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https://www.readbyqxmd.com/read/29722462/the-alkylquinolone-repertoire-of-pseudomonas-aeruginosa-is-linked-to-structural-flexibility-of-the-fabh-like-pqs-biosynthesis-enzyme-pqsbc
#1
Florian Witzgall, Tobias Depke, Michael Hoffmann, Martin Empting, Mark Brönstrup, Rolf Müller, Wulf Blankenfeldt
Pseudomonas aeruginosa is a bacterial pathogen that causes life-threatening infections in immunocompromised patients. It produces a large armory of saturated and mono-unsaturated 2-alkyl-4(1H)-quinolones (AQs) or AQ N-oxides (AQNOs) that serve as signaling molecules to control the production of virulence factors, are involved in membrane vesicle formation and iron chelation and also have e.g. antibiotic properties. It has been shown that the FabH-like heterodimeric enzyme PqsBC catalyzes the last step in the biosynthesis of the most abundant AQ congener 2-heptyl-4(1H)-quinolone (HHQ) by condensing octanoyl-coenzyme A (CoA) with 2-aminobenzoylacetate (2-ABA), but the basis for the large number of other AQs/AQNOs produced by P...
May 3, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29718276/the-expanding-horizon-of-alkyl-quinolone-signalling-and-communication-in-polycellular-interactomes
#2
F Jerry Reen, Gerard P McGlacken, Fergal O'Gara
Population dynamics within natural ecosystems is underpinned by microbial diversity and the heterogeneity of host-microbe and microbe-microbe interactions. Small molecule signals that intersperse between species have been shown to govern many virulence-related processes in established and emerging pathogens. Understanding the capacity of microbes to decode diverse languages and adapt to the presence of 'non-self' cells will provide an important new direction to the understanding of the 'polycellular' interactome...
May 1, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29708862/assessment-of-nitrogen-oxides-and-ground-level-ozone-behavior-in-a-dense-air-quality-station-network-case-study-in-the-lesser-antilles-arc
#3
Thomas Plocoste, Jean-François Dorville, Stéphanie Monjoly, Sandra Jacoby-Koaly, Maïna André
This paper presents a study on ground-level ozone (O3 ), nitrogen oxides (NOx  = NO + NO2 ) concentration and their variabilities in the ambient air of three sites of a tropical archipelago moderately urbanized. Statistical analysis were performed on quite complete (> 80%) five years of measurements (2008-2012). There are few studies on those pollutants and their seasonal behavior in the Caribbean area where pollution level and cities configuration are different from megacities. Analyses are focus on pollutant variations at the scale of the day, the week and the seasons using hourly data...
April 30, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29672238/long-term-meteorologically-independent-trend-analysis-of-ozone-air-quality-at-an-urban-site-in-the-greater-houston-area
#4
Venkata S V Botlaguduru, Raghava R Kommalapati, Ziaul Huque
The Houston-Galveston-Brazoria (HGB) area of Texas has a history of ozone exceedances and is currently classified under moderate nonattainment status for the 2008 8-hr ozone standard of 75 ppb. The HGB area is characterized by intense solar radiation, high temperature, and humidity, which influence day-to-day variations in ozone concentrations. Long-term air quality trends independent of meteorological influence need to be constructed for ascertaining the effectiveness of air quality management in this area...
April 19, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29649507/effects-of-anthraquinones-from-cassia-occidentalis-l-on-ovalbumin-induced-airways-inflammation-in-a-mouse-model-of-allergic-asthma
#5
Wenhao Xu, Meiqun Hu, Qihong Zhang, Jingbo Yu, Weike Su
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia occidentalis Linn. is a traditional ayruvedic edible shrub containing anthraquinones (AQs) as the principle active constituents. In folk medicine, it has a variety of uses including treatment of whooping cough ('pertussis') and inflammatory diseases. Despite these applications, limited data are available to validate the effects of C. occidentalis AQs on airways inflammation in asthma. AIM OF THE STUDY: To explore the anti-inflammatory potential of AQs extracted from C...
