-aminoquinoline (8-AQ) drugs like PQ has been believed to be correlated in part to this methemoglobinemia hemotoxicity: the lower the IP of an 8-AQ derivative, the higher the concentration of methemoglobin generated...
July 18, 2016: Chemical Research in Toxicology
Weihuang Zhu, Mengran Shi, Dan Yu, Chongxuan Liu, Tinglin Huang, Fengchang Wu
The characteristics and kinetics of redox transformation of a redox mediator, anthraquinone-2-sulfonate (AQS), during microbial goethite reduction by Shewanella decolorationis S12, a dissimilatory iron reduction bacterium (DIRB), were investigated to provide insights into "redox mediator-iron oxide" interaction in the presence of DIRB. Two pre-incubation reaction systems of the "strain S12- goethite" and the "strain S12-AQS" were used to investigate the dynamics of goethite reduction and AQS redox transformation...
2016: Scientific Reports
Carrie V Breton, Wendy J Mack, Jin Yao, Kiros Berhane, Milena Amadeus, Fred Lurmann, Frank Gilliland, Rob McConnell, Howard N Hodis, Nino Künzli, Ed Avol
Exposure to ambient air pollutants increases risk for adverse cardiovascular health outcomes in adults. We aimed to evaluate the contribution of prenatal air pollutant exposure to cardiovascular health, which has not been thoroughly evaluated. The Testing Responses on Youth (TROY) study consists of 768 college students recruited from the University of Southern California in 2007-2009. Participants attended one study visit during which blood pressure, heart rate and carotid artery arterial stiffness (CAS) and carotid artery intima-media thickness (CIMT) were assessed...
2016: PloS One
Imke Rodis, Cynthia Vanessa Mahr, Michael K Fehrenbach, Jürgen Meixensberger, Andreas Merkenschlager, Matthias K Bernhard, Stefan Schob, Ulrich Thome, Robin Wachowiak, Franz W Hirsch, Ulf Nestler, Matthias Preuss
UNLABELLED: Treatment of aqueductal stenosis (AQS) has undergone several paradigm shifts during the past decades. Currently, endoscopic ventriculostomy (ETV) is recommended as treatment of choice. Several authors have addressed the issue of variable ETV success rates depending on age and pathogenetic factors. However, success rates have usually been defined as "ETV non-failure." The aim of the study was a retrospective analysis of radiological and neurological treatment response after ETV or VP-shunting (VPS) in age-dependent subtypes of AQS...
April 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Pamela L St Jean, Zhengyu Xue, Nick Carter, Gavin C K W Koh, Stephan Duparc, Maxine Taylor, Claire Beaumont, Alejandro Llanos-Cuentas, Ronnatrai Rueangweerayut, Srivicha Krudsood, Justin A Green, Justin P Rubio
BACKGROUND: Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria. PQ is the only FDA-approved medicine for preventing relapsing Plasmodium vivax infection and TQ is currently in phase 3 clinical trials for the same indication. Recent studies have provided evidence that cytochrome P450 (CYP) metabolism via CYP2D6 plays a role in PQ efficacy against P. vivax and have suggested that this effect may extend to other 8-AQs, including TQ...
2016: Malaria Journal
Z Cui, X M Duan, B Q Yao, H Y Yang, J Li, J H Yuan, T Y Dai, C Y Li, Y B Pan
A doubly Q-switched (DQS) Ho:LuAG laser resonantly pumped by a 1.91-μm laser was first presented with an acoustic-optic modulator (AOM) and a Cr2+:ZnS saturable absorber. A comparison among the active Q-switched (AQS), passively Q-switched (PQS), and DQS laser performances was carried out. The maximum continuous wave (CW) output power of 6 W with the central wavelength of 2100.65 nm was obtained at an incident pump power of 35.2 W. Compared with CW laser, the AQS, PQS, and DQS lasers shared the same central wavelength of 2098...
December 1, 2015: Applied Optics
Lei Yu, Shi Wang, Qing-Wen Tang, Ming-Yue Cao, Jia Li, Kun Yuan, Ping Wang, Wen-Wei Li
Klebsiella oxytoca GS-4-08 is capable of azo dye reduction, but its quinone respiration and Fe(III) reduction abilities have not been reported so far. In this study, the abilities of this strain were reported in detail for the first time. As the biotic reduction of Fe(III) plays an important role in the biogeochemical cycles, two amorphous Fe(III) oxides were tested as the sole electron acceptor during the anaerobic respiration of strain GS-4-08. For the reduction of goethite and hematite, the biogenic Fe(II) concentrations reached 0...
May 2016: Applied Microbiology and Biotechnology
Aaron Butt, Nigel Halliday, Paul Williams, Helen S Atkins, Gregory J Bancroft, Richard W Titball
Kynurenine formamidase (KynB) forms part of the kynurenine pathway which metabolises tryptophan to anthranilate. This metabolite can be used for downstream production of 2-alkyl-4-quinolone (AQ) signalling molecules that control virulence in Pseudomonas aeruginosa. Here we investigate the role of kynB in the production of AQs and virulence-associated phenotypes of Burkholderia pseudomallei K96243, the causative agent of melioidosis. Deletion of kynB resulted in reduced AQ production, increased biofilm formation, decreased swarming and increased tolerance to ciprofloxacin...
April 2016: Research in Microbiology
Marija N Todorović, Mirjana D Perišić, Maja M Kuzmanoski, Andreja M Stojić, Andrej I Sostarić, Zoran R Mijić, Slavica F Rajšić
The aim of this study was to assess PM10 pollution level and estimate required source emission reduction in Belgrade area, the second largest urban center in the Balkans. Daily mass concentrations and trace metal content (As, Cd, Cr, Mn, Ni, Pb) of PM10 were evaluated for three air quality monitoring sites of different types: urban-traffic (Slavija), suburban (Lazarevac) and rural (Grabovac) under the industrial influence, during the period of 2012-13. Noncompliance with current Air Quality Standards (AQS) was noticeable: annual means were higher than AQS at Slavija and Lazarevac, and daily frequency threshold was exceeded at all three locations...
2015: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
G Zengin, N S Degirmenci, L Alpsoy, A Aktumsek
OBJECTIVE: The aim of this work was to investigate the cytotoxic, antioxidative, and enzyme inhibition effects of alizarin, quinizarin, and purpurin, which are anthraquinones (AQ). METHODS: Cytotoxic effects were evaluated with cell inhibition rate by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assay. Different chemical assays, including free radical scavenging activity (1,1-diphenyl-2-picrylhydrazyl and 2,2-azino-bis(3-ethylbenzothiazloine-6-sulfonic acid)), phosphomolybdenum and reducing power (ferric reducing antioxidant power and cupric ion reducing activity), were used to evaluate the antioxidant properties...
May 2016: Human & Experimental Toxicology
Qing Xu, Zheng-hao Hou, Xiu-lei Tian, Chun-mei Niu, Yan-kai Guo, Jing Lian, Jian-bo Guo
Anthraquinone sodium sulfonate (AQS) was immobilized on polyethylene terephthalate (PET) by chemical synthesis, forming quinone functional polymer biocarrier (PET-AQS), and its characteristics in biodenitrification catalysis were analyzed. Quinone group was demonstrated to be successfully immobilized on the surface of the polymer and the concentration of immobilized quinone was 0.140 6 mmol x g(-1) by Attenuated Total Reflectance Spectrometry (ATR-IR) and Energy Dispersive Spectrometry (EDS). The PET-AQS could accelerate biodenitrification...
April 2015: Huan Jing Ke Xue= Huanjing Kexue
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