Alexander Maier, Moritz Braig, Katharina Jakob, Thomas Bienert, Michaela Schäper, Annette Merkle, Carolin Wadle, Marius Menza, Irene Neudorfer, István Bojti, Peter Stachon, Daniel Duerschmied, Ingo Hilgendorf, Timo Heidt, Christoph Bode, Karlheinz Peter, Karin Klingel, Dominik von Elverfeldt, Constantin von Zur Mühlen
MRI sensitivity for diagnosis and localization of early myocarditis is limited, although it is of central clinical interest. The aim of this project was to test a contrast agent targeting activated platelets consisting of microparticles of iron oxide (MPIO) conjugated to a single-chain antibody directed against ligand-induced binding sites (LIBS) of activated glycoprotein IIb/IIIa (= LIBS-MPIO). Myocarditis was induced by subcutaneous injection of an emulsion of porcine cardiac myosin and complete Freund's adjuvant in mice...
August 6, 2020: Scientific Reports