April 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29539593/the-microbial-transformation-of-17%C3%AE-%C3%A2-estradiol-in-an-anaerobic-aqueous-environment-is-mediated-by-changes-in-the-biological-properties-of-natural-dissolved-organic-matter
#6
Lipeng Gu, Bin Huang, Chaochao Lai, Zhixiang Xu, Huan He, Xuejun Pan
Dissolved organic matter (DOM) is shown to act as an electron shuttle mediator which enhances the microbial degradation of steroid estrogens in natural water. Batch studies were conducted with 17β‑estradiol (E2), quinone-reducing bacteria, DOM, and Fe(III) as a terminal electron acceptor. The results show that anthraquinone‑2‑disulfonate (AQS) approximately doubles the microbial degradation of E2 by DOM alone. The effect decreases sharply at AQS concentrations above 1.0mmol·L-1 . Over three oxidation-reduction cycles, the electron-shuttling ability of AQS and the E2 biodegradation rate decreased step by step...
March 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29507088/the-pseudomonas-aeruginosa-prrf1-and-prrf2-small-regulatory-rnas-promote-2-alkyl-4-quinolone-production-through-redundant-regulation-of-the-antr-mrna
#7
Louise Djapgne, Subrata Panja, Luke K Brewer, Jonathan H Gans, Maureen A Kane, Sarah A Woodson, Amanda G Oglesby-Sherrouse
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that requires iron for growth and virulence. Under low-iron conditions, P. aeruginosa transcribes two highly identical (95%) small regulatory RNAs (sRNAs), PrrF1 and PrrF2, which are required for virulence in acute murine lung infection models. The PrrF sRNAs promote the production of 2-akyl-4(1 H )-quinolone metabolites (AQs) that mediate a range of biological activities, including quorum sensing and polymicrobial interactions. Here, we show that the PrrF1 and PrrF2 sRNAs promote AQ production by redundantly inhibiting translation of antR , which encodes a transcriptional activator of the anthranilate degradation genes...
May 15, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29421367/mothers-fathers-sons-and-daughters-are-there-sex-differences-in-the-organization-of-secure-base-behavior-during-early-childhood
#8
Carla Fernandes, Manuela Veríssimo, Ligia Monteiro, Marta Antunes, Brian E Vaughn, António J Santos
Recent empirical studies reporting sex differences in attachment relationships have prompted investigators to consider why and under what conditions such results might be observed. This study was designed to explore possibilities of identifying sex differences in the organization of attachment-relevant behavior during early childhood. Observations of 119 children (59 boys) with their mothers and (separately) with their fathers were completed and children were described using the AQS. Results indicated that girls and boys did not differ with respect to global attachment security but at more specific level analyses revealed differences between parents that reflected differences in the behaviors of girls vs...
February 2018: Infant Behavior & Development
https://www.readbyqxmd.com/read/29326881/interaction-of-anthraquinones-of-cassia-occidentalis-seeds-with-dna-and-glutathione
#9
Gati Krushna Panigrahi, Neeraj Verma, Nivedita Singh, Somya Asthana, Shailendra K Gupta, Anurag Tripathi, Mukul Das
Consumption of Cassia occidentalis (CO) seeds has been associated with the hepatomyoencephalopathy (HME) in children. Recently, we have characterized the toxic anthraquinones (AQs) such as Emodin, Rhein, Aloe-emodin, Chrysophanol and Physcion in CO seeds and detected these moieties in the bio fluids of CO poisoning cases. As AQs were detected in the serum of HME patients, their interaction with key biomolecules including protein, DNA and glutathione (GSH) is imperative. In this regard, we have previously reported the interaction of these AQs with serum albumin protein and their subsequent biological effects...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29319537/a-systematic-review-of-labour-pain-used-as-an-outcome-criterion-in-clinical-research
#10
Christian Dualé, Gaétan Breysse, Bruno Pereira
OBJECTIVES: Research on labour pain currently uses standard scores such as numerical scales as clinical outcomes, but no clear guidelines for such assessment have appeared since a review published in 1998. We wished to describe and estimate the quality of the methods used to assess and analyse such outcomes, in a systematic review of 215 comparative studies published since then, in 27 influential journals. METHODS: In addition to a complete description, we created for each study a composite "analysis quality score" (AQS) based on the methods of both measurement of pain/analgesia, and statistical analysis...
January 9, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29259562/early-adverse-caregiving-experiences-and-preschoolers-current-attachment-affect-brain-responses-during-facial-familiarity-processing-an-erp-study
#11
Melanie T Kungl, Ina Bovenschen, Gottfried Spangler
When being placed into more benign environments like foster care, children from adverse rearing backgrounds are capable of forming attachment relationships to new caregivers within the first year of placement, while certain problematic social behaviors appear to be more persistent. Assuming that early averse experiences shape neural circuits underlying social behavior, neurophysiological studies on individual differences in early social-information processing have great informative value. More precisely, ERP studies have repeatedly shown face processing to be sensitive to experience especially regarding the caregiving background...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29130161/detection-of-2-alkyl-4-quinolones-using-biosensors
#12
Matthew P Fletcher, Stephen P Diggle, Miguel Cámara, Paul Williams
2-Alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-hydroxyquinoline (HHQ) are quorum-sensing signal molecules. Here we describe two methods for AQ detection and quantification that employ thin-layer chromatography (TLC) and microtiter plate assays in combination with a lux-based Pseudomonas aeruginosa AQ biosensor strain. For TLC detection, organic solvent extracts of bacterial cells or spent culture supernatants are chromatographed on TLC plates, which are then dried and overlaid with the AQ biosensor...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29115023/secondary-queens-in-the-parthenogenetic-termite-cavitermes-tuberosus-develop-through-a-transitional-helper-stage
#13
Simon Hellemans, Denis Fournier, Robert Hanus, Yves Roisin
In termite species with asexual queen succession (AQS), parthenogenetically produced immatures mostly differentiate into secondary queens, called "neotenics." In order to elucidate the ontogenetic origin of neotenics in Cavitermes tuberosus (Termitidae: Termitinae), a neotropical termite with AQS, we investigated developmental pathways of offspring according to their sex and genetic origin using both morphometric and genetic tools. The caste system of C. tuberosus follows the classical pathway of Termitidae...
November 2017: Evolution & Development
https://www.readbyqxmd.com/read/29091715/antiquorum-sensing-antibiofilm-formation-and-cytotoxicity-activity-of-commonly-used-medicinal-plants-by-inhabitants-of-borabu-sub-county-nyamira-county-kenya
#14
Eric Omori Omwenga, Andreas Hensel, Susana Pereira, Alfred Anakalo Shitandi, Francisco M Goycoolea
Productions of various bacterial traits like production of virulence factors (e.g. toxins, enzymes), biofilm formation, luminescence among others, have been known to be controlled by quorum sensing (QS), a process that is dependent on chemical signals or autoinducers (AIs). Bacteria known to rely on such AIs are known to be virulent and tend to be resistant against various antimicrobial agents. Therefore, strategies aimed at the inhibition of QS pathways, are regarded as potential novel therapies in managing bacterial virulence hence reducing their ability to induce infections in humans...
2017: PloS One
https://www.readbyqxmd.com/read/29062001/combined-tddft-and-aim-insights-into-photoinduced-excited-state-intramolecular-proton-transfer-esipt-mechanism-in-hydroxyl-and-amino-anthraquinone-solution
#15
Daoyuan Zheng, Mingzhen Zhang, Guangjiu Zhao
Time-dependent density functional theory (TDDFT) and atoms in molecules (AIM) theory are combined to study the photoinduced excited state intramolecular proton transfer (ESIPT) dynamics for eight anthraquinones (AQs) derivatives in solution. The calculated absorption and emission spectra are consistent with the available experimental data, verifying the suitability of the theory selected. The systems with the excited-state exothermic proton transfer, such as 1-HAQ, 1,5-DHAQ and TFAQ, emit completely from transfer structure (T), while the reactions for those without ESIPT including 1,4-DHAQ and AAAQ appear to be endothermic...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042953/oral-colon-specific-drug-delivery-system-reduces-the-nephrotoxicity-of-rhubarb-anthraquinones-when-they-produce-purgative-efficacy
#16
Pei Liu, Hongwei Wei, Jinhua Chang, Guangxin Miao, Xigang Liu, Zhongsi Li, Liyan Liu, Xiangrong Zhang, Cuizhe Liu
Rhubarb is commonly used to treat constipation in China and anthraquinones (AQs) are the active components present in rhubarb. However, an increasing number of studies have reported that AQs induce nephrotoxicity. In the present study, rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) were prepared to determine whether RTFA-OCDD-GN could reduce the nephrotoxicity that occurs when AQs produce purgative efficacy. RTFA-OCDD-GN were prepared using pH-enzyme double-layer coating technology and the cumulative release rate of RTFA in RTFA-OCDD-GN was assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28865375/dramatic-enhancement-of-organics-degradation-and-electricity-generation-via-strengthening-superoxide-radical-by-using-a-novel-3d-aqs-ppy-gf-cathode
#17
Yan Zhang, Jinhua Li, Jing Bai, Linsen Li, Ligang Xia, Shuai Chen, Baoxue Zhou
A dramatic enhancement of organics degradation and electricity generation has been achieved in a wastewater fuel cell (WFC) system via strengthening superoxide radical with radical chain reaction by using a novel 3D anthraquinone/polypyrrole modified graphite felt (AQS/PPy-GF) cathode. The AQS/PPy-GF was synthesized by one-pot electrochemical polymerization method and used to in-situ generate superoxide radical by reducing oxygen under self-imposed electric field. Results showed that methyl orange (MO) were effectively degraded in AQS/PPy-GF/Fe(2+) system with a high apparent rate constant (0...
November 15, 2017: Water Research
https://www.readbyqxmd.com/read/28800554/anthraquinone-2-sulfonate-immobilized-to-conductive-polypyrrole-hydrogel-as-a-bioanode-to-enhance-power-production-in-microbial-fuel-cell
#18
Xinhua Tang, How Yong Ng
In this study, anthraquinone-2-sulfonate (AQS), a redox mediator, was covalently bound to conductive polypyrrole hydrogel (CPH) via electrochemical reduction of the in-situ-generated AQS diazonium salts. The porous structure and hydrophilic surface of this CPH/AQS anode enhanced biofilm formation while the AQS bound on the CPH/AQS anode worked as a redox mediator. The CPH/AQS bioanode reduced the charge transfer resistance from 28.3Ω to 4.1Ω while increased the maximum power density from 762±37mW/m(2) to 1919±69mW/m(2), compared with the bare anode...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28772219/poly-d-l-lactide-co-glycolide-nanoparticles-for-sustained-release-of-tacrolimus-in-rabbit-eyes
#19
Mohd Abul Kalam, Aws Alshamsan
Tacrolimus (TAC)-loaded Ploy-lactide-co-glycolide nanoparticles (PLGA-NPs) was developed by emulsification-diffusion method for topical ocular delivery in certain ocular conditions where therapeutic level of immunomodulator into eyes is required for sufficient duration. So, we optimized TAC-loaded PLGA-NPs with higher TAC payload. The mean particle-size and its distribution, polydispersity, zeta-potentials, morphology, drug encapsulation and loading capacity of NPs were analyzed. Transcorneal permeation through excised rabbit cornea revealed instant and controlled permeation of TAC from TAC-aqueous suspension (TAC-AqS) and from PLGA-NPs, respectively...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28763730/fine-particulate-matter-and-cardiovascular-disease-comparison-of-assessment-methods-for-long-term-exposure
#20
COMPARATIVE STUDY
Laura A McGuinn, Cavin Ward-Caviness, Lucas M Neas, Alexandra Schneider, Qian Di, Alexandra Chudnovsky, Joel Schwartz, Petros Koutrakis, Armistead G Russell, Val Garcia, William E Kraus, Elizabeth R Hauser, Wayne Cascio, David Diaz-Sanchez, Robert B Devlin
BACKGROUND: Adverse cardiovascular events have been linked with PM2.5 exposure obtained primarily from air quality monitors, which rarely co-locate with participant residences. Modeled PM2.5 predictions at finer resolution may more accurately predict residential exposure; however few studies have compared results across different exposure assessment methods. METHODS: We utilized a cohort of 5679 patients who had undergone a cardiac catheterization between 2002-2009 and resided in NC...
November 2017: Environmental Research
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